AiPD: Autoinhibited Protein Database

Q96N96

Gene name	SPATA13
Protein name	Spermatogenesis-associated protein 13
Names	APC-stimulated guanine nucleotide exchange factor 2, Asef2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:221178
EC number
Protein Class	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 (PTHR47544)

Descriptions

SPATA13 is a guanine nucleotide exchange factor (GEF). SPATA13 contains an N-terminal APC binding region (ABR), Src-homology 3 (SH3) domain, DH domain, and PH domain.The ABR-SH3 binds to the C-terminal tail of SPATA13, allowing it to function as an autoinhibitory module within the protein. The primary function of the SH3 is to sequester a C-terminal activation element and prevent the tail from participating in Cdc42 GDP/GTP exchange. Thus, SPATA13 activation involves APC releasing the SH3 from the C-terminal tail, resulting in Cdc42 exchange.

Autoinhibitory domains (AIDs)

Target domain	561-652 (C-terminal tail)
Relief mechanism	Partner binding
Assay	Split protein assay, Deletion assay

AID

98-206 (ABR-SH3 domain)

Target domain

561-652 (C-terminal tail)

Relief mechanism

Partner binding (APC binding to ABR)

Assay

Split protein assay, Deletion assay

Accessory elements

No accessory elements

References

Hamann MJ et al. (2007) "Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element", Molecular and cellular biology, 27, 1380-93

Murayama K et al. (2007) "Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism", The Journal of biological chemistry, 282, 4238-4242

Mitin N et al. (2007) "Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression", Nature structural & molecular biology, 14, 814-23

Autoinhibited structure

Activated structure

1 structures for Q96N96

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96N96-F1	Predicted				AlphaFoldDB

