Q94C25

PR
Gene name
At5g20050 (F28I16.200)
Protein name
Probable receptor-like protein kinase At5g20050
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G20050
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94C25

Entry ID Method Resolution Chain Position Source
AF-Q94C25-F1 Predicted AlphaFoldDB

34 variants for Q94C25

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06999159 7 N>K No 1000Genomes
ENSVATH00633421 13 L>F No 1000Genomes
tmp_5_6774427_C_G 16 A>G No 1000Genomes
ENSVATH00633423 23 A>S No 1000Genomes
ENSVATH03083315 56 S>N No 1000Genomes
tmp_5_6774570_C_A 64 L>I No 1000Genomes
ENSVATH00633425 70 A>V No 1000Genomes
ENSVATH10873671 96 E>D No 1000Genomes
tmp_5_6774702_T_A 108 L>M No 1000Genomes
tmp_5_6774757_G_T 126 S>I No 1000Genomes
tmp_5_6774855_G_T 159 V>F No 1000Genomes
tmp_5_6774895_G_A 172 R>H No 1000Genomes
ENSVATH06999162 180 Y>F No 1000Genomes
ENSVATH10873672 182 V>I No 1000Genomes
ENSVATH00633433 192 P>A No 1000Genomes
ENSVATH00633434 193 D>E No 1000Genomes
ENSVATH10873673 194 R>G No 1000Genomes
ENSVATH00633435 201 G>R No 1000Genomes
ENSVATH06999163 201 G>V No 1000Genomes
tmp_5_6775036_A_G 219 K>R No 1000Genomes
ENSVATH00633436 230 S>A No 1000Genomes
tmp_5_6775165_C_G 262 A>G No 1000Genomes
tmp_5_6775386_A_T 336 M>L No 1000Genomes
ENSVATH14100920 350 I>M No 1000Genomes
tmp_5_6775442_G_C 354 E>D No 1000Genomes
tmp_5_6775458_G_T 360 V>L No 1000Genomes
tmp_5_6775503_T_G 375 S>A No 1000Genomes
ENSVATH06999166 383 M>V No 1000Genomes
ENSVATH00633440 396 E>K No 1000Genomes
ENSVATH06999167 402 V>A No 1000Genomes
ENSVATH06999168 415 A>T No 1000Genomes
tmp_5_6775633_G_A 418 G>D No 1000Genomes
tmp_5_6775647_G_A 423 V>I No 1000Genomes
tmp_5_6775650_A_G 424 N>D No 1000Genomes

No associated diseases with Q94C25

3 regional properties for Q94C25

Type Name Position InterPro Accession
domain Protein kinase domain 1034 - 1310 IPR000719
active_site Serine/threonine-protein kinase, active site 1154 - 1166 IPR008271
binding_site Protein kinase, ATP binding site 1040 - 1063 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05688 IGF1R Insulin-like growth factor 1 receptor Bos taurus (Bovine) SS
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 Homo sapiens (Human) PR
P53667 LIMK1 LIM domain kinase 1 Homo sapiens (Human) PR
P53671 LIMK2 LIM domain kinase 2 Homo sapiens (Human) PR
Q8K4B2 Irak3 Interleukin-1 receptor-associated kinase 3 Mus musculus (Mouse) PR
Q8CFA1 Irak2 Interleukin-1 receptor-associated kinase-like 2 Mus musculus (Mouse) PR
O54785 Limk2 LIM domain kinase 2 Mus musculus (Mouse) PR
Q4QQS0 Irak2 Interleukin-1 receptor-associated kinase-like 2 Rattus norvegicus (Rat) PR
Q9ASQ5 CRCK3 Calmodulin-binding receptor-like cytoplasmic kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCZ4 FER Receptor-like protein kinase FERONIA Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZJ9 CRCK2 Calmodulin-binding receptor-like cytoplasmic kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLW0 At5g24010 Probable receptor-like protein kinase At5g24010 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTC0 PBL19 Probable serine/threonine-protein kinase PBL19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIL7 CRCK1 Calmodulin-binding receptor-like cytoplasmic kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q39203 SD22 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 Arabidopsis thaliana (Mouse-ear cress) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEDKKANIIA TILILALVVV IIAARVSLKL SKTFYLIAGV DISLILAVIC FLIIRSRYNK
70 80 90 100 110 120
ERKLLVSRFA SEGRELRIEY SFLRKVAGVP TKFKLEDLEE ATDGFRSLIG KGGSGSVFKG
130 140 150 160 170 180
VLKDGSQVAV KRIEGEEKGE REFRSEVAAI ASVQHKNLVR LYGYSSSTSA NRPRFLVYDY
190 200 210 220 230 240
IVNSSLDIWI FPDRGNRGRS GGGCLSWEQR YQVAIDVAKA LAYLHHDCRS KILHLDVKPE
250 260 270 280 290 300
NILLDENFRA VVTDFGLSKL IARDESRVLT DIRGTRGYLA PEWLLEHGIS EKSDVYSYGI
310 320 330 340 350 360
VLLEMIGGRR SISRVEVKET KKKKLEYFPR IVNQKMRERK IMEIVDQRLI EVNEVDEEEV
370 380 390 400 410 420
MKLVCVALWC IQEKSKKRPD MTMVIEMLEG RVPVNEPPDS DVVVVDLLAA DDDDASTGVR
430 440 450
RVVNIPKLQI HRERNFRLSS ICSSIISPIS PR