AiPD: Autoinhibited Protein Database

Q96AX2

Gene name	RAB37
Protein name	Ras-related protein Rab-37
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:326624
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-54 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96AX2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96AX2-F1	Predicted				AlphaFoldDB

188 variants for Q96AX2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs766791134	18	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1385555512 CA400942476	39	G>S		No	ClinGen gnomAD
CA400942489 rs750256354	40	V>F		No	ClinGen ExAC TOPMed gnomAD
CA8750192 rs750256354	40	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs149746610 CA8750194	41	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149746610 CA8750193	41	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA400942522 rs746975143	44	C>R		No	ClinGen ExAC TOPMed gnomAD
CA8750195 rs746975143	44	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1248364080 CA400942602	51	D>N		No	ClinGen gnomAD
rs1334325571 CA400942618	52	G>E		No	ClinGen TOPMed
COSM1290755 CA8750197 rs777757102 CA293957990	52	G>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs749330487 CA8750198	53	A>V		No	ClinGen ExAC gnomAD
rs969539196 CA293957993	56	S>F		No	ClinGen TOPMed
TCGA novel	57	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8750201 rs746236671 CA400942659	57	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8750203 rs772385837	58	T>I		No	ClinGen ExAC TOPMed gnomAD
CA8750202 rs772385837	58	T>N		No	ClinGen ExAC TOPMed gnomAD
CA400942685 rs764620456	60	I>L		No	ClinGen ExAC TOPMed gnomAD
CA400942687 rs1254894593	60	I>T		No	ClinGen gnomAD
CA8750205 rs764620456	60	I>V		No	ClinGen ExAC TOPMed gnomAD
CA400942704 rs1428644657	62	T>A		No	ClinGen TOPMed gnomAD
rs140394994 CA8750207	63	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs868407548 CA293958015	64	G>D		No	ClinGen Ensembl
CA8750210 rs199750680	64	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8750209 rs199750680	64	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8750222 rs772318569	70	K>E		No	ClinGen ExAC gnomAD
rs560133058 CA8750223	71	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA400932005 rs1358866411	72	V>A		No	ClinGen gnomAD
TCGA novel	73	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400932068 rs1290711788	76	G>D		No	ClinGen TOPMed gnomAD
CA400932073 rs1290711788	76	G>V		No	ClinGen TOPMed gnomAD
rs145019795 CA8750228	77	V>M		No	ClinGen ESP ExAC gnomAD
CA8750229 rs772822712	80	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA8750231 rs766017145	82	Q>P		No	ClinGen ExAC gnomAD
rs766017145 CA400932165	82	Q>R		No	ClinGen ExAC gnomAD
rs1373729851 CA400932200	83	I>T		No	ClinGen gnomAD
rs1225238831 CA400932203	84	W>G		No	ClinGen gnomAD
CA293917663 rs910837302	84	W>S		No	ClinGen Ensembl
CA8750246 rs772882123 COSM1479973 COSM1479972 COSM1479971	87	A>T	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs146780541 CA8750247	88	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8750249 rs770507152	91	R>G		No	ClinGen ExAC TOPMed gnomAD
rs759107202 CA8750250	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs770507152 COSM562159 CA8750248 COSM562161 COSM562160	91	R>W	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM984111 COSM984113 CA8750252 rs150761775 COSM984112	93	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs760647591 CA8750253	93	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1309701458 CA400932361	94	S>G		No	ClinGen gnomAD
CA400932377 rs763968925	94	S>R		No	ClinGen ExAC TOPMed gnomAD
COSM1385804 CA8750255 COSM1385805 COSM1385803 rs143690968	95	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs929071371 CA293917720	97	H>R		No	ClinGen gnomAD
rs1439304096 CA400932417	97	H>Y		No	ClinGen gnomAD
COSM3796050 COSM3796048 COSM3796049 CA293917747 rs527644258	101	R>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA
rs1403558405 CA400932512	102	D>N		No	ClinGen gnomAD
rs1347003953 CA400932542	104	Q>*		No	ClinGen TOPMed
CA293917813 rs71361632	106	L>FV		No	ClinGen Ensembl
CA8750272 rs148142349	107	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8750274 rs761638080	108	L>P		No	ClinGen ExAC gnomAD
rs909850875 CA400932583	109	L>V		No	ClinGen TOPMed
rs1220928465 CA400932591	110	Y>C		No	ClinGen gnomAD
CA400932597 rs1317747597	111	D>N		No	ClinGen gnomAD
rs1436408440 CA400932622	114	N>K		No	ClinGen TOPMed
CA8750277 rs755279933	116	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767801558 CA8750278	118	F>C		No	ClinGen ExAC TOPMed gnomAD
CA8750279 rs767801558	118	F>S		No	ClinGen ExAC TOPMed gnomAD
CA8750281 rs370945537	119	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1478781668 CA400932661	120	N>I		No	ClinGen gnomAD
rs949231586 CA293917923	121	I>S		No	ClinGen TOPMed gnomAD
CA8750282 rs749864575	122	R>G		No	ClinGen ExAC gnomAD
rs757683419 CA8750283	122	R>K		No	ClinGen ExAC TOPMed gnomAD
CA8750284 rs757683419	122	R>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	123	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1303907212 CA400933574	124	W>*		No	ClinGen gnomAD
rs751558943 CA293918646	125	L>F		No	ClinGen Ensembl
rs200513132 CA400933586	126	T>I		No	ClinGen ExAC TOPMed gnomAD
rs200513132 CA8750307	126	T>N		No	ClinGen ExAC TOPMed gnomAD
CA400933594 rs1232965464	127	E>D		No	ClinGen gnomAD
rs1241391747 CA400933613	130	E>V		No	ClinGen TOPMed
CA8750309 rs769786339	132	A>G		No	ClinGen ExAC gnomAD
CA8750310 rs772174577	133	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA400933640 rs1221144245	134	R>K		No	ClinGen TOPMed
CA8750314 rs147358898 CA400933649	135	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8750311 rs762982946	135	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8750312 rs143298131	135	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762014090 CA8750317	136	V>A		No	ClinGen ExAC TOPMed gnomAD
CA8750315 rs764185728	136	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8750316 rs764185728	136	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	136	V>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400933653 rs1182254894	137	V>M		No	ClinGen gnomAD
rs1157534806 CA400933673	139	M>I		No	ClinGen gnomAD
rs750982235 CA8750319	139	M>L		No	ClinGen ExAC TOPMed gnomAD