492 variants for Q96N96

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6914006 rs771789214	2	T>A		No	ClinGen ExAC gnomAD
CA387542196 rs1338604553	4	A>V		No	ClinGen gnomAD
rs1252362231 CA387542217	6	P>S		No	ClinGen gnomAD
CA387542235 rs1211751374	8	D>Y		No	ClinGen TOPMed
rs1400586642 CA387542273	11	A>T		No	ClinGen gnomAD
CA246727160 rs538499853	16	P>A		No	ClinGen 1000Genomes
rs766640323 CA6914009	17	K>R		No	ClinGen ExAC TOPMed gnomAD
rs143963425 CA6914010	19	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA246727168 rs1034691989	19	A>P		No	ClinGen TOPMed gnomAD
rs1034691989 CA387542358	19	A>S		No	ClinGen TOPMed gnomAD
rs7330736 CA246727181	20	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1016749810 CA246727183	20	R>Q		No	ClinGen TOPMed
rs7330736 CA6914011 VAR_030776	20	R>W		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765671845 CA6914012	21	R>S		No	ClinGen ExAC gnomAD
CA6914013 rs752792781	22	R>S		No	ClinGen ExAC
CA6914014 rs762897184	23	R>C		No	ClinGen ExAC TOPMed gnomAD
rs764428674 CA6914015	23	R>H		No	ClinGen ExAC TOPMed gnomAD
CA387542402 rs1555272419	25	I>V		No	ClinGen Ensembl
CA6914017 rs756006988	27	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1227719898 CA387542430	28	I>L		No	ClinGen gnomAD
CA6914019 rs753630837	28	I>R		No	ClinGen ExAC gnomAD
CA387542433 rs1227719898	28	I>V		No	ClinGen gnomAD
rs80073311 CA6914020	31	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292764788 CA387542462	31	V>I		No	ClinGen TOPMed gnomAD
CA6914022 rs747736036	34	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6914023 rs747736036	34	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1252983159 CA387542497	34	Y>H		No	ClinGen gnomAD
CA387542514 rs1397118814 COSM183504	35	G>V	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA6914024 rs777538536	37	N>K		No	ClinGen ExAC gnomAD
rs1487937076 CA387542536	37	N>S		No	ClinGen TOPMed gnomAD
CA387542539 rs1191369136	38	Q>K		No	ClinGen gnomAD
rs574832935 CA246727238	38	Q>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs746637753 CA6914025	39	T>A		No	ClinGen ExAC gnomAD
rs543934868 CA6914027	39	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA246727247 rs746637753	39	T>P		No	ClinGen ExAC gnomAD
CA6914026 rs746637753	39	T>S		No	ClinGen ExAC gnomAD
CA387542558 rs1427970419	40	E>Q		No	ClinGen gnomAD
CA246727278 rs377093885	43	D>H		No	ClinGen ESP TOPMed gnomAD
rs199892055 CA6914029	44	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914030 rs775826323	45	L>H		No	ClinGen ExAC gnomAD
rs764078951 CA6914032	46	L>P		No	ClinGen ExAC gnomAD
rs751595144 CA6914033	48	Q>*		No	ClinGen ExAC gnomAD
CA6914055 rs765118612	49	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765118612 CA246728188	49	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs758280335 CA6914057	52	R>S		No	ClinGen ExAC gnomAD
CA6914058 rs764040950	53	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6914061 rs780869193	55	M>I		No	ClinGen ExAC gnomAD
CA6914062 rs745517993	56	P>H		No	ClinGen ExAC gnomAD
CA6914063 rs755699463	58	H>D		No	ClinGen ExAC gnomAD
rs1379822437 CA387544107	59	Q>K		No	ClinGen TOPMed
rs975104734 CA246728229	60	V>A		No	ClinGen TOPMed
CA246728214 rs965377088	60	V>L		No	ClinGen Ensembl
rs780300027 CA6914064	61	P>A		No	ClinGen ExAC TOPMed gnomAD
rs749619305 CA6914065	63	Y>H		No	ClinGen ExAC gnomAD
rs1232750956 CA387544193	65	A>S		No	ClinGen TOPMed gnomAD
CA387544190 rs1232750956	65	A>T		No	ClinGen TOPMed gnomAD
rs774891172 CA6914067	66	V>M		No	ClinGen ExAC gnomAD
CA6914068 rs748289915	67	S>L		No	ClinGen ExAC TOPMed gnomAD
CA6914070 rs773634985	68	A>S		No	ClinGen ExAC gnomAD
CA6914074 rs147629761	69	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147629761 CA6914073	69	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766565372 CA6914072	69	R>W		No	ClinGen ExAC gnomAD
rs1593463157 CA387544263	70	F>V		No	ClinGen Ensembl
CA387544280 rs1415903324	71	R>Q		No	ClinGen TOPMed gnomAD
CA6914076 rs377038249	71	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA387544302 rs1593463186	73	F>L		No	ClinGen Ensembl
rs755789458 CA6914080	76	S>C		No	ClinGen ExAC gnomAD
rs370362895 CA246728297	77	Q>*		No	ClinGen ESP TOPMed
CA387544395 rs1593463212	79	T>P		No	ClinGen Ensembl
rs1043971889 CA246728305	80	P>H		No	ClinGen TOPMed
rs1414266905 CA387544408	80	P>S		No	ClinGen gnomAD
rs375832060 CA6914083	81	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs375832060 CA387544420	81	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914084 rs779348512	85	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6914085 rs142261154	85	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA387544481 rs142261154	85	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs374176784 CA246728345	86	V>M		No	ClinGen ESP TOPMed
rs750437771 CA6914086	88	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773438885 CA6914087	88	R>H		No	ClinGen ExAC TOPMed gnomAD
