Q92930
PR
Gene name |
RAB8B |
Protein name |
Ras-related protein Rab-8B |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:51762 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q92930
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q92930-F1 | Predicted | AlphaFoldDB |
109 variants for Q92930
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA392720674 rs1265053694 |
2 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA392720677 rs1265053694 |
2 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA392720694 rs1283859937 |
3 | K>R | No |
ClinGen TOPMed |
|
|
CA272061255 rs916341534 |
4 | T>K | No |
ClinGen TOPMed |
|
|
rs548639638 CA7601708 |
4 | T>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA392720742 rs756914670 |
5 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1487027644 CA392720728 |
5 | Y>D | No |
ClinGen gnomAD |
|
|
CA392720852 rs778733798 |
11 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7601710 rs778733798 |
11 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1459538350 CA392720876 |
12 | L>P | No |
ClinGen gnomAD |
|
|
rs755334952 CA7601712 |
19 | V>I | No |
ClinGen ExAC TOPMed |
|
|
rs1455115996 CA392721154 |
27 | R>C | No |
ClinGen gnomAD |
|
|
rs1286868975 CA392721272 |
32 | A>G | No |
ClinGen gnomAD |
|
|
CA392721407 rs1467129427 |
38 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs142337137 CA272061327 |
39 | S>C | No |
ClinGen ESP |
|
| rs749381235 | 41 | I>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs779183844 CA7601738 |
48 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA272058705 rs867264287 |
49 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA7601739 rs746143967 |
50 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA392718996 rs1304289945 |
50 | I>M | No |
ClinGen gnomAD |
|
|
rs746143967 CA392718992 |
50 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1024618088 CA272058729 |
51 | E>* | No |
ClinGen TOPMed |
|
|
CA392718997 rs1024618088 |
51 | E>K | No |
ClinGen TOPMed |
|
|
CA7601741 rs775094049 |
53 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs775094049 CA392719012 |
53 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA392719010 rs1224846713 |
53 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs760571091 CA7601742 |
55 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392719067 rs1269192148 |
61 | I>V | No |
ClinGen TOPMed |
|
|
rs1239182936 CA392719995 |
62 | W>* | No |
ClinGen gnomAD |
|
| TCGA novel | 64 | T>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 65 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745978202 CA7601757 |
67 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1220240929 CA392720055 |
71 | R>* | No |
ClinGen gnomAD |
|
|
rs996034590 CA272062939 |
72 | T>K | No |
ClinGen TOPMed |
|
|
rs1268267415 CA392720066 |
73 | I>V | No |
ClinGen gnomAD |
|
|
rs758503277 CA7601758 |
74 | T>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 75 | T>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs967991134 CA392720085 |
76 | A>E | No |
ClinGen TOPMed |
|
|
CA272062961 rs967991134 |
76 | A>V | No |
ClinGen TOPMed |
|
|
rs202212117 CA7601763 |
82 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| rs1294842607 | 83 | G>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA392720401 rs1191755399 |
83 | G>D | No |
ClinGen gnomAD |
|
|
CA392720417 rs747288476 CA7601779 |
85 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA272068456 rs534061829 |
88 | Y>C | No |
ClinGen Ensembl |
|
|
CA392720447 rs1394247659 |
90 | I>V | No |
ClinGen TOPMed |
|
|
CA392720470 rs1431019753 |
93 | E>G | No |
ClinGen gnomAD |
|
|
CA7601782 rs139117697 |
98 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7601783 rs769567512 |
101 | N>H | No |
ClinGen ExAC gnomAD |
|
|
rs1316133157 CA392720543 |
103 | I>V | No |
ClinGen gnomAD |
|
|
rs773232758 CA7601784 |
106 | I>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 109 | H>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA392720725 rs1215116823 |
112 | S>C | No |
ClinGen TOPMed |
|
|
CA7601807 rs745407916 |
113 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1360771961 CA392720766 |
114 | V>A | No |
ClinGen gnomAD |
|
|
CA7601810 rs762065157 |
115 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs921776296 CA272069121 |
115 | E>D | No |
ClinGen TOPMed |
|
|
rs762065157 CA392720773 |
115 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272069116 rs762065157 |
115 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 116 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA392720801 rs1487220543 |
116 | R>T | No |
ClinGen gnomAD |
|
| TCGA novel | 117 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA272069127 rs759929278 |
124 | D>G | No |
ClinGen Ensembl |
|
|
rs770248170 CA7601811 |
125 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770248170 CA392720980 |
125 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1190209712 CA392720970 |
125 | M>V | No |
ClinGen gnomAD |
|
|
CA272069138 rs996078145 |
127 | D>N | No |
ClinGen Ensembl |
|
|
CA272069139 rs765527116 |
128 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA272069144 rs1029331888 |
132 | S>* | No |
ClinGen Ensembl |
|
|
rs763449129 CA7601813 |
133 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 134 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs202115341 CA272069152 |
135 | R>G | No |
ClinGen 1000Genomes |
|
|
rs1425205942 CA392721179 |
135 | R>K | No |
ClinGen gnomAD |
|
|
CA7601814 rs767004271 |
136 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7601829 rs532248858 |
141 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs763248326 CA7601830 |
142 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA392722339 rs1287013557 |
144 | G>E | No |
ClinGen TOPMed |
|
|
CA272071794 rs942605627 |
145 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA7601832 rs775037478 |
148 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs1345626853 CA392722448 |
149 | E>D | No |
ClinGen TOPMed |
|
|
CA272071861 rs746347562 |
