Q96NX5
SS
Gene name |
CAMK1G (CLICK3, VWS1) |
Protein name |
Calcium/calmodulin-dependent protein kinase type 1G |
Names |
CaM kinase I gamma, CaM kinase IG, CaM-KI gamma, CaMKI gamma, CaMKIG, CaMK-like CREB kinase III, CLICK III |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:57172 |
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. In human CAMK1, the autoinhibitory region contains two helical structures (αR1 and αR2) and includes a pseudosubstrate sequence within it. The αR2 helix is at the N-terminal of CaM-binding domain. The αR1 interacts with the catalytic core and αR2 interacts with the ATP-binding region of CAMK1 for autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
23-277 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
163-184 (Activation loop from InterPro)
Target domain |
23-277 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yuan T et al. (2004) "Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I", Archives of biochemistry and biophysics, 421, 192-206
- Goldberg J et al. (1996) "Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I", Cell, 84, 875-87
- Stull JT et al. (2011) "Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle", Archives of biochemistry and biophysics, 510, 120-8
- Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426
- Akita T et al. (2018) "De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders", Annals of clinical and translational neurology, 5, 280-296
- Yang E et al. (1999) "Structural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II", The Journal of biological chemistry, 274, 26199-208
- Shohat G et al. (2002) "The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases", Biochimica et biophysica acta, 1600, 45-50
- Cohen O et al. (1997) "DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity", The EMBO journal, 16, 998-1008
- Shohat G et al. (2001) "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism", The Journal of biological chemistry, 276, 47460-7
- Shani G et al. (2001) "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding", The EMBO journal, 20, 1099-113
- Inbal B et al. (2000) "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis", Molecular and cellular biology, 20, 1044-54
- Cheng L et al. (2022) "DCLK1 autoinhibition and activation in tumorigenesis", Innovation (Cambridge (Mass.)), 3, 100191
Autoinhibited structure
Activated structure
2 structures for Q96NX5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2JAM | X-ray | 170 A | A/B | 18-316 | PDB |
| AF-Q96NX5-F1 | Predicted | AlphaFoldDB |
320 variants for Q96NX5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA1374366 rs755683128 |
2 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA1374367 rs140469539 |
3 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374369 rs749190689 |
3 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374368 rs749190689 |
3 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778596149 CA1374370 |
4 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs1314604551 CA344566803 |
8 | D>Y | No |
ClinGen gnomAD |
|
|
rs777060962 CA1374373 |
9 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs576418443 CA1374372 |
9 | C>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs138495087 CA1374374 |
10 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA1374376 rs200386679 |
12 | W>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA36730224 rs865788009 |
16 | T>A | No |
ClinGen Ensembl |
|
|
rs970626616 CA36730229 |
17 | T>I | No |
ClinGen TOPMed |
|
|
rs1317258358 CA344567014 |
18 | N>S | No |
ClinGen TOPMed |
|
|
CA1374380 rs148219739 |
20 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374378 rs375301374 |
20 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs750092537 CA1374382 |
26 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs760257403 CA1374383 |
28 | V>M | No |
ClinGen ExAC |
|
|
CA344567195 rs1186728039 |
29 | L>R | No |
ClinGen gnomAD |
|
|
CA1374384 rs765907363 |
30 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA344568054 rs1571779203 |
32 | G>R | No |
ClinGen Ensembl |
|
|
rs1213345049 CA344568069 |
34 | F>S | No |
ClinGen gnomAD |
|
|
rs146389830 CA1374408 |
38 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1263923014 CA344568095 |
38 | F>Y | No |
ClinGen TOPMed |
|
|
CA344568120 rs1571779237 |
42 | Q>* | No |
ClinGen Ensembl |
|
|
rs543976196 CA1374410 |
43 | R>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1374412 rs563094009 |
48 | L>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA344568161 rs1484580761 |
48 | L>H | No |
ClinGen TOPMed gnomAD |
|
|
rs778796137 CA1374414 |
49 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs748689663 CA1374415 |
