AiPD: Autoinhibited Protein Database

Q96PB8

Gene name	LRRC3B (LRP15, UNQ195/PRO221)
Protein name	Leucine-rich repeat-containing protein 3B
Names	Leucine-rich repeat protein 15
Species	Homo sapiens (Human)
KEGG Pathway	hsa:116135
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-84 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

8-84 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96PB8

Entry ID	Method	Resolution	Chain	Position	Source
5EMA	X-ray	132 A	B	252-259	PDB
AF-Q96PB8-F1	Predicted				AlphaFoldDB

137 variants for Q96PB8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA351960526 rs1230773978	2	N>S		No	ClinGen TOPMed
CA351960537 rs1179017514	4	V>L		No	ClinGen gnomAD
TCGA novel	5	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1342198795 CA351960553	6	L>P		No	ClinGen TOPMed
rs1265424915 CA351960562	7	W>C		No	ClinGen gnomAD
rs1453657703 CA351960572	9	T>S		No	ClinGen gnomAD
CA351960577 rs370610399	10	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs370610399 CA2289950	10	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
COSM84781 rs769780461 CA2289951	10	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773342091 CA2289952	13	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1169534610 CA351960601	14	M>T		No	ClinGen gnomAD
TCGA novel	18	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1440764085 CA351960634	19	Q>P		No	ClinGen gnomAD
rs1559376730 CA351960736	33	M>T		No	ClinGen Ensembl
CA351960764 rs1295394683	37	G>R		No	ClinGen gnomAD
CA72416837 rs1052976295	38	C>Y		No	ClinGen TOPMed
CA351960777 rs1171100167	39	L>V		No	ClinGen TOPMed
CA72416838 COSM1692482 rs916617530	41	S>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1308282665 CA351960805	43	S>C		No	ClinGen gnomAD
rs760414274 CA2289957	44	G>V		No	ClinGen ExAC TOPMed gnomAD
CA2289958 rs766228609	45	G>S		No	ClinGen ExAC gnomAD
rs566309719 CA2289959	45	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351960831 rs1559376782	48	V>I		No	ClinGen Ensembl
CA351960840 rs1260322046	49	T>N		No	ClinGen TOPMed
rs1214454656 CA351960863	52	N>S		No	ClinGen gnomAD
CA72416842 rs948032913	53	A>V		No	ClinGen Ensembl
CA72416843 rs1046704717	54	N>H		No	ClinGen Ensembl
TCGA novel	54	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	55	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351960893 rs1447656470 COSM1692483	57	E>K	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA351960894 rs1447656470	57	E>Q		No	ClinGen TOPMed gnomAD
CA351960902 rs1419982650	58	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	61	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749994595 CA2289962	61	D>G		No	ClinGen ExAC gnomAD
rs374191641 CA2289961	61	D>N		No	ClinGen ESP ExAC gnomAD
rs868070081 CA72416844	63	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA351960957 rs1460053458	66	T>I		No	ClinGen gnomAD
CA351960960 rs1559376847	67	V>D		No	ClinGen Ensembl
rs757960474 CA2289963	67	V>L		No	ClinGen ExAC gnomAD
CA351960969 rs1461487408	68	L>F		No	ClinGen gnomAD
TCGA novel	70	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351960977 rs1327375466	70	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA72416845 rs1053007491	72	D>E		No	ClinGen TOPMed
CA2289964 rs779876180	72	D>H		No	ClinGen ExAC gnomAD
TCGA novel	75	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs891544133 CA72416847	75	Q>R		No	ClinGen Ensembl
CA72416848 rs1011710148	77	T>I		No	ClinGen Ensembl
rs949280435 CA72416850	81	N>D		No	ClinGen TOPMed
rs367798469 CA2289965	81	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA351961054 rs1244259247	82	E>A		No	ClinGen gnomAD
CA72416851 rs865841768	82	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA351961060 rs1463103085	83	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	84	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288592459 CA351961088	86	D>E		No	ClinGen gnomAD
CA351961100 rs1363135172	88	H>L		No	ClinGen gnomAD
TCGA novel	88	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	93	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	98	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1175836219 CA351961180	100	I>N		No	ClinGen gnomAD
rs779945211 CA72416852	101	E>A		No	ClinGen Ensembl
CA351961190 rs1275190304	101	E>D		No	ClinGen gnomAD
rs1463445267 CA351961194	102	F>Y		No	ClinGen gnomAD
CA2289967 rs781567226	103	I>T		No	ClinGen ExAC gnomAD
