Q92800
SS
Gene name |
EZH1 (KIAA0388) |
Protein name |
Histone-lysine N-methyltransferase EZH1 |
Names |
EC 2.1.1.356 , ENX-2 , Enhancer of zeste homolog 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2145 |
EC number |
2.1.1.356: Methyltransferases |
Protein Class |
|
Descriptions
The histone-lysine N-methyltransferase EZH2 (EZH2) is a catalytic subunit of the polycomb repressive complex 2 (PRC2) and is involved in histone methylation and transcriptional repression. Autoinhibition of EZH2 is achieved through the C-terminus folding back into the active site, effectively blocking substrate engagement. This conformational state is inactive, preventing enzymatic activity and ensuring EZH2 only functions when properly complexed, preventing aberrant methylation activity. The inhibited activity of EZH2 could be alleviated by interactions with its binding partners EED and SUZ12, which could induce a conformational change in EZH2
Autoinhibitory domains (AIDs)
Target domain |
647-732 (Active sites of SET domain) |
Relief mechanism |
Partner binding, Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q92800
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7KSO | EM | 390 A | A | 1-747 | PDB |
| 7KSR | EM | 410 A | A | 1-747 | PDB |
| 7KTP | EM | 480 A | A | 1-747 | PDB |
| 7TD5 | X-ray | 299 A | A/F | 1-747 | PDB |
| AF-Q92800-F1 | Predicted | AlphaFoldDB |
436 variants for Q92800
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV001255619 rs2053293877 RCV003294165 |
678 | A>G | EZH1-neurodevelopmental syndrome [ClinVar] | Yes |
ClinVar Ensembl dbSNP |
| rs746093812 | 3 | I>M | No |
ExAC TOPMed gnomAD |
|
| rs2053881433 | 4 | P>A | No | Ensembl | |
| rs1597855392 | 5 | N>I | No | Ensembl | |
| rs1413076086 | 6 | P>H | No |
TOPMed gnomAD |
|
| rs376554057 | 7 | P>A | No |
ESP ExAC TOPMed gnomAD |
|
| rs867508196 | 9 | S>F | No |
TOPMed gnomAD |
|
| TCGA novel | 12 | I>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1389999641 | 12 | I>V | No | gnomAD | |
| TCGA novel | 14 | Y>G | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM706273 | 21 | S>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs778710525 | 23 | Y>H | No |
ExAC gnomAD |
|
| rs2053880202 | 24 | M>T | No | Ensembl | |
| COSM979608 | 25 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM3819665 rs1693554854 |
27 | R>* | Variant assessed as Somatic; HIGH impact. breast [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated TOPMed |
| rs754966338 | 27 | R>Q | No | ExAC | |
| TCGA novel | 28 | Q>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs753285574 | 29 | L>I | No |
ExAC TOPMed gnomAD |
|
| rs760277636 | 31 | R>Q | No |
ExAC gnomAD |
|
| rs765876793 | 31 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs767244181 | 33 | Q>* | No |
ExAC gnomAD |
|
| COSM706274 | 33 | Q>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2053879425 | 35 | N>D | No | Ensembl | |
| rs1194330891 | 36 | M>I | No | gnomAD | |
| rs2053879320 | 36 | M>V | No | TOPMed | |
| rs969050561 | 40 | A>T | No |
TOPMed gnomAD |
|
| rs1209219306 | 41 | L>V | No |
TOPMed gnomAD |
|
| rs755595172 | 42 | Y>H | No |
ExAC gnomAD |
|
| rs2053850227 | 43 | V>L | No |
TOPMed gnomAD |
|
| rs2053850171 | 44 | A>V | No | TOPMed | |
| rs1267102173 | 48 | K>E | No | gnomAD | |
| rs749985288 | 49 | V>F | No |
ExAC gnomAD |
|
| rs749985288 | 49 | V>I | No |
ExAC gnomAD |
|
| rs1349278047 | 50 | Q>R | No | gnomAD | |
| rs138789077 | 51 | E>K | No |
ESP ExAC TOPMed gnomAD |
|
| rs138789077 | 51 | E>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs1597853439 | 52 | K>E | No | Ensembl | |
| rs761588489 | 52 | K>R | No |
ExAC TOPMed gnomAD |
|
|
TCGA novel rs2053849579 |
53 | T>N | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed |
| rs267604889 | 54 | Q>* | No | Ensembl | |
| rs1386478282 | 57 | N>H | No |
TOPMed gnomAD |
|
| rs145586889 | 57 | N>S | No |
ESP ExAC TOPMed gnomAD |
|
|
COSM4832954 rs867021719 |
58 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic Ensembl NCI-TCGA |
| rs1439142197 | 60 | W>* | No | Ensembl | |
| TCGA novel | 63 | L>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs917590262 | 64 | R>C | No |
TOPMed gnomAD |
|
| rs770961875 | 64 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs199830078 | 68 | V>I | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs199830078 | 68 | V>L | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1284876132 | 69 | Q>R | No |
TOPMed gnomAD |
|
| rs1197942975 | 70 | S>A | No | gnomAD | |
| rs1197942975 | 70 | S>P | No | gnomAD | |
| rs2053847916 | 71 | M>I | No | Ensembl | |
| rs1291958592 | 71 | M>R | No | gnomAD | |
| rs140377472 | 71 | M>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs199753838 | 73 | P>T | No |
1000Genomes gnomAD |
|
| rs773976800 | 74 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs768459667 | 75 | S>G | No |
ExAC TOPMed gnomAD |
|
| rs530196145 | 75 | S>N | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs200504064 | 75 | S>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs530196145 | 75 | S>T | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs2053847380 | 76 | G>R | No | Ensembl | |
| rs745361319 | 78 | P>L | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 78 | P>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs146736585 | 78 | P>T | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1319202364 | 79 | F>C | No | gnomAD | |
| rs780768939 | 80 | L>P | No |
ExAC gnomAD |
|
| rs756796549 | 81 | K>T | No |
ExAC gnomAD |
|
| rs769663372 | 83 | C>R | No |
ExAC gnomAD |
|
| rs1567998201 | 85 | I>T | No | Ensembl | |
| rs1335187211 | 85 | I>V | No | gnomAD | |
| rs780531216 | 88 | I>F | No |
ExAC gnomAD |
|
| rs868175843 | 89 | F>C | No | Ensembl | |
| rs1396708479 | 90 | P>L | No |
TOPMed gnomAD |
|
| rs1451105979 | 90 | P>S | No | TOPMed | |
| rs1015659917 | 91 | G>E | No | Ensembl | |
| rs372139294 | 92 | F>S | No |
ESP ExAC TOPMed gnomAD |
|
| rs777539005 | 95 | Q>H | No |
ExAC gnomAD |
|
| rs1482022257 | 96 | H>N | No | gnomAD | |
| rs534076480 | 96 | H>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs765698931 | 97 | M>I | No |
ExAC TOPMed gnomAD |
|
| rs768571484 | 97 | M>K | No | gnomAD | |
| rs753051260 | 97 | M>L | No |
ExAC TOPMed gnomAD |
|
| rs768571484 | 97 | M>T | No | gnomAD | |
| rs369111500 | 100 | R>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs150134802 | 101 | S>L | No |
ESP TOPMed gnomAD |
|
| rs754390812 | 103 | N>K | No |
ExAC gnomAD |
|
| rs2053775416 | 104 | T>I | No | Ensembl | |
| rs1300525501 | 106 | A>E | No | gnomAD | |
| TCGA novel | 109 | P>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1000322448 | 109 | P>S | No |
TOPMed gnomAD |
|
| rs1158866506 | 111 | M>R | No | TOPMed | |
| rs766839992 | 111 | M>V | No |
ExAC gnomAD |
|
| TCGA novel | 114 | W>L | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2053774861 | 116 | P>S | No | gnomAD | |
| rs2143812737 | 117 | L>P | No | Ensembl | |
| rs1284834316 | 119 | Q>* | No | gnomAD | |
| rs773344466 | 120 | N>I | No |
ExAC gnomAD |
|
|
rs1470814709 COSM1578670 |
122 | M>I | meninges [Cosmic] | No |
cosmic curated gnomAD |
| rs780604960 | 123 | V>I | No |
ExAC gnomAD |
|
| rs756635466 | 127 | T>M | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 129 | L>C | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2053743404 | 129 | L>V | No | Ensembl | |
| rs2053743331 | 129 | L>W | No | Ensembl | |
| rs2053743058 | 139 | V>A | No | TOPMed | |
| rs2053743124 | 139 | V>M | No | Ensembl | |
