Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q96P09
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1XB0 | X-ray | 220 A | A/B/C/D/E/F | 1-95 | PDB |
| 1XB1 | X-ray | 270 A | A/B/C/D/E/F | 1-95 | PDB |
| AF-Q96P09-F1 | Predicted | AlphaFoldDB |
5 variants for Q96P09
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_055944 rs35880972 |
156 | A>T | No |
UniProt dbSNP |
|
|
VAR_055945 rs34092035 |
165 | L>S | No |
UniProt dbSNP |
|
|
rs8109165 VAR_028282 |
196 | H>Y | No |
UniProt dbSNP |
|
|
VAR_055946 rs35700345 |
225 | A>T | No |
UniProt dbSNP |
|
|
VAR_055947 rs34683072 |
225 | A>V | No |
UniProt dbSNP |
No associated diseases with Q96P09
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| metal ion binding | Binding to a metal ion. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90660 | ITA | Inhibitor of apoptosis protein | Gallus gallus (Chicken) | SS |
| Q95M72 | BIRC8 | Baculoviral IAP repeat-containing protein 8 | Pan troglodytes (Chimpanzee) | PR |
| A1E2V0 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Homo sapiens (Human) | SS |
| Q13490 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | Homo sapiens (Human) | EV |
| O08863 | Birc3 | Baculoviral IAP repeat-containing protein 3 | Mus musculus (Mouse) | SS |
| Q62210 | Birc2 | Baculoviral IAP repeat-containing protein 2 | Mus musculus (Mouse) | SS |
| O62640 | PIAP | Putative inhibitor of apoptosis | Sus scrofa (Pig) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGYEARLIT | FGTWMYSVNK | EQLARAGFYA | IGQEDKVQCF | HCGGGLANWK | PKEDPWEQHA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KWYPGCKYLL | EEKGHEYINN | IHLTRSLEGA | LVQTTKKTPS | LTKRISDTIF | PNPMLQEAIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MGFDFKDVKK | IMEERIQTSG | SNYKTLEVLV | ADLVSAQKDT | TENELNQTSL | QREISPEEPL |
| 190 | 200 | 210 | 220 | 230 | |
| RRLQEEKLCK | ICMDRHIAVV | FIPCGHLVTC | KQCAEAVDRC | PMCSAVIDFK | QRVFMS |