50 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA344568183 rs1571779259 |
52 | K>R | No |
ClinGen Ensembl |
|
|
rs747415736 CA1374418 |
54 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs773689930 CA1374417 |
54 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374419 rs771198006 |
55 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344568210 rs1319168163 |
56 | K>T | No |
ClinGen gnomAD |
|
|
rs1344804746 CA344568225 |
58 | P>L | No |
ClinGen gnomAD |
|
|
CA36734039 rs541677675 |
58 | P>S | No |
ClinGen Ensembl |
|
|
rs1428767509 CA344568230 |
59 | A>V | No |
ClinGen gnomAD |
|
|
CA1374421 rs759054187 |
61 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs145309971 CA1374420 COSM271146 |
61 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA1374422 rs764833638 |
62 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344568244 rs764833638 |
62 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762527676 CA1374424 |
64 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs778787113 CA344568297 |
69 | I>N | No |
ClinGen TOPMed gnomAD |
|
|
CA36734052 rs778787113 |
69 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA344568302 rs1464975170 |
70 | A>T | No |
ClinGen TOPMed |
|
|
rs372707538 CA36734063 |
71 | V>E | No |
ClinGen ESP TOPMed |
|
|
rs751536292 CA1374426 |
71 | V>M | No |
ClinGen ExAC |
|
|
CA344568318 rs1253070204 |
73 | K>E | No |
ClinGen gnomAD |
|
|
rs767156458 CA1374428 |
74 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA1374429 rs754098619 |
74 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1461034289 CA344568666 COSM1500656 |
74 | K>N | lung [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA344568747 rs1571781662 |
80 | I>T | No |
ClinGen Ensembl |
|
|
rs1328622195 CA344568814 |
87 | Y>H | No |
ClinGen gnomAD |
|
|
rs1486114545 CA344568822 |
88 | E>K | No |
ClinGen TOPMed |
|
|
CA1374451 rs752913572 |
92 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs758533189 CA1374452 |
94 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1438464501 CA344569552 |
100 | V>I | No |
ClinGen gnomAD |
|
|
rs1176068980 CA344569687 |
106 | F>S | No |
ClinGen gnomAD |
|
|
rs760454966 CA1374466 |
108 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374465 rs376036886 |
108 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374467 rs766150299 |
111 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs144255822 CA1374469 |
112 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM366001 rs144255822 CA1374468 |
112 | R>Q | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA344569804 rs1314268242 COSM1199463 |
112 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA344569890 rs1465880726 |
116 | T>I | No |
ClinGen gnomAD |
|
|
rs369359024 CA1374471 |
122 | L>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA344570086 rs1174663356 |
125 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1171132542 CA344570101 |
126 | Q>R | No |
ClinGen gnomAD |
|
|
rs757329417 CA1374472 |
127 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs781615396 CA1374473 |
128 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs141169338 COSM1199464 CA1374475 |
129 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA344570169 rs1381208455 |
130 | A>P | No |
ClinGen gnomAD |
|
|
CA36737489 rs76562658 |
132 | K>E | No |
ClinGen Ensembl |
|
|
rs1317940530 CA344570244 |
133 | Y>* | No |
ClinGen gnomAD |
|
|
CA344570344 rs1287292799 |
138 | G>V | No |
ClinGen TOPMed |
|
|
CA36737494 rs748976817 |
139 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1466273377 CA344570349 |
139 | I>V | No |
ClinGen gnomAD |
|
|
rs768376674 CA1374478 |
140 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA36737503 rs768376674 |
140 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1374744917 CA344570412 |
142 | R>K | No |
ClinGen gnomAD |
|
|
rs147371769 CA36737881 |
147 | E>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374501 rs147371769 |
147 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs770903249 CA1374502 |
149 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs1234309560 CA344570856 |
155 | E>V | No |
ClinGen TOPMed |
|
|
CA1374506 rs774446976 |
156 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs962736514 CA36737907 |
160 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs767522588 CA1374508 |
161 | M>K | No |
ClinGen ExAC gnomAD |
|
|
rs1558140443 CA344571037 |
163 | T>A | No |
ClinGen Ensembl |
|
|
CA1374510 rs760818427 |
168 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA344571155 rs1558140458 |
169 | K>R | No |
ClinGen Ensembl |
|
|
rs745333577 CA36737920 |
170 | M>V | No |
ClinGen Ensembl |
|
|
CA1374511 rs767035299 |