| COSM979606 | 142 | E>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1252172630 | 145 | T>N | No | gnomAD | |
| TCGA novel | 146 | F>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 146 | F>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs761988205 | 147 | I>V | No | ExAC | |
| rs748670427 | 152 | N>S | No |
TOPMed gnomAD |
|
| rs944543032 | 158 | V>I | No | Ensembl | |
|
rs759344526 COSM979605 |
162 | E>* | Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD |
| rs763144680 | 164 | M>I | No |
ExAC gnomAD |
|
| rs2053683338 | 166 | P>S | No | Ensembl | |
| rs766116813 | 169 | V>I | No |
ExAC TOPMed gnomAD |
|
| rs1472973980 | 172 | S>N | No | gnomAD | |
| rs906561674 | 174 | A>T | No |
TOPMed gnomAD |
|
| COSM4916638 | 178 | E>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1015592884 | 180 | V>I | No |
TOPMed gnomAD |
|
| rs1597843195 | 181 | D>G | No | Ensembl | |
| rs541410310 | 181 | D>N | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1369771439 | 185 | Q>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs2053682254 | 192 | E>K | No | Ensembl | |
| rs773788984 | 194 | H>D | No |
ExAC gnomAD |
|
| rs773788984 | 194 | H>Y | No |
ExAC gnomAD |
|
| rs150955298 | 195 | N>S | No |
ESP TOPMed gnomAD |
|
| rs1465203821 | 196 | D>G | No | gnomAD | |
| rs933531876 | 197 | T>A | No | Ensembl | |
| rs1378626218 | 197 | T>I | No |
TOPMed gnomAD |
|
| rs768293257 | 198 | S>A | No |
ExAC TOPMed gnomAD |
|
| rs1380880034 | 199 | D>G | No |
TOPMed gnomAD |
|
| rs748900681 | 199 | D>N | No |
ExAC gnomAD |
|
| rs2053681530 | 203 | D>E | No | Ensembl | |
| rs1048976029 | 203 | D>N | No |
TOPMed gnomAD |
|
| rs2143795687 | 205 | S>N | No | Ensembl | |
| rs2053681461 | 206 | K>E | No | Ensembl | |
| rs892174481 | 208 | D>N | No | TOPMed | |
| rs1052201410 | 208 | D>V | No | Ensembl | |
| rs770171359 | 210 | P>S | No |
ExAC gnomAD |
|
| rs1200145415 | 211 | V>L | No |
TOPMed gnomAD |
|
| rs924951980 | 212 | T>A | No | Ensembl | |
| COSM6081288 | 214 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs746283926 | 214 | K>Q | No |
ExAC gnomAD |
|
| rs781642151 | 217 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs773742282 | 217 | R>L | No |
TOPMed gnomAD |
|
| rs773742282 | 217 | R>Q | No |
TOPMed gnomAD |
|
| rs1339732674 | 219 | A>P | No | gnomAD | |
| rs1296856855 | 220 | I>V | No |
TOPMed gnomAD |
|
| rs757829145 | 221 | E>Q | No |
ExAC gnomAD |
|
| rs1225419026 | 223 | N>K | No |
TOPMed gnomAD |
|
| rs769480255 | 225 | K>T | No |
ExAC TOPMed gnomAD |
|
| rs746226793 | 226 | S>R | No |
ExAC TOPMed gnomAD |
|
| rs2053659986 | 226 | S>T | No | Ensembl | |
| rs777039568 | 228 | K>M | No |
ExAC gnomAD |
|
| rs777039568 | 228 | K>R | No |
ExAC gnomAD |
|
| rs1482782029 | 230 | Q>P | No | TOPMed | |
| rs1482782029 | 230 | Q>R | No | TOPMed | |
| rs1597841742 | 234 | D>V | No | Ensembl | |
| rs1597841738 | 235 | M>I | No | Ensembl | |
| rs2053659650 | 236 | I>T | No | TOPMed | |
| rs1350309722 | 237 | F>V | No | gnomAD | |
| rs1597841699 | 243 | M>V | No | Ensembl | |
| rs1419961479 | 249 | V>I | No | TOPMed | |
| rs1163780709 | 254 | K>* | No | TOPMed | |
| TCGA novel | 255 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1366545814 | 255 | E>Q | No |
TOPMed gnomAD |
|
| rs2053659096 | 256 | R>K | No | TOPMed | |
| rs751414770 | 258 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs751414770 | 258 | R>G | No |
ExAC gnomAD |
|
| rs777571053 | 258 | R>Q | No |
ExAC gnomAD |
|
| rs537354614 | 261 | T>I | No | gnomAD | |
| rs1490375435 | 263 | M>V | No | TOPMed | |
| rs1555648569 | 265 | D>H | No | Ensembl | |
| rs1235417794 | 266 | P>S | No | gnomAD | |
| rs201328092 | 267 | N>I | No |
ExAC TOPMed gnomAD |
|
| rs201328092 | 267 | N>S | No |
ExAC TOPMed gnomAD |
|
