Q92914
SS
Gene name |
FGF11 (FHF3) |
Protein name |
Fibroblast growth factor 11 |
Names |
FGF-11 , Fibroblast growth factor homologous factor 3 , FHF-3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2256 |
EC number |
|
Protein Class |
|
Descriptions
The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core. Sequence alignment of FGFs shows that most of the residues that participate in this interface in FGF9 are conserved in FGF16, suggesting that FGF16 may also dimerize for autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
73-199 (beta-trefoil core) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q92914
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q92914-F1 | Predicted | AlphaFoldDB |
264 variants for Q92914
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs756128069 | 2 | A>E | No |
ExAC TOPMed gnomAD |
|
| rs752546716 | 2 | A>S | No |
ExAC TOPMed gnomAD |
|
| rs752546716 | 2 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs756128069 | 2 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs1908216787 | 3 | A>T | No | Ensembl | |
| rs1233753512 | 6 | S>G | No |
TOPMed gnomAD |
|
| rs1233753512 | 6 | S>R | No |
TOPMed gnomAD |
|
| rs1045972226 | 9 | I>F | No |
TOPMed gnomAD |
|
| TCGA novel | 10 | R>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1293588693 | 10 | R>Q | No | gnomAD | |
| rs1019626573 | 10 | R>W | No |
TOPMed gnomAD |
|
| rs1908218335 | 13 | R>P | No | TOPMed | |
| rs1908218720 | 14 | E>D | No | TOPMed | |
| rs868698478 | 16 | R>C | No | Ensembl | |
| rs1412235679 | 16 | R>L | No | gnomAD | |
| rs1908219711 | 17 | E>A | No | Ensembl | |
| rs1908219528 | 17 | E>K | No | Ensembl | |
| rs1908220108 | 18 | P>L | No | TOPMed | |
| rs1486586201 | 18 | P>S | No | gnomAD | |
| rs745910451 | 19 | G>E | No |
ExAC TOPMed gnomAD |
|
| rs1384254781 | 19 | G>R | No | gnomAD | |
| rs745910451 | 19 | G>V | No |
ExAC TOPMed gnomAD |
|
| rs772146262 | 20 | G>S | No |
ExAC TOPMed gnomAD |
|
| rs1387537496 | 22 | R>W | No | gnomAD | |
| rs1343923204 | 24 | V>E | No |
TOPMed gnomAD |
|
| rs1343923204 | 24 | V>G | No |
TOPMed gnomAD |
|
| rs2150832841 | 25 | S>L | No | Ensembl | |
| rs1455332269 | 26 | A>P | No | gnomAD | |
| rs1382316079 | 28 | R>G | No | gnomAD | |
| rs768867939 | 28 | R>P | No |
ExAC gnomAD |
|
| rs1303614666 | 29 | R>P | No | Ensembl | |
| rs1359976553 | 29 | R>S | No | gnomAD | |
| rs1222966379 | 30 | V>L | No | gnomAD | |
| rs1222966379 | 30 | V>M | No | gnomAD | |
| rs1359555778 | 31 | C>Y | No |
TOPMed gnomAD |
|
| rs975520947 | 32 | P>H | No |
TOPMed gnomAD |
|
| rs866337216 | 33 | R>C | No |
TOPMed gnomAD |
|
| rs777100094 | 33 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs777100094 | 33 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs866337216 | 33 | R>S | No |
TOPMed gnomAD |
|
| rs748481604 | 34 | G>C | No |
ExAC gnomAD |
|
| rs1908223865 | 34 | G>D | No |
TOPMed gnomAD |
|
| rs1185121362 | 35 | T>I | No |
TOPMed gnomAD |
|
| rs1185121362 | 35 | T>N | No |
TOPMed gnomAD |
|
| TCGA novel | 36 | K>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs773858153 | 36 | K>N | No |
ExAC gnomAD |
|