175 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1328333630 CA344571328 |
177 | S>T | No |
ClinGen TOPMed |
|
|
rs1408251332 CA344571360 |
179 | A>D | No |
ClinGen TOPMed |
|
|
rs1408251332 CA344571362 |
179 | A>G | No |
ClinGen TOPMed |
|
|
rs1409479540 CA344571358 |
179 | A>S | No |
ClinGen gnomAD |
|
|
CA1374514 rs765580376 |
184 | G>A | No |
ClinGen ExAC |
|
|
rs777172542 CA1374517 |
186 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1277325714 CA344571987 |
187 | A>V | No |
ClinGen TOPMed |
|
|
rs1357607231 CA344572002 |
190 | V>M | No |
ClinGen gnomAD |
|
|
rs1433037180 CA344572020 |
193 | Q>* | No |
ClinGen gnomAD |
|
|
rs1571785380 CA344572039 |
195 | P>R | No |
ClinGen Ensembl |
|
|
rs751606116 CA36738744 |
196 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1365114369 CA344572049 |
197 | S>G | No |
ClinGen gnomAD |
|
|
CA344572066 rs1398132058 |
199 | A>S | No |
ClinGen TOPMed |
|
|
CA344572114 COSM1929027 rs1349002035 |
206 | G>S | prostate [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA1374540 rs757176272 |
207 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749151931 CA1374541 |
208 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA1374542 rs768334520 |
210 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA1374557 rs780108701 |
214 | C>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144298174 CA1374558 |
216 | Y>* | No |
ClinGen ESP ExAC gnomAD |
|
|
rs372047332 CA1374560 |
218 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374561 rs747266239 |
218 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1323405995 CA344572530 |
220 | Y>C | No |
ClinGen TOPMed |
|
|
rs199812064 CA1374564 |
223 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344572606 rs1571786293 |
225 | S>A | No |
ClinGen Ensembl |
|
|
CA1374566 rs776077217 |
225 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374569 rs774645531 |
229 | E>G | No |
ClinGen ExAC |
|
|
rs769092278 CA1374568 |
229 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1356591445 CA344572720 |
232 | K>R | No |
ClinGen gnomAD |
|
|
rs762140202 CA1374570 |
235 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs767195803 CA1374571 |
235 | Y>S | No |
ClinGen ExAC |
|
|
CA36739508 rs1019025157 |
242 | F>S | No |
ClinGen TOPMed |
|
|
CA36739511 rs567514631 |
243 | W>* | No |
ClinGen gnomAD |
|
|
CA36739509 rs567514631 |
243 | W>C | No |
ClinGen gnomAD |
|
|
rs878869929 CA36739517 |
244 | D>G | No |
ClinGen gnomAD |
|
|
CA344572929 rs1355578721 |
244 | D>N | No |
ClinGen gnomAD |
|
|
CA344572939 rs878869929 |
244 | D>V | No |
ClinGen gnomAD |
|
|
CA1374573 rs760294215 |
246 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA1374574 rs765752817 |
248 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1393850353 CA344573469 |
252 | D>V | No |
ClinGen gnomAD |
|
|
rs35561962 VAR_040600 CA1374605 |
259 | E>Q | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA1374606 rs201972342 |
260 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1434206258 CA344573688 |
262 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA1374610 rs770539963 |
264 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769369395 CA1374613 |
265 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759185718 CA1374612 |
265 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs980743552 CA36740212 |
267 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1188444480 CA344573800 |
268 | C>G | No |
ClinGen gnomAD |
|
|
rs1422104646 CA344574316 |
277 | I>T | No |
ClinGen gnomAD |
|
|
CA344574324 rs370631457 |
278 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374639 rs765327727 |
279 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs778211724 CA1374642 |
285 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369181812 CA1374641 |
285 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA344574370 rs1195581708 |
286 | D>Y | No |
ClinGen TOPMed |
|
|
rs1026238276 CA36740918 |
287 | I>V | No |
ClinGen TOPMed |
|
|
CA1374644 rs140065354 |
289 | P>L | No |
ClinGen ESP ExAC |
|
|
rs1227936352 CA344574390 |
289 | P>S | No |
ClinGen gnomAD |
|
|
CA344574399 rs1326931098 |
290 | S>L | No |
ClinGen TOPMed |
|
|
CA344574423 rs1324043676 |
294 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1324043676 CA344574421 |
294 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
rs187124482 CA1374645 COSM903286 |
297 | K>N | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA344574523 rs1197902006 |
302 | S>G | No |
ClinGen gnomAD |
|
|
rs373011174 CA1374647 |
302 | S>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779820981 CA1374648 |
302 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA1374649 rs377745870 |
