AiPD: Autoinhibited Protein Database

Q96N95

Gene name	ZNF396 (ZSCAN14)
Protein name	Zinc finger protein 396
Names	Zinc finger and SCAN domain-containing protein 14
Species	Homo sapiens (Human)
KEGG Pathway	hsa:252884
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-60 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96N95

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96N95-F1	Predicted				AlphaFoldDB

276 variants for Q96N95

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA402283664 rs1316732961	2	S>C		No	ClinGen TOPMed
CA8937670 rs762134932	3	A>S		No	ClinGen ExAC
CA402283656 rs1198935239	4	K>E		No	ClinGen TOPMed
rs1258100157 CA402283646	5	L>S		No	ClinGen gnomAD
CA402283641 rs1295274774	6	G>R		No	ClinGen TOPMed gnomAD
CA8937667 rs768643264	8	S>*		No	ClinGen ExAC gnomAD
CA8937668 rs774661109	8	S>T		No	ClinGen ExAC TOPMed gnomAD
CA298622077 rs866491642	10	S>L		No	ClinGen Ensembl
rs1278469567 CA402283611	11	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs912340816 CA298622076	11	L>P		No	ClinGen TOPMed
CA402283612 rs1278469567	11	L>V		No	ClinGen gnomAD
CA8937664 rs770875788	14	Q>E		No	ClinGen ExAC gnomAD
CA298622075 rs140642117	15	T>I		No	ClinGen ESP
rs1272810365 CA402283580	16	S>*		No	ClinGen gnomAD
rs1382049397 CA402283576	17	E>G		No	ClinGen gnomAD
rs370565271 CA8937663	17	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937661 rs758121706	18	E>D		No	ClinGen ExAC gnomAD
CA8937662 rs777539789	18	E>Q		No	ClinGen ExAC gnomAD
rs1309504554 CA402283545	21	G>V		No	ClinGen gnomAD
TCGA novel	23	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs934883170 CA298622074	26	K>E		No	ClinGen TOPMed gnomAD
CA402283504 rs1168106373	27	M>I		No	ClinGen gnomAD
rs924773183 CA298622073	27	M>R		No	ClinGen TOPMed
CA402283492 rs1406870350	29	E>G		No	ClinGen gnomAD
rs778576252 CA402283487	30	E>K		No	ClinGen ExAC TOPMed gnomAD
rs778576252 CA8937659	30	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1187062603 CA402283478	31	E>*		No	ClinGen TOPMed gnomAD
CA402283463 rs1255432859	33	T>A		No	ClinGen gnomAD
CA402283459 rs1179005981	33	T>I		No	ClinGen gnomAD
CA402283447 rs1481107043	35	D>G		No	ClinGen TOPMed gnomAD
CA402283449 rs1368036752	35	D>N		No	ClinGen TOPMed
rs1276202082 CA402283442	36	P>T		No	ClinGen TOPMed
rs753367083 CA8937657	37	D>E		No	ClinGen ExAC TOPMed gnomAD
CA402283424 rs1598705887	38	S>C		No	ClinGen Ensembl
rs1218742110 CA402283422	39	S>G		No	ClinGen TOPMed
rs1373412478 CA402283416	39	S>R		No	ClinGen gnomAD
CA8937656 rs766854143	40	L>I		No	ClinGen ExAC gnomAD
rs766854143 CA402283415	40	L>V		No	ClinGen ExAC gnomAD
rs1259373273 CA402283407	41	H>P		No	ClinGen TOPMed
rs761240670 CA8937655	42	W>*		No	ClinGen ExAC gnomAD
CA402283397 rs1220282310	42	W>*		No	ClinGen TOPMed
rs1233170136 CA402283393	43	S>G		No	ClinGen gnomAD
rs750898040 CA8937654	43	S>I		No	ClinGen ExAC gnomAD
CA402283388 rs1266466534	43	S>R		No	ClinGen TOPMed
rs376934742 CA8937652	47	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA8937649 rs753830014	51	F>*		No	ClinGen ExAC
CA8937646 rs143642761	52	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143642761 CA8937647	52	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375524014 CA8937644	52	R>H		No	ClinGen ExAC TOPMed gnomAD
rs375524014 CA8937645	52	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8937642 rs746953539	53	Q>H		No	ClinGen ExAC
CA402283325 rs1195951921	53	Q>K		No	ClinGen TOPMed
rs773074174 CA8937641	54	Q>H		No	ClinGen ExAC
rs1169638705 CA402283297	57	Q>K		No	ClinGen gnomAD
