Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q96NW7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6X5G | X-ray | 185 A | B | 797-818 | PDB |
| 7QQM | X-ray | 160 A | A | 1445-1536 | PDB |
| AF-Q96NW7-F1 | Predicted | AlphaFoldDB |
2 variants for Q96NW7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| VAR_035715 | 235 | L>M | a breast cancer sample; somatic mutation [UniProt] | No | UniProt |
|
VAR_049727 rs12069888 |
1054 | H>Y | No |
UniProt dbSNP |
No associated diseases with Q96NW7
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| specific granule lumen | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| receptor clustering | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. |
| receptor localization to synapse | Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
40 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q92796 | DLG3 | Disks large homolog 3 | Homo sapiens (Human) | SS |
| Q12959 | DLG1 | Disks large homolog 1 | Homo sapiens (Human) | SS |
| P78352 | DLG4 | Disks large homolog 4 | Homo sapiens (Human) | SS |
| Q15700 | DLG2 | Disks large homolog 2 | Homo sapiens (Human) | SS |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTKRKIIGR | LVPCRCFRGE | EEIISVLDYS | HCSLQQVPKE | VFNFERTLEE | LYLDANQIEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPKQLFNCQA | LRKLSIPDND | LSNLPTTIAS | LVNLKELDIS | KNGVQEFPEN | IKCCKCLTII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EASVNPISKL | PDGFTQLLNL | TQLYLNDAFL | EFLPANFGRL | VKLRILELRE | NHLKTLPKSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HKLAQLERLD | LGNNEFGELP | EVLDQIQNLR | ELWMDNNALQ | VLPGSIGKLK | MLVYLDMSKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIETVDMDIS | GCEALEDLLL | SSNMLQQLPD | SIGLLKKLTT | LKVDDNQLTM | LPNTIGNLSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEEFDCSCNE | LESLPSTIGY | LHSLRTLAVD | ENFLPELPRE | IGSCKNVTVM | SLRSNKLEFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEEIGQMQKL | RVLNLSDNRL | KNLPFSFTKL | KELAALWLSD | NQSKALIPLQ | TEAHPETKQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLTNYMFPQQ | PRGDEDFQSD | SDSFNPTLWE | EQRQQRMTVA | FEFEDKKEDD | ENAGKVKDLS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CQAPWERGQR | GITLQPARLS | GDCCTPWARC | DQQIQDMPVP | QNDPQLAWGC | ISGLQQERSM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CTPLPVAAQS | TTLPSLSGRQ | VEINLKRYPT | PYPEDLKNMV | KSVQNLVGKP | SHGVRVENSN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PTANTEQTVK | EKYEHKWPVA | PKEITVEDSF | VHPANEMRIG | ELHPSLAETP | LYPPKLVLLG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KDKKESTDES | EVDKTHCLNN | SVSSGTYSDY | SPSQASSGSS | NTRVKVGSLQ | TTAKDAVHNS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LWGNRIAPSF | PQPLDSKPLL | SQREAVPPGN | IPQRPDRLPM | SDTFTDNWTD | GSHYDNTGFV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AEETTAENAN | SNPLLSSKSR | STSSHGRRPL | IRQDRIVGVP | LELEQSTHRH | TPETEVPPSN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PWQNWTRTPS | PFEDRTAFPS | KLETTPTTSP | LPERKEHIKE | STEIPSPFSP | GVPWEYHDSN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PNRSLSNVFS | QIHCRPESSK | GVISISKSTE | RLSPLMKDIK | SNKFKKSQSI | DEIDIGTYKV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YNIPLENYAS | GSDHLGSHER | PDKMLGPEHG | MSSMSRSQSV | PMLDDEMLTY | GSSKGPQQQK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ASMTKKVYQF | DQSFNPQGSV | EVKAEKRIPP | PFQHNPEYVQ | QASKNIAKDL | ISPRAYRGYP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PMEQMFSFSQ | PSVNEDAVVN | AQFASQGARA | GFLRRADSLV | SATEMAMFRR | VNEPHELPPT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| DRYGRPPYRG | GLDRQSSVTV | TESQFLKRNG | RYEDEHPSYQ | EVKAQAGSFP | VKNLTQRRPL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SARSYSTESY | GASQTRPVSA | RPTMAALLEK | IPSDYNLGNY | GDKPSDNSDL | KTRPTPVKGE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ESCGKMPADW | RQQLLRHIEA | RRLDRNAAYK | HNTVNLGMLP | YGGISAMHAG | RSMTLNLQTK |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| SKFDHQELPL | QKTPSQQSNI | LDNGQEDVSP | SGQWNPYPLG | RRDVPPDTIT | KKAGSHIQTL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MGSQSLQHRS | REQQPYEGNI | NKVTIQQFQS | PLPIQIPSSQ | ATRGPQPGRC | LIQTKGQRSM |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| DGYPEQFCVR | IEKNPGLGFS | ISGGISGQGN | PFKPSDKGIF | VTRVQPDGPA | SNLLQPGDKI |
| 1510 | 1520 | 1530 | |||
| LQANGHSFVH | MEHEKAVLLL | KSFQNTVDLV | IQRELTV |