304 | W>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374650 rs377745870 |
304 | W>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA344574565 rs1301867762 |
305 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1301867762 CA344574566 |
305 | R>T | No |
ClinGen TOPMed gnomAD |
|
|
CA344574664 rs763192311 |
307 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763192311 CA1374679 |
307 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374680 rs764099572 |
309 | N>Y | No |
ClinGen ExAC gnomAD |
|
|
CA1374682 rs374701638 |
310 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs750952662 CA1374684 |
314 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA1374683 rs367925085 |
314 | V>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA1374686 rs756559169 |
315 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs756559169 CA1374685 |
315 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1195250957 CA344574775 |
316 | H>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1195250957 CA344574777 |
316 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA344574783 rs1427607438 |
317 | M>L | No |
ClinGen gnomAD |
|
|
CA1374687 rs150063130 |
318 | R>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA344574812 rs1320455959 |
319 | K>R | No |
ClinGen TOPMed |
|
|
CA1374690 rs747734197 |
321 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs145387182 CA1374692 |
322 | M>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs145387182 CA1374693 |
322 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200699828 CA1374694 |
323 | N>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA344574912 rs780912545 |
325 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745624571 CA1374697 |
326 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768959300 CA1374699 |
326 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374701 rs772219308 |
327 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762009520 CA1374700 |
327 | P>S | No |
ClinGen ExAC |
|
|
rs11119315 VAR_020530 CA1374704 |
329 | V>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA344574962 rs1478490067 |
330 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA1374705 rs776808728 COSM903287 |
330 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs759788204 CA1374706 |
331 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1571788966 CA344574983 |
333 | V>G | No |
ClinGen Ensembl |
|
|
rs148199770 CA36741177 |
334 | E>D | No |
ClinGen ESP TOPMed |
|
|
CA1374710 rs777200877 |
334 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA1374709 rs752282907 |
334 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752282907 CA1374708 |
334 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344574995 rs1456061643 |
335 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA344575001 rs1558142827 |
336 | R>K | No |
ClinGen Ensembl |
|
|
CA344575008 rs138107739 |
336 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA36741189 rs568676041 |
337 | P>L | No |
ClinGen 1000Genomes |
|
|
CA1374714 rs745739420 |
340 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1209953004 CA344575070 |
342 | A>T | No |
ClinGen TOPMed |
|
|
CA1374715 rs769462883 |
347 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1571789026 CA344575142 |
348 | P>L | No |
ClinGen Ensembl |
|
|
rs1055555041 CA36741215 |
349 | S>G | No |
ClinGen gnomAD |
|
|
rs1327012705 CA344575155 |
350 | S>A | No |
ClinGen gnomAD |
|
|
rs1229910134 CA344575161 |
350 | S>C | No |
ClinGen gnomAD |
|
|
CA1374717 rs138637491 |
351 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA344575198 rs1267124286 |
354 | T>A | No |
ClinGen gnomAD |
|
|
CA1374718 rs554479000 |
355 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA36741223 rs373639592 |
356 | T>I | No |
ClinGen ESP TOPMed |
|
|
COSM678816 CA1374720 rs760816448 |
357 | E>K | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA1374723 rs760008213 |
359 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1290365437 CA344575264 |
360 | V>A | No |
ClinGen TOPMed |
|
|
CA344575260 rs1415133413 |
360 | V>F | No |
ClinGen gnomAD |
|
|
rs752401839 CA1374725 |
364 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA344575302 rs1321981406 |
364 | S>R | No |
ClinGen gnomAD |
|
|
CA36741274 rs576518024 |
366 | A>T | No |
ClinGen Ensembl |
|
|
rs762540918 CA1374726 |
367 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA1374727 rs763711352 |
368 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1306891937 CA344575340 |
368 | P>S | No |
ClinGen gnomAD |
|
|
CA344575346 rs1284756895 |
369 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1374729 rs201370771 |
