Q94125

PR
Gene name
age-1
Protein name
Phosphatidylinositol 3-kinase age-1
Names
PI3-kinase age-1, PI3K age-1, PtdIns-3-kinase age-1, Aging alteration protein 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_B0334.8
EC number
2.7.1.137: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94125

Entry ID Method Resolution Chain Position Source
AF-Q94125-F1 Predicted AlphaFoldDB

No variants for Q94125

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q94125

No associated diseases with Q94125

7 regional properties for Q94125

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain 241 - 361 IPR000341
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 853 - 1182 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 601 - 798 IPR001263
domain C2 phosphatidylinositol 3-kinase-type domain 417 - 579 IPR002420
domain Phosphatidylinositol 3-kinase, adaptor-binding domain 74 - 177 IPR003113
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 889 - 903 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1016 - 1036 IPR018936-2

Functions

Description
EC Number 2.7.1.137 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
non-motile cilium A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

21 GO annotations of biological process

Name Definition
aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to salt Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
chemosensory behavior Behavior that is dependent upon the sensation of chemicals.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
dauer entry Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development.
dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time.
phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
regulation of synaptic assembly at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.
reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to salt Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32871 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Bos taurus (Bovine) PR
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Homo sapiens (Human) PR
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Homo sapiens (Human) PR
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Homo sapiens (Human) PR
P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (Human) PR
O35904 Pik3cd Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Mus musculus (Mouse) PR
P42337 Pik3ca Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (Mouse) PR
Q8BTI9 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Mus musculus (Mouse) PR
Q9JHG7 Pik3cg Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (Mouse) PR
O02697 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Sus scrofa (Pig) PR
Q9Z1L0 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSMGRSPSTT FRSRTGSHGA RDLIAGHGRN SRRISQMHVN ILHPQLQTMV EQWQMRERPS
70 80 90 100 110 120
LETENGKGSL LLENEGVADI ITMCPFGEVI SVVFPWFLAN VRTSLEIKLS DFKHQLFELI
130 140 150 160 170 180
APMKWGTYSV KPQDYVFRQL NNFGEIEVIF NDDQPLSKLE LHGTFPMLFL YQPDGINRDK
190 200 210 220 230 240
ELMSDISHCL GYSLDKLEES LDEELRQFRA SLWARTKKTC LTRGLEGTSH YAFPEEQYLC
250 260 270 280 290 300
VGESCPKDLE SKVKAAKLSY QMFWRKRKAE INGVCEKMMK IQIEFNPNET PKSLLHTFLY
310 320 330 340 350 360
EMRKLDVYDT DDPADEGWFL QLAGRTTFVT NPDVKLTSYD GVRSELESYR CPGFVVRRQS
370 380 390 400 410 420
LVLKDYCRPK PLYEPHYVRA HERKLALDVL SVSIDSTPKQ SKNSDMVMTD FRPTASLKQV
430 440 450 460 470 480
SLWDLDANLM IRPVNISGFD FPADVDMYVR IEFSVYVGTL TLASKSTTKV NAQFAKWNKE
490 500 510 520 530 540
MYTFDLYMKD MPPSAVLSIR VLYGKVKLKS EEFEVGWVNM SLTDWRDELR QGQFLFHLWA
550 560 570 580 590 600
PEPTANRSRI GENGARIGTN AAVTIEISSY GGRVRMPSQG QYTYLVKHRS TWTETLNIMG
610 620 630 640 650 660
DDYESCIRDP GYKKLQMLVK KHESGIVLEE DEQRHVWMWR RYIQKQEPDL LIVLSELAFV
670 680 690 700 710 720
WTDRENFSEL YVMLEKWKPP SVAAALTLLG KRCTDRVIRK FAVEKLNEQL SPVTFHLFIL
730 740 750 760 770 780
PLIQALKYEP RAQSEVGMML LTRALCDYRI GHRLFWLLRA EIARLRDCDL KSEEYRRISL
790 800 810 820 830 840
LMEAYLRGNE EHIKIITRQV DMVDELTRIS TLVKGMPKDV ATMKLRDELR SISHKMENMD
850 860 870 880 890 900
SPLDPVYKLG EMIIDKAIVL GSAKRPLMLH WKNKNPKSDL HLPFCAMIFK NGDDLRQDML
910 920 930 940 950 960
VLQVLEVMDN IWKAANIDCC LNPYAVLPMG EMIGIIEVVP NCKTIFEIQV GTGFMNTAVR
970 980 990 1000 1010 1020
SIDPSFMNKW IRKQCGIEDE KKKSKKDSTK NPIEKKIDNT QAMKKYFESV DRFLYSCVGY
1030 1040 1050 1060 1070 1080
SVATYIMGIK DRHSDNLMLT EDGKYFHIDF GHILGHGKTK LGIQRDRQPF ILTEHFMTVI
1090 1100 1110 1120 1130 1140
RSGKSVDGNS HELQKFKTLC VEAYEVMWNN RDLFVSLFTL MLGMELPELS TKADLDHLKK
1150 1160 1170 1180
TLFCNGESKE EARKFFAGIY EEAFNGSWST KTNWLFHAVK HY