Q95ZV7

PR
Gene name
ddr-2
Protein name
Discoidin domain-containing receptor tyrosine kinase B
Names
Discoidin domain-containing receptor B
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F11D5.3
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95ZV7

Entry ID Method Resolution Chain Position Source
AF-Q95ZV7-F1 Predicted AlphaFoldDB

No variants for Q95ZV7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95ZV7

No associated diseases with Q95ZV7

5 regional properties for Q95ZV7

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 24 - 181 IPR000421
domain Protein kinase domain 527 - 785 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 530 - 784 IPR001245
active_site Tyrosine-protein kinase, active site 641 - 653 IPR008266
domain Tyrosine-protein kinase, catalytic domain 527 - 785 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, axon
  • Perikaryon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase collagen receptor activity Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

6 GO annotations of biological process

Name Definition
interneuron axon guidance The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5F3X2 DDR1 receptor protein-tyrosine kinase Gallus gallus (Chicken) SS
Q7YR43 DDR1 Epithelial discoidin domain-containing receptor 1 Pan troglodytes (Chimpanzee) SS
Q16832 DDR2 Discoidin domain-containing receptor 2 Homo sapiens (Human) SS
Q08345 DDR1 Epithelial discoidin domain-containing receptor 1 Homo sapiens (Human) EV
Q03146 Ddr1 Epithelial discoidin domain-containing receptor 1 Mus musculus (Mouse) SS
Q62371 Ddr2 Discoidin domain-containing receptor 2 Mus musculus (Mouse) SS
Q63474 Ddr1 Epithelial discoidin domain-containing receptor 1 Rattus norvegicus (Rat) SS
G5EGK5 cam-1 Tyrosine-protein kinase receptor cam-1 Caenorhabditis elegans SS
O61460 vab-1 Ephrin receptor 1 Caenorhabditis elegans SS
H2KZU7 svh-2 Tyrosine-protein kinase receptor svh-2 Caenorhabditis elegans SS
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
E7F3X9 ddr1 receptor protein-tyrosine kinase Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKLLLYLFGV TFHSNTVVAL ELRECSHQLG MSNRKIRDEQ ISASSSFDLQ STGPQHARAH
70 80 90 100 110 120
QESGSGAWCP KNQINSLSKE WLQISFSVDT VITSVETQGR FDDGRGMEYA TAFKIQYWRP
130 140 150 160 170 180
SLNAWASYKD DFELETIPAN NDTEHAIRRH LDRAIIARRI RIVPVSNSTR TVCMRVEVFG
190 200 210 220 230 240
CPFDDSLVFY NVDQGDLQSG ISYHDFSYDG NLANSPHLTG GIGKLYDGEV GKNNVFVNHH
250 260 270 280 290 300
KWVGWRRKRN GNVKLAFEFS ELRNISGILI HTSNEFKKSA KAFSSATVLF SINGKDFSDT
310 320 330 340 350 360
IVHFNNPEDT ESEVPRWIRI PVNNRIAKVA KIRLNFGTDS DWLFISEVNF ESNHTNIELL
370 380 390 400 410 420
NDDVVIPDSV SYFSVTEHDD GTSMFAFIIF FFMFLIVAVI ILTVLYRKRE YRVKASSPSP
430 440 450 460 470 480
NAKREILLTI DGNTIKHHVS PSTYQMARDN LQNALIEKMP MSPIISDYAE PDISVCSDVT
490 500 510 520 530 540
ANTPLLYGID GPYDTQKRSN PLSSMVKYSD YGEVYCTTLP EIARDKLICV SRIGQGEFGE
550 560 570 580 590 600
VDLCQLENRK VAVKKLHGIS QADEFSFHRE IRVLGSLKHP NVVEVVGVCT IQKPILCIME
610 620 630 640 650 660
YMENGDLKSY ILKNPTIQTS QCISICTQLA AGLAYLESCN FVHRDIAARN CLVDGEGNVK
670 680 690 700 710 720
IADFGMARSL YSQEYYKVEG KFVLPIRWMA WEALLLGKFS TASDVWGFGV TMWEIFSLCS
730 740 750 760 770 780
EKPYSDMTDD DVVENLQSMS STGSLKQVLS RPRMCPSKLY NEQILPCWNY ESSRRPSFEN
790
VHLHLQSLVH TSPHIHF