Q96285
PR
Gene name |
LECRK55 |
Protein name |
L-type lectin-domain containing receptor kinase V.5 |
Names |
Arabidopsis thaliana lectin-receptor kinase a1, Ath.lecRK1, AthlecRK-a1, LecRK-V.5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G59700 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
481-505 (Activation loop from InterPro)
Target domain |
338-657 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q96285
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q96285-F1 | Predicted | AlphaFoldDB |
146 variants for Q96285
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00428098 | 2 | S>F | No | 1000Genomes | |
| tmp_3_22052162_T_A | 6 | I>N | No | 1000Genomes | |
| tmp_3_22052174_A_G | 10 | Q>R | No | 1000Genomes | |
| ENSVATH06344883 | 13 | L>F | No | 1000Genomes | |
| tmp_3_22052219_G_A | 25 | G>D | No | 1000Genomes | |
| tmp_3_22052236_G_A | 31 | G>R | No | 1000Genomes | |
| ENSVATH00428099 | 33 | V>L | No | 1000Genomes | |
| ENSVATH12836891 | 36 | G>S | No | 1000Genomes | |
| tmp_3_22052256_C_G | 37 | F>L | No | 1000Genomes | |
| ENSVATH06344885 | 47 | T>P | No | 1000Genomes | |
| tmp_3_22052300_G_A | 52 | G>D | No | 1000Genomes | |
| ENSVATH06344886 | 52 | G>S | No | 1000Genomes | |
| ENSVATH14456356 | 53 | Q>K | No | 1000Genomes | |
| ENSVATH06344887 | 69 | V>I | No | 1000Genomes | |
| ENSVATH12836892 | 70 | I>V | No | 1000Genomes | |
| ENSVATH14456357 | 78 | F>V | No | 1000Genomes | |
| ENSVATH06344888 | 79 | F>V | No | 1000Genomes | |
| ENSVATH12836893 | 80 | A>S | No | 1000Genomes | |
| ENSVATH02526521 | 82 | V>I | No | 1000Genomes | |
| ENSVATH06344889 | 88 | Q>* | No | 1000Genomes | |
| ENSVATH14456358 | 89 | G>S | No | 1000Genomes | |
| tmp_3_22052424_G_A | 93 | M>I | No | 1000Genomes | |
| ENSVATH02526522 | 94 | T>A | No | 1000Genomes | |
| ENSVATH02526522 | 94 | T>P | No | 1000Genomes | |
| ENSVATH02526523 | 99 | P>S | No | 1000Genomes | |
| ENSVATH02526524 | 100 | T>I | No | 1000Genomes | |
| tmp_3_22052453_T_A | 103 | L>H | No | 1000Genomes | |
| tmp_3_22052468_C_A | 108 | S>Y | No | 1000Genomes | |
| ENSVATH06344891 | 133 | D>H | No | 1000Genomes | |
| ENSVATH14456359 | 137 | D>E | No | 1000Genomes | |
| ENSVATH02526525 | 148 | V>I | No | 1000Genomes | |
| tmp_3_22052602_A_C | 153 | N>H | No | 1000Genomes | |
| tmp_3_22052609_T_A | 155 | L>* | No | 1000Genomes | |
| ENSVATH14456360 | 155 | L>F | No | 1000Genomes | |
| ENSVATH12836894 | 164 | G>S | No | 1000Genomes | |
| ENSVATH02526526 | 170 | D>H | No | 1000Genomes | |
| ENSVATH06344894 | 176 | L>F | No | 1000Genomes | |
| ENSVATH06344895 | 177 | S>P | No | 1000Genomes | |
| ENSVATH06344896 | 180 | S>R | No | 1000Genomes | |
| ENSVATH06344897 | 182 | E>V | No | 1000Genomes | |
| tmp_3_22052741_T_A | 199 | V>D | No | 1000Genomes | |
| tmp_3_22052761_A_T | 206 | I>F | No | 1000Genomes | |
| ENSVATH06344898 | 207 | P>R | No | 1000Genomes | |
| tmp_3_22052783_C_T | 213 | P>L | No | 1000Genomes | |
| tmp_3_22052786_T_C | 214 | L>P | No | 1000Genomes | |
| ENSVATH12836895 | 220 | D>V | No | 1000Genomes | |
| tmp_3_22052815_T_A | 224 | Y>N | No | 1000Genomes | |
| ENSVATH02526528 | 226 | L>F | No | 1000Genomes | |
| tmp_3_22052855_C_T | 237 | T>M | No | 1000Genomes | |
| tmp_3_22052854_A_C | 237 | T>P | No | 1000Genomes | |
| tmp_3_22052857_G_T | 238 | G>W | No | 1000Genomes | |
| tmp_3_22052866_G_A | 241 | G>R | No | 1000Genomes | |
| tmp_3_22052882_T_G | 246 | L>W | No | 1000Genomes | |
| ENSVATH06344901 | 247 | M>I | No | 1000Genomes | |
| tmp_3_22052892_G_A | 249 | W>* | No | 1000Genomes | |
| ENSVATH02526529 | 250 | L>F | No | 1000Genomes | |
| tmp_3_22052911_G_C | 256 | E>Q | No | 1000Genomes | |
| ENSVATH14456363 | 262 | L>F | No | 1000Genomes | |
| ENSVATH06344902 | 262 | L>H | No | 1000Genomes | |