| rs184297654 | 268 | A>G | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1434480858 | 269 | L>F | No | gnomAD | |
| rs1160632888 | 269 | L>R | No | TOPMed | |
| rs1405243290 | 270 | P>L | No | TOPMed | |
| rs766058759 | 271 | P>T | No |
ExAC TOPMed gnomAD |
|
| rs933828283 | 272 | Q>E | No | Ensembl | |
| rs2143788352 | 274 | T>P | No | Ensembl | |
| rs1367464176 | 275 | P>R | No | TOPMed | |
| rs1401708007 | 277 | I>V | No | gnomAD | |
| rs1307567740 | 278 | D>G | No | TOPMed | |
| rs867221826 | 278 | D>N | No | Ensembl | |
| rs2053648071 | 279 | G>D | No | Ensembl | |
| rs2053647897 | 281 | N>D | No | Ensembl | |
| rs772397566 | 281 | N>I | No |
ExAC TOPMed gnomAD |
|
| rs772397566 | 281 | N>S | No |
ExAC TOPMed gnomAD |
|
| rs762383115 | 282 | A>T | No |
ExAC gnomAD |
|
| TCGA novel | 285 | V>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1217556849 | 287 | R>Q | No | gnomAD | |
|
COSM1195434 rs2053647589 |
287 | R>W | lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated TOPMed |
| rs1277427428 | 288 | E>K | No |
TOPMed gnomAD |
|
| rs2053647003 | 300 | R>W | No | Ensembl | |
| rs780395800 | 301 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs780395800 | 301 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs768296055 | 301 | R>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs770125478 | 306 | D>N | No |
ExAC gnomAD |
|
| rs923918969 | 311 | P>A | No |
TOPMed gnomAD |
|
| rs923918969 | 311 | P>S | No |
TOPMed gnomAD |
|
| TCGA novel | 313 | H>M | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1224911337 | 313 | H>P | No |
TOPMed gnomAD |
|
| COSM5590846 | 313 | H>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1220002873 | 321 | R>C | No |
TOPMed gnomAD |
|
| rs2143786003 | 321 | R>H | No | Ensembl | |
| COSM70667 | 322 | K>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2143785979 | 323 | N>I | No | Ensembl | |
| COSM979604 | 325 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM4066640 rs1597840052 |
325 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic Ensembl |
| rs1055400007 | 326 | I>S | No | Ensembl | |
| rs1273862752 | 328 | I>T | No | gnomAD | |
| COSM300766 | 329 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs746107510 | 332 | P>R | No |
ExAC gnomAD |
|
| COSM417508 | 335 | T>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM979603 | 339 | L>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1308909144 | 342 | E>V | No |
TOPMed gnomAD |
|
| rs2053527809 | 346 | E>D | No | Ensembl | |
| rs765391947 | 349 | M>I | No |
ExAC gnomAD |
|
| rs2053527653 | 349 | M>V | No | gnomAD | |
| rs1278569083 | 353 | P>R | No | Ensembl | |
| rs1017280875 | 354 | R>C | No | TOPMed | |
| rs1287970047 | 354 | R>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs2053527331 | 355 | S>C | No | gnomAD | |
| rs776879514 | 356 | K>R | No |
ExAC TOPMed gnomAD |
|
| rs1346546310 | 357 | C>F | No | gnomAD | |
| rs987962156 | 358 | S>A | No |
TOPMed gnomAD |
|
| TCGA novel | 359 | G>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1454055017 | 360 | R>C | No | gnomAD | |
| rs1396223464 | 361 | R>H | No |
TOPMed gnomAD |
|
| rs747924624 | 362 | R>G | No |
ExAC gnomAD |
|
| rs774145217 | 362 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs747924624 | 362 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs1271888733 | 363 | R>K | No |
TOPMed gnomAD |
|
| rs1205739115 | 365 | H>N | No | gnomAD | |
| COSM3517752 | 366 | H>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2053526498 | 367 | I>T | No | TOPMed | |
| rs768509416 | 367 | I>V | No | ExAC | |
| rs2053526344 | 369 | S>G | No | TOPMed | |
|
COSM239760 rs1254416020 |
371 | S>F | prostate [Cosmic] | No |
cosmic curated gnomAD |
| rs2053526210 | 372 | C>Y | No | TOPMed | |