rs745333635 CA6914089	89	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201402934 CA6914088 VAR_080767	89	R>W	found in two consanguineous families with intellectual disability; unknown pathological significance [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6914091 rs762702436	90	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs776877407 CA6914090	90	R>W		No	ClinGen ExAC gnomAD
CA246728367 rs770233205	92	M>L		No	ClinGen gnomAD
rs1420142166 CA387544585	94	A>S		No	ClinGen gnomAD
CA6914092 rs768481237	95	S>Y		No	ClinGen ExAC gnomAD
rs1447474589 CA387552207	97	V>A		No	ClinGen TOPMed
CA387544626 rs146456606	97	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914093 COSM3384781 rs146456606 COSM3384780	97	V>I	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA387552224 rs1250372749	100	D>G		No	ClinGen gnomAD
CA6914175 rs755213595	100	D>N		No	ClinGen ExAC TOPMed gnomAD
CA387552222 rs755213595	100	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1044536629 CA246752021	101	G>R		No	ClinGen TOPMed
CA387552237 rs778961788	102	G>A		No	ClinGen ExAC TOPMed gnomAD
CA387552236 rs778961788	102	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6914176 rs778961788	102	G>V		No	ClinGen ExAC TOPMed gnomAD
rs199595659 CA6914177	104	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781243649 CA6914179	105	P>L		No	ClinGen ExAC gnomAD
rs769785566 CA6914181	112	N>S		No	ClinGen ExAC gnomAD
CA6914183 rs531600403	113	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531600403 CA246752067	113	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768466442 CA6914184	114	S>G		No	ClinGen ExAC gnomAD
CA387552311 rs78997458	114	S>I		No	ClinGen 1000Genomes ExAC gnomAD
CA6914185 rs78997458	114	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA387552312 rs60974700	114	S>R		No	ClinGen 1000Genomes gnomAD
rs762296887 CA6914186	118	F>I		No	ClinGen ExAC
rs990477708 CA246752080	120	Y>C		No	ClinGen TOPMed
rs990477708 CA387552357	120	Y>F		No	ClinGen TOPMed
rs1266391837 CA387552355	120	Y>H		No	ClinGen TOPMed
rs1293867873 CA387552372	122	D>G		No	ClinGen gnomAD
CA6914187 rs772320278	123	L>V		No	ClinGen ExAC gnomAD
CA246752085 rs752072405	124	C>R		No	ClinGen Ensembl
CA387552391 rs1305063675	125	Q>P		No	ClinGen gnomAD
CA387552399 rs1349953532	126	A>D		No	ClinGen gnomAD
rs1349953532 CA387552401	126	A>V		No	ClinGen gnomAD
rs201006373 CA6914189	128	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914191 rs376912782	129	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs755337296 CA6914190	129	R>W		No	ClinGen ExAC TOPMed gnomAD
CA387552422 rs1390688120	130	Y>C		No	ClinGen TOPMed
CA387552438 rs1489640991	132	Q>H		No	ClinGen gnomAD
rs1233825323 CA387552445	134	G>S		No	ClinGen gnomAD
CA6914194 rs752845172	135	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1415637218 CA387552459	136	E>A		No	ClinGen gnomAD
rs1593497657 CA387552457	136	E>Q		No	ClinGen Ensembl
CA246752157 rs977440609	139	A>T		No	ClinGen Ensembl
CA387552484 rs1165336436	140	I>N		No	ClinGen gnomAD
rs148292690 CA6914196	140	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387552489 rs1260187075	141	N>D		No	ClinGen TOPMed gnomAD
rs1377887383 CA387552494	141	N>K		No	ClinGen TOPMed
rs140515823 CA6914197	141	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914225 rs58889617	145	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746364346 CA6914227	146	D>V		No	ClinGen ExAC
CA6914228 rs770276802	147	G>D		No	ClinGen ExAC TOPMed gnomAD
CA387552808 rs1330046571	147	G>R		No	ClinGen TOPMed
CA246753953 rs770276802	147	G>V		No	ClinGen ExAC TOPMed gnomAD
rs775452366 CA6914230	148	N>I		No	ClinGen ExAC gnomAD
rs775452366 CA6914229	148	N>S		No	ClinGen ExAC gnomAD
rs774702277 CA6914232	149	V>A		No	ClinGen ExAC gnomAD
CA6914231 rs372766436	149	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
COSM551048 COSM1140362 rs1566193583 CA387552823	150	V>F	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1282848401 CA387552832	151	C>F		No	ClinGen gnomAD
rs766285133 CA6914234	152	A>S		No	ClinGen ExAC gnomAD
rs766285133 CA246754004	152	A>T		No	ClinGen ExAC gnomAD
CA6914237 rs376088972	155	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914238 rs752186774	158	H>N		No	ClinGen ExAC gnomAD
CA246754041 rs1001697277	158	H>R		No	ClinGen Ensembl
rs1477143810 CA387552887	160	T>A		No	ClinGen TOPMed
rs777456034 CA6914240	161	M>V		No	ClinGen ExAC gnomAD
rs202004588 CA6914241	162	D>G		No	ClinGen ExAC TOPMed gnomAD
CA246754050 rs769572904	162	D>N		No	ClinGen TOPMed
rs1430341743 CA387552916	164	Q>*		No	ClinGen TOPMed
rs781549486 CA6914243	164	Q>R		No	ClinGen ExAC gnomAD
rs1474132339 CA387552927	165	E>D		No	ClinGen gnomAD
CA387552937 rs1187967753	167	G>D		No	ClinGen TOPMed gnomAD
CA6914244 rs746193464	169	K>T		No	ClinGen ExAC TOPMed gnomAD
CA387552961 rs776044608	171	G>R		No	ClinGen ExAC gnomAD
COSM3955455 COSM3955454 rs776044608 COSM3955456 CA6914246	171	G>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6914247 rs749386397	172	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs768852418 CA6914248	175	Q>R		No	ClinGen ExAC gnomAD
CA387552998 rs1330843799	176	V>A		No	ClinGen gnomAD
CA6914249 rs774505967	184	W>*		No	ClinGen ExAC gnomAD
