Q95L46

PR
Gene name
EIF4G2
Protein name
Eukaryotic translation initiation factor 4 gamma 2
Names
eIF-4-gamma 2, eIF-4G 2, eIF4G 2, p97
Species
Bos taurus (Bovine)
KEGG Pathway
bta:286870
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95L46

Entry ID Method Resolution Chain Position Source
AF-Q95L46-F1 Predicted AlphaFoldDB

No variants for Q95L46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95L46

No associated diseases with Q95L46

3 regional properties for Q95L46

Type Name Position InterPro Accession
domain W2 domain 720 - 904 IPR003307
domain MIF4G-like, type 3 78 - 308 IPR003890
domain Initiation factor eIF-4 gamma, MA3 543 - 666 IPR003891

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H074 PAIP1 Polyadenylate-binding protein-interacting protein 1 Homo sapiens (Human) PR
O43432 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 Homo sapiens (Human) EV
Q04637 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 Homo sapiens (Human) EV
P78344 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 Homo sapiens (Human) PR
Q8VE62 Paip1 Polyadenylate-binding protein-interacting protein 1 Mus musculus (Mouse) PR
Q6NZJ6 Eif4g1 Eukaryotic translation initiation factor 4 gamma 1 Mus musculus (Mouse) SS
Q80XI3 Eif4g3 Eukaryotic translation initiation factor 4 gamma 3 Mus musculus (Mouse) SS
Q62448 Eif4g2 Eukaryotic translation initiation factor 4 gamma 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW IPARSTRRDD
70 80 90 100 110 120
NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL LNVGVESKLI LKGVILLIVD
130 140 150 160 170 180
KALEEPKYSS LYAQLCLRLA EDAPNFDGPA AEGQPGQKQS TTFRRLLISK LQDEFENRTR
190 200 210 220 230 240
NVDVYDKREN PLLPEEEEQR AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK
250 260 270 280 290 300
RVQLKDMGED LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD
310 320 330 340 350 360
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF FLEGPFMPPR
370 380 390 400 410 420
MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR HRSNQLFNGH GGHIMPPTQS
430 440 450 460 470 480
QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL QGQSKDMPPR FSKKGQLNAD EISLRPAQSF
490 500 510 520 530 540
LMNKNQVPKL QPQITMIPPS AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS
550 560 570 580 590 600
KEELLKLTET VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA
610 620 630 640 650 660
SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA IISELVSISE
670 680 690 700 710 720
LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN MQKMLPEIDQ NKDRMLEILE
730 740 750 760 770 780
GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI YKWIKDNISP KLHVDKGFVN ILMTSFLQYI
790 800 810 820 830 840
SSEVNPPSDE TDSSSAPSKE QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN
850 860 870 880 890 900
SNFPKGMLLR FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE
ESEEEAD