AiPD: Autoinhibited Protein Database

Q96BX8

Gene name	MOB3A (MOBKL2A)
Protein name	MOB kinase activator 3A
Names	MOB-LAK , Mob1 homolog 2A , Mps one binder kinase activator-like 2A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:126308
EC number
Protein Class

Descriptions

MOB1A is a multifunctional protein involved in key signaling pathways like Hippo and NDR pathway signaling in metazoans and the Mitotic Exit Network in yeast. It regulates protein interactions by binding to upstream kinases MST1 and MST2 and downstream AGC group kinases LATS1, LATS2, NDR1, and NDR2. The autoinhibition of MOB1A occurs when its nonphosphorylated N-terminal extension binds to the core domain, blocking the kinase-binding site. This inhibitory interaction is relieved upon phosphorylation at specific sites (T12 and T35), which induces a conformational change that exposes the kinase-binding surface. Phosphorylation of MOB1A at T12 and T35 is crucial for regulating its interactions with both upstream and downstream kinases. The phosphorylation status dictates the binding affinity of MOB1A, enabling or inhibiting interactions with other proteins. The phosphorylation-dependent conformational changes in MOB1A are essential for the proper functioning of the Hippo signaling pathway, which is critical for cell proliferation and tissue growth regulation.

Autoinhibitory domains (AIDs)

27-41 (N-terminal extension) SS

Target domain	56-217 (MOB1A core domain)
Relief mechanism	PTM
Assay

AID

27-41 (N-terminal extension)

Target domain

56-217 (MOB1A core domain)

Relief mechanism

PTM (Phosphorylation of Thr12 and Thr35)

Assay

Accessory elements

No accessory elements

References

Xiong S et al. (2017) "Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation", Molecular & cellular proteomics : MCP, 16, 1111-1125