| rs1222450711 | 373 | S>C | No | Ensembl | |
| rs2053526016 | 374 | N>D | No | TOPMed | |
| rs779379403 | 374 | N>S | No | ExAC | |
| rs2053525872 | 375 | A>S | No | TOPMed | |
| rs755626306 | 379 | A>S | No |
ExAC TOPMed gnomAD |
|
| COSM1470990 | 383 | T>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1162687116 | 383 | T>I | No | TOPMed | |
| TCGA novel | 385 | E>missing | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2053525409 | 385 | E>D | No | Ensembl | |
| COSM3932609 | 385 | E>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs757033020 | 391 | D>E | No |
ExAC gnomAD |
|
| rs1405415826 | 397 | A>P | No | TOPMed | |
| TCGA novel | 397 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 402 | E>G | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2053503190 | 403 | A>S | No | TOPMed | |
| COSM3517751 | 405 | S>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs779458965 | 406 | R>C | No |
ExAC TOPMed gnomAD |
|
|
RCV001028098 rs1597832055 |
406 | R>H | No |
ClinVar Ensembl dbSNP |
|
| COSM1493875 | 415 | A>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs531032842 | 417 | P>A | No |
1000Genomes ExAC gnomAD |
|
| rs915978630 | 418 | A>S | No | Ensembl | |
| rs1475668758 | 419 | P>L | No | gnomAD | |
| rs766476524 | 419 | P>S | No |
ExAC gnomAD |
|
| rs2053502153 | 420 | P>R | No | TOPMed | |
| rs1259830470 | 420 | P>S | No | gnomAD | |
| rs750620982 | 423 | C>S | No |
ExAC gnomAD |
|
|
COSM3378203 rs139326526 |
424 | V>I | pancreas [Cosmic] | No |
cosmic curated ESP ExAC TOPMed gnomAD |
| rs1481352061 | 425 | V>A | No | gnomAD | |
| rs1481352061 | 425 | V>E | No | gnomAD | |
| rs2053501682 | 425 | V>M | No | Ensembl | |
|
rs374952991 COSM1734428 |
429 | S>L | pancreas [Cosmic] | No |
cosmic curated ESP ExAC TOPMed gnomAD |
| rs374952991 | 429 | S>W | No |
ESP ExAC TOPMed gnomAD |
|
| rs1450434474 | 431 | P>T | No | Ensembl | |
| rs1758652458 | 432 | V>M | No |
TOPMed gnomAD |
|
| rs2053500950 | 434 | W>* | No | TOPMed | |
| rs1237409185 | 436 | G>R | No | gnomAD | |
| rs2053500623 | 440 | S>C | No | Ensembl | |
| COSM175634 | 443 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM4772566 rs2053500378 |
443 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic TOPMed |
| rs1335538743 | 444 | V>D | No | gnomAD | |
| rs1393619685 | 445 | F>L | No | gnomAD | |
| rs1330190644 | 445 | F>L | No |
TOPMed gnomAD |
|
| rs770590331 | 446 | H>R | No |
ExAC TOPMed gnomAD |
|
| rs2053499896 | 447 | G>S | No | gnomAD | |
| rs1420314373 | 451 | N>D | No | gnomAD | |
| rs1420314373 | 451 | N>H | No | gnomAD | |
| rs2053499578 | 452 | N>S | No | Ensembl | |
| TCGA novel | 454 | C>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs377297295 | 458 | R>K | No |
ESP ExAC gnomAD |
|
| TCGA novel | 460 | L>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs755471626 | 461 | G>E | No |
ExAC TOPMed gnomAD |
|
| rs2053499081 | 463 | K>R | No | Ensembl | |
| TCGA novel | 465 | C>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs372323124 | 466 | K>N | No |
ESP ExAC TOPMed gnomAD |
|
| rs751756992 | 468 | V>D | No |
ExAC gnomAD |
|
| rs757460665 | 468 | V>I | No |
ExAC gnomAD |
|
| rs867755265 | 472 | A>V | No | Ensembl | |
| rs1567986718 | 474 | K>R | No | Ensembl | |
| rs1421355777 | 476 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1345682259 | 478 | I>T | No | gnomAD | |
| rs754701931 | 479 | L>M | No |
ExAC TOPMed gnomAD |
|
| rs1597828379 | 480 | K>N | No | Ensembl | |
| TCGA novel | 484 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 487 | M>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM4399728 | 489 | P>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1352413655 | 491 | Q>E | No | TOPMed | |
| rs766358599 | 491 | Q>P | No |
