Q96L34
SS
Gene name |
MARK4 (KIAA1860, MARKL1) |
Protein name |
MAP/microtubule affinity-regulating kinase 4 |
Names |
EC 2.7.11.1 , MAP/microtubule affinity-regulating kinase-like 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:57787 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MARK1 is a Ser/Thr protein kinase involved in various cellular processes. It is part of the CAMK-like kinase family and has roles in diseases like Alzheimer’s and cancer. The kinase’s autoinhibition is mediated by its C-terminal KA1 domain, which interacts with the kinase domain to prevent substrate binding and activation. The KA1 domain binds to the αD-helix, blocking the peptide substrate binding site and inhibiting the kinase. This autoinhibition is alleviated by the binding of anionic phospholipid membranes to the KA1 domain, which reverses MARK1 autoinhibition and stimulates kinase activity.
Autoinhibitory domains (AIDs)
Target domain |
59-310 (Protein kinase domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
198-220 (Activation loop from InterPro)
Target domain |
59-310 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
3 structures for Q96L34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5ES1 | X-ray | 280 A | A | 44-370 | PDB |
| 8XFL | X-ray | 300 A | A/B | 44-370 | PDB |
| AF-Q96L34-F1 | Predicted | AlphaFoldDB |
541 variants for Q96L34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs776034001 CA9510736 |
5 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510738 rs764522470 |
8 | A>T | No |
ClinGen ExAC |
|
|
rs765601545 CA308950046 |
9 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510741 rs765601545 |
9 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762115064 CA9510740 |
9 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA9510743 rs758622248 |
10 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1233457397 CA406340012 |
11 | N>K | No |
ClinGen TOPMed |
|
|
rs767552399 CA9510744 |
11 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406340014 rs1268869960 |
12 | D>N | No |
ClinGen gnomAD |
|
|
rs1331054790 CA406340040 |
15 | S>L | No |
ClinGen gnomAD |
|
|
rs1277909022 CA406340054 |
17 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
rs752538573 CA9510763 |
18 | H>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 19 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406341894 rs1467649062 |
20 | T>A | No |
ClinGen TOPMed |
|
|
CA308956773 rs760686813 |
20 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510764 rs760686813 |
20 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766196910 CA308956780 |
23 | S>I | No |
ClinGen Ensembl |
|
|
COSM1686288 COSM1686289 CA9510765 rs547487115 |
25 | R>C | skin [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA406341943 rs547487115 |
25 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9510766 rs143817847 |
25 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757101512 CA9510767 |
26 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs778478961 CA9510768 |
27 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1423133877 CA406341959 |
27 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
CA406341975 rs1599778190 |
28 | D>G | No |
ClinGen Ensembl |
|
|
rs779634872 CA9510771 |
29 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs536838942 CA308956814 |
30 | G>A | No |
ClinGen 1000Genomes gnomAD |
|
|
CA9510772 rs200047371 |
30 | G>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA406341991 rs536838942 |
30 | G>V | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1181867140 COSM1129790 CA406342002 |
31 | P>L | Variant assessed as Somatic; impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1568490052 CA406341996 |
31 | P>S | No |
ClinGen Ensembl |
|
|
CA308956845 rs893023482 |
32 | S>F | No |
ClinGen TOPMed |
|
|
rs1253802185 CA406342007 |
32 | S>P | No |
ClinGen TOPMed |
|
|
CA406342031 rs1599778224 |
34 | S>A | No |
ClinGen Ensembl |
|
|
rs781613152 CA406342043 |
35 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510775 rs781613152 |
35 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510776 rs748513050 |
36 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs770299929 CA9510777 |
36 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs770299929 CA406342053 |
36 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA9510780 rs770869019 |
39 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774468821 CA9510781 |
40 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510782 rs759575925 |
41 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs944493070 CA308956885 |
41 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA9510783 rs764078045 |
42 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA9510785 rs201262565 |
43 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510784 rs753786354 |
43 | R>W | No |
ClinGen ExAC |
|
|
CA9510786 rs765045934 |
45 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA9510789 rs758021513 |
47 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1750973 COSM1750974 CA9510788 rs758021513 |
47 | A>T | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA406342181 rs754507921 |
51 | E>* | No |
ClinGen ExAC gnomAD |
|
|
COSM3823405 COSM3823406 rs754507921 CA9510791 |
51 | E>K | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA308956945 rs764644423 |
53 | Q>H | No |
ClinGen gnomAD |
|
|
CA9510793 rs748672133 |
54 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA9510795 COSM998156 COSM1590144 rs778306514 |
56 | V>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA9510797 rs771153722 |
60 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510798 rs774505246 |
60 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774505246 CA406342245 |
60 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs888057141 CA308956975 |
65 | I>T | No |
ClinGen Ensembl |
|
|
rs1157095034 CA406342299 |
69 | N>S | No |
ClinGen gnomAD |
|
|
rs1387750050 CA406342307 |
70 | F>S | No |
ClinGen gnomAD |
|
|
rs1380372619 CA406342313 |