rs1038966065 CA246754110	185	W>*		No	ClinGen TOPMed
COSM26285 rs267603784 CA246754121	186	W>*	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA387553066 rs1276191687	186	W>R		No	ClinGen gnomAD
CA6914251 rs142906131	188	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs966369987 CA246754137	188	R>H		No	ClinGen TOPMed gnomAD
CA246754138 rs966369987	188	R>L		No	ClinGen TOPMed gnomAD
CA387553082 rs1377009289	189	S>G		No	ClinGen gnomAD
CA387553112 rs1331100189	191	D>H		No	ClinGen gnomAD
CA387553143 COSM1720527 COSM1720528 rs1207950357	193	E>K	NS [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA6914252 rs371187650	194	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1407347149 CA387553192	195	W>*		No	ClinGen TOPMed
CA6914253 rs200244378	196	F>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763599007 CA387553250	198	A>E		No	ClinGen ExAC TOPMed gnomAD
rs762433072 CA6914256	198	A>T		No	ClinGen ExAC gnomAD
CA6914257 rs763599007	198	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1463645710 CA387553276	199	S>R		No	ClinGen TOPMed
rs142244461 CA6914260	201	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142244461 CA246754173	201	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1371876337 CA387553398	204	R>*		No	ClinGen gnomAD
CA387553399 rs1393786934	204	R>Q		No	ClinGen gnomAD
CA6914279 rs143889062	208	E>D		No	ClinGen ESP ExAC gnomAD
CA246754375 rs1006326818	208	E>K		No	ClinGen TOPMed
rs964443603 CA246754390	211	S>L		No	ClinGen TOPMed gnomAD
CA387553475 rs1341134582	215	S>I		No	ClinGen gnomAD
CA6914281 rs780480617	216	S>G		No	ClinGen ExAC TOPMed gnomAD
rs754107229 CA6914283	216	S>I		No	ClinGen ExAC gnomAD
rs754107229 CA6914282	216	S>N		No	ClinGen ExAC gnomAD
CA246754410 rs148608098	216	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA387553479 rs780480617	216	S>R		No	ClinGen ExAC TOPMed gnomAD
CA246754423 rs903502840	217	T>P		No	ClinGen Ensembl
CA387553485 rs1198786108	217	T>S		No	ClinGen gnomAD
rs772262158 CA387553489	218	P>H		No	ClinGen ExAC TOPMed gnomAD
rs772262158 CA6914286	218	P>L		No	ClinGen ExAC TOPMed gnomAD
CA387553490 rs772262158	218	P>R		No	ClinGen ExAC TOPMed gnomAD
rs748284162 CA6914285	218	P>S		No	ClinGen ExAC gnomAD
CA6914288 rs9580914	219	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387553495 rs1449174517	219	S>R		No	ClinGen TOPMed gnomAD
CA6914289 rs9580914	219	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1593501219 CA387553509	221	E>G		No	ClinGen Ensembl
rs1168914733 CA387553517	222	Q>R		No	ClinGen gnomAD
rs1454542335 CA387553521	223	D>Y		No	ClinGen TOPMed gnomAD
CA387553531 rs548405842	224	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548405842 CA6914292	224	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528255708 CA6914291	224	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1402243140 CA387553536	225	E>Q		No	ClinGen gnomAD
CA246754451 rs935033821	226	A>P		No	ClinGen Ensembl
CA6914293 rs150738256	230	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA387553573 rs150738256	230	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914295 rs139669908	230	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914294 rs139669908	230	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914296 rs772539861	231	H>D		No	ClinGen ExAC TOPMed gnomAD
rs1566194249 CA387553592	233	H>R		No	ClinGen Ensembl
rs145196203 CA6914298	233	H>Y		No	ClinGen ESP ExAC gnomAD
rs913130253 CA246754505	234	C>*		No	ClinGen TOPMed
rs1029227077 CA246754511	236	N>T		No	ClinGen Ensembl
CA387553645 rs1231290257	240	M>L		No	ClinGen gnomAD
CA387553647 rs1255516315	240	M>T		No	ClinGen gnomAD
rs1206130544 CA387553653	241	R>Q		No	ClinGen TOPMed gnomAD
rs755374246 CA6914300	241	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6914303 rs371788710	243	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs568317408 CA6914301	243	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA246754537 rs1042925088 COSM293092	244	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1431125002 CA387553712	246	R>L		No	ClinGen gnomAD
rs1431125002 CA387553715	246	R>Q		No	ClinGen gnomAD
rs777917933 CA6914304	246	R>W		No	ClinGen ExAC TOPMed gnomAD
CA387553755 rs1438997383	248	I>S		No	ClinGen gnomAD
rs927091620 CA246754546	249	M>I		No	ClinGen TOPMed
rs1593501426 CA387553764	249	M>L		No	ClinGen Ensembl
CA387553851 rs1156935581	253	R>Q		No	ClinGen gnomAD
rs199614790 CA6914306	253	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6914308 rs375234139	257	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914307 rs142300800	257	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914309 rs768437129	261	D>N		No	ClinGen ExAC gnomAD
rs764475375 CA246754630	262	I>T		No	ClinGen Ensembl
rs1359568687 CA387554150	265	G>S		No	ClinGen Ensembl
rs1309701296 CA387554172	266	Y>C		No	ClinGen gnomAD
rs1320360967 CA387554182	267	I>V		No	ClinGen gnomAD
CA6914326 rs776988973	268	R>Q		No	ClinGen ExAC gnomAD
rs748667154 CA6914327	271	R>C		No	ClinGen ExAC gnomAD
rs531638025 CA6914328	271	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531638025 CA6914329	271	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387554250 rs1566195719	272	K>E		No	ClinGen Ensembl