COSM1043410 CA2289968 rs764546245	104	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA72416853 rs867930462	105	E>K		No	ClinGen Ensembl
CA72416854 rs889491208	109	K>E		No	ClinGen TOPMed
rs1486737127 CA351961251	110	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1170416847 CA351961256	111	V>E		No	ClinGen TOPMed
CA72416855 rs1019519887	111	V>I		No	ClinGen gnomAD
CA351961292 rs1026627648	116	Q>H		No	ClinGen TOPMed gnomAD
CA351961304 rs1236420358	118	L>R		No	ClinGen TOPMed
CA2289973 COSM1692484 rs146258223	122	D>N	skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA351961344 rs1433291714	124	R>L		No	ClinGen gnomAD
CA351961342 rs1433291714	124	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759744526 CA2289974	124	R>W		No	ClinGen ExAC TOPMed gnomAD
rs776555450 CA2289976	126	Q>R		No	ClinGen ExAC
rs761482645 CA2289977	129	H>P		No	ClinGen ExAC gnomAD
TCGA novel	131	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA72416857 rs984243636	135	N>D		No	ClinGen Ensembl
CA2289979 rs750339961	135	N>K		No	ClinGen ExAC gnomAD
CA72416860 rs969406430	137	K>M		No	ClinGen TOPMed gnomAD
CA72416859 rs969406430	137	K>R		No	ClinGen TOPMed gnomAD
CA351961450 rs1377921930	140	A>S		No	ClinGen TOPMed
rs868235124 CA72416861	146	P>L		No	ClinGen Ensembl
rs1575188089 CA351961492	146	P>S		No	ClinGen Ensembl
CA351961520 rs1352026072	150	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs753150343 CA2289985	154	Q>*		No	ClinGen ExAC gnomAD
CA2289987 rs778280761	160	M>I		No	ClinGen ExAC TOPMed gnomAD
rs749724681 CA2289988	161	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA351961629 rs1238396365	165	E>D		No	ClinGen TOPMed
TCGA novel	166	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296169098 CA351961652	169	N>D		No	ClinGen gnomAD
rs779020530 CA2289990	171	I>T		No	ClinGen ExAC gnomAD
rs1334251578 CA351961700	176	V>M		No	ClinGen gnomAD
rs761690621 CA2289994	178	D>E		No	ClinGen ExAC gnomAD
TCGA novel	178	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs946884716 CA72416864	181	A>D		No	ClinGen Ensembl
CA2289996 rs773287847	183	R>G		No	ClinGen ExAC
CA72416865 rs998100430	184	P>A		No	ClinGen TOPMed
rs1279254174 CA351961754	184	P>Q		No	ClinGen gnomAD
CA351961785 rs1212820384	189	A>T		No	ClinGen gnomAD
rs1270413454 CA351961792	190	N>D		No	ClinGen gnomAD
CA2290001 rs146526715	191	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2290002 rs752250087 COSM2151768	192	A>T	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1040665618 CA72416867	199	K>I		No	ClinGen gnomAD
TCGA novel	199	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2290006 rs200924005	200	K>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2290007 rs139556197	204	Y>D		No	ClinGen ESP ExAC gnomAD
rs781054615 CA72416869	206	M>V		No	ClinGen gnomAD
CA351961926 rs1371693507	210	M>V		No	ClinGen gnomAD
CA72416870 rs867210963	212	G>C		No	ClinGen Ensembl
rs746010738 CA2290008	214	F>L		No	ClinGen ExAC
rs758361679 CA351961966	215	T>I		No	ClinGen ExAC gnomAD
rs758361679 CA2290009	215	T>S		No	ClinGen ExAC gnomAD
rs1268262307 CA351961972	216	M>T		No	ClinGen gnomAD
CA72416871 rs867290980	219	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA351962009 rs956953900	222	V>I		No	ClinGen TOPMed
rs956953900 CA72416872	222	V>L		No	ClinGen TOPMed
rs749094552 CA2290015	226	R>K		No	ClinGen ExAC TOPMed gnomAD
CA72416873 rs868107552	229	Q>*		No	ClinGen Ensembl
CA2290017 rs774103753	229	Q>H		No	ClinGen ExAC gnomAD
rs1157621446 CA351962088	233	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM1043414 rs1421674966 CA351962087	233	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA351962104 rs1459915991	235	H>Q		No	ClinGen gnomAD
CA72416874 rs917994529	236	L>R		No	ClinGen TOPMed gnomAD
rs760377591 CA2290021 COSM1043415	237	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1315880750 CA351962119	238	Y>H		No	ClinGen gnomAD
CA2290023 rs763729953	243	P>A		No	ClinGen ExAC gnomAD
CA351962153 rs763729953	243	P>S		No	ClinGen ExAC gnomAD
CA351962170 rs1559377434	245	R>S		No	ClinGen Ensembl
CA351962175 rs1559377439	246	Q>P		No	ClinGen Ensembl
rs750855004 CA2290027	252	P>L		No	ClinGen ExAC gnomAD
rs1469253772 CA351962220	252	P>S		No	ClinGen gnomAD
CA351962228 rs1575188693	253	D>V		No	ClinGen Ensembl
rs1260034150 CA351962231	254	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA351962245 rs1479283075	255	I>M		No	ClinGen TOPMed gnomAD
rs758512026 CA2290028	258	V>M		No	ClinGen ExAC gnomAD

