Q95YD4

PR
Gene name
kin-32
Protein name
Inactive tyrosine-protein kinase kin-32
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C30F8.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

258-388 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95YD4

Entry ID Method Resolution Chain Position Source
AF-Q95YD4-F1 Predicted AlphaFoldDB

No variants for Q95YD4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95YD4

No associated diseases with Q95YD4

9 regional properties for Q95YD4

Type Name Position InterPro Accession
repeat Leucine-rich repeat 86 - 152 IPR001611-1
repeat Leucine-rich repeat 153 - 211 IPR001611-2
repeat Leucine-rich repeat 222 - 280 IPR001611-3
repeat Leucine-rich repeat, typical subtype 105 - 127 IPR003591-1
repeat Leucine-rich repeat, typical subtype 128 - 151 IPR003591-2
repeat Leucine-rich repeat, typical subtype 175 - 197 IPR003591-3
repeat Leucine-rich repeat, typical subtype 198 - 220 IPR003591-4
repeat Leucine-rich repeat, typical subtype 221 - 243 IPR003591-5
repeat Leucine-rich repeat, typical subtype 244 - 267 IPR003591-6

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
signal complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00944 PTK2 Focal adhesion kinase 1 Gallus gallus (Chicken) EV
Q13470 TNK1 Non-receptor tyrosine-protein kinase TNK1 Homo sapiens (Human) PR
Q05397 PTK2 Focal adhesion kinase 1 Homo sapiens (Human) EV
Q14289 PTK2B Protein-tyrosine kinase 2-beta Homo sapiens (Human) PR
Q99ML2 Tnk1 Non-receptor tyrosine-protein kinase TNK1 Mus musculus (Mouse) PR
P34152 Ptk2 Focal adhesion kinase 1 Mus musculus (Mouse) SS
Q9QVP9 Ptk2b Protein-tyrosine kinase 2-beta Mus musculus (Mouse) PR
P70600 Ptk2b Protein-tyrosine kinase 2-beta Rattus norvegicus (Rat) PR
O35346 Ptk2 Focal adhesion kinase 1 Rattus norvegicus (Rat) SS
O01798 spe-8 Spermatocyte protein spe-8 Caenorhabditis elegans PR
O16262 nipi-4 Protein nipi-4 Caenorhabditis elegans PR
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
Q8I7I5 rol-3 Protein roller-3 Caenorhabditis elegans PR
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
P03949 abl-1 Tyrosine-protein kinase abl-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MEGLARVFLI GGASKAVRYD EQTTIERVIH VVARGIGISQ VAVAHFALRL VTGPSPQTAG
70 80 90 100 110 120
SGDSLWLHPM LRITQLPHIY ARHLPIGVCD EIKLEMRMRF MPQSVYELQA TDSSAFVYLH
130 140 150 160 170 180
EQVVDEFFSH VAWRSSVEVA LEVAALKVCR DFAEHQHNKG ADHHLEDLDI EACIQSLIPN
190 200 210 220 230 240
VLHNPGFKHS HLKKTFTAYI KKFSATSPNE SIIRSLALLL EVVKFDVELF KASLGAGWTK
250 260 270 280 290 300
PVELVVGPHT GLSYRLNERC DSSRLLELRT IAEITIRKME NGSEKTLMQL NLSGAAKPVL
310 320 330 340 350 360
ITLSTEELSQ SLAHLLDGYQ MLYNQRDSVF KLKGIERCET LTMHEATIRP KTPNNIDSNI
370 380 390 400 410 420
RLRRELITLK ELIGGGQFGN VYKAVYHDLE KDERIAVAVK VCKTDAEPAD TQLILQESSL
430 440 450 460 470 480
MRNFRHSNII QLIGVCVDQP MWLVLELAPK GELREYLQQE KDWLPLRILT LFCSQICDSL
490 500 510 520 530 540
VYLHSTRFVH RDIAARNILV CSPQCVKLAD FGLSRALDYD AVYTASRGKL PIKWLAPESV
550 560 570 580 590 600
NYRQFSMASD VWMFGVCMWE IFSLGVKPWA GVTNSDVIMH IEQGSRPPCP EKCPTALYNF
610 620 630 640 650 660
IRSKMWAIEP HKRPTVDQIY AIIEDVRQQI IQNIPPEQII VGKPMTAAGV IVAEMSSLPG
670 680 690 700 710 720
LTLYRTMEDQ KRQAEEDAKW LEQEDDEDED DQDIDQIPST SHSSVENIRT SNGYLHHTPT
730 740 750 760 770 780
STRSLRFEDK TSRGLRRSVD GVCDAVTKLQ NSFNNLTHND DFLHSVKEVT SQLREMLIVA
790 800 810 820 830 840
SGMRDRVTTT TQRTDVDMTK TLIANDMKQM SRVMGKLQVN GHQATYNTLR RDVVRICGEL
850 860
AVNCTTLQLQ LTQPPLENEF SSLLSNC