CA8937638 rs137966135	59	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1164162234 CA402283266	61	Q>*		No	ClinGen gnomAD
rs778481234 CA402283264	61	Q>L		No	ClinGen ExAC gnomAD
rs778481234 CA8937637	61	Q>R		No	ClinGen ExAC gnomAD
rs754646015 CA8937636	64	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748816802 CA8937635	65	G>E		No	ClinGen ExAC gnomAD
CA298622072 rs760413873	68	E>K		No	ClinGen gnomAD
CA8937633 rs755631539	70	L>V		No	ClinGen ExAC gnomAD
rs372161434 CA8937632	71	S>N		No	ClinGen ExAC TOPMed gnomAD
CA402283197 rs141128029	72	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs141128029 CA8937630	72	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs150745506 CA8937631	72	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA298622070 CA298622071 rs148190809	74	W>R		No	ClinGen ESP
CA402283177 rs1239203737	75	E>D		No	ClinGen gnomAD
rs751926567 CA8937629	75	E>K		No	ClinGen ExAC
CA8937628 rs764277597	76	L>F		No	ClinGen ExAC gnomAD
rs144629150 CA402283159	78	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed
rs144629150 CA8937627	78	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA402283161 COSM563328 rs1304416750	78	H>Y	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA402283154 rs1376334307	79	L>F		No	ClinGen TOPMed
TCGA novel	82	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775507601 CA8937626	83	P>L		No	ClinGen ExAC TOPMed gnomAD
rs775507601 CA298622069	83	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1271410957 CA402283129	83	P>T		No	ClinGen Ensembl
CA8937623 rs773162152	84	E>*		No	ClinGen ExAC gnomAD
CA8937624 rs773162152	84	E>K		No	ClinGen ExAC gnomAD
CA8937620 rs751718795	87	T>A		No	ClinGen ExAC gnomAD
rs1454379423 CA402283086	89	E>D		No	ClinGen gnomAD
CA402283047 rs1363262013	95	L>R		No	ClinGen gnomAD
CA402283018 rs1214941243	100	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8937619 rs377112324	100	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs768269256 CA8937618	103	I>V		No	ClinGen ExAC gnomAD
CA8937617 rs748987673	104	L>F		No	ClinGen ExAC TOPMed
CA298622066 rs761854981	106	K>R		No	ClinGen Ensembl
rs1049434483 CA298622065	107	E>D		No	ClinGen Ensembl
rs779527153 CA8937616	109	Q>H		No	ClinGen ExAC gnomAD
CA402282954 rs1264491001	110	A>V		No	ClinGen gnomAD
rs1219426913 CA402282945	111	W>C		No	ClinGen TOPMed
rs1225630792 CA402282936	113	Q>K		No	ClinGen gnomAD
TCGA novel	113	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1373478926 CA402282932	113	Q>R		No	ClinGen gnomAD
CA402282927 rs1567956573	114	K>E		No	ClinGen Ensembl
CA402282920 rs1485275614	115	H>N		No	ClinGen gnomAD
rs745342325 CA402282913	115	H>Q		No	ClinGen ExAC gnomAD
CA402282916 rs1258380645	115	H>R		No	ClinGen TOPMed gnomAD
CA402282887 rs1302226746	119	N>I		No	ClinGen TOPMed gnomAD
rs1302226746 CA402282886	119	N>S		No	ClinGen TOPMed gnomAD
rs527836273 CA8937612	121	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA298622064 rs753885904	122	E>V		No	ClinGen gnomAD
rs574464698 CA298622063	125	T>A		No	ClinGen Ensembl
rs751931646 CA8937610	126	M>I		No	ClinGen ExAC TOPMed gnomAD
CA402282844 rs1567956519	126	M>V		No	ClinGen Ensembl
CA298622062 rs763792375	128	E>K		No	ClinGen gnomAD
rs764520319 CA8937609	129	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1296465161 CA402282808	131	E>G		No	ClinGen gnomAD
rs1446695707 CA402282792	133	E>D		No	ClinGen TOPMed
CA8937608 rs373546518	133	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8937607 rs113297988	134	L>P		No	ClinGen ExAC gnomAD
CA402282766 rs1452967852	137	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	142	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402282720 rs1287538142	142	F>V		No	ClinGen TOPMed