371 | T>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374730 rs781247619 |
373 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1276442720 CA344575381 |
373 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
CA344575394 rs1206088954 |
374 | P>A | No |
ClinGen gnomAD |
|
|
rs1251323365 CA344575398 |
374 | P>H | No |
ClinGen gnomAD |
|
|
CA344575391 rs1206088954 |
374 | P>S | No |
ClinGen gnomAD |
|
|
rs886231844 CA36741308 |
375 | C>F | No |
ClinGen Ensembl |
|
|
CA344575412 rs1436203092 |
375 | C>W | No |
ClinGen gnomAD |
|
|
rs1189693651 CA344575420 |
376 | Q>R | No |
ClinGen gnomAD |
|
|
rs201488482 COSM1317580 CA1374731 |
378 | G>D | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
rs372169686 CA1374732 |
379 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs375273380 CA1374733 |
379 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs375273380 CA36741312 |
379 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1374735 rs538751935 |
380 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374734 rs748406333 |
380 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1558142953 CA344575477 |
382 | T>I | No |
ClinGen Ensembl |
|
|
rs1345858627 CA344575493 |
384 | P>H | No |
ClinGen TOPMed |
|
|
rs1334174094 CA344575514 |
386 | G>A | No |
ClinGen gnomAD |
|
|
CA344575524 rs1339821775 |
387 | R>K | No |
ClinGen gnomAD |
|
|
rs1255469866 CA344575533 |
388 | S>A | No |
ClinGen TOPMed |
|
|
rs778110659 CA1374737 |
388 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA344575531 rs1255469866 |
388 | S>P | No |
ClinGen TOPMed |
|
|
rs778110659 CA1374736 |
388 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA344575547 rs1571789229 |
390 | N>H | No |
ClinGen Ensembl |
|
|
CA344575571 rs1571789233 |
391 | C>S | No |
ClinGen Ensembl |
|
|
CA344575661 rs1365713218 |
395 | G>D | No |
ClinGen gnomAD |
|
|
CA344575677 rs1274588354 |
396 | S>P | No |
ClinGen gnomAD |
|
|
CA344575713 rs1309445777 |
397 | L>F | No |
ClinGen TOPMed |
|
|
CA344575722 rs1571789259 |
397 | L>P | No |
ClinGen Ensembl |
|
|
CA344575763 rs1299550480 |
399 | I>S | No |
ClinGen TOPMed |
|
|
CA344575851 rs1364177577 |
402 | S>R | No |
ClinGen TOPMed |
|
|
rs777212544 CA1374740 |
406 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344575948 rs1397680191 |
407 | H>Y | No |
ClinGen TOPMed |
|
|
CA344575979 rs1188309770 |
409 | G>W | No |
ClinGen gnomAD |
|
|
CA344575990 rs1571789306 |
410 | S>A | No |
ClinGen Ensembl |
|
|
CA1374744 rs763269724 |
412 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA1374748 rs200585732 |
413 | A>S | No |
ClinGen ExAC TOPMed |
|
|
rs200585732 CA1374746 |
413 | A>T | No |
ClinGen ExAC TOPMed |
|
|
CA36741350 rs766870629 |
414 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374750 rs766870629 |
414 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750404048 CA1374751 |
416 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs755954596 CA1374752 |
417 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1198735585 CA344576174 |
418 | C>S | No |
ClinGen TOPMed |
|
|
CA344576214 rs1324919560 |
421 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA1374753 rs142776782 |
421 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1235625978 CA344576223 |
421 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs754816814 CA1374756 |
425 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747174044 CA1374757 |
425 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374755 rs754816814 |
425 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757366522 CA1374758 |
426 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs867571755 CA36741380 |
427 | S>N | No |
ClinGen Ensembl |
|
|
CA344576346 rs781095316 |
427 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA344576372 rs1452175982 |
428 | K>N | No |
ClinGen gnomAD |
|
|
CA1374760 rs745935850 |
428 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374761 rs770241569 |
430 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA1374762 rs775968262 |
431 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs966818017 CA36741387 |
431 | S>P | No |
ClinGen gnomAD |
|
|
CA36741401 rs941904876 |
432 | S>P | No |
ClinGen TOPMed |
|
|
CA1374763 rs749707922 |
433 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA1374764 rs768950826 |
434 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs61729828 CA36741419 |
435 | S>P | No |
ClinGen TOPMed |
|
|
CA1374765 rs371880689 |
436 | E>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1456583995 CA344576506 |
436 | E>Q | No |
ClinGen gnomAD |
|
|
rs371880689 CA1374766 |
436 | E>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs939624820 CA36741431 |