71 | A>S | No |
ClinGen gnomAD |
|
|
CA9510800 rs772048704 |
72 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 75 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs139770233 CA308956994 |
77 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs139770233 CA9510802 |
77 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 77 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs765205181 CA9510803 |
79 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs766037732 CA9510806 |
82 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs751188496 CA9510807 |
83 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1013318216 CA308957021 |
83 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 84 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1396676671 CA406342425 |
87 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA308960621 rs57927646 |
88 | K>E | No |
ClinGen Ensembl |
|
|
rs1307019708 CA406342435 |
89 | I>S | No |
ClinGen gnomAD |
|
|
CA9510825 rs201439573 |
89 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1443710354 CA406342446 |
91 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1599780703 CA406342462 |
93 | T>P | No |
ClinGen Ensembl |
|
|
CA9510827 rs369856550 |
94 | Q>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9510828 rs755754212 |
99 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406342509 rs1386706763 |
100 | L>M | No |
ClinGen gnomAD |
|
|
CA406342522 rs1304549957 |
102 | K>Q | No |
ClinGen gnomAD |
|
|
rs1274946963 CA406342554 |
104 | F>L | No |
ClinGen gnomAD |
|
|
rs1181776226 CA406342574 |
108 | R>C | No |
ClinGen TOPMed |
|
|
rs750744530 CA9510850 |
108 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs758818170 CA9510851 |
109 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA406342644 rs1292504832 |
118 | I>V | No |
ClinGen TOPMed |
|
|
rs1227932659 CA406342708 |
125 | I>T | No |
ClinGen gnomAD |
|
|
rs1410956211 CA406342730 |
128 | E>D | No |
ClinGen TOPMed |
|
|
rs756689817 CA308962376 |
128 | E>K | No |
ClinGen Ensembl |
|
|
rs781520471 CA9510873 |
130 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406342795 rs1482425171 |
138 | A>T | No |
ClinGen gnomAD |
|
|
CA406342876 rs1289943426 |
148 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs756211354 CA9510901 |
149 | S>L | Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA406342892 rs1363924890 |
150 | H>R | No |
ClinGen gnomAD |
|
|
CA9510904 rs373067738 |
152 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA308962822 rs866208477 |
152 | R>H | No |
ClinGen Ensembl |
|
|
rs759837890 TCGA novel CA9510906 |
153 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC gnomAD NCI-TCGA |
| TCGA novel | 159 | R>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs565736296 CA9510907 |
159 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1273080625 CA406342978 |
163 | R>* | No |
ClinGen gnomAD |
|
|
COSM1394564 COSM1394563 CA9510924 rs534682723 |
167 | S>L | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs775891258 CA9510926 |
169 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA406343071 rs768910204 |
175 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs768910204 CA9510928 |
175 | K>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 176 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1418680771 CA406343087 |
177 | I>V | No |
ClinGen gnomAD |
|
|
CA9510929 rs777001749 |
181 | D>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 183 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1392491632 CA406343187 |
189 | L>P | No |
ClinGen gnomAD |
|
|
CA9510949 rs770193332 |
190 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs767481098 CA9510952 |
192 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs572492438 CA9510951 |
192 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
CA406343223 rs1456231301 |
195 | I>V | No |
ClinGen TOPMed |
|
|
CA308969273 rs1010263943 |
197 | I>T | No |
ClinGen TOPMed |
|
|
CA308969306 rs12460449 |
205 | E>Q | No |
ClinGen Ensembl |
|
| TCGA novel | 206 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9510956 rs753441567 |
207 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs968227279 CA308969325 |
207 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA406343330 rs1169062430 |
210 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1463128184 CA406343350 |
213 | D>E | No |
ClinGen gnomAD |
|
|
CA406343405 rs1358790851 |
221 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA308969365 rs866503314 |
222 | A>V | No |
ClinGen Ensembl |
|
|
rs1328035585 CA406343424 |
224 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 228 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9510964 rs781671493 |
230 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs748565950 CA9510965 |
231 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9510967 rs773367969 |
233 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406343489 rs1447493288 COSM1286102 COSM1286101 |
234 | G>R | Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1599786294 CA406343514 |
237 | V>G | No |
ClinGen Ensembl |
|
|
rs1169047957 CA406343542 |
241 | S>N | No |
ClinGen TOPMed |
|
|
COSM998162 CA9510973 rs764069402 COSM1153397 |
244 | V>F | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA9510972 rs764069402 |
244 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA406343582 rs1599786329 |
248 | T>P | No |
ClinGen Ensembl |
|
|
rs750047588 CA9510976 |
250 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA406343608 rs1568494506 |
252 | G>S | No |
ClinGen Ensembl |
|
| TCGA novel | 253 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs765826413 CA9510978 |
254 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA406343641 rs1216363548 |
255 | P>L | No |
ClinGen gnomAD |
|
|
rs777985280 CA9510984 |
258 | G>E | No |
ClinGen ExAC gnomAD |
|
|
COSM2149374 rs1033007935 CA308931642 COSM2149375 |
265 | R>Q | Variant assessed as Somatic; impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1375220874 CA406345559 |
