Q94A06

PR
Gene name
MKK1 (MEK1, At4g26070, F20B18.180)
Protein name
Mitogen-activated protein kinase kinase 1
Names
AtMKK1, MAP kinase kinase 1, AtMEK1, NMAPKK
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G26070
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

207-230 (Activation loop from InterPro)

Target domain

68-328 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q94A06

Entry ID Method Resolution Chain Position Source
7W5C X-ray 220 A Q 187-199 PDB
AF-Q94A06-F1 Predicted AlphaFoldDB

10 variants for Q94A06

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06777095 47 L>Q No 1000Genomes
tmp_4_13218354_T_A 65 L>M No 1000Genomes
tmp_4_13218711_T_C 155 L>S No 1000Genomes
ENSVATH06777115 159 G>E No 1000Genomes
tmp_4_13218731_C_G 162 P>A No 1000Genomes
ENSVATH12232787 288 P>S No 1000Genomes
ENSVATH06777137 292 A>V No 1000Genomes
tmp_4_13219371_C_T 306 S>L No 1000Genomes
ENSVATH12232790 315 D>A No 1000Genomes
ENSVATH12232792 343 T>S No 1000Genomes

No associated diseases with Q94A06

3 regional properties for Q94A06

Type Name Position InterPro Accession
domain Protein kinase domain 68 - 328 IPR000719
active_site Serine/threonine-protein kinase, active site 186 - 198 IPR008271
binding_site Protein kinase, ATP binding site 74 - 97 IPR017441

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

8 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to other organism Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
pollen-pistil interaction The interaction between a pollen grain and pistil.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to molecule of bacterial origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90891 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Gallus gallus (Chicken) PR
Q9XT09 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Pan troglodytes (Chimpanzee) PR
Q1HG70 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q24324 Dsor1 Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster (Fruit fly) PR
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens (Human) EV
Q13163 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens (Human) PR
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens (Human) EV
Q9WVS7 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Mus musculus (Mouse) PR
P31938 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Mus musculus (Mouse) PR
Q63932 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Mus musculus (Mouse) PR
Q01986 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Rattus norvegicus (Rat) PR
Q62862 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Rattus norvegicus (Rat) PR
P36506 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Rattus norvegicus (Rat) SS
Q5QN75 MKK1 Mitogen-activated protein kinase kinase 1 Oryza sativa subsp japonica (Rice) PR
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q9FJV0 MKK6 Mitogen-activated protein kinase kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S7U9 MKK2 Mitogen-activated protein kinase kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNRGSLCPNP ICLPPLEQSI SKFLTQSGTF KDGDLRVNKD GIQTVSLSEP GAPPPIEPLD
70 80 90 100 110 120
NQLSLADLEV IKVIGKGSSG NVQLVKHKLT QQFFALKVIQ LNTEESTCRA ISQELRINLS
130 140 150 160 170 180
SQCPYLVSCY QSFYHNGLVS IILEFMDGGS LADLLKKVGK VPENMLSAIC KRVLRGLCYI
190 200 210 220 230 240
HHERRIIHRD LKPSNLLINH RGEVKITDFG VSKILTSTSS LANSFVGTYP YMSPERISGS
250 260 270 280 290 300
LYSNKSDIWS LGLVLLECAT GKFPYTPPEH KKGWSSVYEL VDAIVENPPP CAPSNLFSPE
310 320 330 340 350
FCSFISQCVQ KDPRDRKSAK ELLEHKFVKM FEDSDTNLSA YFTDAGSLIP PLAN