Q96LW2

PR
Gene name
RSKR
Protein name
Ribosomal protein S6 kinase-related protein
Names
Sugen kinase 494
Species
Homo sapiens (Human)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

246-268 (Activation loop from InterPro)

Target domain

107-359 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q96LW2

Entry ID Method Resolution Chain Position Source
AF-Q96LW2-F1 Predicted AlphaFoldDB

No variants for Q96LW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96LW2

No associated diseases with Q96LW2

3 regional properties for Q96LW2

Type Name Position InterPro Accession
domain Protein kinase domain 107 - 359 IPR000719
active_site Serine/threonine-protein kinase, active site 225 - 237 IPR008271
domain Serine/Threonine Kinase AGC, catalytic domain 115 - 359 IPR045270

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
A1A4I4 PKN1 Serine/threonine-protein kinase N1 Bos taurus (Bovine) SS
Q9NBK5 trc Serine/threonine-protein kinase tricornered Drosophila melanogaster (Fruit fly) SS
A1Z7T0 Pkn Serine/threonine-protein kinase N Drosophila melanogaster (Fruit fly) SS
P83099 Pkcdelta Putative protein kinase C delta type homolog Drosophila melanogaster (Fruit fly) PR
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q04759 PRKCQ Protein kinase C theta type Homo sapiens (Human) PR
Q6P5Z2 PKN3 Serine/threonine-protein kinase N3 Homo sapiens (Human) SS
Q02156 PRKCE Protein kinase C epsilon type Homo sapiens (Human) SS
P24723 PRKCH Protein kinase C eta type Homo sapiens (Human) SS
Q16512 PKN1 Serine/threonine-protein kinase N1 Homo sapiens (Human) EV
Q16513 PKN2 Serine/threonine-protein kinase N2 Homo sapiens (Human) EV
Q05655 PRKCD Protein kinase C delta type Homo sapiens (Human) SS
P32298 GRK4 G protein-coupled receptor kinase 4 Homo sapiens (Human) SS
Q15835 GRK1 Rhodopsin kinase GRK1 Homo sapiens (Human) PR
P43250 GRK6 G protein-coupled receptor kinase 6 Homo sapiens (Human) EV
P34947 GRK5 G protein-coupled receptor kinase 5 Homo sapiens (Human) EV
P25098 GRK2 Beta-adrenergic receptor kinase 1 Homo sapiens (Human) PR
P35626 GRK3 Beta-adrenergic receptor kinase 2 Homo sapiens (Human) PR
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
Q63433 Pkn1 Serine/threonine-protein kinase N1 Rattus norvegicus (Rat) SS
Q64617 Prkch Protein kinase C eta type Rattus norvegicus (Rat) PR
P09216 Prkce Protein kinase C epsilon type Rattus norvegicus (Rat) PR
P09215 Prkcd Protein kinase C delta type Rattus norvegicus (Rat) PR
O08874 Pkn2 Serine/threonine-protein kinase N2 Rattus norvegicus (Rat) SS
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
P34722 tpa-1 Protein kinase C-like 1 Caenorhabditis elegans PR
A7MBL8 pkn2 Serine/threonine-protein kinase N2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG
70 80 90 100 110 120
HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT
130 140 150 160 170 180
VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQR QINHPFVHSL GDSWQGKRHL
190 200 210 220 230 240
FIMCSYCSTD LYSLWSAVGC FPEASIRLFA AELVLVLCYL HDLGIMHRDV KVENILLDER
250 260 270 280 290 300
GHLKLTDFGL SRHVPQGAQA YTICGTLQYM APEVLSGGPY NHAADWWSLG VLLFSLATGK
310 320 330 340 350 360
FPVAAERDHV AMLASVTHSD SEIPASLNQG LSLLLHELLC QNPLHRLRYL HHFQVHPFFR
370 380 390 400
GVAFDPELLQ KQPVNFVTET QATQPSSAET MPFDDFDCDL ESFLLYPIPA