267 | R>* | No |
ClinGen gnomAD |
|
|
CA406345560 rs1231877137 |
267 | R>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 272 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406345604 rs1383296490 |
274 | R>G | No |
ClinGen TOPMed |
|
|
rs1348192931 CA406345606 |
274 | R>Q | No |
ClinGen gnomAD |
|
|
rs374169232 CA9511016 |
275 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374169232 CA308931646 |
275 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1436781474 CA406345619 |
277 | F>I | No |
ClinGen gnomAD |
|
|
rs1181712866 CA406345632 |
278 | Y>C | No |
ClinGen gnomAD |
|
|
rs1234006879 CA406345645 |
280 | S>T | No |
ClinGen gnomAD |
|
|
rs1441904414 CA406345651 |
281 | T>A | No |
ClinGen gnomAD |
|
|
CA9511019 rs770478941 |
286 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406345726 rs1193850502 |
292 | V>M | No |
ClinGen TOPMed |
|
|
CA308931651 rs1028846573 |
298 | R>S | No |
ClinGen Ensembl |
|
|
rs568500500 CA9511022 |
302 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs568500500 CA9511023 |
302 | E>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs777505581 CA9511052 |
312 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1425861201 CA406346554 |
313 | G>S | No |
ClinGen gnomAD |
|
|
CA308931870 rs991460032 |
315 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 320 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745701249 CA9511056 |
323 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA9511058 rs775293247 |
326 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406346767 rs1382449232 |
327 | E>K | No |
ClinGen gnomAD |
|
|
CA406346806 rs1599791159 |
330 | G>R | No |
ClinGen Ensembl |
|
|
CA9511060 rs201594646 |
331 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372438669 CA308931886 |
332 | T>N | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs377009401 CA9511062 |
334 | R>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1419404121 CA406347174 |
337 | V>M | No |
ClinGen gnomAD |
|
|
rs1044748141 CA308932426 |
338 | M>I | No |
ClinGen TOPMed |
|
|
rs370351779 CA9511092 |
341 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA406347305 rs767675987 |
344 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511094 rs767675987 |
344 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406347319 rs147096694 |
345 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147096694 CA9511097 |
345 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760897998 CA9511096 |
345 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs750413952 CA9511098 |
346 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA406347370 rs1396436634 |
347 | E>D | No |
ClinGen gnomAD |
|
|
CA406347410 rs1388702200 |
349 | K>E | No |
ClinGen TOPMed |
|
|
rs1160826661 CA406347442 |
350 | E>Q | No |
ClinGen TOPMed |
|
|
rs1599792242 CA406347460 |
351 | S>P | No |
ClinGen Ensembl |
|
|
CA406347504 rs1311917866 |
353 | T>P | No |
ClinGen gnomAD |
|
|
rs758214414 CA9511099 |
354 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1233824784 CA406347548 CA406347551 |
354 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA406347573 rs1302324590 |
355 | Q>R | No |
ClinGen gnomAD |
|
|
CA9511101 rs779872451 |
356 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA9511102 rs754653981 |
357 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs1200233771 CA406347745 |
361 | T>N | No |
ClinGen gnomAD |
|
|
rs778215022 CA9511107 |
369 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA308932467 rs897629217 |
370 | K>T | No |
ClinGen TOPMed |
|
|
rs771477599 CA9511108 |
371 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1428874460 CA406348808 |
374 | G>C | No |
ClinGen gnomAD |
|
|
CA9511130 rs747208586 |
375 | G>E | No |
ClinGen ExAC |
|
|
CA9511129 CA406348841 rs775804180 |
375 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511131 rs769036242 |
376 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511132 rs776846141 |
376 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs35070611 CA9511135 |
377 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9511134 VAR_040766 rs35070611 |
377 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen UniProt 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs762042850 CA9511133 |
377 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752537511 CA9511138 |
379 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406348936 rs1166918249 |
380 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs911141339 CA308932569 |
380 | P>S | No |
ClinGen Ensembl |
|
|
rs771693942 CA9511139 |
381 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA406348992 rs1263505330 |
383 | A>P | No |
ClinGen gnomAD |
|
|
rs1263505330 CA406348990 |
383 | A>S | No |
ClinGen gnomAD |
|
|
rs922306204 CA308932583 |
386 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA9511140 rs553814643 |
386 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA406349058 rs1255343271 |
387 | V>M | No |
ClinGen TOPMed |
|
|
CA406349092 rs768263726 |
388 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA9511142 rs768263726 |
388 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA9511141 rs753337213 |
388 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA9511143 rs779413121 |
389 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1399365099 CA406349140 |
390 | P>S | No |
ClinGen gnomAD |
|
|
CA9511145 rs369919934 |
391 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs562431271 CA9511148 |
392 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs562431271 CA9511147 |
392 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1224773186 CA406349222 |
394 | T>P | No |
ClinGen TOPMed |
|
|
CA9511149 rs777005812 |
394 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA406349255 rs1306626778 |
395 | N>I | No |
ClinGen TOPMed |
|
|
rs144143514 CA406349263 |
395 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9511151 CA9511152 rs181363063 |
396 | G>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1229552843 CA406349318 |
