Q94CB1

SS
Gene name
PME25 (ARATH25, At3g10720, T7M13.20)
Protein name
Probable pectinesterase/pectinesterase inhibitor 25
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G10720
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

78-231 (PMEI region) SS

Target domain

303-601 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94CB1

Entry ID Method Resolution Chain Position Source
AF-Q94CB1-F1 Predicted AlphaFoldDB

49 variants for Q94CB1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_3357575_T_A 3 M>L No 1000Genomes
ENSVATH05805415 14 F>C No 1000Genomes
ENSVATH05805414 15 L>F No 1000Genomes
ENSVATH05805413 22 C>W No 1000Genomes
tmp_3_3357494_G_T 30 Q>K No 1000Genomes
ENSVATH00315758 36 H>P No 1000Genomes
tmp_3_3357463_G_T 40 P>Q No 1000Genomes
ENSVATH10591011 41 S>L No 1000Genomes
ENSVATH05805410 43 L>P No 1000Genomes
ENSVATH00315757 45 F>S No 1000Genomes
ENSVATH00315756 48 P>S No 1000Genomes
tmp_3_3357437_C_T 49 V>I No 1000Genomes
tmp_3_3357425_A_T 53 F>I No 1000Genomes
tmp_3_3357415_G_A 56 P>L No 1000Genomes
ENSVATH02129536 58 Q>* No 1000Genomes
ENSVATH02129535 58 Q>P No 1000Genomes
ENSVATH10591005 62 F>L No 1000Genomes
ENSVATH10590984 63 V>L No 1000Genomes
ENSVATH05805408 72 P>S No 1000Genomes
ENSVATH05805406 137 S>N No 1000Genomes
tmp_3_3357160_G_A 141 S>L No 1000Genomes
ENSVATH05805405 145 E>D No 1000Genomes
tmp_3_3357064_G_A 173 T>M No 1000Genomes
ENSVATH13894489 209 G>S No 1000Genomes
ENSVATH13894488 218 M>I No 1000Genomes
tmp_3_3356882_G_A 234 H>Y No 1000Genomes
tmp_3_3356822_C_T 254 G>R No 1000Genomes
ENSVATH05805402 264 T>N No 1000Genomes
tmp_3_3355999_C_T 274 D>N No 1000Genomes
tmp_3_3355948_C_T 291 E>K No 1000Genomes
ENSVATH00315747 359 M>I No 1000Genomes
ENSVATH10590886 364 N>K No 1000Genomes
ENSVATH05805383 371 N>D No 1000Genomes
tmp_3_3355704_T_C 372 H>R No 1000Genomes
ENSVATH13894462 437 V>I No 1000Genomes
ENSVATH05805379 443 F>Y No 1000Genomes
ENSVATH00315742 456 I>L No 1000Genomes
ENSVATH13894458 463 I>V No 1000Genomes
ENSVATH05805372 475 M>I No 1000Genomes
ENSVATH00315741 476 A>T No 1000Genomes
ENSVATH10590821 481 A>E No 1000Genomes
ENSVATH05805371 506 A>T No 1000Genomes
ENSVATH00315740 512 E>D No 1000Genomes
tmp_3_3354965_C_T 512 E>K No 1000Genomes
tmp_3_3354913_C_G 529 R>T No 1000Genomes
ENSVATH10590820 543 P>S No 1000Genomes
tmp_3_3354866_C_G 545 G>R No 1000Genomes
ENSVATH13894457 548 E>A No 1000Genomes
tmp_3_3354644_C_A 619 E>* No 1000Genomes

No associated diseases with Q94CB1

3 regional properties for Q94CB1

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 303 - 601 IPR000070
domain Pectinesterase inhibitor domain 74 - 231 IPR006501
active_site Pectinesterase, Asp active site 449 - 458 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MKMQTLNFTS SLLFLSFIFL SCALLISSQQ SPSQPHSEPP SQLPFEPPVE SPFFPPSQPP
70 80 90 100 110 120
IFVPPSQPPS LPPSQSQSPS LACKSTPYPK LCRTILNAVK SSPSDPYRYG KFTIKQCLKQ
130 140 150 160 170 180
ASRLSKVITS YARRVESKPG SATAEEIGAV ADCGELSELS VNYLETVTTE LKTAQVMTAA
190 200 210 220 230 240
LVEHVNSLLS GVVTNQQTCL DGLVEAKSGF AAAIGSPMGN LTRLYSISLG LVSHALNRNL
250 260 270 280 290 300
KRFKASKGKI LGGGNSTYRE PLETLIKGLR KTCDNDKDCR KTSRNLGELG ETSGGSILVS
310 320 330 340 350 360
KAVIVGPFKS DNFTTITDAI AAAPNNTRPE DGYFVIYARE GVYEEYIVVP INKKNLMLMG
370 380 390 400 410 420
DGINKTIITG NHNVVDGWTT YNCSSFAVVG ERFMAVDVTF RNTAGPEKHQ AVALRNNAEG
430 440 450 460 470 480
SSFYRCSFEG YQDTLYVHSL RQFYRECDIY GTVDFIFGNA AAIFQNCNIY ARKPMAKQKN
490 500 510 520 530 540
AITAHGRLDP NQNTGISIIN CTIKAAPDLA AEPKSAMTFL GRPWKPYSRT VFMQSYISDI
550 560 570 580 590 600
VQPVGWLEWN GTIGLDTIYY GEYSNFGPGA NTNQRVQWLG YNLLNLAEAM NFTVYNFTMG
610
DTWLPQTDIP FYGGLLSKE