155 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1289293214 CA392722586 |
156 | A>G | No |
ClinGen TOPMed |
|
|
rs914570976 CA272071885 |
156 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs767773032 CA7601834 |
158 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs918077777 CA272074567 |
167 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
rs774984428 CA7601850 |
167 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs541852366 CA7601851 |
168 | D>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7601854 rs775592874 |
169 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1463109450 CA392723251 |
173 | L>P | No |
ClinGen TOPMed |
|
|
rs1415707782 CA392723255 |
174 | N>H | No |
ClinGen TOPMed |
|
|
rs1273516084 CA392723596 |
180 | S>N | No |
ClinGen TOPMed |
|
|
rs375228979 CA272075406 |
180 | S>R | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1326455520 CA392723616 |
181 | N>S | No |
ClinGen TOPMed |
|
|
CA7601869 rs779363509 |
184 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA272075413 rs759542171 |
185 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs149310109 CA7601870 |
186 | G>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1213750386 CA392723692 |
186 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA272075431 rs866440877 |
188 | P>Q | No |
ClinGen Ensembl |
|
|
CA392723720 rs1174016278 |
189 | V>L | No |
ClinGen TOPMed |
|
|
rs1196952797 CA392723776 |
191 | I>M | No |
ClinGen gnomAD |
|
|
CA7601871 rs772669326 |
194 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775904028 CA7601872 |
195 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1179299285 CA392723898 |
198 | K>E | No |
ClinGen gnomAD |
|
|
rs747093133 CA7601873 |
198 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs768679955 CA7601874 |
200 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7601875 rs776912093 CA392723941 COSM1222957 |
201 | F>L | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD NCI-TCGA |
|
CA7601876 rs761951855 |
203 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1406627143 CA392723981 |
204 | C>R | No |
ClinGen gnomAD |
|
|
CA272075493 COSM470927 rs373850007 |
205 | S>L | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA7601878 rs368594258 |
208 | L>G | No |
ClinGen ESP ExAC gnomAD |
No associated diseases with Q92930
1 regional properties for Q92930
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ZipA, C-terminal FtsZ-binding domain | 204 - 335 | IPR007449 |
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| peroxisomal membrane | The lipid bilayer surrounding a peroxisome. |
| phagocytic vesicle | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| trans-Golgi network transport vesicle | A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| TPR domain binding | Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
| cell-substrate junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix. |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| Golgi vesicle fusion to target membrane | The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. |
| positive regulation of cell projection organization | Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. |
| positive regulation of corticotropin secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell. |
| protein import into peroxisome membrane | The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein secretion | The controlled release of proteins from a cell. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07560 | SEC4 | Ras-related protein SEC4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A4FV54 | RAB8A | Ras-related protein Rab-8A | Bos taurus (Bovine) | PR |
| Q1RMR4 | RAB15 | Ras-related protein Rab-15 | Bos taurus (Bovine) | PR |
| Q2HJI8 | RAB8B | Ras-related protein Rab-8B | Bos taurus (Bovine) | PR |
| Q5F470 | RAB8A | Ras-related protein Rab-8A | Gallus gallus (Chicken) | PR |
| P0C0E4 | RAB40AL | Ras-related protein Rab-40A-like | Homo sapiens (Human) | PR |
| Q12829 | RAB40B | Ras-related protein Rab-40B | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| Q8WXH6 | RAB40A | Ras-related protein Rab-40A | Homo sapiens (Human) | PR |
| Q96S21 | RAB40C | Ras-related protein Rab-40C | Homo sapiens (Human) | PR |
| P61006 | RAB8A | Ras-related protein Rab-8A | Homo sapiens (Human) | PR |
| P59190 | RAB15 | Ras-related protein Rab-15 | Homo sapiens (Human) | PR |
| P55258 | Rab8a | Ras-related protein Rab-8A | Mus musculus (Mouse) | PR |
| Q8K386 | Rab15 | Ras-related protein Rab-15 | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| Q9DD03 | Rab13 | Ras-related protein Rab-13 | Mus musculus (Mouse) | PR |
| Q8CB87 | Rab44 | Ras-related protein Rab-44 | Mus musculus (Mouse) | PR |
| Q8VHP8 | Rab40b | Ras-related protein Rab-40B | Mus musculus (Mouse) | PR |
| Q8VHQ4 | Rab40c | Ras-related protein Rab-40C | Mus musculus (Mouse) | PR |
| P61028 | Rab8b | Ras-related protein Rab-8B | Mus musculus (Mouse) | PR |
| P35289 | Rab15 | Ras-related protein Rab-15 | Rattus norvegicus (Rat) | PR |
| P35280 | Rab8a | Ras-related protein Rab-8A | Rattus norvegicus (Rat) | PR |
| P35284 | Rab12 | Ras-related protein Rab-12 | Rattus norvegicus (Rat) | PR |
| P35281 | Rab10 | Ras-related protein Rab-10 | Rattus norvegicus (Rat) | PR |
| P70550 | Rab8b | Ras-related protein Rab-8B | Rattus norvegicus (Rat) | PR |
| O24466 | RABE1A | Ras-related protein RABE1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SF91 | RABE1E | Ras-related protein RABE1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZD4 | RABE1D | Ras-related protein RABE1d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKTYDYLFK | LLLIGDSGVG | KTCLLFRFSE | DAFNTTFIST | IGIDFKIRTI | ELDGKKIKLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWDTAGQERF | RTITTAYYRG | AMGIMLVYDI | TNEKSFDNIK | NWIRNIEEHA | SSDVERMILG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKCDMNDKRQ | VSKERGEKLA | IDYGIKFLET | SAKSSANVEE | AFFTLARDIM | TKLNRKMNDS |
| 190 | 200 | ||||
| NSAGAGGPVK | ITENRSKKTS | FFRCSLL |