Autoinhibited structure

Activated structure

0 structures for Q96BX8

Entry ID	Method	Resolution	Chain	Position	Source
No available structures

276 variants for Q96BX8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2017447417	2	S>P		No	gnomAD
rs767591156	3	N>I		No	ExAC TOPMed gnomAD
rs767591156	3	N>S		No	ExAC TOPMed gnomAD
rs146746090	11	N>D		No	1000Genomes ExAC TOPMed gnomAD
rs146746090	11	N>Y		No	1000Genomes ExAC TOPMed gnomAD
rs2017447055	12	K>E		No	TOPMed
rs1198507081	12	K>T		No	TOPMed gnomAD
rs2017446928	14	K>E		No	TOPMed
rs369840893	14	K>R		No	ESP ExAC TOPMed gnomAD
COSM27251 rs772930574	16	F>L	lung [Cosmic]	No	cosmic curated ExAC gnomAD
rs1479718258	16	F>Y		No	gnomAD
rs769117561	17	R>C		No	ExAC TOPMed gnomAD
rs775925366 COSM993564	17	R>H	endometrium [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs775925366	17	R>L		No	ExAC TOPMed gnomAD
rs2017446538	18	P>L		No	Ensembl
rs2017446465	19	K>R		No	Ensembl
rs140289197	20	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140289197	20	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774690228	20	R>H		No	ExAC TOPMed gnomAD
rs774690228	20	R>L		No	ExAC TOPMed gnomAD
rs771380624	21	K>T		No	ExAC TOPMed gnomAD
rs749416931	22	F>S		No	ExAC gnomAD
rs1370048765	23	E>K		No	gnomAD
rs756110390	24	P>L		No	ExAC TOPMed gnomAD
rs1270358475	25	G>S		No	TOPMed gnomAD
rs1470129890	27	Q>*		No	gnomAD
rs781472812	28	R>C		No	ExAC TOPMed gnomAD
COSM1172606 rs200815914	28	R>H	oesophagus [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs200815914	28	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs200815914	28	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs1249876333	29	F>I		No	TOPMed gnomAD
rs10419889	29	F>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs45509008	30	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs1031160632	31	L>R		No	TOPMed gnomAD
rs892602111	31	L>V		No	TOPMed gnomAD
rs1052215638	32	H>P		No	TOPMed gnomAD
rs1052215638	32	H>R		No	TOPMed gnomAD
rs750002430	32	H>Y		No	ExAC
rs764962668	33	K>E		No	ExAC TOPMed gnomAD
rs2017445092	34	K>R		No	TOPMed
rs1316038193	35	A>E		No	TOPMed gnomAD
rs1316038193 COSM1391927	35	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs776084991	36	Q>H		No	ExAC gnomAD
rs1224980733	36	Q>R		No	gnomAD
COSM1680486 rs763656568	37	A>V	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs542254202	38	S>L		No	1000Genomes TOPMed gnomAD
rs542254202	38	S>W		No	1000Genomes TOPMed gnomAD
rs943005930	40	N>H		No	TOPMed gnomAD
rs749697378	40	N>K		No	ExAC TOPMed gnomAD
rs888789619	41	A>P		No	TOPMed gnomAD
rs888789619	41	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1383874358	42	G>E		No	gnomAD
rs146426852	42	G>R		No	ESP ExAC TOPMed gnomAD
rs781417807	43	L>V		No	ExAC TOPMed gnomAD
rs1599404008	44	D>A		No	Ensembl
rs780070843	46	R>Q		No	ExAC gnomAD
rs34059622	46	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2017443876	47	L>P		No	gnomAD
rs758077908	47	L>V		No	ExAC gnomAD
rs750207997	48	A>G		No	ExAC gnomAD
rs145491125	49	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145491125 COSM1711590	49	V>M	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs369959216	50	Q>*		No	ESP ExAC TOPMed gnomAD
rs2017443402	50	Q>H		No	TOPMed
rs369959216	50	Q>K		No	ESP ExAC TOPMed gnomAD
rs766935259	50	Q>R		No	ExAC TOPMed gnomAD
rs1293098443	52	P>L		No	TOPMed gnomAD
rs1384993549	52	P>S		No	gnomAD
rs374732708	53	P>L		No	ESP ExAC TOPMed gnomAD
rs2017442933	54	G>S		No	gnomAD
rs2144919892	55	E>A		No	Ensembl
rs2017442788	55	E>D		No	gnomAD
rs201880293 COSM993563	55	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs768815614	56	D>N		No	ExAC TOPMed gnomAD
rs147335373	57	L>V		No	ESP ExAC gnomAD
rs927233752	59	D>E		No	TOPMed
rs367923371	59	D>N		No	ESP ExAC TOPMed gnomAD
rs2017442511	60	W>*		No	gnomAD
rs1191401179	62	A>S		No	TOPMed gnomAD
rs1191401179	62	A>T		No	TOPMed gnomAD
TCGA novel	63	V>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4702805 rs201134829	65	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1451555697	66	V>M		No	TOPMed gnomAD
rs745857478	67	D>E		No	ExAC gnomAD
rs865877744	68	F>L		No	gnomAD
rs201527418	68	F>S		No	1000Genomes ExAC gnomAD
rs201527418	68	F>Y		No	1000Genomes ExAC gnomAD
rs753426918	69	F>L		No	ExAC gnomAD
rs1222597008	69	F>L		No	gnomAD