| rs370206139 | 37 | S>F | No |
ESP ExAC TOPMed gnomAD |
|
| rs1289071984 | 38 | L>V | No |
TOPMed gnomAD |
|
| rs766044761 | 39 | C>* | No |
ExAC gnomAD |
|
| rs774143444 | 40 | Q>* | No |
ExAC TOPMed gnomAD |
|
| rs774143444 | 40 | Q>K | No |
ExAC TOPMed gnomAD |
|
| rs1468298640 | 45 | I>T | No | gnomAD | |
| rs1257872428 | 47 | L>M | No | TOPMed | |
| rs1341272579 | 48 | S>F | No | gnomAD | |
| rs1277485347 | 49 | K>E | No | gnomAD | |
| rs982971059 | 50 | V>G | No | Ensembl | |
| rs908750803 | 51 | R>Q | No |
TOPMed gnomAD |
|
| rs1200628606 | 52 | L>M | No |
TOPMed gnomAD |
|
| rs578202767 | 54 | G>A | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs578202767 | 54 | G>E | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs767195617 | 54 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs578202767 | 54 | G>V | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs767195617 | 54 | G>W | No |
ExAC TOPMed gnomAD |
|
| rs755895006 | 55 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs889630696 | 55 | G>V | No | TOPMed | |
| rs1908228218 | 56 | R>G | No | gnomAD | |
| rs1181544552 | 56 | R>Q | No |
TOPMed gnomAD |
|
| rs896178972 | 58 | A>T | No |
TOPMed gnomAD |
|
| rs1471354007 | 58 | A>V | No | gnomAD | |
| rs780142908 | 59 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs780142908 | 59 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs1212669659 | 59 | R>W | No | gnomAD | |
| rs1468346731 | 60 | P>L | No |
1000Genomes TOPMed gnomAD |
|
| rs1468346731 | 60 | P>R | No |
1000Genomes TOPMed gnomAD |
|
| rs1169112247 | 60 | P>T | No | TOPMed | |
| rs1403183198 | 61 | D>E | No |
TOPMed gnomAD |
|
| rs1908230088 | 61 | D>H | No | gnomAD | |
| rs1908230088 | 61 | D>N | No | gnomAD | |
| rs947793619 | 62 | R>C | No |
TOPMed gnomAD |
|
| rs947793619 | 62 | R>G | No |
TOPMed gnomAD |
|
| rs947793619 | 62 | R>S | No |
TOPMed gnomAD |
|
| rs1327083209 | 63 | G>R | No | gnomAD | |
| rs1044827794 | 64 | P>L | No |
TOPMed gnomAD |
|
| rs781416201 | 65 | E>D | No |
ExAC gnomAD |
|
| rs1908230816 | 65 | E>K | No | gnomAD | |
| rs548417562 | 66 | P>L | No |
1000Genomes TOPMed gnomAD |
|
| rs752918878 | 66 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs1214795707 | 67 | Q>R | No |
TOPMed gnomAD |
|
| rs927319104 | 68 | L>V | No | Ensembl | |
| rs1375032530 | 70 | G>V | No | gnomAD | |
| rs969208480 | 71 | I>M | No |
TOPMed gnomAD |
|
| rs778322970 | 71 | I>V | No |
ExAC gnomAD |
|
| rs373533671 | 72 | V>I | No |
ExAC TOPMed gnomAD |
|
| rs373533671 | 72 | V>L | No |
ExAC TOPMed gnomAD |
|
| rs779321880 | 73 | T>I | No |
ExAC gnomAD |
|
| rs1224225866 | 75 | L>P | No | TOPMed | |
| rs1384141677 | 77 | C>* | No |
TOPMed gnomAD |
|
| COSM3522106 | 77 | C>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM4818722 rs201458275 |
78 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic Ensembl NCI-TCGA |
| rs374336597 | 78 | R>H | No |
ESP ExAC TOPMed gnomAD |
|
| rs374336597 | 78 | R>P | No |
ESP ExAC TOPMed gnomAD |
|
| rs1358293844 | 79 | Q>R | No |
TOPMed gnomAD |
|
| rs375861089 | 80 | G>A | No |
ESP ExAC TOPMed gnomAD |
|
| rs375861089 | 80 | G>D | No |