CA8750320 rs758877227	140	L>R		No	ClinGen ExAC gnomAD
CA400933685 rs1295856023	142	G>A		No	ClinGen gnomAD
CA8750321 rs779578722	142	G>C		No	ClinGen ExAC TOPMed gnomAD
CA400933688 rs1479157700	143	N>D		No	ClinGen TOPMed
CA293918775 rs112606240	143	N>S		No	ClinGen Ensembl
rs1555595919 CA400933698	144	K>T		No	ClinGen Ensembl
CA8750374 rs748208881	145	A>E		No	ClinGen ExAC TOPMed gnomAD
CA400933717 rs748208881	145	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8750375 rs770015617	146	D>A		No	ClinGen ExAC gnomAD
rs773354446 CA8750376	147	M>I		No	ClinGen ExAC TOPMed gnomAD
CA400933727 rs1358558768	147	M>K		No	ClinGen gnomAD
CA293919239 rs936156108	147	M>V		No	ClinGen TOPMed gnomAD
rs1233402952 CA400933735	148	S>N		No	ClinGen TOPMed
rs1369400532 CA400933742	149	S>G		No	ClinGen gnomAD
rs201839620 CA293919245	149	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	150	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774756333 CA8750379	150	E>G		No	ClinGen ExAC TOPMed gnomAD
rs137872401 CA8750378	150	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA400933757 rs1241703012	151	R>K		No	ClinGen gnomAD
TCGA novel	151	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400933764 rs1598331248	152	V>A		No	ClinGen Ensembl
CA400933765 rs1598331248	152	V>G		No	ClinGen Ensembl
rs907993927 CA293919287	153	I>T		No	ClinGen Ensembl
CA293919294 rs543387119	154	R>C		No	ClinGen 1000Genomes gnomAD
rs149486886 CA8750380	154	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149486886 CA8750381	154	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149486886 CA400933774	154	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8750384 rs774889397	156	E>K		No	ClinGen ExAC gnomAD
CA400933792 rs895360538	157	D>E		No	ClinGen TOPMed
CA8750385 rs760208960	157	D>H		No	ClinGen ExAC gnomAD
CA8750386 rs760208960	157	D>N		No	ClinGen ExAC gnomAD
rs143915644 CA8750388	158	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA400933799 rs1424800509	159	E>Q		No	ClinGen gnomAD
CA400933809 rs1567817135	160	T>A		No	ClinGen Ensembl
CA400933817 rs756945292	160	T>I		No	ClinGen ExAC gnomAD
CA8750389 rs756945292	160	T>N		No	ClinGen ExAC gnomAD
rs1160533812 CA400933829	161	L>F		No	ClinGen gnomAD
rs1427279841 CA400933826	161	L>S		No	ClinGen TOPMed
rs374935761 CA8750390	163	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA400933850 rs1598331346	163	R>S		No	ClinGen Ensembl
rs963741004 CA293919502	164	E>G		No	ClinGen Ensembl
rs762740730 CA400933916	165	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs867840244 CA293919509	166	G>D		No	ClinGen Ensembl
rs766081840 CA8750411	166	G>S		No	ClinGen ExAC TOPMed gnomAD
rs751557494 CA8750412	168	P>S		No	ClinGen ExAC gnomAD
CA400933993 rs1328925117	172	T>N		No	ClinGen gnomAD
CA400934010 rs977071609	173	S>R		No	ClinGen gnomAD
CA400933999 rs1375693483	173	S>R		No	ClinGen gnomAD
CA8750413 rs754889461	174	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1227060514 CA400934043	176	T>A		No	ClinGen gnomAD
rs777871045 CA8750414	176	T>I		No	ClinGen ExAC TOPMed gnomAD
CA8750415 rs148637613	178	M>V		No	ClinGen ESP ExAC gnomAD
rs1167229844 CA400934154	181	E>D		No	ClinGen TOPMed
rs779143134 CA8750417	182	L>*		No	ClinGen ExAC gnomAD
CA400934182 rs1256474430	182	L>F		No	ClinGen gnomAD
rs1567817307 CA400934248	186	A>T		No	ClinGen Ensembl
rs772557537 CA8750419	187	I>M		No	ClinGen ExAC gnomAD
TCGA novel	187	I>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746225239 CA8750418	187	I>V		No	ClinGen ExAC TOPMed gnomAD
rs34215331 VAR_034434 CA293919631	188	A>P		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs34215331 CA8750421	188	A>T		No	ClinGen ExAC TOPMed gnomAD
rs775475701 CA8750462	190	E>K		No	ClinGen ExAC gnomAD
rs775475701 CA400934408	190	E>Q		No	ClinGen ExAC gnomAD
rs1452003879 CA400934431	191	L>R		No	ClinGen gnomAD
CA293919960 rs914677226	193	Y>N		No	ClinGen TOPMed
CA8750466 rs150021744	194	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8750465 rs150021744	194	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8750464 rs765394498	194	R>W		No	ClinGen ExAC TOPMed
CA8750468 CA8750469 rs139440620	196	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM361180 CA400934509 COSM361181 COSM361182 rs1158729238	196	G>V	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs781678010 CA400934514	197	H>D		No	ClinGen ExAC gnomAD
rs1567817566 CA400934523	197	H>Q		No	ClinGen Ensembl
CA8750471 rs200335281	197	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781678010 CA8750470	197	H>Y		No	ClinGen ExAC gnomAD
CA8750472 rs756549615	198	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs368389878 CA8750473	198	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA400934551 rs748698308	199	A>E		No	ClinGen ExAC gnomAD
rs748698308 CA8750474	199	A>V		No	ClinGen ExAC gnomAD
rs534120632 CA8750476	200	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8750477 rs745519873	201	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1310103092 CA400934606	202	P>L		No	ClinGen gnomAD
COSM1385811 COSM1385809 COSM1385810 CA400934658 rs1356004989	205	Q>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8750478 rs771915095	206	I>V		No	ClinGen ExAC TOPMed gnomAD
rs760695554 CA400934690	207	R>*		No	ClinGen ExAC TOPMed gnomAD
rs763884748 CA8750481	207	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs202002183 CA8750482	208	D>A		No	ClinGen 1000Genomes ExAC gnomAD
CA293920073 rs951347274	209	Y>D		No	ClinGen TOPMed gnomAD
CA293920065 rs951347274	209	Y>H		No	ClinGen TOPMed gnomAD
CA8750484 rs766562014	211	E>K		No	ClinGen ExAC TOPMed gnomAD
CA400934783 rs1180452795	212	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs898251293 CA293920079	214	K>E		No	ClinGen TOPMed
rs759808920 CA8750486	215	K>Q		No	ClinGen ExAC gnomAD
rs768035222 CA8750487	216	R>C		No	ClinGen ExAC TOPMed gnomAD
rs537134838 CA8750488	216	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1175113339 CA400934859	220	C>G		No	ClinGen TOPMed
rs201555817 CA8750489	221	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	222	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1306312077 CA400934925	223	M>I		No	ClinGen gnomAD
CA8750490 rs778084858	223	M>V		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q96AX2