rs1483061251 CA387554312	274	T>A		No	ClinGen gnomAD
CA6914332 rs746590103	276	M>I		No	ClinGen ExAC TOPMed gnomAD
rs773003583 CA6914331	276	M>K		No	ClinGen ExAC gnomAD
rs748371142 CA246755910	276	M>V		No	ClinGen Ensembl
rs889855726 CA246755929	278	T>N		No	ClinGen Ensembl
CA387554425 rs1593504034	278	T>P		No	ClinGen Ensembl
rs145716754 CA6914335	279	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145716754 CA6914334	279	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914336 rs769518462	280	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1566195785 CA387554520	283	A>T		No	ClinGen Ensembl
CA6914339 rs148921365	285	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA387554597 rs1417316034	287	G>R		No	ClinGen gnomAD
rs762315531 CA6914341	289	I>T		No	ClinGen ExAC gnomAD
CA246755978 rs766558345	291	D>G		No	ClinGen gnomAD
rs777963759 CA246755990	297	R>I		No	ClinGen Ensembl
rs1225736155 CA387554858	301	K>R		No	ClinGen gnomAD
rs1273466371 CA387554873	303	L>H		No	ClinGen gnomAD
rs375569975 CA246755996	306	Q>H		No	ClinGen ESP TOPMed
rs756360388 CA6914344	310	E>G		No	ClinGen ExAC TOPMed gnomAD
CA387554940 rs1593504233	312	P>T		No	ClinGen Ensembl
rs1003715210 CA246756004	317	I>T		No	ClinGen Ensembl
rs758116808 CA6914347	323	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs777830854 CA6914348	323	Q>L		No	ClinGen ExAC gnomAD
rs777440197 CA6914367	325	Q>K		No	ClinGen ExAC gnomAD
rs751316498 CA6914368	325	Q>R		No	ClinGen ExAC gnomAD
rs1441139808 CA387555110	327	G>R		No	ClinGen TOPMed
CA6914369 rs757288229	329	A>D		No	ClinGen ExAC gnomAD
CA6914371 rs745419856	333	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1346110428 CA387555150	333	E>K		No	ClinGen TOPMed gnomAD
CA387555156 rs1272647872	334	Y>H		No	ClinGen gnomAD
rs1593506052 CA387555158	334	Y>S		No	ClinGen Ensembl
rs1256386004 CA387555165	335	C>S		No	ClinGen TOPMed
rs779821499 CA6914373	336	N>S		No	ClinGen ExAC TOPMed gnomAD
CA387555190 rs1593506098	338	H>P		No	ClinGen Ensembl
rs1335518351 CA387555188	338	H>Y		No	ClinGen TOPMed
rs748908677 CA6914374	339	P>L		No	ClinGen ExAC TOPMed gnomAD
CA387555204 rs1207985576	340	G>D		No	ClinGen TOPMed gnomAD
rs145134345 CA6914375	341	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914376 rs774609819	342	C>Y		No	ClinGen ExAC gnomAD
CA6914377 rs748515409	344	E>A		No	ClinGen ExAC gnomAD
rs772619502 CA6914378	346	A>S		No	ClinGen ExAC TOPMed gnomAD
rs772619502 CA246757412	346	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1471910422 CA387555245	347	N>S		No	ClinGen gnomAD
CA387555251 rs1159004150	348	L>F		No	ClinGen TOPMed gnomAD
rs1160907247 CA387555261	349	M>I		No	ClinGen TOPMed
rs760813325 CA6914380	349	M>T		No	ClinGen ExAC TOPMed gnomAD
CA6914379 rs375500284	349	M>V		No	ClinGen ESP ExAC gnomAD
CA387555267 rs1321242287	350	K>M		No	ClinGen gnomAD
CA246757433 rs947302803	356	H>Y		No	ClinGen Ensembl
rs1348033947 CA387555354	362	R>C		No	ClinGen gnomAD
CA387555366 rs1227720945	364	L>P		No	ClinGen gnomAD
CA387555390 rs1439323626	367	M>I		No	ClinGen gnomAD
rs1248162484 CA387555386	367	M>L		No	ClinGen gnomAD
CA387555405 rs1182518732	369	D>E		No	ClinGen gnomAD
rs765455230 CA6914384	369	D>N		No	ClinGen ExAC gnomAD
rs1043397044 CA246757439	370	I>V		No	ClinGen Ensembl
CA6914386 COSM1266567 COSM1266566 rs138946174	371	A>T	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1223442521 CA387555420	372	I>L		No	ClinGen TOPMed gnomAD
CA387555422 rs1271159246	372	I>T		No	ClinGen gnomAD
CA387555418 rs1223442521	372	I>V		No	ClinGen TOPMed gnomAD
rs1181801456 CA387555429	373	D>G		No	ClinGen TOPMed gnomAD
rs756059244 CA6914389	374	G>R		No	ClinGen ExAC
CA6914390 rs779455250	374	G>V		No	ClinGen ExAC
CA246757479 rs1057126282	381	Q>*		No	ClinGen Ensembl
rs28624140 CA246757480	382	K>E		No	ClinGen Ensembl
rs1461676815 CA387555602	386	Y>H		No	ClinGen gnomAD
rs375839910 CA6914393	387	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914392 rs754626684	387	P>S		No	ClinGen ExAC gnomAD
rs772423715 CA6914395	389	Q>H		No	ClinGen ExAC gnomAD
rs1408679634 CA387555688	392	E>Q		No	ClinGen gnomAD
rs1593506439 CA387555726	395	K>Q		No	ClinGen Ensembl
rs747524682 CA6914397	396	Y>H		No	ClinGen ExAC gnomAD
rs776601790 CA6914399	399	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA6914400 rs150474130	400	E>K		No	ClinGen ESP ExAC gnomAD
rs138395874 CA6914403	402	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387537548 rs1427578555	404	Y>C		No	ClinGen gnomAD
rs148314715 CA6914424	406	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6914425 rs766288438	408	K>R		No	ClinGen ExAC TOPMed gnomAD
CA246715446 rs144501887	409	A>G		No	ClinGen ESP TOPMed gnomAD
CA246715454 rs144501887	409	A>V		No	ClinGen ESP TOPMed gnomAD
CA6914427 rs759328855	410	A>V		No	ClinGen ExAC gnomAD
CA6914428 rs764821255	411	Y>H		No	ClinGen ExAC gnomAD
CA387537634 rs1164938558	412	E>D		No	ClinGen TOPMed
rs1406618400 CA387537651	414	M>T		No	ClinGen TOPMed
