Q93Z81
Gene name |
CAX3 (At3g51860, ATEM1.11) |
Protein name |
Vacuolar cation/proton exchanger 3 |
Names |
Ca, 2+/H, + antiporter CAX3 , Ca, 2+/H, + exchanger 3 , Protein CATION EXCHANGER 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G51860 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
56-62 (7 amino acids within the first quarter of CAX1) |
Relief mechanism |
PTM, Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Pittman JK et al. (2002) "Mechanism of N-terminal autoinhibition in the Arabidopsis Ca(2+)/H(+) antiporter CAX1", The Journal of biological chemistry, 277, 26452-9
- Pittman JK et al. (2001) "Regulation of CAX1, an Arabidopsis Ca(2+)/H+ antiporter. Identification of an N-terminal autoinhibitory domain", Plant physiology, 127, 1020-9
Autoinhibited structure
Activated structure
1 structures for Q93Z81
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93Z81-F1 | Predicted | AlphaFoldDB |
33 variants for Q93Z81
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_19239492_C_G | 12 | A>G | No | 1000Genomes | |
| ENSVATH12715908 | 25 | S>G | No | 1000Genomes | |
| tmp_3_19239579_C_T | 41 | S>L | No | 1000Genomes | |
| ENSVATH06297216 | 77 | L>F | No | 1000Genomes | |
| ENSVATH06297217 | 85 | A>S | No | 1000Genomes | |
| ENSVATH02492285 | 91 | Y>H | No | 1000Genomes | |
| ENSVATH14421581 | 103 | L>M | No | 1000Genomes | |
| tmp_3_19240656_G_T | 121 | A>S | No | 1000Genomes | |
| ENSVATH00415160 | 126 | P>R | No | 1000Genomes | |
| ENSVATH12715960 | 151 | N>H | No | 1000Genomes | |
| tmp_3_19241311_G_A | 238 | R>Q | No | 1000Genomes | |
| ENSVATH08153980 | 243 | V>A | No | 1000Genomes | |
| tmp_3_19241331_C_T | 245 | L>F | No | 1000Genomes | |
| tmp_3_19241334_A_C | 246 | I>L | No | 1000Genomes | |
| tmp_3_19241374_A_G | 259 | H>R | No | 1000Genomes | |
| ENSVATH12715996 | 276 | E>K | No | 1000Genomes | |
| tmp_3_19241496_G_A | 277 | V>I | No | 1000Genomes | |
| ENSVATH12715997 | 280 | E>D | No | 1000Genomes | |
| ENSVATH12715998 | 285 | I>L | No | 1000Genomes | |
| tmp_3_19241540_T_G | 291 | F>L | No | 1000Genomes | |
| tmp_3_19241562_A_G | 299 | I>V | No | 1000Genomes | |
| tmp_3_19241570_C_G | 301 | I>M | No | 1000Genomes | |
| tmp_3_19241598_A_T | 311 | T>S | No | 1000Genomes | |
| tmp_3_19241707_G_A | 317 | D>N | No | 1000Genomes | |
| tmp_3_19241720_T_C | 321 | L>P | No | 1000Genomes | |
| tmp_3_19242196_T_C | 380 | I>T | No | 1000Genomes | |
| ENSVATH06297284 | 402 | I>V | No | 1000Genomes | |
| ENSVATH14421584 | 410 | D>A | No | 1000Genomes | |
| tmp_3_19242373_A_G | 412 | T>A | No | 1000Genomes | |
| tmp_3_19242405_G_T | 422 | L>F | No | 1000Genomes | |
| tmp_3_19242446_A_C | 436 | Q>P | No | 1000Genomes | |
| ENSVATH12716003 | 444 | D>G | No | 1000Genomes | |
| ENSVATH06297285 | 452 | N>Y | No | 1000Genomes |
No associated diseases with Q93Z81
2 regional properties for Q93Z81
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sodium/calcium exchanger membrane region | 97 - 257 | IPR004837-1 |
| domain | Sodium/calcium exchanger membrane region | 290 - 433 | IPR004837-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcium:proton antiporter complex | A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction |
| plant-type vacuole membrane | The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular calcium ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. |
| intracellular manganese ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell. |
| intracellular zinc ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell. |
| lithium ion transport | The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| monoatomic cation transport | The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. |
| phosphate ion homeostasis | Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. |
| phosphorus metabolic process | The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). |
| regulation of stomatal movement | Any process that modulates the frequency, rate or extent of stomatal movement. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| response to nematode | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q39253 | CAX1 | Vacuolar cation/proton exchanger 1 | Arabidopsis thaliana (Mouse-ear cress) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSIVEPWAA | IAENGNANVT | AKGSSRELRH | GRTAHNMSSS | SLRKKSDLRL | VQKVPCKTLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NILSNLQEVI | LGTKLTLLFL | AIPLAILANS | YNYGRPLIFG | LSLIGLTPLA | ERVSFLTEQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFYTGPTVGG | LLNATCGNAT | ELIIAILALA | NNKVAVVKYS | LLGSILSNLL | LVLGTSLFFG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIANIRREQR | FDRKQADVNF | FLLLMGLLCH | LLPLLLKYAA | TGEVSTSMIN | KMSLTLSRTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SIVMLIAYIA | YLIFQLWTHR | QLFEAQQDDD | DAYDDEVSVE | ETPVIGFWSG | FAWLVGMTIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IALLSEYVVD | TIEDASDSWG | LSVSFISIIL | LPIVGNAAEH | AGAIIFAFKN | KLDISLGVAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSATQISLFV | VPLSVIVAWI | LGIKMDLNFN | ILETSSLALA | IIITAFTLQD | GTSHYMKGLV |
| 430 | 440 | 450 | |||
| LLLCYVIIAA | CFFVDQIPQP | NDLDVGLQPM | NNLGEVFSA |