Q94527

EV
Gene name
Rel
Protein name
Nuclear factor NF-kappa-B p110 subunit
Names
Rel-p110, Relish protein
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG11992
EC number
Protein Class
NUCLEAR FACTOR NF-KAPPA-B PROTEIN (PTHR24169)

Descriptions

The Rel/NF-kappaB transcription factor Relish plays a key role in the humoral immune response. The truncation of its C-terminal ankyrin domain region activates the protein, and the ankyrin domain is known to shield the nuclear localization signal (NLS) and inhibits DNA binding of the N-terminal Rel/NF-kappaB homology domain.

Autoinhibitory domains (AIDs)

640-738 (Ankyrin domain) EV

Target domain

147-446 (RHD); 452-457 (Nuclear localization signal)

Relief mechanism

Cleavage

Assay

Split protein assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94527

Entry ID Method Resolution Chain Position Source
AF-Q94527-F1 Predicted AlphaFoldDB

5 variants for Q94527

Variant ID(s) Position Change Description Diseaes Association Provenance
82 N>S strain: Zim2 [UniProt] No
110 F>L strain: Zim3 [UniProt] No
699 T>I strain: Zim8 [UniProt] No
845 E>G strain: Zim1 [UniProt] No
862 S>N strain: Zim8 [UniProt] No

No associated diseases with Q94527

8 regional properties for Q94527

Type Name Position InterPro Accession
repeat Ankyrin repeat 598 - 626 IPR002110-1
repeat Ankyrin repeat 640 - 740 IPR002110-2
repeat Ankyrin repeat 745 - 775 IPR002110-3
repeat Ankyrin repeat 783 - 812 IPR002110-4
domain IPT domain 342 - 445 IPR002909
domain Rel homology domain, DNA-binding domain 147 - 339 IPR011539
domain Rel homology dimerisation domain 344 - 447 IPR032397
domain NFkappaB IPT domain 343 - 446 IPR033926

Functions

Description
EC Number
Subcellular Localization
  • [Nuclear factor NF-kappa-B p68 subunit]: Nucleus
  • ;
PANTHER Family PTHR24169 NUCLEAR FACTOR NF-KAPPA-B PROTEIN
PANTHER Subfamily PTHR24169:SF28 NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT
PANTHER Protein Class DNA-binding transcription factor
Rel homology transcription factor
immunoglobulin fold transcription factor
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding Binding to an identical protein or proteins.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

24 GO annotations of biological process

Name Definition
cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.
peptidoglycan recognition protein signaling pathway The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
peripheral nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
positive regulation of antibacterial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
positive regulation of antifungal peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
positive regulation of antimicrobial peptide production Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
positive regulation of defense response to virus by host Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of nitric oxide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P98150 NFKB2 Nuclear factor NF-kappa-B p100 subunit Gallus gallus (Chicken) SS
Q04861 NFKB1 Nuclear factor NF-kappa-B p105 subunit Gallus gallus (Chicken) SS
Q6F3J0 NFKB1 Nuclear factor NF-kappa-B p105 subunit Canis lupus familiaris (Dog) (Canis familiaris) SS
Q99549 MPHOSPH8 M-phase phosphoprotein 8 Homo sapiens (Human) PR
Q8N9B4 ANKRD42 Ankyrin repeat domain-containing protein 42 Homo sapiens (Human) PR
Q6ZVZ8 ASB18 Ankyrin repeat and SOCS box protein 18 Homo sapiens (Human) PR
Q00653 NFKB2 Nuclear factor NF-kappa-B p100 subunit Homo sapiens (Human) SS
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens (Human) SS
Q04206 RELA Transcription factor p65 Homo sapiens (Human) EV
Q9CZK6 Anks3 Ankyrin repeat and SAM domain-containing protein 3 Mus musculus (Mouse) PR
Q8VHA6 Asb18 Ankyrin repeat and SOCS box protein 18 Mus musculus (Mouse) PR
P25799 Nfkb1 Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] Mus musculus (Mouse) EV
Q9WTK5 Nfkb2 Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] Mus musculus (Mouse) EV
Q04207 Rela Transcription factor p65 Mus musculus (Mouse) SS
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
O22265 CAO Signal recognition particle 43 kDa protein, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZI3 NPR2 Regulatory protein NPR2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNMNQYYDLD NGKNVMFMND ASSTSGYSSS TSPNSTNRSF SPAHSPKTME LQTDFANLNL
70 80 90 100 110 120
PGGNSPHQPP MANSPYQNQL LNNGGICQLG ATNLINSTGV SFGVANVTSF GNMYMDHQYF
130 140 150 160 170 180
VPAPATVPPS QNFGYHQNGL ASDGDIKHVP QLRIVEQPVE KFRFRYKSEM HGTHGSLNGA
190 200 210 220 230 240
NSKRTPKTFP EVTLCNYDGP AVIRCSLFQT NLDSPHSHQL VVRKDDRDVC DPHDLHVSKE
250 260 270 280 290 300
RGYVAQFINM GIIHTAKKYI FEELCKKKQD RLVFQMNRRE LSHKQLQELH QETEREAKDM
310 320 330 340 350 360
NLNQVRLCFE AFKIEDNGAW VPLAPPVYSN AINNRKSAQT GELRIVRLSK PTGGVMGNDE
370 380 390 400 410 420
LILLVEKVSK KNIKVRFFEE DEDGETVWEA YAKFRESDVH HQYAIVCQTP PYKDKDVDRE
430 440 450 460 470 480
VNVYIELIRP SDDERSFPAL PFRYKPRSVI VSRKRRRTGS SANSSSSGTE SSNNSLDLPK
490 500 510 520 530 540
TLGLAQPPNG LPNLSQHDQT ISEEFGREKH LNEFIASEDF RKLIEHNSSD LEKICQLDMG
550 560 570 580 590 600
ELQHDGHNRA EVPSHRNRTI KCLDDLFEIY KQDRISPIKI SHHKVEKWFI EHALNNYNRD
610 620 630 640 650 660
TLLHEVISHK KDKLKLAIQT IQVMNYFNLK DVVNSTLNAD GDSALHVACQ QDRAHYIRPL
670 680 690 700 710 720
LGMGCNPNLK NNAGNTPLHV AVKEEHLSCV ESFLNGVPTV QLDLSLTNDD GLTPLHMAIR
730 740 750 760 770 780
QNKYDVAKKL ISYDRTSISV ANTMDGNNAL HMAVLEQSVE LLVLILDAQN ENLTDILQAQ
790 800 810 820 830 840
NAAGHTPLEL AERKANDRVV QLLKNVYPEK GELAMTWIPC KVKEEIDSSS DESSDAGQLE
850 860 870 880 890 900
IKSEEMDIET KDEDSVELDL SSGPRRQKDE SSRDTEMDNN KLQLLLKNKF IYDRLCSLLN
910 920 930 940 950 960
QPLGHGSDPQ DRKWMQLARQ THLKQFAFIW LGAEDLLDHV KRKGASVEFS TFARALQAVD
970
PQAYALLVNP T