397 | T>A | No |
ClinGen TOPMed |
|
|
rs1285949131 CA406349327 |
398 | S>G | No |
ClinGen gnomAD |
|
|
rs759369644 CA9511153 |
398 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA406349430 rs1286224327 |
402 | G>A | No |
ClinGen gnomAD |
|
|
rs1286224327 CA406349433 |
402 | G>V | No |
ClinGen gnomAD |
|
|
CA9511155 rs775263734 |
403 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA9511156 rs760525141 |
405 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA406349504 rs1363518222 |
406 | S>N | No |
ClinGen Ensembl |
|
|
CA406349556 rs1442561413 |
408 | G>R | No |
ClinGen gnomAD |
|
|
COSM116823 rs756740251 COSM1564359 CA9511159 |
410 | R>Q | ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA9511158 rs753496642 |
410 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749985213 CA9511161 |
415 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA308932626 rs749985213 |
415 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs758823777 CA9511162 |
416 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
VAR_040767 rs780763668 COSM20391 CA9511165 |
418 | R>C | large_intestine a colorectal adenocarcinoma sample; somatic mutation [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt ExAC dbSNP gnomAD |
|
CA9511166 COSM1214581 COSM190843 rs755396651 |
418 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA9511164 COSM1564358 COSM1564357 rs780763668 |
418 | R>S | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
| TCGA novel | 419 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406349859 rs1296870778 |
420 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
COSM1214580 COSM1214579 rs1336065779 CA406349870 |
420 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA406349862 rs1336065779 |
420 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs781523807 CA406349950 |
423 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406349960 rs1441157638 |
424 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA9511181 rs749883970 |
427 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA406351615 rs1201016192 |
429 | S>F | No |
ClinGen gnomAD |
|
|
CA406351628 rs1240427247 |
431 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1240427247 CA406351630 |
431 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1477561155 CA406351638 |
431 | A>V | No |
ClinGen gnomAD |
|
|
rs762538035 CA9511182 |
432 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA406351645 rs1568500532 |
432 | P>L | No |
ClinGen Ensembl |
|
|
CA406351672 rs1157433914 |
434 | H>L | No |
ClinGen TOPMed |
|
|
rs865820710 CA308935680 |
434 | H>N | No |
ClinGen Ensembl |
|
|
CA406351705 rs1379873999 |
436 | K>N | No |
ClinGen TOPMed |
|
|
CA9511184 rs752141498 |
437 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA308935710 rs954745201 |
437 | R>H | No |
ClinGen TOPMed |
|
|
CA406351709 rs954745201 |
437 | R>L | No |
ClinGen TOPMed |
|
|
CA406351715 rs1162441471 |
438 | S>T | No |
ClinGen gnomAD |
|
|
CA9511185 rs755345178 |
439 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1412059953 CA406351729 |
440 | T>A | No |
ClinGen gnomAD |
|
|
rs753148066 CA406351735 |
440 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753148066 CA9511187 |
440 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1394572 CA9511189 rs778118260 COSM1394571 |
442 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA406351806 rs547448729 |
445 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1265240901 CA406351799 |
445 | A>T | No |
ClinGen gnomAD |
|
|
rs547448729 CA9511192 |
445 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs979192616 CA308935746 |
447 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1194519624 CA406351903 |
449 | E>D | No |
ClinGen gnomAD |
|
|
CA406351914 rs1265165331 |
450 | E>G | No |
ClinGen gnomAD |
|
|
CA406351910 rs1356396444 |
450 | E>K | No |
ClinGen gnomAD |
|
|
COSM1394574 rs1039550856 CA308935762 COSM1394573 |
451 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA406351925 rs1186826614 |
451 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs761721413 CA9511196 |
454 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1459282233 CA406351958 |
454 | G>S | No |
ClinGen gnomAD |
|
|
rs761721413 CA406351970 |
454 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA9511198 rs144227300 |
455 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs202113425 CA9511197 |
455 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9511199 rs377173611 |
457 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406352043 rs1413458717 |
459 | C>R | No |
ClinGen TOPMed gnomAD |
|
|
CA308935779 rs1057193981 |
459 | C>Y | No |
ClinGen TOPMed |
|
|
CA9511201 rs549577494 |
462 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9511202 rs375594459 |
462 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1353268937 CA406352114 |
463 | G>E | No |
ClinGen gnomAD |
|
|
rs569559385 CA9511204 |
464 | S>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA406352140 rs1484768311 |
465 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1216041814 CA406352167 |
466 | S>R | No |
ClinGen TOPMed |
|
|
rs1047483446 CA308935820 |
467 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs756518643 CA9511205 |
467 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1369037663 CA406352217 |
470 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA406352214 rs1369037663 |
470 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs764159321 CA406352225 |
471 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs757281634 CA406352235 |
471 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757281634 CA9511208 |
471 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764159321 CA9511207 |
471 | P>S | Variant assessed as Somatic; 5.103e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs764159321 CA9511206 |
471 | P>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 472 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1037811811 CA308935837 |
472 | S>P | No |
ClinGen TOPMed |
|
