Q93VD3

PR
Gene name
CIPK23 (LKS1, PKS17, SnRK3.23)
Protein name
CBL-interacting serine/threonine-protein kinase 23
Names
Protein LOW-K(+)-SENSITIVE 1, SNF1-related kinase 3.23, SOS2-like protein kinase PKS17
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G30270
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

171-196 (Activation loop from InterPro)

Target domain

31-286 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for Q93VD3

Entry ID Method Resolution Chain Position Source
4CZT X-ray 230 A A/B/C/D 25-482 PDB
4CZU X-ray 190 A A/B/C/D 25-482 PDB
AF-Q93VD3-F1 Predicted AlphaFoldDB

18 variants for Q93VD3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_10655277_C_A 3 S>Y No 1000Genomes
ENSVATH14007130 8 S>A No 1000Genomes
tmp_1_10655325_G_C 19 G>A No 1000Genomes
ENSVATH00051549 23 G>C No 1000Genomes
ENSVATH00051549 23 G>S No 1000Genomes
ENSVATH14007131 24 G>V No 1000Genomes
ENSVATH14007161 114 G>A No 1000Genomes
ENSVATH04673546 135 F>L No 1000Genomes
tmp_1_10656342_C_T 164 A>V No 1000Genomes
ENSVATH12366239 255 F>S No 1000Genomes
ENSVATH00051558 268 D>N No 1000Genomes
tmp_1_10657420_T_C 320 V>A No 1000Genomes
tmp_1_10657456_C_T 332 T>M No 1000Genomes
tmp_1_10657507_C_T 349 S>L No 1000Genomes
tmp_1_10658477_A_T 468 T>S No 1000Genomes
tmp_1_10658490_T_C 472 M>T No 1000Genomes
ENSVATH04673582 474 N>K No 1000Genomes
ENSVATH04673583 475 R>Q No 1000Genomes

No associated diseases with Q93VD3

1 regional properties for Q93VD3

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 5 - 159 IPR005225

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Associated to the plasma membrane when associated with AKT1, CBL1 and CBL9
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of stomatal movement Any process that modulates the frequency, rate or extent of stomatal movement.
response to nutrient Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
stomatal movement The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata).