TCGA novel	142	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402282714 rs1256138741	143	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	143	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8937585 rs200861128	144	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs200723166 CA8937584	144	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs763909301 CA8937583	145	R>G		No	ClinGen ExAC gnomAD
TCGA novel	146	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775409603 CA8937581	147	D>E		No	ClinGen ExAC gnomAD
CA8937582 rs762857777	147	D>Y		No	ClinGen ExAC gnomAD
rs779377576 CA298622040	148	M>V		No	ClinGen Ensembl
CA8937580 rs769635315	149	I>M		No	ClinGen ExAC gnomAD
rs1274980941 CA402282673	149	I>T		No	ClinGen TOPMed gnomAD
CA8937579 rs759262254	152	K>N		No	ClinGen ExAC gnomAD
CA298622039 rs939661760	154	A>G		No	ClinGen Ensembl
CA402282639 rs1598704876	155	P>A		No	ClinGen Ensembl
CA402282616 rs1337817376	158	I>T		No	ClinGen gnomAD
rs1031088285 CA298622038	159	T>I		No	ClinGen TOPMed gnomAD
rs772446501 CA8937574	162	L>F		No	ClinGen ExAC gnomAD
rs1406285747 CA402282586	163	P>A		No	ClinGen TOPMed
CA402282579 rs1567956201	164	S>G		No	ClinGen Ensembl
CA8937573 rs748615438	164	S>N		No	ClinGen ExAC TOPMed gnomAD
CA8937570 rs566770838	167	L>H		No	ClinGen 1000Genomes ExAC gnomAD
CA298622036 rs114717482	168	M>I		No	ClinGen 1000Genomes gnomAD
CA298622037 rs999178831	168	M>R		No	ClinGen TOPMed
CA298622035 rs866296045	169	P>S		No	ClinGen TOPMed
rs756260955 CA402282540	170	V>L		No	ClinGen ExAC TOPMed gnomAD
rs756260955 CA8937568	170	V>M		No	ClinGen ExAC TOPMed gnomAD
rs560556722 CA8937567	172	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1468008298 CA402282515	173	Q>H		No	ClinGen gnomAD
rs1043444688 CA298622034	173	Q>R		No	ClinGen TOPMed
CA402282505 rs1271183142	175	Q>*		No	ClinGen gnomAD
rs764148234 CA8937566	176	G>E		No	ClinGen ExAC TOPMed gnomAD
rs375802840 CA298622033	177	A>T		No	ClinGen ESP TOPMed gnomAD
CA402282480 rs1239783886	179	W>*		No	ClinGen gnomAD
CA402282481 rs1238545537	179	W>G		No	ClinGen gnomAD
CA8937564 rs202174493	181	L>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937563 rs368248319	182	Q>R		No	ClinGen ESP ExAC gnomAD
rs759356031 CA8937562	184	L>*		No	ClinGen ExAC gnomAD
rs371734040 CA298622030	184	L>V		No	ClinGen Ensembl
CA8937561 rs138495232	188	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1598700568 CA402282234	190	D>E		No	ClinGen Ensembl
rs1598700579 CA402282240	190	D>N		No	ClinGen Ensembl
TCGA novel	190	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371305060 CA402282226	191	I>M		No	ClinGen TOPMed
rs371299934 CA8937528	201	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs754951042 CA8937526	206	L>S		No	ClinGen ExAC gnomAD
rs1320034401 CA402282115	208	I>T		No	ClinGen TOPMed
CA8937525 rs9963473 VAR_057418	211	H>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs775808351 CA402282094	211	H>Q		No	ClinGen ExAC gnomAD
CA298621671 rs9963473	211	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	211	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8937523 rs140666989	212	C>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs543145168 CA8937522	213	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1215406107 CA402282055	217	I>T		No	ClinGen TOPMed
CA8937520 rs761366844	219	H>R		No	ClinGen ExAC gnomAD
rs751058626 CA8937519	220	M>I		No	ClinGen ExAC gnomAD
CA402282034 rs1207133270	220	M>R		No	ClinGen gnomAD
rs1258696060 CA402282024	221	N>K		No	ClinGen gnomAD