rs35793500 CA387537682	416	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA246715464 rs764210666	417	V>A		No	ClinGen Ensembl
CA6914430 rs758074509	418	A>S		No	ClinGen ExAC TOPMed gnomAD
rs758074509 CA387537691	418	A>T		No	ClinGen ExAC TOPMed gnomAD
rs777370643 CA6914431	419	C>R		No	ClinGen ExAC gnomAD
rs1328343163 CA387537721	421	I>T		No	ClinGen gnomAD
rs770141276 CA246715482	424	R>C		No	ClinGen ExAC TOPMed gnomAD
rs770141276 CA6914436	424	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6914437 COSM3793200 COSM3793201 COSM183525 rs777744409	424	R>H	large_intestine urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6914438 rs777744409	424	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1365984 CA387537768 rs1205426761 COSM1365985	425	K>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6914441 rs760457002	426	R>C		No	ClinGen ExAC TOPMed gnomAD
rs147201038 CA6914442	426	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA387537800 rs1429329093	429	E>*		No	ClinGen gnomAD
CA6914444 rs759544607	430	S>N		No	ClinGen ExAC TOPMed gnomAD
CA246715504 rs966615109	430	S>R		No	ClinGen Ensembl
CA387537821 rs1156783194	431	I>V		No	ClinGen TOPMed gnomAD
CA6914446 rs752240893	432	D>N		No	ClinGen ExAC TOPMed gnomAD
rs762424477 CA6914447	433	K>R		No	ClinGen ExAC TOPMed gnomAD
CA387537855 rs1387378056	434	I>L		No	ClinGen gnomAD
rs201424215 CA6914448	434	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs140467795 CA6914449	436	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA246715523 rs886934434	436	R>H		No	ClinGen TOPMed gnomAD
rs886934434 CA246715525	436	R>L		No	ClinGen TOPMed gnomAD
rs1593511951 CA387537917	439	V>G		No	ClinGen Ensembl
rs756792701 CA387537912	439	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6914450 rs756792701	439	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6914451 rs781629339	441	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6914453 COSM3955457 rs756684808 COSM3955458 COSM3955459	442	V>M	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA387538016 rs1490677896	443	G>A		No	ClinGen gnomAD
rs1245094485 CA387538013	443	G>C		No	ClinGen TOPMed
CA6914455 rs780686074	445	E>G		No	ClinGen ExAC TOPMed gnomAD
CA6914484 rs142231073	447	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA246716537 rs924587870	452	R>*		No	ClinGen TOPMed
rs767260316 CA6914487	452	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA387539313 rs1460745773	453	S>N		No	ClinGen gnomAD
CA387539335 rs1204028810	455	E>D		No	ClinGen gnomAD
CA387539363 rs1244701171	458	H>D		No	ClinGen gnomAD
CA6914489 rs760340043	463	T>S		No	ClinGen ExAC TOPMed gnomAD
CA6914491 rs754210107	464	K>T		No	ClinGen ExAC gnomAD
CA387539475 rs1469704444	468	Q>E		No	ClinGen gnomAD
CA6914493 rs765626462	468	Q>H		No	ClinGen ExAC gnomAD
rs1455849977 CA387539488	469	G>D		No	ClinGen gnomAD
CA6914495 rs758392859	471	S>N		No	ClinGen ExAC gnomAD
rs778120365 CA6914497	472	Q>H		No	ClinGen ExAC gnomAD
CA387539547 rs751732780	474	R>G		No	ClinGen ExAC gnomAD
CA6914499 COSM1562337 COSM1562338 rs371749849	474	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6914498 rs751732780	474	R>W		No	ClinGen ExAC gnomAD
CA387539555 rs1566202143	475	T>A		No	ClinGen Ensembl
CA6914500 rs145656991	475	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387539631 rs1463323062	481	H>R		No	ClinGen gnomAD
CA246716615 rs935000938	481	H>Y		No	ClinGen TOPMed gnomAD
CA6914502 rs768629886	482	Q>E		No	ClinGen ExAC gnomAD
CA246716622 rs111499388	482	Q>R		No	ClinGen Ensembl
CA246716627 rs1052503405	484	V>L		No	ClinGen TOPMed
rs778704021 CA6914504	485	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6914507 rs185289809	492	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs139258444 CA6914508	492	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs770671632 CA6914509	493	R>K		No	ClinGen ExAC
rs1318865646 CA387539777	495	M>I		No	ClinGen TOPMed
rs1324790042 CA387539769	495	M>V		No	ClinGen gnomAD
rs765827913 CA6914512	501	R>Q		No	ClinGen ExAC gnomAD
CA246716682 rs1001614874	503	D>G		No	ClinGen TOPMed gnomAD
CA6914514 rs763447520	503	D>N		No	ClinGen ExAC gnomAD
CA6914515 rs764093283	504	M>V		No	ClinGen ExAC gnomAD
rs1368602053 CA387539899	507	M>L		No	ClinGen gnomAD
CA6914516 rs149993979	509	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA387539923 rs1285106073	510	V>A		No	ClinGen gnomAD
rs1222971866 CA387539927	511	D>G		No	ClinGen TOPMed gnomAD
CA6914517 rs757501827	511	D>N		No	ClinGen ExAC gnomAD
CA6914518 rs781369878	512	L>P		No	ClinGen ExAC gnomAD
CA246716698 rs145192781	513	G>A		No	ClinGen ESP TOPMed
CA6914519 rs753692252	514	D>N		No	ClinGen ExAC TOPMed gnomAD
CA387539941 rs753692252	514	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6914520 rs754726668	516	R>C		No	ClinGen ExAC gnomAD
CA6914521 rs778704858	516	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6914525 rs746491345	517	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1271660342 CA387539977	519	D>G		No	ClinGen gnomAD
CA387539987 rs1468964478	520	C>*		No	ClinGen gnomAD
rs770751818 CA6914526	521	N>D		No	ClinGen ExAC gnomAD
