Q93107

EV
Gene name
Protein name
Non-specific serine/threonine protein kinase
Names
Species
Acanthamoeba castellanii (Amoeba)
KEGG Pathway
EC number
Protein Class
SERINE/THREONINE-PROTEIN KINASE TAO (PTHR48015)

Descriptions

The myosin I heavy chain kinase (MIHCK) is a serine/threonine protein kinase and phosphorylates the three class-I myosins, which increases their actin-activated MgATPase activities. MIHCK is similar to PAK1. When the peptide containing the PAN domain (91-157) was supplied, the activity of the catalytic domain was inhibited.

Autoinhibitory domains (AIDs)

91-157 (PAN domain) EV

Target domain

469-725 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Peptide inhibitor test, Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q93107

Entry ID Method Resolution Chain Position Source
AF-Q93107-F1 Predicted AlphaFoldDB

No variants for Q93107

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q93107

No associated diseases with Q93107

5 regional properties for Q93107

Type Name Position InterPro Accession
domain CRIB domain 93 - 150 IPR000095
domain Protein kinase domain 469 - 725 IPR000719
active_site Serine/threonine-protein kinase, active site 587 - 599 IPR008271
binding_site Protein kinase, ATP binding site 475 - 498 IPR017441
domain p21 activated kinase binding domain 91 - 136 IPR033923

Functions

Description
EC Number
Subcellular Localization
PANTHER Family PTHR48015 SERINE/THREONINE-PROTEIN KINASE TAO
PANTHER Subfamily PTHR48015:SF35 SERINE_THREONINE-PROTEIN KINASE PAK
PANTHER Protein Class non-receptor serine/threonine protein kinase
protein modifying enzyme
PANTHER Pathway Category Inflammation mediated by chemokine and cytokine signaling pathway
PAK
Cytoskeletal regulation by Rho GTPase
PAK
Angiogenesis
PAK

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENNDVKSGL ASILAGDLKT DELYRQMGLQ AGGPPKGGSM IVPPSSSPTN GVKTGEKDKK
70 80 90 100 110 120
KLDSAKNKKK KGFWGQVGGF FGVKEEEEDA TPISGPTNFK REMHIGFDSQ TGTFEGLPEE
130 140 150 160 170 180
WKIMLGTSGL SQKEIESDPK TLVEVMQFQQ NLLRGGAPPP PPPPGGSAAF VDDEPPPPPP
190 200 210 220 230 240
PRDDGEFEAP PPPPVPREQE PEPQQAPLSP PPRPISLPPG ARPPVQVAPG ADLPVPPRPN
250 260 270 280 290 300
QPPPMRGRGG PMRRGAPPGR PSPGRTLPPP PGGAPAGPGP TTGRGLPPRP GAPNGAPMPL
310 320 330 340 350 360
QRGGASGDAP LPLTRGPPGG GAPRGPGAPP PRPGQPAPMR PGQPGGQGVP PPRPGQPAPG
370 380 390 400 410 420
RPTMRPSQPG GPPRPPMPAP VPTTPTAAVT PAPVPVPAPA PAPAPADTTP AAGPPRPTPP
430 440 450 460 470 480
IATGARPAPP RPQPPKAGGA PPPAAAPQPA RPQVNIRDLI SQGDPLTIFK DMEIIGQGAS
490 500 510 520 530 540
GSVYSAIDTR TGKKVAVKQM IMSKQVKQDI IINEIQIMKD SHHHAIVNYI DSYIVEGTLW
550 560 570 580 590 600
VVMELINGGS LAELIEVCKT MNETQIATVC KVVLEGLEYL HTRANPIIHR DIKSDNILLG
610 620 630 640 650 660
LDGSIKITDF GYGAQLGVGA GQDKRASVVG TTYWMAPEVV KGKDYTCKVD VWSLGIMALE
670 680 690 700 710 720
MLEGEPPYIN ESMLRALFLI ASKGCPDFKD PDGMSEEFKD FIRKCTVMDP EQRMSTTQLL
730 740 750
SHPFLTMGGP ESDLIPLVER TKNEAQRDFS MFF