COSM1391926 rs777437440	71	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs755574962	71	R>H		No	ExAC TOPMed gnomAD
rs777437440	71	R>S		No	ExAC TOPMed gnomAD
rs766978628	72	V>I		No	ExAC TOPMed gnomAD
rs763512868	73	N>S		No	ExAC TOPMed gnomAD
rs1402073270	73	N>Y		No	TOPMed gnomAD
rs1302564936	74	L>F		No	TOPMed gnomAD
rs1379855650	75	I>V		No	TOPMed gnomAD
rs750951116	76	Y>C		No	ExAC
rs776944146	77	G>D		No	ExAC gnomAD
rs762298832	77	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	77	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM269610	78	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2017441131	79	I>V		No	gnomAD
rs547046447	81	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs772099363 COSM5176769	82	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1199454228	83	C>Y		No	gnomAD
rs778716537	84	T>A		No	ExAC gnomAD
rs770676649	84	T>M		No	ExAC TOPMed gnomAD
rs2017440630	86	Q>E		No	gnomAD
rs1001023040	86	Q>P		No	TOPMed gnomAD
rs1568252360	87	S>F		No	Ensembl
rs755734519	89	P>A		No	ExAC gnomAD
rs1321593466	89	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1321593466	89	P>R		No	TOPMed gnomAD
rs140161770	90	V>F		No	ESP ExAC TOPMed gnomAD
rs140161770 COSM1215327	90	V>I	large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs140161770	90	V>L		No	ESP ExAC TOPMed gnomAD
rs1161234432	91	M>I		No	TOPMed
rs762458194	91	M>T		No	ExAC TOPMed gnomAD
rs199687461	92	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs754222416	92	S>P		No	ExAC gnomAD
rs199687461	92	S>W		No	1000Genomes ExAC TOPMed gnomAD
rs767562827	93	G>E		No	ExAC gnomAD
rs767562827	93	G>V		No	ExAC gnomAD
rs200521330 TCGA novel	94	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD NCI-TCGA
rs1176676602	94	G>C		No	TOPMed gnomAD
rs200521330	94	G>D		No	ESP ExAC TOPMed gnomAD
rs1176676602	94	G>S		No	TOPMed gnomAD
rs200521330	94	G>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	96	K>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1361554017	97	Y>H		No	TOPMed gnomAD
COSM1391925 rs772988384	100	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs769636520	100	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2145720812	101	W>*		No	Ensembl
rs747779065	101	W>R		No	ExAC gnomAD
rs780713213	102	Q>E		No	ExAC gnomAD
rs2017439092	103	D>Y		No	Ensembl
rs200182881	104	E>A		No	1000Genomes
rs1257905770	104	E>D		No	TOPMed
rs746478633	104	E>K		No	ExAC gnomAD
rs1277845338	105	H>Q		No	gnomAD
rs779749175	105	H>R		No	ExAC TOPMed gnomAD
rs761800513	106	K>*		No	Ensembl
rs1336824788	107	F>L		No	TOPMed gnomAD
rs200952352	108	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141394714	108	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141394714	108	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200952352	108	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs752921081	109	K>R		No	ExAC TOPMed gnomAD
rs1431644291	110	P>S		No	gnomAD
rs34147715	111	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs34147715	111	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1157423970	112	A>S		No	TOPMed gnomAD
rs1157423970	112	A>T		No	TOPMed gnomAD
rs762865411	112	A>V		No	ExAC TOPMed gnomAD
rs768162656	115	A>T		No	ExAC TOPMed
rs375441695	115	A>V		No	ESP ExAC TOPMed gnomAD
rs375581326	116	P>A		No	ESP ExAC TOPMed gnomAD
rs375581326	116	P>S		No	ESP ExAC TOPMed gnomAD
rs778451889	117	R>G		No	ExAC gnomAD
rs370127247	118	Y>*		No	ESP ExAC TOPMed gnomAD
rs2145720703	119	M>I		No	1000Genomes
rs752986154	119	M>L		No	ExAC gnomAD
rs752986154	119	M>V		No	ExAC gnomAD
rs755154653	123	M>R		No	ExAC TOPMed gnomAD
rs755154653	123	M>T		No	ExAC TOPMed gnomAD
rs766390236	124	D>G		No	ExAC TOPMed gnomAD
rs751838168	124	D>N		No	ExAC TOPMed gnomAD
rs751838168	124	D>Y		No	ExAC TOPMed gnomAD
rs2017437261	125	W>C		No	TOPMed
rs765062703	127	E>G		No	ExAC TOPMed gnomAD
rs144738923	127	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199931377 COSM1391924	128	A>V	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1385788272	129	Q>*		No	TOPMed gnomAD
rs771426975	129	Q>H		No	ExAC TOPMed gnomAD
rs1474324305	130	I>N		No	gnomAD
rs2017436767	130	I>V		No	Ensembl
rs1241350038	131	N>D		No	gnomAD
rs760343875	132	N>S		No	ExAC gnomAD
rs558924895	133	E>K		No	1000Genomes TOPMed gnomAD
TCGA novel	135	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs201519607	139	N>I		No	ExAC TOPMed gnomAD