|
CA406352242 rs1037811811 |
472 | S>T | No |
ClinGen TOPMed |
|
| TCGA novel | 473 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1171117247 CA406352305 |
475 | M>I | No |
ClinGen TOPMed |
|
|
CA406352299 rs1163088116 |
475 | M>T | No |
ClinGen gnomAD |
|
|
rs778930505 CA9511209 |
478 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1373064843 CA406352339 |
478 | S>T | No |
ClinGen gnomAD |
|
|
rs1302730305 CA406352352 |
479 | A>S | No |
ClinGen gnomAD |
|
|
CA406352364 rs1403582046 |
480 | H>Y | No |
ClinGen gnomAD |
|
|
CA9511211 rs754891876 |
483 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 483 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781198705 CA9511212 |
485 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406352456 rs1255703084 |
488 | P>A | No |
ClinGen TOPMed |
|
|
CA406352474 rs369776865 |
489 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150856880 CA9511217 |
490 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9511216 rs748925785 |
490 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA9511218 rs773994218 |
491 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406352485 rs1193799588 |
491 | R>W | No |
ClinGen gnomAD |
|
|
rs1305515142 CA406352499 |
492 | K>R | No |
ClinGen TOPMed |
|
|
rs759177245 CA9511219 |
494 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767858037 CA9511220 |
495 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs776071313 CA9511221 |
496 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs760911941 CA9511222 |
496 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406352554 rs868136934 |
498 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs868136934 CA308935891 |
498 | P>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 499 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406353240 rs1441573307 |
501 | L>F | No |
ClinGen gnomAD |
|
|
CA406353266 rs1424301162 |
503 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1424301162 CA406353264 |
503 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1170896099 CA406353261 |
503 | P>S | No |
ClinGen gnomAD |
|
|
rs1245048103 CA406353275 |
504 | S>N | No |
ClinGen TOPMed |
|
|
rs963161094 CA308939290 |
504 | S>R | No |
ClinGen TOPMed |
|
| TCGA novel | 506 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406353323 rs201397444 |
507 | T>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201397444 CA9511268 |
507 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs900545702 CA308939298 |
508 | R>C | No |
ClinGen gnomAD |
|
|
CA9511269 rs763202566 |
508 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 512 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1210551803 CA406353409 |
513 | V>I | No |
ClinGen TOPMed |
|
|
rs1599802465 CA406353436 |
515 | T>A | No |
ClinGen Ensembl |
|
|
rs372480258 CA9511271 |
517 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs554206425 CA9511272 |
517 | R>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9511274 rs144086640 |
518 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9511273 rs764057922 |
518 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs778833911 CA9511276 |
520 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778833911 CA9511277 |
520 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1015510362 CA308939321 |
521 | E>G | No |
ClinGen Ensembl |
|
|
CA406353562 rs1265597749 |
522 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs146014354 CA9511278 |
522 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA9511280 rs771693803 |
523 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1416347061 CA406353649 |
526 | L>F | No |
ClinGen TOPMed |
|
|
CA308939341 rs201834748 |
527 | P>S | No |
ClinGen gnomAD |
|
|
rs773561008 CA9511285 |
529 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406353738 rs1421416914 |
531 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA9511287 rs139967935 |
532 | N>D | No |
ClinGen ESP ExAC gnomAD |
|
|
CA406353774 rs774443076 |
533 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA9511288 rs774443076 |
533 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs760846965 CA9511310 |
534 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA9511314 rs552947392 |
536 | T>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1599804971 CA406354773 |
536 | T>P | No |
ClinGen Ensembl |
|
|
CA9511313 rs552947392 |
536 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1488026174 CA406354803 |
537 | P>A | No |
ClinGen gnomAD |
|
|
CA9511315 rs751408917 |
537 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA308940494 rs1045474061 |
538 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA308940492 rs928807888 |
538 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA406354913 rs1446072679 |
541 | P>L | No |
ClinGen gnomAD |
|
|
CA308940496 rs926860553 |
542 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1599805036 CA406354931 |
543 | S>P | No |
ClinGen Ensembl |
|
|
rs1419833516 CA406354946 |
544 | P>T | No |
ClinGen gnomAD |
|
|
CA406354973 rs1387816086 |
545 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
CA308940497 rs989448872 |
548 | S>R | No |
ClinGen Ensembl |
|
|
CA406355147 rs778304169 |
551 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374997070 CA308940499 |
551 | P>L | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA9511320 rs778304169 |
551 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1307407485 CA406355153 |
552 | P>A | No |
ClinGen gnomAD |
|
|
CA406355157 rs1353012949 |
552 | P>Q | No |
ClinGen gnomAD |
|
|
rs1307407485 CA406355154 |
552 | P>S | No |
ClinGen gnomAD |
|
|
rs1262346080 CA406355173 |
553 | S>P | No |
ClinGen gnomAD |
|
|
CA406355195 rs1342807435 |
554 | G>R | No |
ClinGen gnomAD |
|
|
rs1555767349 CA406355202 |
554 | G>V | No |
ClinGen Ensembl |
|
|
rs1342807435 CA406355194 |
554 | G>W | No |
ClinGen gnomAD |
|
|
CA406355228 rs1555767350 |
555 | E>D | No |
ClinGen Ensembl |
|
|
CA9511322 rs757834794 |
556 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749782930 CA9511321 |