ESP ExAC TOPMed gnomAD |
|
| rs375861089 | 80 | G>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs760390266 | 81 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs768412913 | 81 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs776358182 | 82 | Y>C | No |
ExAC gnomAD |
|
| rs1408982327 | 84 | Q>R | No | TOPMed | |
| rs765090559 | 85 | A>E | No |
ExAC TOPMed gnomAD |
|
| rs2150834145 | 85 | A>T | No | Ensembl | |
|
rs765090559 COSM984355 |
85 | A>V | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs1350538559 | 86 | N>K | No | gnomAD | |
| rs756454648 | 88 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs754216280 | 89 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs1241496100 | 91 | I>L | No | gnomAD | |
| rs779420311 | 92 | Q>K | No |
ExAC TOPMed gnomAD |
|
| rs1908325807 | 92 | Q>R | No | TOPMed | |
| rs147368108 | 93 | G>A | No |
ESP ExAC TOPMed gnomAD |
|
| rs147368108 | 93 | G>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1451461824 | 94 | T>A | No | gnomAD | |
| rs138002470 | 95 | P>A | No |
ESP ExAC TOPMed gnomAD |
|
| rs1322722699 | 96 | E>G | No | TOPMed | |
| rs779474070 | 96 | E>Q | No |
ExAC gnomAD |
|
| rs746539448 | 97 | D>G | No |
ExAC gnomAD |
|
| rs1206545491 | 98 | T>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs766129751 | 98 | T>S | No | gnomAD | |
| rs1908327323 | 99 | S>C | No | gnomAD | |
| rs1384479293 | 101 | F>L | No | gnomAD | |
| rs1908327616 | 101 | F>S | No | Ensembl | |
| rs1290806577 | 102 | T>S | No | gnomAD | |
| rs932209973 | 104 | F>L | No | Ensembl | |
| rs1908338849 | 104 | F>S | No | gnomAD | |
| rs143467121 | 105 | N>S | No |
ESP ExAC TOPMed gnomAD |
|
| rs368001702 | 108 | P>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs368001702 | 108 | P>T | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs772938223 | 110 | G>C | No |
ExAC gnomAD |
|
| rs1908340087 | 110 | G>V | No | TOPMed | |
| rs749121439 | 111 | L>F | No |
ExAC TOPMed gnomAD |
|
| rs770705672 | 111 | L>P | No |
ExAC gnomAD |
|
|
rs1206968256 COSM2978886 |
112 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD |
|
rs774460715 COSM252502 |
112 | R>H | ovary [Cosmic] | No |
cosmic curated ExAC gnomAD |
| TCGA novel | 114 | V>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1908341595 | 115 | T>I | No | TOPMed | |
| rs201620905 | 116 | I>N | No |
1000Genomes ExAC |
|
| rs1426732588 | 117 | Q>* | No | gnomAD | |
| rs764315658 | 118 | S>R | No |
ExAC TOPMed gnomAD |
|
| rs1370964148 | 119 | A>T | No |
TOPMed gnomAD |
|
| rs1350487238 | 120 | K>N | No | gnomAD | |
| rs1249976535 | 122 | G>A | No | TOPMed | |
| rs1249976535 | 122 | G>D | No | TOPMed | |
| rs2150834421 | 124 | Y>C | No | Ensembl | |
| rs1310200555 | 125 | M>V | No | gnomAD | |
| rs1438909109 | 127 | M>T | No | gnomAD | |
| rs112893032 | 128 | N>S | No |
ExAC gnomAD |
|
| rs112893032 | 128 | N>T | No |
ExAC gnomAD |
|
| rs750691204 | 130 | E>K | No |
ExAC gnomAD |
|
| rs1908344697 | 131 | G>E | No | TOPMed | |
| rs1908344442 | 131 | G>R | No | TOPMed | |
| rs1555551247 | 135 | S>G | No | Ensembl | |
|
COSM169517 rs754455619 |