rs1291250008	140	V>A		No	TOPMed gnomAD
rs778537308	140	V>I		No	ExAC TOPMed gnomAD
rs747397350	141	G>D		No	ExAC TOPMed gnomAD
rs150299462	141	G>S		No	ESP ExAC TOPMed gnomAD
rs1599402800	142	T>P		No	Ensembl
rs575702897	142	T>S		No	1000Genomes ExAC TOPMed gnomAD
rs758613979	143	P>L		No	ExAC TOPMed gnomAD
rs758613979	143	P>Q		No	ExAC TOPMed gnomAD
rs1479905484	144	F>L		No	TOPMed gnomAD
rs1568251741	144	F>S		No	TOPMed
rs1568251741	144	F>Y		No	TOPMed
rs2017419440	145	P>S		No	Ensembl
rs1351173558	146	K>E		No	Ensembl
rs576174515	146	K>R		No	ExAC gnomAD
rs1403479346	147	N>D		No	TOPMed gnomAD
rs1568251713	150	Q>K		No	Ensembl
rs773889547 COSM3937960	151	T>M	oesophagus [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs770604419	153	R>G		No	ExAC TOPMed gnomAD
rs998560047	153	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs770604419	153	R>W		No	ExAC TOPMed gnomAD
rs141042584	154	K>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs939436083	154	K>N		No	TOPMed gnomAD
rs141042584	154	K>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs543937620	155	I>T		No	1000Genomes ExAC gnomAD
rs1272349990	156	L>V		No	TOPMed gnomAD
rs1403604686 COSM5960057	157	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs774070272	157	S>P		No	ExAC gnomAD
rs1403604686	157	S>W		No	gnomAD
rs151181290	158	R>Q		No	ESP ExAC TOPMed gnomAD
rs1469476216	158	R>W		No	gnomAD
rs747581677	160	F>L		No	ExAC TOPMed gnomAD
rs1417421473	160	F>V		No	TOPMed gnomAD
rs1179793963	161	R>C		No	gnomAD
rs772437903	162	V>L		No	ExAC gnomAD
rs772437903	162	V>M		No	ExAC gnomAD
rs576809612	163	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs757233836	164	V>M		No	ExAC TOPMed gnomAD
TCGA novel	165	H>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1261288224	165	H>R		No	TOPMed gnomAD
rs1206946466	165	H>Y		No	TOPMed gnomAD
rs778043036	166	V>I		No	ExAC gnomAD
rs1195616778	167	Y>N		No	Ensembl
rs557526411	168	I>L		No	TOPMed gnomAD
rs557526411	168	I>V		No	TOPMed gnomAD
rs756119804	170	H>R		No	ExAC gnomAD
rs752742337	171	F>L		No	ExAC gnomAD
rs879546370	171	F>L		No	TOPMed gnomAD
rs370786420	173	R>C		No	ESP ExAC TOPMed gnomAD
rs534131418	173	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs534131418	173	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs751133450	174	I>T		No	ExAC TOPMed gnomAD
rs142102227	175	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs142102227	175	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs762563833 COSM1391923	175	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs764782777	177	M>V		No	ExAC TOPMed gnomAD
rs1383941278	178	G>A		No	TOPMed gnomAD
rs1382386577	178	G>R		No	TOPMed
rs761111804	179	S>A		No	ExAC TOPMed gnomAD
rs761111804	179	S>P		No	ExAC TOPMed gnomAD
rs373826686	182	H>Q		No	ESP ExAC TOPMed gnomAD
rs746262774 COSM4076094	183	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs774625797	184	N>I		No	ExAC TOPMed gnomAD
rs774625797	184	N>S		No	ExAC TOPMed gnomAD
rs771149865	185	T>A		No	ExAC
rs1357115031	185	T>I		No	TOPMed gnomAD
rs771149865	185	T>P		No	ExAC
rs749543358	189	H>Q		No	ExAC gnomAD
TCGA novel rs1568251545	190	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2145719451	191	Y>F		No	Ensembl
rs777988945	191	Y>H		No	ExAC TOPMed gnomAD
rs1380744607	192	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2017416237	192	Y>H		No	Ensembl
rs1476181414	193	F>I		No	Ensembl
rs371597769	194	V>I		No	ESP ExAC TOPMed gnomAD
rs748034778	195	K>E		No	ExAC TOPMed gnomAD
rs781311202	196	E>A		No	ExAC gnomAD
rs1568251527	198	G>D		No	Ensembl
TCGA novel	199	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751349284	201	D>Y		No	ExAC TOPMed gnomAD
rs1385060345	202	T>N		No	gnomAD
rs1599402512	205	L>R		No	Ensembl
rs750088021	206	E>K		No	ExAC TOPMed gnomAD
rs750088021	206	E>Q		No	ExAC TOPMed gnomAD
rs764660429	208	L>R		No	ExAC gnomAD
rs755588493	209	K>E		No	ExAC gnomAD
rs752069035	211	M>I		No	ExAC TOPMed gnomAD
rs1181528947	212	T>N		No	gnomAD
rs142028177	213	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs142028177	213	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141783611	214	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs377375695	214	R>W		No	ESP ExAC TOPMed gnomAD
rs2017364157	215	M>I		No	gnomAD
rs900734213	215	M>V		No	TOPMed
rs1240035843	217	H>R		No	TOPMed gnomAD