CA402282027 rs1245939098	221	N>S		No	ClinGen TOPMed
CA8937518 rs764654556	222	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1217286825 CA402282003	225	S>G		No	ClinGen TOPMed gnomAD
rs1413629001 CA402281968	230	G>R		No	ClinGen TOPMed gnomAD
rs1376593452 CA402281949	233	E>K		No	ClinGen gnomAD
rs776005598 CA8937516	234	Q>P		No	ClinGen ExAC gnomAD
rs770073755 CA8937515	235	D>H		No	ClinGen ExAC
rs759901946 CA8937514	236	G>R		No	ClinGen ExAC gnomAD
TCGA novel	236	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs574043787 CA8937511	238	F>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200256118 CA8937510	239	E>A		No	ClinGen ExAC TOPMed gnomAD
rs200256118 CA402281904	239	E>G		No	ClinGen ExAC TOPMed gnomAD
CA402281900 rs1165830566	240	K>E		No	ClinGen gnomAD
rs772223147 CA8937509	241	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	243	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402281866 rs1388328724	244	N>K		No	ClinGen TOPMed
CA298621670 rs780003016	245	P>A		No	ClinGen ExAC gnomAD
rs780003016 CA8937507	245	P>T		No	ClinGen ExAC gnomAD
CA402281858 rs1436229369	246	S>Y		No	ClinGen TOPMed
rs1377551062 CA402281845	248	K>E		No	ClinGen TOPMed
rs200991704 RCV000971074	250	Q>missing		No	ClinVar dbSNP
rs755905627 CA8937506	250	Q>K		No	ClinGen ExAC
CA298621669 rs1029091625	250	Q>R		No	ClinGen TOPMed
rs1567953938 CA402281804	253	C>S		No	ClinGen Ensembl
rs374004274 CA8937504	255	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8937503 rs557349808	256	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA8937502 rs756901477	256	C>Y		No	ClinGen ExAC gnomAD
rs751142511 CA8937501	258	K>N		No	ClinGen ExAC gnomAD
CA8937500 rs145740578	261	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567953899 CA402281746	261	S>I		No	ClinGen Ensembl
rs1567953899 CA402281747	261	S>T		No	ClinGen Ensembl
rs905416291 CA298621668	264	S>*		No	ClinGen Ensembl
rs1319329589 CA402281727	264	S>T		No	ClinGen gnomAD
rs1223942329 CA402281719	265	A>D		No	ClinGen gnomAD
CA8937498 rs753172094	271	R>I		No	ClinGen ExAC gnomAD
CA402281678 rs753172094	271	R>K		No	ClinGen ExAC gnomAD
CA8937497 rs765742311	271	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1395200863 CA402281667	273	H>D		No	ClinGen gnomAD
rs1209055115 CA402281646	276	K>E		No	ClinGen TOPMed
CA8937494 rs777040842	276	K>R		No	ClinGen ExAC gnomAD
rs374149724 CA298621667	278	P>H		No	ClinGen ESP ExAC gnomAD
CA8937493 rs374149724	278	P>L		No	ClinGen ESP ExAC gnomAD
rs773518822 CA8937491	279	Y>*		No	ClinGen ExAC
rs760992408 CA8937492	279	Y>C		No	ClinGen ExAC gnomAD
CA8937486 rs777224773	281	C>*		No	ClinGen ExAC gnomAD
CA8937490 rs149796653	281	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8937489 rs200984340	281	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA402281609 rs1292466006	282	D>N		No	ClinGen gnomAD
CA8937487 rs769759761	283	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745720795 CA8937485	285	A>S		No	ClinGen ExAC gnomAD
rs1256219929 CA402281580	286	K>E		No	ClinGen TOPMed
CA8937484 rs780973619	288	F>Y		No	ClinGen ExAC gnomAD
CA8937483 rs369731655	290	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA402281551 rs369731655	290	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
COSM988147 CA8937482 rs745879283	290	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs116404576 CA402281542	291	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757883580 CA402281540	292	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8937480 rs757883580	292	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs375219933 CA8937479	295	I>L		No	ClinGen ESP ExAC gnomAD
