Q94C77

PR
Gene name
At4g34220 (F10M10.12, F28A23_20)
Protein name
Receptor protein kinase-like protein At4g34220
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G34220
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

359-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

622-646 (Activation loop from InterPro)

Target domain

471-753 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q94C77

Entry ID Method Resolution Chain Position Source
AF-Q94C77-F1 Predicted AlphaFoldDB

63 variants for Q94C77

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12384671
ENSVATH00551869
 6 S>R No 1000Genomes
ENSVATH12384670 33 L>I No 1000Genomes
tmp_4_16383941_T_G 38 K>N No 1000Genomes
tmp_4_16383927_G_C 43 T>S No 1000Genomes
tmp_4_16383875_G_T 60 C>* No 1000Genomes
ENSVATH06822357 71 G>A No 1000Genomes
tmp_4_16383828_G_C 76 P>R No 1000Genomes
ENSVATH06822356 105 L>I No 1000Genomes
ENSVATH06822355 141 G>A No 1000Genomes
ENSVATH02956547 143 L>M No 1000Genomes
ENSVATH00551865 149 S>R No 1000Genomes
ENSVATH00551864 166 E>Q No 1000Genomes
ENSVATH06822353 183 S>L No 1000Genomes
ENSVATH06822354 183 S>T No 1000Genomes
ENSVATH02956544 186 T>S No 1000Genomes
ENSVATH02956543 201 L>F No 1000Genomes
tmp_4_16383436_G_T 207 L>I No 1000Genomes
tmp_4_16383427_C_T 210 G>S No 1000Genomes
ENSVATH00551863 238 N>D No 1000Genomes
ENSVATH02956542 238 N>S No 1000Genomes
ENSVATH02956541 262 S>N No 1000Genomes
ENSVATH12384668 267 L>F No 1000Genomes
ENSVATH02956540 280 L>F No 1000Genomes
ENSVATH02956538 323 T>S No 1000Genomes
ENSVATH00551858 325 K>T No 1000Genomes
tmp_4_16383021_G_A 345 A>V No 1000Genomes
ENSVATH00551857 348 V>A No 1000Genomes
tmp_4_16382995_C_A 354 G>C No 1000Genomes
ENSVATH02956537 381 C>Y No 1000Genomes
tmp_4_16382886_G_A 390 S>L No 1000Genomes
ENSVATH02956536 392 P>Q No 1000Genomes
ENSVATH06822349 393 S>T No 1000Genomes
ENSVATH06822348 403 P>L No 1000Genomes
ENSVATH06822348 403 P>Q No 1000Genomes
ENSVATH02956535 405 A>D No 1000Genomes
ENSVATH00551854 408 T>A No 1000Genomes
ENSVATH12384667 458 V>I No 1000Genomes
tmp_4_16382548_T_C,G 503 T>A No 1000Genomes
tmp_4_16382548_T_C,G 503 T>P No 1000Genomes
tmp_4_16382545_C_T 504 E>K No 1000Genomes
ENSVATH06822347 509 A>V No 1000Genomes
tmp_4_16382476_G_A 527 P>S No 1000Genomes
tmp_4_16382416_C_T 547 D>N No 1000Genomes
ENSVATH06822345 578 T>N No 1000Genomes
ENSVATH06822343 598 E>G No 1000Genomes
tmp_4_16382131_T_G 599 K>T No 1000Genomes
ENSVATH12384633 614 N>T No 1000Genomes
tmp_4_16382068_A_G 620 I>T No 1000Genomes
ENSVATH06822342 631 T>I No 1000Genomes
ENSVATH06822341 634 R>P No 1000Genomes
ENSVATH06822340 636 S>F No 1000Genomes
ENSVATH00551845 642 T>S No 1000Genomes
tmp_4_16381983_C_A 648 Q>H No 1000Genomes
ENSVATH06822339 653 S>A No 1000Genomes
ENSVATH14334936 664 V>I No 1000Genomes
tmp_4_16381892_C_T 679 V>M No 1000Genomes
tmp_4_16381855_T_G 691 N>T No 1000Genomes
tmp_4_16381838_C_T 697 A>T No 1000Genomes
tmp_4_16381798_G_A 710 A>V No 1000Genomes
ENSVATH00551844 714 D>N No 1000Genomes
ENSVATH02956532 730 I>V No 1000Genomes
tmp_4_16381682_C_T 749 V>M No 1000Genomes
ENSVATH02956531 753 I>F No 1000Genomes

No associated diseases with Q94C77

3 regional properties for Q94C77

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 316 IPR000719
active_site Serine/threonine-protein kinase, active site 148 - 160 IPR008271
binding_site Protein kinase, ATP binding site 26 - 50 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

4 GO annotations of biological process

Name Definition
cellular response to water deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.
positive regulation of abscisic acid-activated signaling pathway Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling.
positive regulation of seed germination Any process that activates or increase the rate of seed germination.
protein phosphorylation The process of introducing a phosphate group on to a protein.

22 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase Homo sapiens (Human) EV
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens (Human) EV
Q16288 NTRK3 NT-3 growth factor receptor Homo sapiens (Human) SS
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens (Human) EV
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
O12990 jak1 Tyrosine-protein kinase JAK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTSNRSNLLF SLVLFHFLFV PTQLQALNTD GVLLLTFKYS ILTDPLSVLR NWNYDDATPC
70 80 90 100 110 120
LWTGVTCTEL GKPNTPDMFR VTSLVLPNKH LLGSITPDLF SIPYLRILDL SSNFFNGSLP
130 140 150 160 170 180
DSVFNATELQ SISLGSNNLS GDLPKSVNSV TNLQLLNLSA NAFTGEIPLN ISLLKNLTVV
190 200 210 220 230 240
SLSKNTFSGD IPSGFEAAQI LDLSSNLLNG SLPKDLGGKS LHYLNLSHNK VLGEISPNFA
250 260 270 280 290 300
EKFPANATVD LSFNNLTGPI PSSLSLLNQK AESFSGNQEL CGKPLKILCS IPSTLSNPPN
310 320 330 340 350 360
ISETTSPAIA VKPRSTAPIN PLTEKPNQTG KSKLKPSTIA AITVADIVGL AFIGLLVLYV
370 380 390 400 410 420
YQVRKRRRYP ESSKFSFFKF CLEKNEAKKS KPSTTEVTVP ESPEAKTTCG SCIILTGGRY
430 440 450 460 470 480
DETSTSESDV ENQQTVQAFT RTDGGQLKQS SQTQLVTVDG ETRLDLDTLL KASAYILGTT
490 500 510 520 530 540
GTGIVYKAVL ENGTAFAVRR IETESCAAAK PKEFEREVRA IAKLRHPNLV RIRGFCWGDD
550 560 570 580 590 600
EKLLISDYVP NGSLLCFFTA TKASSSSSSS SSLQNPLTFE ARLKIARGMA RGLSYINEKK
610 620 630 640 650 660
QVHGNIKPNN ILLNAENEPI ITDLGLDRLM TPARESHTTG PTSSSPYQPP EWSTSLKPNP
670 680 690 700 710 720
KWDVYSFGVI LLELLTSKVF SVDHDIDQFS NLSDSAAEEN GRFLRLIDGA IRSDVARHED
730 740 750
AAMACFRLGI ECVSSLPQKR PSMKELVQVL EKICVLV