556 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA308940501 rs947367859 |
557 | S>N | No |
ClinGen Ensembl |
|
|
rs779119139 CA9511323 |
558 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746305472 CA9511324 |
558 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511325 rs772358301 |
560 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406355349 rs1160662525 |
560 | A>V | No |
ClinGen gnomAD |
|
|
rs775855591 CA9511326 |
561 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs1172545611 CA406355356 |
561 | R>H | No |
ClinGen gnomAD |
|
|
rs1172545611 CA406355358 |
561 | R>L | No |
ClinGen gnomAD |
|
|
rs776819644 CA9511330 |
562 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs768638967 CA9511328 |
562 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776819644 CA9511329 |
562 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA9511331 rs770967713 |
565 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA406355453 rs1391975984 COSM1394575 COSM1394576 |
566 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1309226953 CA406355454 |
566 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1232406023 CA406355499 |
567 | S>R | No |
ClinGen gnomAD |
|
|
CA406355578 rs1325360947 |
570 | H>R | No |
ClinGen gnomAD |
|
|
rs1457945248 CA406355622 |
572 | G>D | No |
ClinGen gnomAD |
|
|
CA9511334 rs555456890 |
572 | G>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9511336 rs760132221 |
575 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752380003 CA9511335 |
575 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511338 rs575765166 |
577 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9511337 rs763492742 |
577 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs867551302 CA308940507 |
578 | R>L | No |
ClinGen gnomAD |
|
|
rs867551302 CA406355731 |
578 | R>Q | No |
ClinGen gnomAD |
|
|
CA406355728 rs1168996493 |
578 | R>W | No |
ClinGen gnomAD |
|
|
CA406355761 rs1462687396 |
579 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA406355748 rs1165074322 |
579 | A>T | No |
ClinGen TOPMed |
|
|
CA406355764 rs1462687396 |
579 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA406355809 rs1411050968 |
581 | G>V | No |
ClinGen TOPMed |
|
|
rs1365552587 CA406355813 |
582 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1365552587 CA406355817 |
582 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
rs1018372761 CA406355921 |
586 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA308940521 rs1018372761 |
586 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1263336067 CA406355947 |
587 | V>A | No |
ClinGen gnomAD |
|
|
CA406356104 rs1487849062 |
595 | P>S | No |
ClinGen gnomAD |
|
|
rs1487849062 CA406356098 |
595 | P>T | No |
ClinGen gnomAD |
|
|
rs1270152171 CA406356144 |
597 | L>P | No |
ClinGen gnomAD |
|
|
CA406356149 rs1223181986 |
598 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA308940524 rs12972277 |
601 | A>D | No |
ClinGen gnomAD |
|
|
CA406356217 rs12972277 |
601 | A>V | No |
ClinGen gnomAD |
|
|
rs201889023 CA308940528 |
606 | A>T | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs376422468 CA308940530 |
607 | G>R | No |
ClinGen ESP TOPMed gnomAD |
|
| TCGA novel | 607 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1398035769 CA406356346 |
608 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1398035769 CA406356351 |
608 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA308940533 rs956531909 |
608 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA9511347 rs781125990 |
609 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs540971776 CA9511346 |
609 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs560177223 CA308940537 |
610 | R>C | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA9511348 rs200675001 |
610 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA308940540 rs200675001 |
610 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406356413 rs1487047558 |
612 | T>I | No |
ClinGen gnomAD |
|
|
CA406356402 rs1293310751 |
612 | T>P | No |
ClinGen gnomAD |
|
|
CA406356421 rs1215060811 |
613 | T>I | No |
ClinGen gnomAD |
|
|
rs1426361859 CA406356483 |
618 | K>R | No |
ClinGen TOPMed |
|
|
rs770715812 CA406356556 |
625 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511349 rs770715812 |
625 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511416 rs747962450 |
628 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406357342 rs1426025093 |
628 | A>T | No |
ClinGen gnomAD |
|
|
rs777582208 CA9511418 |
630 | E>K | No |
ClinGen ExAC gnomAD |
|
|
COSM1148209 rs1360769623 CA406357405 |
632 | E>Q | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA406357431 rs1453317406 |
634 | I>V | No |
ClinGen gnomAD |
|
|
rs770596158 CA9511420 |
635 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs760065314 CA9511422 |
639 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs957282680 CA308941280 |
640 | T>I | No |
ClinGen Ensembl |
|
|
rs772511341 CA9511423 |
641 | S>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 641 | S>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1462371282 CA406358067 |
642 | C>G | No |
ClinGen gnomAD |
|
|
CA9511441 rs772561382 |
643 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202029642 CA9511442 |
645 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA406358149 rs1419206065 |
647 | D>N | No |
ClinGen gnomAD |
|
|
rs760976192 CA9511443 |
648 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs760976192 CA406358168 |
648 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs142546580 CA308942198 |
649 | T>M | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs768981596 CA9511444 |
652 | A>T | No |
ClinGen ExAC TOPMed |
|
|
CA9511445 rs777033275 |
652 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA406358253 rs1471058645 |
653 | P>A | No |
ClinGen gnomAD |
|
|
CA9511447 rs762012816 |
654 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750452926 CA406358280 |
654 | R>L | No |
ClinGen ExAC gnomAD |
|
