Q969T4

PR
Gene name
UBE2E3 (UBCE4, UBCH9)
Protein name
Ubiquitin-conjugating enzyme E2 E3
Names
E2 ubiquitin-conjugating enzyme E3, UbcH9, Ubiquitin carrier protein E3, Ubiquitin-conjugating enzyme E2-23 kDa, Ubiquitin-protein ligase E3
Species
Homo sapiens (Human)
KEGG Pathway
hsa:10477
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q969T4

Entry ID Method Resolution Chain Position Source
AF-Q969T4-F1 Predicted AlphaFoldDB

71 variants for Q969T4

Variant ID(s) Position Change Description Diseaes Association Provenance
TCGA novel 2 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1433622947
CA349722945
 2 S>P No ClinGen
gnomAD
CA349723015
rs1445212824
 11 E>V No ClinGen
gnomAD
rs1574150072
CA349723023
 12 S>T No ClinGen
Ensembl
rs1574150099
CA349723040
 15 T>P No ClinGen
Ensembl
rs759906451
CA2008995
 19 S>R No ClinGen
ExAC
gnomAD
rs1574150120
CA349723100
 23 D>A No ClinGen
Ensembl
rs1183973304
CA349723115
 25 R>P No ClinGen
TOPMed
rs760700986
CA2008998
 26 D>A No ClinGen
ExAC
gnomAD
rs199721038
CA349723123
 27 P>A No ClinGen
1000Genomes
gnomAD
rs199721038
CA62023241
 27 P>T No ClinGen
1000Genomes
gnomAD
rs373139588
CA2009000
 28 A>V No ClinGen
ESP
ExAC
gnomAD
CA349723144
rs1358410849
 30 P>L No ClinGen
TOPMed
CA349723152
rs1232132593
 31 E>D No ClinGen
gnomAD
CA2009002
rs753729488
 32 P>L No ClinGen
ExAC
gnomAD
CA349723153
rs1559109209
 32 P>S No ClinGen
Ensembl
CA349723178
rs1343755487
 35 Q>R No ClinGen
gnomAD
rs994457762
CA62023249
 36 E>D No ClinGen
TOPMed
rs1289058933
CA349723201
 38 R>K No ClinGen
TOPMed
rs1559109250
CA349723208
 39 K>R No ClinGen
Ensembl
rs1211360591
CA349723215
 40 P>L No ClinGen
gnomAD
rs1488771682 41 S>missing Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs750044579
CA2009005
 42 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA2009008
rs746491983
 44 Q>L No ClinGen
ExAC
gnomAD
CA2009009
rs768058829
 45 Q>K No ClinGen
ExAC
gnomAD
rs918808233
CA62023255
 46 K>R No ClinGen
Ensembl
rs1390047884
CA349723268
 48 N>S No ClinGen
TOPMed
gnomAD
CA2009010
rs778285822
 49 T>I No ClinGen
ExAC
gnomAD
rs1387665375
CA349723290
 51 L>H No ClinGen
TOPMed
CA349723296
rs1393524691
 52 S>C No ClinGen
TOPMed
CA349723299
rs1292234439
 53 S>G No ClinGen
TOPMed
TCGA novel 55 T>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1389090032
CA349723327
 57 A>S No ClinGen
gnomAD
CA62023258
rs866428637
 64 K>E No ClinGen
Ensembl
CA62023260
rs576895615
 64 K>R No ClinGen
1000Genomes
CA349723510
rs1176391232
 82 S>C No ClinGen
Ensembl
rs1173199059
CA349723973
 96 T>S No ClinGen
gnomAD
TCGA novel 99 G>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA349723996
rs1433391473
 100 P>S No ClinGen
TOPMed
gnomAD
rs1433391473
CA349723994
 100 P>T No ClinGen
TOPMed
gnomAD
TCGA novel 114 I>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2009082
rs371539531
 117 S>T No ClinGen
ESP
ExAC
gnomAD
rs772049549
CA2009085
 126 K>R No ClinGen
ExAC
gnomAD
CA349724210
rs1193044967
 130 R>C No ClinGen
gnomAD
TCGA novel 132 R>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1340175526
CA349724243
 135 H>D No ClinGen
gnomAD
CA62051722
rs1053303988
 139 N>S No ClinGen
TOPMed
rs937868314
CA62051723
 142 G>A No ClinGen
TOPMed
CA349724301
rs1292544696
 143 V>I No ClinGen
TOPMed
rs1165383913
CA349724368
 152 N>S No ClinGen
gnomAD
CA2009110
rs774720190
 156 A>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs774720190
CA349724396
 156 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1558940397
CA349724411
 158 T>S No ClinGen
Ensembl
COSM4154714
rs201327764
CA2009111
 159 I>V kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs767846679
CA2009112
 161 K>E No ClinGen
ExAC
gnomAD
TCGA novel 161 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs200728679
CA62051726
 164 L>P No ClinGen
1000Genomes
rs1380456739
CA349724456
 166 I>V No ClinGen
TOPMed
gnomAD
CA349724467
rs1308435122
 167 C>F No ClinGen
TOPMed
CA62051727
rs199561506
 168 S>P No ClinGen
1000Genomes
TCGA novel 172 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs371595317 176 A>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs772827469
CA2009135
 176 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs767973313
CA2009137
 181 G>E No ClinGen
ExAC
TOPMed
gnomAD
rs775982774
CA2009138
 182 S>N No ClinGen
ExAC
gnomAD
rs764585793
CA2009140
 192 A>T No ClinGen
ExAC
gnomAD
rs1419426007
CA349724680
 197 I>L No ClinGen
TOPMed
rs1377747244
CA349724710
 201 W>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA62051937
rs2368192
VAR_023392
 201 W>R No ClinGen
UniProt
Ensembl
dbSNP
CA349724722
rs1436490600
 203 K>E No ClinGen
gnomAD
CA349724744
rs1407564429
 206 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD

No associated diseases with Q969T4

2 regional properties for Q969T4

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611
domain U2A'/phosphoprotein 32 family A, C-terminal 128 - 146 IPR003603

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

4 GO annotations of biological process

Name Definition
protein K11-linked ubiquitination A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
protein K48-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LD2 UBE2T Ubiquitin-conjugating enzyme E2 T Bos taurus (Bovine) PR
P35128 ben Ubiquitin-conjugating enzyme E2 N Drosophila melanogaster (Fruit fly) PR
P25867 eff Ubiquitin-conjugating enzyme E2-17 kDa Drosophila melanogaster (Fruit fly) PR
Q96LR5 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 Homo sapiens (Human) PR
Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T Homo sapiens (Human) PR
Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S Homo sapiens (Human) EV
Q9Y385 UBE2J1 Ubiquitin-conjugating enzyme E2 J1 Homo sapiens (Human) PR
Q9H8T0 AKTIP AKT-interacting protein Homo sapiens (Human) PR
P61086 UBE2K Ubiquitin-conjugating enzyme E2 K Homo sapiens (Human) PR
O00762 UBE2C Ubiquitin-conjugating enzyme E2 C Homo sapiens (Human) PR
O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 Homo sapiens (Human) PR
Q7Z7E8 UBE2Q1 Ubiquitin-conjugating enzyme E2 Q1 Homo sapiens (Human) PR
A1L167 UBE2QL1 Ubiquitin-conjugating enzyme E2Q-like protein 1 Homo sapiens (Human) PR
Q9CQ37 Ube2t Ubiquitin-conjugating enzyme E2 T Mus musculus (Mouse) PR
P61079 Ube2d3 Ubiquitin-conjugating enzyme E2 D3 Mus musculus (Mouse) PR
P52483 Ube2e3 Ubiquitin-conjugating enzyme E2 E3 Mus musculus (Mouse) PR
P35129 let-70 Ubiquitin-conjugating enzyme E2 2 Caenorhabditis elegans PR
Q9C8X7 UBC31 Probable ubiquitin-conjugating enzyme E2 31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLE4 UBC29 Ubiquitin-conjugating enzyme E2 29 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJD7 COP10 Constitutive photomorphogenesis protein 10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSSDRQRSDD ESPSTSSGSS DADQRDPAAP EPEEQEERKP SATQQKKNTK LSSKTTAKLS
70 80 90 100 110 120
TSAKRIQKEL AEITLDPPPN CSAGPKGDNI YEWRSTILGP PGSVYEGGVF FLDITFSSDY
130 140 150 160 170 180
PFKPPKVTFR TRIYHCNINS QGVICLDILK DNWSPALTIS KVLLSICSLL TDCNPADPLV
190 200
GSIATQYLTN RAEHDRIARQ WTKRYAT