| ENSVATH06344903 | 273 | K>T | No | 1000Genomes | |
| tmp_3_22052983_A_C | 280 | T>P | No | 1000Genomes | |
| tmp_3_22052986_G_C | 281 | V>L | No | 1000Genomes | |
| ENSVATH02526530 | 284 | V>G | No | 1000Genomes | |
| tmp_3_22053007_G_T | 288 | V>L | No | 1000Genomes | |
| tmp_3_22053037_T_A | 298 | W>R | No | 1000Genomes | |
| tmp_3_22053048_C_A | 301 | F>L | No | 1000Genomes | |
| tmp_3_22053091_G_T | 316 | E>* | No | 1000Genomes | |
| tmp_3_22053106_T_A | 321 | Y>N | No | 1000Genomes | |
| tmp_3_22053124_G_T | 327 | A>S | No | 1000Genomes | |
| tmp_3_22053220_G_C | 359 | G>R | No | 1000Genomes | |
| ENSVATH06344908 | 365 | A>T | No | 1000Genomes | |
| tmp_3_22053256_C_A | 371 | H>N | No | 1000Genomes | |
| tmp_3_22053271_G_A | 376 | G>R | No | 1000Genomes | |
| tmp_3_22053292_G_A | 383 | E>K | No | 1000Genomes | |
| tmp_3_22053311_G_A | 389 | R>H | No | 1000Genomes | |
| ENSVATH06344909 | 391 | R>G | No | 1000Genomes | |
| tmp_3_22053353_G_A | 403 | R>K | No | 1000Genomes | |
| tmp_3_22053381_T_G | 412 | Y>* | No | 1000Genomes | |
| ENSVATH12836906 | 414 | Y>D | No | 1000Genomes | |
| ENSVATH12836908 | 415 | M>I | No | 1000Genomes | |
| ENSVATH06344910 | 429 | N>K | No | 1000Genomes | |
| tmp_3_22053440_G_A | 432 | R>Q | No | 1000Genomes | |
| tmp_3_22053439_C_T | 432 | R>W | No | 1000Genomes | |
| ENSVATH02526533 | 434 | T>S | No | 1000Genomes | |
| ENSVATH12836909 | 446 | A>V | No | 1000Genomes | |
| tmp_3_22053519_A_T | 458 | Q>H | No | 1000Genomes | |
| ENSVATH12836910 | 459 | V>A | No | 1000Genomes | |
| tmp_3_22053531_T_A | 462 | H>Q | No | 1000Genomes | |
| tmp_3_22053530_A_G | 462 | H>R | No | 1000Genomes | |
| ENSVATH14456398 | 463 | R>G | No | 1000Genomes | |
| tmp_3_22053573_G_C | 476 | M>I | No | 1000Genomes | |
| tmp_3_22053577_G_A | 478 | A>T | No | 1000Genomes | |
| ENSVATH14456399 | 481 | G>R | No | 1000Genomes | |
| tmp_3_22053596_G_T | 484 | G>V | No | 1000Genomes | |
| ENSVATH12836911 | 497 | T>K | No | 1000Genomes | |
| ENSVATH14456400 | 505 | G>E | No | 1000Genomes | |
| ENSVATH12836913 | 509 | P>L | No | 1000Genomes | |
| tmp_3_22053688_G_A | 515 | G>R | No | 1000Genomes | |
| ENSVATH06344914 | 520 | S>G | No | 1000Genomes | |
| ENSVATH02526538 | 523 | V>I | No | 1000Genomes | |
| ENSVATH06344915 | 526 | F>Y | No | 1000Genomes | |
| tmp_3_22053739_G_A | 532 | E>K | No | 1000Genomes | |
| ENSVATH12836927 | 539 | I>L | No | 1000Genomes | |
| tmp_3_22053772_C_T | 543 | R>C | No | 1000Genomes | |
| ENSVATH14456401 | 548 | E>V | No | 1000Genomes | |
| ENSVATH06344916 | 551 | L>H | No | 1000Genomes | |
| tmp_3_22053800_T_G,C | 552 | V>A | No | 1000Genomes | |
| tmp_3_22053800_T_G,C | 552 | V>G | No | 1000Genomes | |
| ENSVATH12836930 | 553 | D>Y | No | 1000Genomes | |
| tmp_3_22053807_G_A | 554 | W>* | No | 1000Genomes | |
| ENSVATH06344918 | 561 | N>S | No | 1000Genomes | |
| tmp_3_22053829_G_A | 562 | G>R | No | 1000Genomes | |
| ENSVATH06344919 | 564 | I>L | No | 1000Genomes | |
| tmp_3_22053837_T_G | 564 | I>M | No | 1000Genomes | |
| tmp_3_22053839_T_C | 565 | F>S | No | 1000Genomes | |
| tmp_3_22053843_T_A | 566 | D>E | No | 1000Genomes | |
| tmp_3_22053847_G_T | 568 | A>S | No | 1000Genomes | |
| ENSVATH02526542 | 571 | S>C | No | 1000Genomes | |
| ENSVATH02526543 | 579 | G>* | No | 1000Genomes | |
| ENSVATH12836932 | 581 | V>I | No | 1000Genomes | |
| ENSVATH14456402 | 585 | L>S | No | 1000Genomes | |
| ENSVATH06344920 | 589 | V>A | No | 1000Genomes | |
| ENSVATH06344921 | 591 | C>S | No | 1000Genomes | |
| ENSVATH12836933 | 594 | Q>* | No | 1000Genomes | |
| tmp_3_22053932_C_A | 596 | A>E | No | 1000Genomes | |
| tmp_3_22053944_C_A | 600 | P>Q | No | 1000Genomes | |
| tmp_3_22053965_G_A | 607 | R>K | No | 1000Genomes | |