| rs1568505994 | 654 | R>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA406358277 rs750452926 |
654 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs750452926 CA9511448 |
654 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA9511446 rs762012816 |
654 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767440439 CA9511450 |
657 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA308942235 rs987880072 |
658 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs935010174 CA308942232 |
658 | F>L | No |
ClinGen Ensembl |
|
|
CA9511451 rs752713604 |
659 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs752713604 CA9511452 |
659 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA406358390 rs1325473245 |
660 | W>R | No |
ClinGen gnomAD |
|
|
rs562298714 CA9511454 |
661 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147585056 CA9511455 |
663 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9511457 rs745321890 |
667 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs745321890 CA308942250 |
667 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757865152 CA9511458 |
668 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA406358532 rs1490001627 |
668 | R>L | No |
ClinGen gnomAD |
|
|
rs1051047141 CA308942267 |
674 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs769212607 CA9511461 |
675 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs747496129 CA9511460 |
675 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA406358648 rs1599809382 |
676 | A>G | No |
ClinGen Ensembl |
|
|
CA9511462 rs776978146 |
678 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs200323133 CA308942280 |
678 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200323133 CA9511463 |
678 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA308942282 rs200323133 |
678 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA406358699 rs1363867319 |
680 | A>T | No |
ClinGen gnomAD |
|
|
rs773329195 CA406358725 |
682 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9511465 rs773329195 |
682 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763049576 CA9511466 |
683 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA9511470 rs760675146 |
684 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs760675146 CA9511469 |
684 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA406358781 rs1263131437 |
685 | R>H | No |
ClinGen gnomAD |
|
|
CA9511472 rs753618561 |
685 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA9511474 rs764890978 |
687 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406358823 rs764890978 |
687 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750069517 COSM3389134 CA9511475 |
687 | R>H | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA9511476 rs758123143 |
688 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs576984498 CA9511477 |
689 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs200016116 CA406358881 |
689 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200016116 CA9511478 |
689 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1249876214 CA406358894 |
690 | Q>P | No |
ClinGen TOPMed |
|
|
rs1383436415 CA406358939 |
692 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1424123919 CA406358955 |
693 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1424123919 CA406358953 |
693 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs781675616 CA9511480 |
697 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA406359036 rs1428616960 |
698 | C>R | No |
ClinGen gnomAD |
|
|
rs1568506124 CA406359054 |
700 | H>Y | No |
ClinGen Ensembl |
|
| TCGA novel | 701 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9511482 rs770088036 |
701 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA406359080 rs770088036 |
701 | G>W | No |
ClinGen ExAC gnomAD |
|
|
rs1246076455 CA406359147 |
705 | G>R | No |
ClinGen gnomAD |
|
|
rs1293063645 CA406359176 |
706 | P>L | No |
ClinGen gnomAD |
|
|
rs867443854 CA308942384 |
707 | E>D | No |
ClinGen gnomAD |
|
|
CA9511486 rs774567252 |
709 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1394484655 CA406359288 |
714 | V>L | No |
ClinGen TOPMed |
|
|
rs1430302829 CA406359304 |
715 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
CA308942399 rs528738026 |
721 | R>W | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA406359396 rs1387231134 |
724 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA308942401 rs548639038 |
725 | R>Q | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs377118473 CA9511490 |
725 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 726 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs759055622 CA308942405 |
726 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA406359405 rs1345512120 |
727 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs764906559 CA9511491 |
728 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs911207807 CA308942410 |
729 | F>L | No |
ClinGen TOPMed |
|
|
CA308942411 rs942736550 |
730 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs942736550 CA406359424 |
730 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA9511492 rs750295541 |
730 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750295541 CA406359426 |
730 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1452994599 CA406359430 |
731 | R>H | No |
ClinGen gnomAD |
|
|
rs762512606 CA9511493 |
733 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1222546698 CA406359454 |
734 | G>D | No |
ClinGen gnomAD |
|
|
rs1599809635 CA406359490 |
737 | L>P | No |
ClinGen Ensembl |
|
|
CA406359514 rs1304598414 |
739 | F>C | No |
ClinGen TOPMed |
|
|
rs956355737 CA308942425 |
740 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs764702156 CA9511496 |
740 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1461034039 CA406359539 |
741 | T>I | No |
ClinGen gnomAD |
|
|
CA9511497 rs781635730 |
742 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1468687522 CA406359554 |
743 | V>I | No |
ClinGen gnomAD |
|
|
CA406359581 rs1408629043 |
745 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1053052298 CA308942441 |
