Q93ZG7
PR
Gene name |
RH38 (LOS4, At3g53110, T4D2.40) |
Protein name |
DEAD-box ATP-dependent RNA helicase 38 |
Names |
Low expression of osmotically-responsive genes 4 protein, Protein CRYOPHYTE |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G53110 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q93ZG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93ZG7-F1 | Predicted | AlphaFoldDB |
24 variants for Q93ZG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00416892 | 19 | T>S | No | 1000Genomes | |
| tmp_3_19688025_G_A | 20 | V>I | No | 1000Genomes | |
| ENSVATH00416893 | 24 | N>I | No | 1000Genomes | |
| ENSVATH00416893 | 24 | N>T | No | 1000Genomes | |
| ENSVATH12737596 | 25 | S>I | No | 1000Genomes | |
| tmp_3_19688050_A_T | 28 | K>M | No | 1000Genomes | |
| ENSVATH06305906 | 33 | T>K | No | 1000Genomes | |
| ENSVATH12737597 | 37 | K>R | No | 1000Genomes | |
| ENSVATH02497991 | 46 | D>E | No | 1000Genomes | |
| tmp_3_19688119_T_C | 51 | V>A | No | 1000Genomes | |
| tmp_3_19688156_G_T | 63 | E>D | No | 1000Genomes | |
| tmp_3_19688154_G_C | 63 | E>Q | No | 1000Genomes | |
| tmp_3_19688167_C_T | 67 | S>F | No | 1000Genomes | |
| ENSVATH00416895 | 95 | D>E | No | 1000Genomes | |
| ENSVATH02497994 | 159 | T>K | No | 1000Genomes | |
| tmp_3_19688546_A_T | 159 | T>S | No | 1000Genomes | |
| tmp_3_19688717_G_T | 190 | G>W | No | 1000Genomes | |
| tmp_3_19688863_T_A | 238 | H>Q | No | 1000Genomes | |
| ENSVATH06305913 | 272 | P>A | No | 1000Genomes | |
| tmp_3_19690013_A_G | 416 | N>S | No | 1000Genomes | |
| tmp_3_19690263_G_A | 472 | V>I | No | 1000Genomes | |
| ENSVATH02498008 | 486 | S>N | No | 1000Genomes | |
| ENSVATH06305925 | 494 | L>M | No | 1000Genomes | |
| ENSVATH12737627 | 495 | D>E | No | 1000Genomes |
No associated diseases with Q93ZG7
4 regional properties for Q93ZG7
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on RNA | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBP1 | DDX25 | ATP-dependent RNA helicase DDX25 | Bos taurus (Bovine) | PR |
| Q3ZBV2 | DDX19A | ATP-dependent RNA helicase DDX19A | Bos taurus (Bovine) | SS |
| Q9UHL0 | DDX25 | ATP-dependent RNA helicase DDX25 | Homo sapiens (Human) | PR |
| Q9NUU7 | DDX19A | ATP-dependent RNA helicase DDX19A | Homo sapiens (Human) | PR |
| Q9UMR2 | DDX19B | ATP-dependent RNA helicase DDX19B | Homo sapiens (Human) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q10RI7 | Os03g0158200 | DEAD-box ATP-dependent RNA helicase 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU46 | RH35 | DEAD-box ATP-dependent RNA helicase 35 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADTVEKVPT | VVESSSSSTV | EASNSAEKTE | PTTEKKKWGD | VEDDDDEEEA | VSELNSLSIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEEKPDSILE | EPEDSNIKAV | TSGDTPYTSA | SRFEDLNLSP | ELMKGLYVEM | KFEKPSKIQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISLPMIMTPP | HKHLIAQAHN | GSGKTTCFVL | GMLSRVDPTL | REPQALCICP | TRELANQNME |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLQKMGKFTG | ITAELAVPDS | TRGAPAATRG | APVSAHVVIG | TPGTLKKWMA | FKRLGLNHLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILVFDEADHM | LATDGFRDDS | LKIMKDIGRV | NPNFQVLLFS | ATFNETVKDF | VARTVKDPNQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFVKREDLAL | DSVKQYKVVC | PKEQNKIEVI | KDQIMELGDI | GQTIIFVKTK | ASAQKVHKAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEMGYDVTSV | HGNLTESDRD | KIVKEFKECL | TQVLIATDVI | ARGFDQQRVN | LVVNYNLPTK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YETGEPDYEV | YLHRVGRAGR | FGRKGAVFNL | LLDDGWDKEV | MEKIEKYFEA | NVKEIKSWNS |
| 490 | |||||
| EEEYKSALKE | AGLLDE |