ExAC gnomAD |
|
| TCGA novel | 494 | K>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 495 | R>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1567986094 | 501 | A>S | No | gnomAD | |
| rs2053417662 | 502 | A>S | No | TOPMed | |
| TCGA novel | 506 | K>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1326758482 | 507 | I>M | No | gnomAD | |
| rs763625751 | 514 | S>A | No |
ExAC TOPMed gnomAD |
|
| rs762544916 | 514 | S>C | No |
ExAC TOPMed gnomAD |
|
| rs763625751 | 514 | S>P | No |
ExAC TOPMed gnomAD |
|
| rs762544916 | 514 | S>Y | No |
ExAC TOPMed gnomAD |
|
| rs759893146 | 520 | N>K | No |
ExAC gnomAD |
|
| rs777114649 | 522 | Q>K | No |
ExAC TOPMed gnomAD |
|
| rs771273602 | 523 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs771273602 | 523 | P>T | No |
ExAC TOPMed gnomAD |
|
| rs1288124928 | 525 | D>H | No | gnomAD | |
| rs78868021 | 526 | H>P | No | Ensembl | |
| rs1231964303 | 527 | P>R | No | gnomAD | |
| rs1597825774 | 528 | D>A | No | Ensembl | |
| rs772252090 | 529 | R>C | No |
ExAC gnomAD |
|
|
rs201655400 COSM187130 |
529 | R>H | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs769056328 | 530 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs745590031 | 530 | P>H | No |
ExAC TOPMed gnomAD |
|
| rs769056328 | 530 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs769056328 | 530 | P>T | No |
ExAC TOPMed gnomAD |
|
| rs781046699 | 533 | S>C | No |
ExAC gnomAD |
|
| rs1597825721 | 534 | T>P | No | Ensembl | |
| rs746989137 | 539 | M>I | No |
ExAC TOPMed gnomAD |
|
| rs757105069 | 539 | M>L | No |
ExAC gnomAD |
|
| rs1231363629 | 544 | C>Y | No | gnomAD | |
| TCGA novel | 545 | E>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1209877146 | 552 | P>A | No |
TOPMed gnomAD |
|
|
COSM3189285 rs777686988 |
557 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs905112048 | 557 | R>H | No | gnomAD | |
| COSM3517750 | 559 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs747602257 | 562 | R>C | No |
ExAC gnomAD |
|
| COSM6147034 | 565 | T>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs112755289 | 566 | Q>R | No | Ensembl | |
| rs754534718 | 569 | T>A | No |
ExAC gnomAD |
|
| rs2143717314 | 570 | K>N | No | Ensembl | |
| rs753501930 | 575 | Y>H | No |
ExAC gnomAD |
|
| COSM1325064 | 575 | Y>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM3517749 | 577 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM979599 | 579 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1597823337 | 587 | L>P | No | Ensembl | |
| rs1319563348 | 594 | H>P | No | gnomAD | |
| rs2053348380 | 594 | H>Y | No | TOPMed | |
|
rs950048437 COSM706278 |
595 | W>* | lung Variant assessed as Somatic; HIGH impact. [Cosmic, NCI-TCGA] | No |
cosmic curated TOPMed NCI-TCGA Cosmic |
| rs2053348146 | 595 | W>C | No | Ensembl | |
| rs917276552 | 596 | D>H | No |
TOPMed gnomAD |
|
| rs917276552 | 596 | D>N | No |
TOPMed gnomAD |
|
| COSM1383433 | 598 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1233121758 | 599 | V>L | No | gnomAD | |
| rs1315493653 | 600 | V>I | No |
TOPMed gnomAD |
|
| rs1390188269 | 602 | C>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| TCGA novel | 603 | K>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs750875720 | 604 | N>S | No |
ExAC gnomAD |
|
| rs768077916 | 605 | C>Y | No |
ExAC gnomAD |
|
| rs1399584136 | 606 | S>N | No | TOPMed | |
| TCGA novel | 608 | Q>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs748173627 | 609 | R>H | No | gnomAD | |
| rs1474779637 | 611 | L>I | No | gnomAD | |
| TCGA novel | 615 | L>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1287411309 | 624 | G>R | No | gnomAD | |
| COSM1383432 | 625 | W>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1371312646 | 629 | I>V | No | TOPMed | |