No associated diseases with Q96BX8

No regional properties for Q96BX8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96BX8

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
protein kinase activator activity	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

2 GO annotations of biological process

Name	Definition
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P43563	MOB2	CBK1 kinase activator protein MOB2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40484	MOB1	DBF2 kinase activator protein MOB1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q70IA8	MOB3C	MOB kinase activator 3C	Homo sapiens (Human)	SS
Q86TA1	MOB3B	MOB kinase activator 3B	Homo sapiens (Human)	SS
Q9H8S9	MOB1A	MOB kinase activator 1A	Homo sapiens (Human)	EV
Q7L9L4	MOB1B	MOB kinase activator 1B	Homo sapiens (Human)	SS
Q8BJG4	Mob3c	MOB kinase activator 3C	Mus musculus (Mouse)	SS
Q8VE04	Mob3b	MOB kinase activator 3B	Mus musculus (Mouse)	SS
Q8BSU7	Mob3a	MOB kinase activator 3A	Mus musculus (Mouse)	SS
Q8GYX0	MOB1B	MOB kinase activator-like 1B	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FHI1	MOB1A	MOB kinase activator-like 1A	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MSNPFLKQVF	NKDKTFRPKR	KFEPGTQRFE	LHKKAQASLN	AGLDLRLAVQ	LPPGEDLNDW
70	80	90	100	110	120
VAVHVVDFFN	RVNLIYGTIS	DGCTEQSCPV	MSGGPKYEYR	WQDEHKFRKP	TALSAPRYMD
130	140	150	160	170	180
LLMDWIEAQI	NNEDLFPTNV	GTPFPKNFLQ	TVRKILSRLF	RVFVHVYIHH	FDRIAQMGSE
190	200	210
AHVNTCYKHF	YYFVKEFGLI	DTKELEPLKE	MTARMCH