437 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA1374768 rs185632658 |
439 | L>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs543943116 CA1374769 |
440 | L>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA344576680 rs1330453145 |
442 | K>N | No |
ClinGen gnomAD |
|
|
COSM618 rs1228276529 CA344576689 VAR_040601 |
443 | A>T | a breast infiltrating ductal carcinoma sample; somatic mutation breast [UniProt, Cosmic] | No |
ClinGen cosmic curated UniProt dbSNP gnomAD |
|
rs533703886 CA36741439 |
443 | A>V | No |
ClinGen Ensembl |
|
|
rs769807413 CA344576728 |
444 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374771 rs769807413 |
444 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs929956229 CA36741453 |
446 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs775482310 CA344576789 |
447 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs775482310 CA36741456 |
447 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1571789529 CA344576796 |
447 | Q>L | No |
ClinGen Ensembl |
|
|
CA1374793 rs767686108 |
448 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA344577123 rs1402266136 |
449 | F>S | No |
ClinGen gnomAD |
|
|
CA36741722 rs1024283499 |
451 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
CA36741715 rs186593003 |
451 | S>P | No |
ClinGen 1000Genomes |
|
|
rs200356538 CA1374795 |
452 | E>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA36741740 rs780067705 |
452 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374797 rs754363636 |
453 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA344578288 rs1274979121 |
454 | M>I | No |
ClinGen gnomAD |
|
|
rs1231037633 CA344578286 |
454 | M>T | No |
ClinGen gnomAD |
|
|
rs1571789949 CA344578304 |
455 | V>I | No |
ClinGen Ensembl |
|
|
rs755526025 CA1374798 |
457 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1306555994 CA344578331 |
457 | V>F | No |
ClinGen gnomAD |
|
|
rs748530477 CA1374802 |
461 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA1374801 rs779362541 |
461 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA1374803 rs772471536 |
462 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA1374804 rs777305509 |
462 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA1374805 rs746608566 |
462 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs770600382 CA1374806 |
463 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs776234229 CA1374807 |
464 | H>P | No |
ClinGen ExAC gnomAD |
|
|
CA344578522 rs1323866847 |
465 | C>Y | No |
ClinGen TOPMed |
|
|
CA1374809 rs769916493 |
466 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1374808 rs759097752 |
466 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA36741797 rs758265764 |
467 | A>V | No |
ClinGen Ensembl |
|
|
CA1374812 rs751998428 |
469 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs543075805 CA1374811 |
469 | Q>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA344578663 rs1228222534 |
470 | T>S | No |
ClinGen TOPMed |
|
|
rs1360852796 CA344578714 |
472 | V>A | No |
ClinGen gnomAD |
|
|
rs1290234738 CA344578768 |
474 | L>R | No |
ClinGen TOPMed |
No associated diseases with Q96NX5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcium- and calmodulin-dependent protein kinase complex | An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
106 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| Q9UEE5 | STK17A | Serine/threonine-protein kinase 17A | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| Q16816 | PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | Homo sapiens (Human) | PR |
| P15735 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Homo sapiens (Human) | PR |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q80YE7 | Dapk1 | Death-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRKEEDDCS | SWKKQTTNIR | KTFIFMEVLG | SGAFSEVFLV | KQRLTGKLFA | LKCIKKSPAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDSSLENEIA | VLKKIKHENI | VTLEDIYEST | THYYLVMQLV | SGGELFDRIL | ERGVYTEKDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLVIQQVLSA | VKYLHENGIV | HRDLKPENLL | YLTPEENSKI | MITDFGLSKM | EQNGIMSTAC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTPGYVAPEV | LAQKPYSKAV | DCWSIGVITY | ILLCGYPPFY | EETESKLFEK | IKEGYYEFES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PFWDDISESA | KDFICHLLEK | DPNERYTCEK | ALSHPWIDGN | TALHRDIYPS | VSLQIQKNFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSKWRQAFNA | AAVVHHMRKL | HMNLHSPGVR | PEVENRPPET | QASETSRPSS | PEITITEAPV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDHSVALPAL | TQLPCQHGRR | PTAPGGRSLN | CLVNGSLHIS | SSLVPMHQGS | LAAGPCGCCS |
| 430 | 440 | 450 | 460 | 470 | |
| SCLNIGSKGK | SSYCSEPTLL | KKANKKQNFK | SEVMVPVKAS | GSSHCRAGQT | GVCLIM |