136 | S>L | large_intestine [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs1038050896 | 136 | S>T | No |
TOPMed gnomAD |
|
|
COSM1386307 rs756968452 |
137 | P>= | Variant assessed as Somatic; LOW impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA |
| rs777240470 | 137 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs777240470 | 137 | P>R | No |
ExAC TOPMed gnomAD |
|
| rs1466059533 | 137 | P>T | No |
TOPMed gnomAD |
|
| rs778915774 | 138 | H>N | No |
ExAC gnomAD |
|
| rs112393051 | 138 | H>R | No | Ensembl | |
| rs1908379840 | 140 | T>R | No | TOPMed | |
| rs745783269 | 141 | A>S | No |
ExAC gnomAD |
|
| TCGA novel | 141 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs772073808 | 143 | C>G | No | ExAC | |
| rs780176806 | 144 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs780176806 | 144 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs530767669 | 144 | R>H | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs780176806 | 144 | R>S | No |
ExAC TOPMed gnomAD |
|
| rs763304002 | 147 | E>A | No |
ExAC TOPMed gnomAD |
|
| rs1908381300 | 147 | E>D | No |
TOPMed gnomAD |
|
| rs763304002 | 147 | E>V | No |
ExAC TOPMed gnomAD |
|
| rs1908381464 | 148 | C>S | No | gnomAD | |
| rs370683367 | 148 | C>W | No |
ESP ExAC TOPMed gnomAD |
|
|
rs1908381608 COSM4069550 |
148 | C>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic TOPMed gnomAD |
| rs1908381917 | 149 | V>A | No | Ensembl | |
| rs1285672348 | 150 | F>S | No | gnomAD | |
| rs774641172 | 152 | N>D | No |
ExAC gnomAD |
|
| rs1908382476 | 152 | N>S | No | Ensembl | |
| rs759897578 | 153 | Y>N | No |
ExAC gnomAD |
|
| rs150878424 | 155 | V>I | No |
ESP ExAC TOPMed gnomAD |
|
| rs760079006 | 156 | L>M | No |
ExAC gnomAD |
|
| rs763698496 | 157 | Y>F | No |
ExAC gnomAD |
|
| rs757025000 | 158 | A>P | No |
ExAC TOPMed gnomAD |
|
| rs757025000 | 158 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs1908384683 | 159 | S>P | No | TOPMed | |
| rs1597744993 | 162 | Y>H | No | Ensembl | |
|
COSM3820539 rs4151131 |
163 | R>C | breast [Cosmic] | No |
cosmic curated 1000Genomes ExAC TOPMed gnomAD |
| VAR_018886 | 163 | R>G | No | UniProt | |
| rs548703936 | 163 | R>H | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs548703936 | 163 | R>L | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs757929271 | 165 | R>C | No |
TOPMed gnomAD |
|
| rs542329042 | 165 | R>H | No |
1000Genomes ExAC TOPMed gnomAD |
|
|
COSM3522109 rs1405632678 |
166 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD |
| rs1405632678 | 166 | R>G | No |
TOPMed gnomAD |
|
| rs150032836 | 166 | R>H | No |
ESP ExAC TOPMed gnomAD |
|
| rs1336390752 | 168 | G>D | No | gnomAD | |
| rs1285258974 | 168 | G>S | No |
TOPMed gnomAD |
|
| rs749341752 | 169 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs146590295 | 169 | R>W | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs771075010 | 170 | A>D | No |
ExAC TOPMed gnomAD |
|
| rs140063384 | 173 | L>I | No |
ESP TOPMed gnomAD |
|
| rs267605069 | 174 | G>D | No | Ensembl | |
| rs200684010 | 174 | G>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs200684010 | 174 | G>S | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1908390061 | 176 | D>N | No | gnomAD | |