No associated diseases with Q96PB8

6 regional properties for Q96PB8

Type	Name	Position	InterPro Accession
domain	Leucine-rich repeat N-terminal domain	33 - 68	IPR000372
repeat	Leucine-rich repeat	69 - 111	IPR001611-1
repeat	Leucine-rich repeat	114 - 136	IPR001611-2
repeat	Leucine-rich repeat, typical subtype	67 - 86	IPR003591-1
repeat	Leucine-rich repeat, typical subtype	87 - 110	IPR003591-2
repeat	Leucine-rich repeat, typical subtype	115 - 135	IPR003591-3

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
extracellular matrix	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6H789	LRRC3B	Leucine-rich repeat-containing protein 3B	Bos taurus (Bovine)	PR
Q8IWK6	ADGRA3	Adhesion G protein-coupled receptor A3	Homo sapiens (Human)	PR
Q86UN2	RTN4RL1	Reticulon-4 receptor-like 1	Homo sapiens (Human)	PR
Q96FE5	LINGO1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Homo sapiens (Human)	PR
Q7TT36	Adgra3	Adhesion G protein-coupled receptor A3	Mus musculus (Mouse)	PR
Q8VCH9	Lrrc3b	Leucine-rich repeat-containing protein 3B	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MNLVDLWLTR	SLSMCLLLQS	FVLMILCFHS	ASMCPKGCLC	SSSGGLNVTC	SNANLKEIPR
70	80	90	100	110	120
DLPPETVLLY	LDSNQITSIP	NEIFKDLHQL	RVLNLSKNGI	EFIDEHAFKG	VAETLQTLDL
130	140	150	160	170	180
SDNRIQSVHK	NAFNNLKARA	RIANNPWHCD	CTLQQVLRSM	ASNHETAHNV	ICKTSVLDEH
190	200	210	220	230	240
AGRPFLNAAN	DADLCNLPKK	TTDYAMLVTM	FGWFTMVISY	VVYYVRQNQE	DARRHLEYLK
250
SLPSRQKKAD	EPDDISTVV