| tmp_3_22053968_T_C | 608 | I>T | No | 1000Genomes | |
| ENSVATH00428101 | 609 | L>V | No | 1000Genomes | |
| ENSVATH12836934 | 611 | G>V | No | 1000Genomes | |
| ENSVATH06344923 | 619 | L>P | No | 1000Genomes | |
| tmp_3_22054010_T_G | 622 | V>G | No | 1000Genomes | |
| tmp_3_22054022_A_T | 626 | E>V | No | 1000Genomes | |
| tmp_3_22054033_G_A | 630 | E>K | No | 1000Genomes | |
| tmp_3_22054042_G_A | 633 | E>K | No | 1000Genomes | |
| tmp_3_22054048_T_A | 635 | S>T | No | 1000Genomes | |
| tmp_3_22054061_T_C | 639 | L>P | No | 1000Genomes | |
| tmp_3_22054069_G_T | 642 | D>Y | No | 1000Genomes | |
| ENSVATH06344924 | 645 | T>A | No | 1000Genomes | |
| ENSVATH06344925 | 649 | L>M | No | 1000Genomes | |
| ENSVATH06344926 | 652 | T>P | No | 1000Genomes | |
| tmp_3_22054102_G_A | 653 | D>N | No | 1000Genomes | |
| tmp_3_22054114_G_A | 657 | V>I | No | 1000Genomes | |
| ENSVATH12836940 | 659 | H>R | No | 1000Genomes | |
| ENSVATH12836939 | 659 | H>Y | No | 1000Genomes | |
| tmp_3_22054126_C_G | 661 | R>G | No | 1000Genomes |
1 associated diseases with Q96285
[MIM: 614104]: Intellectual developmental disorder, autosomal dominant 7 (MRD7)
A disease characterized by primary microcephaly, severe intellectual disability without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Intellectual disability is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:21294719, ECO:0000269|PubMed:23160955}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disease characterized by primary microcephaly, severe intellectual disability without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Intellectual disability is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:21294719, ECO:0000269|PubMed:23160955}. Note=The disease is caused by variants affecting the gene represented in this entry.
No regional properties for Q96285
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q96285 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| negative regulation of defense response to bacterium | Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of stomatal closure | Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P51842 | Gucy2f | Retinal guanylyl cyclase 2 | Rattus norvegicus (Rat) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSR8 | LECRK19 | L-type lectin-domain containing receptor kinase I.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRELIILCQ | PILVLFLTLF | YNSHGYFVSQ | GSVGIGFNGY | FTLTNTTKHT | FGQAFENEHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIKNSSTGVI | SSFSVNFFFA | IVPEHNQQGS | HGMTFVISPT | RGLPGASSDQ | YLGIFNKTNN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKASNNVIAI | ELDIHKDEEF | GDIDDNHVGI | NINGLRSVAS | ASAGYYDDKD | GSFKKLSLIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| REVMRLSIVY | SQPDQQLNVT | LFPAEIPVPP | LKPLLSLNRD | LSPYLLEKMY | LGFTASTGSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GAIHYLMGWL | VNGVIEYPRL | ELSIPVLPPY | PKKTSNRTKT | VLAVCLTVSV | FAAFVASWIG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVFYLRHKKV | KEVLEEWEIQ | YGPHRFAYKE | LFNATKGFKE | KQLLGKGGFG | QVYKGTLPGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DAEIAVKRTS | HDSRQGMSEF | LAEISTIGRL | RHPNLVRLLG | YCRHKENLYL | VYDYMPNGSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DKYLNRSENQ | ERLTWEQRFR | IIKDVATALL | HLHQEWVQVI | IHRDIKPANV | LIDNEMNARL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GDFGLAKLYD | QGFDPETSKV | AGTFGYIAPE | FLRTGRATTS | TDVYAFGLVM | LEVVCGRRII |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ERRAAENEEY | LVDWILELWE | NGKIFDAAEE | SIRQEQNRGQ | VELVLKLGVL | CSHQAASIRP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AMSVVMRILN | GVSQLPDNLL | DVVRAEKFRE | WPETSMELLL | LDVNTSSSLE | LTDSSFVSHG |
| R |