| rs759214190 | 178 | E>G | No |
TOPMed gnomAD |
|
| rs972643265 | 178 | E>K | No | Ensembl | |
| rs1274129303 | 179 | G>C | No | TOPMed | |
| rs761308484 | 180 | Q>* | No |
ExAC TOPMed gnomAD |
|
| rs763496669 | 180 | Q>H | No |
ExAC gnomAD |
|
| rs1266555875 | 180 | Q>R | No |
TOPMed gnomAD |
|
| rs776146460 | 181 | V>A | No |
ExAC gnomAD |
|
| rs149118209 | 184 | G>E | No |
ESP ExAC TOPMed gnomAD |
|
| rs1477081619 | 185 | N>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1174579152 | 185 | N>S | No | gnomAD | |
| rs764937105 | 186 | R>* | No |
ExAC TOPMed gnomAD |
|
|
rs370094891 COSM437377 |
186 | R>Q | Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic] | No |
cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs143161190 | 187 | V>I | No |
ESP ExAC TOPMed gnomAD |
|
| rs1908393543 | 188 | K>E | No | TOPMed | |
| rs1372343074 | 188 | K>R | No | gnomAD | |
| rs151198463 | 192 | A>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs937079841 | 193 | A>T | No | Ensembl | |
| rs1306955471 | 194 | A>V | No | TOPMed | |
| rs1328889545 | 198 | P>L | No |
TOPMed gnomAD |
|
| rs754887121 | 199 | K>N | No |
ExAC gnomAD |
|
| rs1908395100 | 201 | L>P | No | Ensembl | |
| rs780997215 | 202 | E>D | No |
ExAC TOPMed gnomAD |
|
| rs772998713 | 203 | V>= | Variant assessed as Somatic; LOW impact. [NCI-TCGA] | No | NCI-TCGA |
| rs546541096 | 203 | V>L | No |
ExAC TOPMed gnomAD |
|
| rs546541096 | 203 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs1908411094 | 205 | M>I | No | Ensembl | |
| rs762753911 | 205 | M>T | No |
ExAC gnomAD |
|
| rs1908411340 | 207 | Q>* | No | Ensembl | |
| rs1908411340 | 207 | Q>K | No | Ensembl | |
| rs140341581 | 208 | E>K | No |
ESP ExAC TOPMed gnomAD |
|
| rs1189580411 | 209 | P>A | No | TOPMed | |
| rs1189580411 | 209 | P>T | No | TOPMed | |
| rs552124436 | 210 | S>F | No |
1000Genomes TOPMed gnomAD |
|
| rs1246673868 | 212 | H>Y | No | gnomAD | |
| rs1908414294 | 213 | S>N | No | 1000Genomes | |
| rs1449873654 | 214 | V>A | No |
TOPMed gnomAD |
|
| rs532651729 | 215 | P>S | No |
ExAC gnomAD |
|
| rs201773281 | 216 | E>K | No | gnomAD | |
| rs938006101 | 217 | A>P | No |
TOPMed gnomAD |
|
| rs779030552 | 218 | S>P | No | ExAC | |
| rs1342780456 | 218 | S>Y | No |
TOPMed gnomAD |
|
| rs1908417630 | 219 | P>A | No | TOPMed | |
| rs1567675107 | 221 | S>R | No | Ensembl | |
| rs1597745562 | 222 | P>T | No | Ensembl | |
| rs746073027 | 223 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs373959662 | 223 | P>L | No |
TOPMed gnomAD |
|
| rs746073027 | 223 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs758586117 | 224 | A>D | No |
ExAC TOPMed gnomAD |
|
| rs758586117 | 224 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs1341209409 | 225 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
Ensembl NCI-TCGA |
| rs1908420958 | 226 | P>W | No | Ensembl |
No associated diseases with Q92914
10 regional properties for Q92914
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 228 - 298 | IPR001452 |
| domain | PDZ domain | 139 - 220 | IPR001478 |
| domain | L27 domain | 10 - 68 | IPR004172-1 |