| rs757206193 | 632 | S>P | No |
TOPMed gnomAD |
|
| TCGA novel | 632 | S>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1468755074 | 633 | V>M | No |
TOPMed gnomAD |
|
| TCGA novel | 634 | Q>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM4847816 | 635 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
rs1316478374 COSM280912 |
637 | E>K | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD |
| rs1159977413 | 639 | I>V | No |
TOPMed gnomAD |
|
| COSM3370737 | 642 | Y>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2053324997 | 643 | C>G | No | TOPMed | |
| rs1013373536 | 644 | G>A | No |
TOPMed gnomAD |
|
| rs771829365 | 644 | G>R | No |
ExAC gnomAD |
|
| rs376492983 | 654 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA |
| rs774028217 | 655 | R>C | No |
ExAC gnomAD |
|
| COSM979598 | 655 | R>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM436648 | 655 | R>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| TCGA novel | 656 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2053313351 | 657 | K>T | No |
TOPMed gnomAD |
|
| rs1165600748 | 661 | K>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1201520847 | 663 | M>I | No | gnomAD | |
| rs1423816665 | 663 | M>R | No | gnomAD | |
| rs1423816665 | 663 | M>T | No | gnomAD | |
| rs1684131251 | 663 | M>V | No | Ensembl | |
| rs2143709127 | 664 | S>C | No | Ensembl | |
| rs2053312795 | 666 | F>L | No |
TOPMed gnomAD |
|
| rs2053312732 | 669 | N>D | No | TOPMed | |
| rs2053312661 | 671 | N>K | No | TOPMed | |
| rs1246184458 | 682 | G>A | No |
TOPMed gnomAD |
|
| COSM269124 | 685 | I>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM1177177 rs1458266017 |
686 | R>* | Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD |
| COSM349331 | 686 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| TCGA novel | 690 | H>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1521500 rs775259824 COSM6147035 |
692 | V>L | lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD |
| rs2053293182 | 694 | P>L | No | Ensembl | |
| rs2053293002 | 696 | C>R | No |
TOPMed gnomAD |
|
| rs2053274971 | 700 | V>A | No | gnomAD | |
| rs2053274739 | 707 | H>Q | No | TOPMed | |
| rs760268061 | 707 | H>Y | No |
ExAC gnomAD |
|
| rs2053274654 | 708 | R>Q | No | TOPMed | |
| rs1181566122 | 714 | K>N | No | gnomAD | |
| rs2143701528 | 715 | R>G | No | Ensembl | |
| rs946695802 | 715 | R>T | No |
TOPMed gnomAD |
|
| rs1426226188 | 717 | I>V | No | gnomAD | |
| COSM4066636 | 719 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
rs1260794915 COSM74564 |
721 | E>K | ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD |
| TCGA novel | 730 | S>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs865941092 | 732 | A>S | No | Ensembl | |
| rs868468000 | 735 | L>F | No |
TOPMed gnomAD |
|
| rs868468000 | 735 | L>I | No |
TOPMed gnomAD |
|
| rs1460480684 | 738 | V>M | No | gnomAD | |
| rs2053264701 | 740 | I>T | No | Ensembl | |
| rs866623552 | 741 | E>* | No | gnomAD | |
| rs866623552 | 741 | E>K | No | gnomAD | |
| rs902644962 | 743 | E>* | No |
TOPMed gnomAD |
|
| rs866128457 | 743 | E>D | No | Ensembl | |
| rs902644962 | 743 | E>Q | No |
TOPMed gnomAD |
|
| rs760086887 | 745 | D>E | No |
ExAC gnomAD |
|
| rs138757221 | 745 | D>N | No |
ESP ExAC TOPMed gnomAD |
|
| rs532006849 | 746 | V>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
| rs1405057211 | 747 | L>P | No | gnomAD |
No associated diseases with Q92800
9 regional properties for Q92800
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SANT/Myb domain | 135 - 263 | IPR001005-1 |
| domain | SANT/Myb domain | 430 - 478 | IPR001005-2 |
| domain | SET domain | 613 - 734 | IPR001214 |
| domain | CXC domain | 504 - 606 | IPR026489 |