1 regional properties for Q96AX2

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	29 - 184	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle	Secretory granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
azurophil granule membrane	The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
endoplasmic reticulum-Golgi intermediate compartment	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
specific granule membrane	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

2 GO annotations of molecular function

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name	Definition
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9H082	RAB33B	Ras-related protein Rab-33B	Homo sapiens (Human)	PR
Q9JKM7	Rab37	Ras-related protein Rab-37	Mus musculus (Mouse)	PR
P25766	RGP1	Ras-related protein RGP1	Oryza sativa subsp japonica (Rice)	PR
Q9LNK1	RABA3	Ras-related protein RABA3	Arabidopsis thaliana (Mouse-ear cress)	PR
O04486	RABA2A	Ras-related protein RABA2a	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LNW1	RABA2B	Ras-related protein RABA2b	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LH50	RABA4D	Ras-related protein RABA4d	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FE79	RABA4C	Ras-related protein RABA4c	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJZ5	RABA4E	Putative Ras-related protein RABA4e	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MTGTPGAVAT	RDGEAPERSP	PCSPSYDLTG	KVMLLGDTGV	GKTCFLIQFK	DGAFLSGTFI
70	80	90	100	110	120
ATVGIDFRNK	VVTVDGVRVK	LQIWDTAGQE	RFRSVTHAYY	RDAQALLLLY	DITNKSSFDN
130	140	150	160	170	180
IRAWLTEIHE	YAQRDVVIML	LGNKADMSSE	RVIRSEDGET	LAREYGVPFL	ETSAKTGMNV
190	200	210	220
ELAFLAIAKE	LKYRAGHQAD	EPSFQIRDYV	ESQKKRSSCC	SFM