Q965G5

SS
Gene name
mak-2 (C44C8.6)
Protein name
MAP kinase-activated protein kinase mak-2
Names
MAPK-activated protein kinase mak-2 , EC 2.7.11.1
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPKAPK2 is a stress-activated serine/threonine-protein kinase. MAPKAPK2, contains an autoinhibitory α-helix overlapping with a leucine-rich nuclear export signal (NES), and also lies close to the nuclear localization signal (NLS). The closed conformation of MAPKAPK2 prevents exportin binding to NES. Phosphorylation of MAPKAPK2 at threonine 317 induces a conformational change, thus unmasks and increases the activity of NES.

Autoinhibitory domains (AIDs)

283-303 (Autoinhibitory A-helix) SS

Target domain

0-276 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

155-179 (Activation loop from InterPro)

Target domain

13-276 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q965G5

Entry ID Method Resolution Chain Position Source
AF-Q965G5-F1 Predicted AlphaFoldDB

No variants for Q965G5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q965G5

No associated diseases with Q965G5

3 regional properties for Q965G5

Type Name Position InterPro Accession
domain Protein kinase domain 13 - 276 IPR000719
active_site Serine/threonine-protein kinase, active site 131 - 143 IPR008271
binding_site Protein kinase, ATP binding site 19 - 42 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Perikaryon
  • Nucleus
  • Synapse
  • Colocalizes with snb-1 and partially with cebp-1 at synapses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein serine/threonine kinase activity Calcium-dependent catalysis of the reactions
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions
metal ion binding Binding to a metal ion.
mitogen-activated protein kinase binding Binding to a mitogen-activated protein kinase.
protein serine kinase activity Catalysis of the reactions

8 GO annotations of biological process

Name Definition
behavioral response to nicotine Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of 3'-UTR-mediated mRNA stabilization Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
positive regulation of axon extension involved in regeneration Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
regulation of 3'-UTR-mediated mRNA stabilization Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
regulation of axon extension involved in axon guidance Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.
regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYZ2 MAPKAPK3 MAP kinase-activated protein kinase 3 Bos taurus (Bovine) SS
P49071 MAPk-Ak2 MAP kinase-activated protein kinase 2 Drosophila melanogaster (Fruit fly) SS
Q8IW41 MAPKAPK5 MAP kinase-activated protein kinase 5 Homo sapiens (Human) SS
Q16644 MAPKAPK3 MAP kinase-activated protein kinase 3 Homo sapiens (Human) SS
P49137 MAPKAPK2 MAP kinase-activated protein kinase 2 Homo sapiens (Human) EV
O54992 Mapkapk5 MAP kinase-activated protein kinase 5 Mus musculus (Mouse) EV
P49138 Mapkapk2 MAP kinase-activated protein kinase 2 Mus musculus (Mouse) EV
Q3UMW7 Mapkapk3 MAP kinase-activated protein kinase 3 Mus musculus (Mouse) SS
Q66H84 Mapkapk3 MAP kinase-activated protein kinase 3 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MAFHEYPVTQ DYRISRKVLG VGINGKVVEC EHRQSGDKFA LKVLRDTQKA RREVELHVMA
70 80 90 100 110 120
SGHGHVVSVH DVYKNSYNGV DCLLVVMENM KGGELFNRIQ ERGQKAFTER EAAGIVNEIC
130 140 150 160 170 180
SAVAHLHRMS IAHRDLKPEN LLYVTTASNA ALKLTDFGFA KKTDESEPQG LKTACFTPYY
190 200 210 220 230 240
CAPEVLGTEK YDKSCDLWSI GVIMYILLCG YPPFYSQHGQ PMSPGMKAKI KSGQYTFPSP
250 260 270 280 290 300
EWDCVSEAAK DLIRKLLRTE PTERITIEQT MEHKWISHYR RVPDTPLFTS SNLNDQREQW
310 320 330 340 350 360
TDMQDEMEAT LASMRVGPEN IQIKSLGDSN NKLLAKRRKG GASPKDDPMD DIKEEEKDDE
EEKMIS