745 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1599809687 CA406359602 |
747 | S>P | No |
ClinGen Ensembl |
|
|
CA9511499 rs756693005 |
748 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA308942447 rs914966258 |
749 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA308942451 rs530446825 |
751 | E>K | No |
ClinGen 1000Genomes gnomAD |
No associated diseases with Q96L34
16 regional properties for Q96L34
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1579 - 1695 | IPR000008 |
| domain | Dbl homology (DH) domain | 1237 - 1423 | IPR000219 |
| domain | EH domain | 14 - 108 | IPR000261-1 |
| domain | EH domain | 214 - 310 | IPR000261-2 |
| conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | 1371 - 1396 | IPR001331 |
| domain | SH3 domain | 740 - 806 | IPR001452-1 |
| domain | SH3 domain | 913 - 971 | IPR001452-2 |
| domain | SH3 domain | 1002 - 1060 | IPR001452-3 |
| domain | SH3 domain | 1074 - 1138 | IPR001452-4 |
| domain | SH3 domain | 1155 - 1214 | IPR001452-5 |
| domain | Pleckstrin homology domain | 1440 - 1593 | IPR001849 |
| domain | EF-hand domain | 53 - 88 | IPR002048-1 |
| domain | EF-hand domain | 254 - 289 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 66 - 78 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 267 - 279 | IPR018247-2 |
| domain | Intersectin-1, AP2 binding region | 803 - 917 | IPR032140 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| gamma-tubulin complex | A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cytoskeletal anchor activity | The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. |
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| tau protein binding | Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
| tau-protein kinase activity | Catalysis of the reaction |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cilium organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| microtubule bundle formation | A process that results in a parallel arrangement of microtubules. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| positive regulation of cell cycle | Any process that activates or increases the rate or extent of progression through the cell cycle. |
| positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
| positive regulation of NLRP3 inflammasome complex assembly | Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly. |
| positive regulation of programmed cell death | Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
| positive regulation of protein localization to centrosome | Any process that activates or increases the frequency, rate or extent of protein localization to centrosome. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of centrosome cycle | Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57059 | SIK1 | Serine/threonine-protein kinase SIK1 | Homo sapiens (Human) | PR |
| Q8N5S9 | CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 | Homo sapiens (Human) | SS |
| Q9P0L2 | MARK1 | Serine/threonine-protein kinase MARK1 | Homo sapiens (Human) | EV |
| Q7KZI7 | MARK2 | Serine/threonine-protein kinase MARK2 | Homo sapiens (Human) | SS |
| Q96RG2 | PASK | PAS domain-containing serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| P27448 | MARK3 | MAP/microtubule affinity-regulating kinase 3 | Homo sapiens (Human) | SS |
| Q8VHJ5 | Mark1 | Serine/threonine-protein kinase MARK1 | Mus musculus (Mouse) | SS |
| Q8C0N0 | Gm4922 | Sperm motility kinase Z | Mus musculus (Mouse) | PR |
| Q8C0X8 | Sperm motility kinase X | Mus musculus (Mouse) | PR | |
| Q03141 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Mus musculus (Mouse) | SS |
| A0AUV4 | Gm7168 | Sperm motility kinase Y | Mus musculus (Mouse) | PR |
| Q05512 | Mark2 | Serine/threonine-protein kinase MARK2 | Mus musculus (Mouse) | SS |
| Q8CIP4 | Mark4 | MAP/microtubule affinity-regulating kinase 4 | Mus musculus (Mouse) | SS |
| O08678 | Mark1 | Serine/threonine-protein kinase MARK1 | Rattus norvegicus (Rat) | SS |
| Q8VHF0 | Mark3 | MAP/microtubule affinity-regulating kinase 3 | Rattus norvegicus (Rat) | SS |
| O08679 | Mark2 | Serine/threonine-protein kinase MARK2 | Rattus norvegicus (Rat) | SS |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q852Q0 | OSK3 | Serine/threonine protein kinase OSK3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q9TW45 | par-1 | Serine/threonine-protein kinase par-1 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSRTVLAPG | NDRNSDTHGT | LGSGRSSDKG | PSWSSRSLGA | RCRNSIASCP | EEQPHVGNYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLRTIGKGNF | AKVKLARHIL | TGREVAIKII | DKTQLNPSSL | QKLFREVRIM | KGLNHPNIVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFEVIETEKT | LYLVMEYASA | GEVFDYLVSH | GRMKEKEARA | KFRQIVSAVH | YCHQKNIVHR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLKAENLLLD | AEANIKIADF | GFSNEFTLGS | KLDTFCGSPP | YAAPELFQGK | KYDGPEVDIW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLGVILYTLV | SGSLPFDGHN | LKELRERVLR | GKYRVPFYMS | TDCESILRRF | LVLNPAKRCT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEQIMKDKWI | NIGYEGEELK | PYTEPEEDFG | DTKRIEVMVG | MGYTREEIKE | SLTSQKYNEV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TATYLLLGRK | TEEGGDRGAP | GLALARVRAP | SDTTNGTSSS | KGTSHSKGQR | SSSSTYHRQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RHSDFCGPSP | APLHPKRSPT | STGEAELKEE | RLPGRKASCS | TAGSGSRGLP | PSSPMVSSAH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPNKAEIPER | RKDSTSTPNN | LPPSMMTRRN | TYVCTERPGA | ERPSLLPNGK | ENSSGTPRVP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PASPSSHSLA | PPSGERSRLA | RGSTIRSTFH | GGQVRDRRAG | GGGGGGVQNG | PPASPTLAHE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AAPLPAGRPR | PTTNLFTKLT | SKLTRRVADE | PERIGGPEVT | SCHLPWDQTE | TAPRLLRFPW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SVKLTSSRPP | EALMAALRQA | TAAARCRCRQ | PQPFLLACLH | GGAGGPEPLS | HFEVEVCQLP |
| 730 | 740 | 750 | |||
| RPGLRGVLFR | RVAGTALAFR | TLVTRISNDL | EL |