| domain | Tesmin/TSO1-like CXC domain | 556 - 593 | IPR033467 |
| domain | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain | 159 - 262 | IPR041343 |
| domain | Pre-SET CXC domain | 560 - 591 | IPR041355 |
| domain | EZH1, SET domain | 608 - 743 | IPR044438 |
| domain | EZH1/2, MCSS domain | 270 - 322 | IPR048358 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.356 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| ESC/E(Z) complex | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. |
| heterochromatin | A compact and highly condensed form of chromatin that is refractory to transcription. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone H3K27 methyltransferase activity | Catalysis of the reaction |
| histone H3K27 trimethyltransferase activity | Catalysis of the reaction |
| molecular condensate scaffold activity | Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. |
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure morphogenesis | The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| heterochromatin formation | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| hippocampus development | The progression of the hippocampus over time from its initial formation until its mature state. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| subtelomeric heterochromatin formation | The compaction of chromatin into heterochromatin at the subtelomeric region. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7E2Z2 | EZH1 | Histone-lysine N-methyltransferase EZH1 | Bos taurus (Bovine) | SS |
| P42124 | E(z) | Histone-lysine N-methyltransferase E | Drosophila melanogaster (Fruit fly) | SS |
| Q15910 | EZH2 | Histone-lysine N-methyltransferase EZH2 | Homo sapiens (Human) | EV |
| Q61188 | Ezh2 | Histone-lysine N-methyltransferase EZH2 | Mus musculus (Mouse) | SS |
| P70351 | Ezh1 | Histone-lysine N-methyltransferase EZH1 | Mus musculus (Mouse) | SS |
| O65312 | MEA | Histone-lysine N-methyltransferase MEDEA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28D84 | ezh2 | Histone-lysine N-methyltransferase EZH2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q08BS4 | ezh2 | Histone-lysine N-methyltransferase EZH2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIPNPPTSK | CITYWKRKVK | SEYMRLRQLK | RLQANMGAKA | LYVANFAKVQ | EKTQILNEEW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKLRVQPVQS | MKPVSGHPFL | KKCTIESIFP | GFASQHMLMR | SLNTVALVPI | MYSWSPLQQN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FMVEDETVLC | NIPYMGDEVK | EEDETFIEEL | INNYDGKVHG | EEEMIPGSVL | ISDAVFLELV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DALNQYSDEE | EEGHNDTSDG | KQDDSKEDLP | VTRKRKRHAI | EGNKKSSKKQ | FPNDMIFSAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASMFPENGVP | DDMKERYREL | TEMSDPNALP | PQCTPNIDGP | NAKSVQREQS | LHSFHTLFCR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RCFKYDCFLH | PFHATPNVYK | RKNKEIKIEP | EPCGTDCFLL | LEGAKEYAML | HNPRSKCSGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRRRHHIVSA | SCSNASASAV | AETKEGDSDR | DTGNDWASSS | SEANSRCQTP | TKQKASPAPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLCVVEAPSE | PVEWTGAEES | LFRVFHGTYF | NNFCSIARLL | GTKTCKQVFQ | FAVKESLILK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LPTDELMNPS | QKKKRKHRLW | AAHCRKIQLK | KDNSSTQVYN | YQPCDHPDRP | CDSTCPCIMT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QNFCEKFCQC | NPDCQNRFPG | CRCKTQCNTK | QCPCYLAVRE | CDPDLCLTCG | ASEHWDCKVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SCKNCSIQRG | LKKHLLLAPS | DVAGWGTFIK | ESVQKNEFIS | EYCGELISQD | EADRRGKVYD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KYMSSFLFNL | NNDFVVDATR | KGNKIRFANH | SVNPNCYAKV | VMVNGDHRIG | IFAKRAIQAG |
| 730 | 740 | ||||
| EELFFDYRYS | QADALKYVGI | ERETDVL |