74 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02066 Abscisic acid-inducible protein kinase Triticum aestivum (Wheat) PR
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q5GLH2 TRIB2 Tribbles homolog 2 Bos taurus (Bovine) SS
Q0VCE3 TRIB3 Tribbles homolog 3 Bos taurus (Bovine) SS
Q3SZW1 TSSK1B Testis-specific serine/threonine-protein kinase 1 Bos taurus (Bovine) PR
O61661 grp Serine/threonine-protein kinase grp Drosophila melanogaster (Fruit fly) SS
Q92519 TRIB2 Tribbles homolog 2 Homo sapiens (Human) SS
Q96RU7 TRIB3 Tribbles homolog 3 Homo sapiens (Human) PR
Q14680 MELK Maternal embryonic leucine zipper kinase Homo sapiens (Human) EV
Q96RU8 TRIB1 Tribbles homolog 1 Homo sapiens (Human) EV
Q15831 STK11 Serine/threonine-protein kinase STK11 Homo sapiens (Human) PR
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
Q9BXA7 TSSK1B Testis-specific serine/threonine-protein kinase 1 Homo sapiens (Human) PR
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens (Human) EV
O60285 NUAK1 NUAK family SNF1-like kinase 1 Homo sapiens (Human) PR
Q9NRH2 SNRK SNF-related serine/threonine-protein kinase Homo sapiens (Human) SS
P57059 SIK1 Serine/threonine-protein kinase SIK1 Homo sapiens (Human) PR
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens (Human) EV
Q8K4K3 Trib2 Tribbles homolog 2 Mus musculus (Mouse) SS
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
Q8K4K2 Trib3 Tribbles homolog 3 Mus musculus (Mouse) SS
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q8K4K4 Trib1 Tribbles homolog 1 Mus musculus (Mouse) SS
Q5EG47 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus (Mouse) SS
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
Q641K5 Nuak1 NUAK family SNF1-like kinase 1 Mus musculus (Mouse) PR
Q8C0X8 Sperm motility kinase X Mus musculus (Mouse) PR
A0AUV4 Gm7168 Sperm motility kinase Y Mus musculus (Mouse) PR
Q8C0N0 Gm4922 Sperm motility kinase Z Mus musculus (Mouse) PR
A2KF29 Smoktcr Sperm motility kinase Tcr mutant form Mus musculus (Mouse) PR
Q28948 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Sus scrofa (Pig) SS
Q09136 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Sus scrofa (Pig) SS
Q9WTQ6 Trib3 Tribbles homolog 3 Rattus norvegicus (Rat) SS
P54645 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus (Rat) EV
Q09137 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Rattus norvegicus (Rat) EV
Q5QNM6 CIPK13 Putative CBL-interacting protein kinase 13 Oryza sativa subsp japonica (Rice) PR
Q5JLQ9 CIPK30 CBL-interacting protein kinase 30 Oryza sativa subsp japonica (Rice) PR
Q5N942 SAPK4 Serine/threonine-protein kinase SAPK4 Oryza sativa subsp japonica (Rice) PR
Q852Q0 OSK3 Serine/threonine protein kinase OSK3 Oryza sativa subsp. japonica (Rice) SS
Q75LR7 SAPK1 Serine/threonine-protein kinase SAPK1 Oryza sativa subsp japonica (Rice) PR
Q75H77 SAPK10 Serine/threonine-protein kinase SAPK10 Oryza sativa subsp japonica (Rice) PR
Q7Y0B9 SAPK8 Serine/threonine-protein kinase SAPK8 Oryza sativa subsp japonica (Rice) PR
Q7XQP4 SAPK7 Serine/threonine-protein kinase SAPK7 Oryza sativa subsp japonica (Rice) PR
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q0D4J7 SAPK2 Serine/threonine-protein kinase SAPK2 Oryza sativa subsp japonica (Rice) PR
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q6ERS4 CIPK16 CBL-interacting protein kinase 16 Oryza sativa subsp japonica (Rice) PR
P0C5D6 SAPK3 Serine/threonine-protein kinase SAPK3 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q75V57 SAPK9 Serine/threonine-protein kinase SAPK9 Oryza sativa subsp japonica (Rice) PR
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q21017 kin-29 Serine/threonine-protein kinase kin-29 Caenorhabditis elegans SS
P45894 aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Caenorhabditis elegans SS
Q95ZQ4 aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans SS
Q2V452 CIPK3 CBL-interacting serine/threonine-protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
O22971 CIPK13 CBL-interacting serine/threonine-protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
O64812 SRK2J Serine/threonine-protein kinase SRK2J Arabidopsis thaliana (Mouse-ear cress) PR
O65554 CIPK6 CBL-interacting serine/threonine-protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
P43292 SRK2G Serine/threonine-protein kinase SRK2G Arabidopsis thaliana (Mouse-ear cress) PR
Q39193 SRK2I Serine/threonine-protein kinase SRK2I Arabidopsis thaliana (Mouse-ear cress) PR
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C958 SRK2B Serine/threonine-protein kinase SRK2B Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFP9 SRK2H Serine/threonine-protein kinase SRK2H Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJ54 CIPK20 CBL-interacting serine/threonine-protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9E9 SRK2C Serine/threonine-protein kinase SRK2C Arabidopsis thaliana (Mouse-ear cress) PR
P43291 SRK2A Serine/threonine-protein kinase SRK2A Arabidopsis thaliana (Mouse-ear cress) PR
Q39192 SRK2D Serine/threonine-protein kinase SRK2D Arabidopsis thaliana (Mouse-ear cress) PR
Q940H6 SRK2E Serine/threonine-protein kinase SRK2E Arabidopsis thaliana (Mouse-ear cress) PR
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MASRTTPSRS TPSRSTPSGS SSGGRTRVGK YELGRTLGEG TFAKVKFARN VENGDNVAIK
70 80 90 100 110 120
VIDKEKVLKN KMIAQIKREI STMKLIKHPN VIRMFEVMAS KTKIYFVLEF VTGGELFDKI
130 140 150 160 170 180
SSNGRLKEDE ARKYFQQLIN AVDYCHSRGV YHRDLKPENL LLDANGALKV SDFGLSALPQ
190 200 210 220 230 240
QVREDGLLHT TCGTPNYVAP EVINNKGYDG AKADLWSCGV ILFVLMAGYL PFEDSNLTSL
250 260 270 280 290 300
YKKIFKAEFT CPPWFSASAK KLIKRILDPN PATRITFAEV IENEWFKKGY KAPKFENADV
310 320 330 340 350 360
SLDDVDAIFD DSGESKNLVV ERREEGLKTP VTMNAFELIS TSQGLNLGSL FEKQMGLVKR
370 380 390 400 410 420
KTRFTSKSSA NEIVTKIEAA AAPMGFDVKT NNYKMKLTGE KSGRKGQLAV ATEVFQVAPS
430 440 450 460 470 480
LYMVEMRKSG GDTLEFHKFY KNLTTGLKDI VWKTIDEEKE EGTDGGGTNG AMANRTIAKQ
ST