| domain | L27 domain | 65 - 125 | IPR004172-2 |
| domain | Guanylate kinase-like domain | 368 - 560 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 367 - 563 | IPR008145 |
| domain | L27 domain, C-terminal | 16 - 67 | IPR014775-1 |
| domain | L27 domain, C-terminal | 75 - 124 | IPR014775-2 |
| conserved_site | Guanylate kinase, conserved site | 403 - 420 | IPR020590 |
| domain | MPP7, SH3 domain | 232 - 292 | IPR035599 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48801 | FGF3 | Fibroblast growth factor 3 | Gallus gallus (Chicken) | SS |
| O15520 | FGF10 | Fibroblast growth factor 10 | Homo sapiens (Human) | SS |
| O43320 | FGF16 | Fibroblast growth factor 16 | Homo sapiens (Human) | EV SS |
| P10767 | FGF6 | Fibroblast growth factor 6 | Homo sapiens (Human) | SS |
| P11487 | FGF3 | Fibroblast growth factor 3 | Homo sapiens (Human) | SS |
| P31371 | FGF9 | Fibroblast growth factor 9 | Homo sapiens (Human) | EV |
| Q9HCT0 | FGF22 | Fibroblast growth factor 22 | Homo sapiens (Human) | SS |
| Q9NP95 | FGF20 | Fibroblast growth factor 20 | Homo sapiens (Human) | SS |
| Q9NSA1 | FGF21 | Fibroblast growth factor 21 | Homo sapiens (Human) | PR |
| P08620 | FGF4 | Fibroblast growth factor 4 | Homo sapiens (Human) | PR |
| P21658 | Fgf6 | Fibroblast growth factor 6 | Mus musculus (Mouse) | SS |
| Q9ESS2 | Fgf22 | Fibroblast growth factor 22 | Mus musculus (Mouse) | SS |
| O35565 | Fgf10 | Fibroblast growth factor 10 | Mus musculus (Mouse) | SS |
| P54130 | Fgf9 | Fibroblast growth factor 9 | Mus musculus (Mouse) | SS |
| Q9JJN1 | Fgf21 | Fibroblast growth factor 21 | Mus musculus (Mouse) | PR |
| Q9ESL8 | Fgf16 | Fibroblast growth factor 16 | Mus musculus (Mouse) | SS |
| Q9ESL9 | Fgf20 | Fibroblast growth factor 20 | Mus musculus (Mouse) | SS |
| P11403 | Fgf4 | Fibroblast growth factor 4 | Mus musculus (Mouse) | PR |
| P61329 | Fgf12 | Fibroblast growth factor 12 | Mus musculus (Mouse) | PR |
| P05524 | Fgf3 | Fibroblast growth factor 3 | Mus musculus (Mouse) | SS |
| Q95L12 | FGF9 | Fibroblast growth factor 9 | Sus scrofa (Pig) | SS |
| Q9EST9 | Fgf20 | Fibroblast growth factor 20 | Rattus norvegicus (Rat) | SS |
| O54769 | Fgf16 | Fibroblast growth factor 16 | Rattus norvegicus (Rat) | SS |
| P36364 | Fgf9 | Fibroblast growth factor 9 | Rattus norvegicus (Rat) | SS |
| P70492 | Fgf10 | Fibroblast growth factor 10 | Rattus norvegicus (Rat) | SS |
| Q6PBT8 | fgf1 | Putative fibroblast growth factor 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q2HXK8 | fgf16 | Fibroblast growth factor 16 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| P48802 | fgf3 | Fibroblast growth factor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAALASSLIR | QKREVREPGG | SRPVSAQRRV | CPRGTKSLCQ | KQLLILLSKV | RLCGGRPARP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRGPEPQLKG | IVTKLFCRQG | FYLQANPDGS | IQGTPEDTSS | FTHFNLIPVG | LRVVTIQSAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGHYMAMNAE | GLLYSSPHFT | AECRFKECVF | ENYYVLYASA | LYRQRRSGRA | WYLGLDKEGQ |
| 190 | 200 | 210 | 220 | ||
| VMKGNRVKKT | KAAAHFLPKL | LEVAMYQEPS | LHSVPEASPS | SPPAP |