CA6914527 rs776406678	521	N>S		No	ClinGen ExAC gnomAD
rs770055743 CA6914529	524	V>M		No	ClinGen ExAC gnomAD
CA6914532 rs199770674 COSM183528	531	V>I	large_intestine breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA387540089 rs1593515790	535	T>I		No	ClinGen Ensembl
CA387540098 rs1242670318	537	E>K		No	ClinGen TOPMed gnomAD
CA387540099 rs1242670318	537	E>Q		No	ClinGen TOPMed gnomAD
CA387540111 rs1305562720	538	V>G		No	ClinGen TOPMed
rs750649425 CA6914536	539	Y>F		No	ClinGen ExAC gnomAD
rs756303982 CA6914537	542	C>G		No	ClinGen ExAC TOPMed gnomAD
CA6914539 rs752500167	543	A>V		No	ClinGen ExAC gnomAD
CA387540148 rs1318721228	544	K>E		No	ClinGen TOPMed
rs776128198 CA246716789	545	K>N		No	ClinGen Ensembl
rs886802848 CA246716793	546	Q>H		No	ClinGen Ensembl
CA387540181 rs1251338091	548	D>V		No	ClinGen gnomAD
CA387540196 rs113723819	550	A>G		No	ClinGen TOPMed gnomAD
CA246716796 rs113723819	550	A>V		No	ClinGen TOPMed gnomAD
CA387540199 rs1181643143	551	R>K		No	ClinGen gnomAD
rs1233820442 CA387540215	553	L>Q		No	ClinGen gnomAD
rs1566202667 CA387540222	554	Q>R		No	ClinGen Ensembl
rs758310897 CA6914540	555	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1176137002 CA387540234	556	C>Y		No	ClinGen TOPMed
CA246716801 rs1003862805	557	A>T		No	ClinGen TOPMed
rs777835504 CA6914541	558	D>V		No	ClinGen ExAC gnomAD
CA6914543 rs756818873	562	R>Q		No	ClinGen ExAC gnomAD
rs1377491240 CA387540274	562	R>W		No	ClinGen TOPMed
CA387540282 rs1593515982	563	V>G		No	ClinGen Ensembl
CA387540311 rs1409308979	567	K>N		No	ClinGen gnomAD
CA6914544 rs141312904	567	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914545 rs141312904	567	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222166962 CA387540358	572	E>K		No	ClinGen gnomAD
rs1462043940 CA387540394	576	N>K		No	ClinGen gnomAD
rs1175226422 COSM404034 CA387540399	577	Q>R	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs748679247 CA6914569	581	A>V		No	ClinGen ExAC gnomAD
rs1566204368 CA387540436	582	M>I		No	ClinGen Ensembl
CA6914572 rs773323858	586	Q>E		No	ClinGen ExAC gnomAD
rs760790234 CA6914573	587	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6914574 rs766572942	588	A>E		No	ClinGen ExAC gnomAD
CA387540474 rs1479425057	588	A>T		No	ClinGen gnomAD
rs776903993 CA6914575	590	H>P		No	ClinGen ExAC gnomAD
rs759606721 CA6914576	591	G>E		No	ClinGen ExAC gnomAD
CA387540670 rs1179550409	597	N>S		No	ClinGen gnomAD
rs369378402 CA6914598	598	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442965467 CA387540683	599	C>Y		No	ClinGen gnomAD
rs1425794098 CA387540689	600	P>A		No	ClinGen TOPMed
CA6914600 rs767621545	601	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1462716861 CA387540703	602	A>G		No	ClinGen TOPMed gnomAD
CA387540710 rs1202934482	603	P>L		No	ClinGen TOPMed
rs1165017447 CA387540705	603	P>S		No	ClinGen TOPMed gnomAD
CA246719571 rs766100648	604	P>L		No	ClinGen gnomAD
CA6914605 rs753245659	606	Q>H		No	ClinGen ExAC gnomAD
rs1048725200 CA246719611	611	I>F		No	ClinGen TOPMed
rs1270415344 CA387540761	611	I>M		No	ClinGen Ensembl
CA246719615 rs889622258	612	H>R		No	ClinGen TOPMed
rs758752942 COSM1365989 COSM1365988 CA6914609	614	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6914610 rs574642354	614	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771296388 CA6914612	618	M>V		No	ClinGen ExAC TOPMed gnomAD
CA387540817 rs1480860593	620	T>A		No	ClinGen TOPMed gnomAD
CA246719629 rs372421924	621	S>N		No	ClinGen gnomAD
CA387540825 rs372421924	621	S>T		No	ClinGen gnomAD
rs745913840 CA6914614	622	V>I		No	ClinGen ExAC TOPMed gnomAD
CA387540838 rs1291549491	623	P>R		No	ClinGen TOPMed gnomAD
rs775843017 CA6914616	626	Q>*		No	ClinGen ExAC gnomAD
rs1169010015 CA387540861	626	Q>H		No	ClinGen gnomAD
rs1348407704 CA387540867	627	V>A		No	ClinGen TOPMed
CA6914617 rs749454221	630	L>M		No	ClinGen ExAC gnomAD
rs1593522051 CA387540886	630	L>R		No	ClinGen Ensembl
CA6914619 rs771913988	631	A>G		No	ClinGen ExAC gnomAD
CA246719638 rs1030752431	631	A>T		No	ClinGen gnomAD
CA6914618 rs771913988	631	A>V		No	ClinGen ExAC gnomAD
rs766192666 CA6914621	634	K>E		No	ClinGen ExAC gnomAD
rs759208554 CA6914623	638	S>L		No	ClinGen ExAC TOPMed gnomAD
rs776250969 CA6914622	638	S>T		No	ClinGen ExAC gnomAD
rs752355550 CA6914625	642	H>R		No	ClinGen ExAC gnomAD
rs1220330423 CA387540981	645	N>D		No	ClinGen gnomAD
rs143829548 CA6914626	645	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA387540996 rs1238243877	647	L>H		No	ClinGen gnomAD
rs751832948 CA6914628	647	L>I		No	ClinGen ExAC TOPMed gnomAD
CA387540994 rs751832948	647	L>V		No	ClinGen ExAC TOPMed gnomAD
rs969190256 CA246719702	648	T>N		No	ClinGen TOPMed gnomAD
rs376254629 CA6914629	649	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914631 rs376254629	649	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376254629 CA6914630	649	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6914633 rs200138957	651	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6914632 rs756258666	651	R>W		No	ClinGen ExAC gnomAD
rs749542130 CA6914634	652	K>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q96N96