rs112874582 CA8937478	296	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937476 rs770977648	298	R>*		No	ClinGen ExAC TOPMed gnomAD
rs766873525 CA8937475	298	R>Q		No	ClinGen ExAC gnomAD
CA8937474 rs761080609	299	R>*		No	ClinGen ExAC TOPMed gnomAD
rs949401279 COSM988146 CA298621666	299	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA402281483 rs566238013	301	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA8937472 rs115597469	302	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937471 rs761858803	306	P>L		No	ClinGen ExAC TOPMed gnomAD
CA402281448 rs761858803	306	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1431984276 CA402281441	307	Y>*		No	ClinGen TOPMed gnomAD
CA8937470 rs774488647	307	Y>C		No	ClinGen ExAC gnomAD
CA402281431 rs1351265463	309	C>R		No	ClinGen TOPMed
TCGA novel	309	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535584134 CA8937468	310	H>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8937469 rs535584134	310	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA298621665 rs867241216	311	D>E		No	ClinGen Ensembl
CA402281410 rs192743555	312	C>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937467 rs192743555	312	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8937466 rs139312528	312	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA298621664 rs139312528	312	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402281395 rs1179320078	314	K>I		No	ClinGen TOPMed
TCGA novel	315	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402281392 rs1212518459	315	A>T		No	ClinGen gnomAD
rs867840508 CA298621663	315	A>V		No	ClinGen Ensembl
CA8937464 rs116074936	316	F>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781036174 CA8937462	321	N>D		No	ClinGen ExAC TOPMed gnomAD
CA8937461 rs778490037	321	N>T		No	ClinGen ExAC gnomAD
CA8937458 rs766963640	322	L>H		No	ClinGen ExAC TOPMed gnomAD
rs766963640 CA8937459	322	L>R		No	ClinGen ExAC TOPMed gnomAD
rs754397738 CA8937460	322	L>V		No	ClinGen ExAC gnomAD
rs1416907581 CA402281339	323	F>V		No	ClinGen gnomAD
rs1335400492 CA402281329	324	R>I		No	ClinGen TOPMed gnomAD
TCGA novel	324	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464845884 CA402281301	328	R>K		No	ClinGen gnomAD
rs1375299078 CA402281296	329	H>N		No	ClinGen gnomAD
CA402281290 rs1567953637	329	H>Q		No	ClinGen Ensembl
CA402281285 rs1171652579	330	I>N		No	ClinGen gnomAD
rs1003186692 CA298621661	330	I>V		No	ClinGen Ensembl
rs1567953617 CA402281279	331	R>K		No	ClinGen Ensembl
rs1260477904 CA402281270	332	K>R		No	ClinGen TOPMed gnomAD
CA402281267 rs1371462545	333	K>E		No	ClinGen TOPMed
rs868211897 CA298621659	334	V>A		No	ClinGen Ensembl
rs1028896564 CA298621660	334	V>I		No	ClinGen TOPMed
CA8937455 rs750806462	335	P>T		No	ClinGen ExAC gnomAD

No associated diseases with Q96N95

1 regional properties for Q96N95

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	16 - 165	IPR005225

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Nucleus ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name	Definition
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSAKLGKSSS	LLTQTSEECN	GILTEKMEEE	EQTCDPDSSL	HWSSSYSPET	FRQQFRQFGY
70	80	90	100	110	120
QDSPGPHEAL	SRLWELCHLW	LRPEVHTKEQ	ILELLVLEQF	LAILPKELQA	WVQKHHPENG
130	140	150	160	170	180
EETVTMLEDV	ERELDGPKQI	FFGRRKDMIA	EKLAPSEITE	ELPSSQLMPV	KKQLQGASWE
190	200	210	220	230	240
LQSLRPHDED	IKTTNVKSAS	RQKTSLGIEL	HCNVSNILHM	NGSQSSTYRG	TYEQDGRFEK
250	260	270	280	290	300
RQGNPSWKKQ	QKCDECGKIF	SQSSALILHQ	RIHSGKKPYA	CDECAKAFSR	SAILIQHRRT
310	320	330
HTGEKPYKCH	DCGKAFSQSS	NLFRHRKRHI	RKKVP