3 regional properties for Q96N96

Type	Name	Position	InterPro Accession
domain	Dbl homology (DH) domain	240 - 424	IPR000219
domain	SH3 domain	147 - 206	IPR001452
domain	Pleckstrin homology domain	455 - 563	IPR001849

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell projection, filopodium Cell projection, lamellipodium Cell projection, ruffle membrane	Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment
PANTHER Family	PTHR47544	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
PANTHER Subfamily	PTHR47544:SF2	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9
PANTHER Protein Class	guanyl-nucleotide exchange factor G-protein modulator protein-binding activity modulator
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
filopodium	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
identical protein binding	Binding to an identical protein or proteins.

5 GO annotations of biological process

Name	Definition
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
filopodium assembly	The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
lamellipodium assembly	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58DL7	ARHGEF9	Rho guanine nucleotide exchange factor 9	Bos taurus (Bovine)	SS
Q70Z35	PREX2	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	Homo sapiens (Human)	SS
Q6XZF7	DNMBP	Dynamin-binding protein	Homo sapiens (Human)	PR
Q9NR80	ARHGEF4	Rho guanine nucleotide exchange factor 4	Homo sapiens (Human)	EV
A1IGU5	ARHGEF37	Rho guanine nucleotide exchange factor 37	Homo sapiens (Human)	PR
Q8TCU6	PREX1	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	Homo sapiens (Human)	EV
O43307	ARHGEF9	Rho guanine nucleotide exchange factor 9	Homo sapiens (Human)	SS
Q3LAC4	Prex2	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	Mus musculus (Mouse)	SS
Q7TNR9	Arhgef4	Rho guanine nucleotide exchange factor 4	Mus musculus (Mouse)	EV
Q69ZK0	Prex1	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	Mus musculus (Mouse)	SS
Q3UTH8	Arhgef9	Rho guanine nucleotide exchange factor 9	Mus musculus (Mouse)	SS
Q5DU57	Spata13	Spermatogenesis-associated protein 13	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MTSASPEDQN	APVGCPKGAR	RRRPISVIGG	VSLYGTNQTE	ELDNLLTQPA	SRPPMPAHQV
70	80	90	100	110	120
PPYKAVSARF	RPFTFSQSTP	IGLDRVGRRR	QMRASNVSSD	GGTEPSALVD	DNGSEEDFSY
130	140	150	160	170	180
EDLCQASPRY	LQPGGEQLAI	NELISDGNVV	CAEALWDHVT	MDDQELGFKA	GDVIQVLEAS
190	200	210	220	230	240
NKDWWWGRSE	DKEAWFPASF	VRLRVNQEEL	SENSSSTPSE	EQDEEASQSR	HRHCENKQQM
250	260	270	280	290	300
RTNVIREIMD	TERVYIKHLR	DICEGYIRQC	RKHTGMFTVA	QLATIFGNIE	DIYKFQRKFL
310	320	330	340	350	360
KDLEKQYNKE	EPHLSEIGSC	FLQNQEGFAI	YSEYCNNHPG	ACLELANLMK	QGKYRHFFEA
370	380	390	400	410	420
CRLLQQMIDI	AIDGFLLTPV	QKICKYPLQL	AELLKYTTQE	HGDYSNIKAA	YEAMKNVACL
430	440	450	460	470	480
INERKRKLES	IDKIARWQVS	IVGWEGLDIL	DRSSELIHSG	ELTKITKQGK	SQQRTFFLFD
490	500	510	520	530	540
HQLVSCKKDL	LRRDMLYYKG	RLDMDEMELV	DLGDGRDKDC	NLSVKNAFKL	VSRTTDEVYL
550	560	570	580	590	600
FCAKKQEDKA	RWLQACADER	RRVQEDKEMG	MEISENQKKL	AMLNAQKAGH	GKSKGYNRCP
610	620	630	640	650
VAPPHQGLHP	IHQRHITMPT	SVPQQQVFGL	AEPKRKSSLF	WHTFNRLTPF	RK