Q92688

SS
Gene name
ANP32B (APRIL, PHAPI2)
Protein name
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Names
Acidic protein rich in leucines , Putative HLA-DR-associated protein I-2 , PHAPI2 , Silver-stainable protein SSP29
Species
Homo sapiens (Human)
KEGG Pathway
hsa:10541
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

121-161 (Autoinhibitory domain) SS

Target domain

1-161 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q92688

Entry ID Method Resolution Chain Position Source
2ELL NMR - A 1-161 PDB
2RR6 NMR - A 1-161 PDB
AF-Q92688-F1 Predicted AlphaFoldDB

208 variants for Q92688

Variant ID(s) Position Change Description Diseaes Association Provenance
TCGA novel 2 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1277307714 3 M>V No gnomAD
rs1440265144 4 K>N No TOPMed
gnomAD
rs1211785897 5 R>W No gnomAD
rs1246417199 6 R>K No TOPMed
rs1237744954 7 I>T No gnomAD
rs1827634496 8 H>P No Ensembl
rs771283871 8 H>Q No ExAC
TOPMed
gnomAD
rs1827634445 8 H>Y No gnomAD
rs866406709 9 L>M No gnomAD
rs1443098778 10 E>K No TOPMed
gnomAD
rs1382043461 10 E>V No gnomAD
TCGA novel 12 R>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1416295914 14 R>W No TOPMed
gnomAD
rs1017983718 15 T>A No TOPMed
gnomAD
rs374378445 15 T>I No ESP
ExAC
TOPMed
gnomAD
rs866732118 16 P>L No TOPMed
gnomAD
rs866732118 16 P>Q No TOPMed
gnomAD
rs1276585548 17 A>E No TOPMed
gnomAD
rs1827635154 17 A>S No TOPMed
rs1827635154 17 A>T No TOPMed
rs1234200164 18 A>D No TOPMed
gnomAD
rs1234200164 18 A>G No TOPMed
gnomAD
COSM3432694 20 R>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs776354657 20 R>Q No ExAC
TOPMed
gnomAD
COSM752335 29 S>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM1314305 30 N>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs142118802 33 K>N No ESP
ExAC
rs376602943 34 I>T No ESP
TOPMed
gnomAD
rs748208608 38 T>R No Ensembl
rs1358288838 39 A>D No gnomAD
rs1358288838 39 A>G No gnomAD
rs1469384005 39 A>T No gnomAD
rs1827878040 42 V>L No Ensembl
rs1291021086 43 N>H No Ensembl
rs1218929127 45 E>D No gnomAD
rs767568260 47 L>P No ExAC
gnomAD
rs973099581 48 S>G No TOPMed
rs756222170 52 V>I No ExAC
gnomAD
rs1044321383 55 I>M No TOPMed
gnomAD
COSM1464343 60 L>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1827878502 61 P>S No TOPMed
gnomAD
COSM3835257 62 K>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1473362999 63 L>M No gnomAD
rs764181693 64 P>H No ExAC
gnomAD
rs1827878679 66 L>V No TOPMed
rs1827878724 67 K>E No TOPMed
COSM1103077 68 K>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1827878758 68 K>R No gnomAD
rs138669342 71 L>F No ESP
ExAC
TOPMed
gnomAD
rs1311655242 72 S>G No gnomAD
rs1564138196 74 N>D No Ensembl
rs991523817 79 G>S No gnomAD
rs1231206458 79 G>V No gnomAD
rs1324561783 80 L>M No gnomAD
rs914567050 82 M>I No Ensembl
rs753976201 84 A>T No ExAC
gnomAD
rs1178261907 84 A>V No TOPMed
gnomAD
rs757567396 85 E>G No ExAC
gnomAD
rs1827941869 86 K>E No TOPMed
TCGA novel 86 K>N Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs967950783 86 K>R No Ensembl
rs765686344 87 L>P No ExAC
gnomAD
rs750761331 88 P>L No ExAC
gnomAD
rs1378945982 89 N>Y No gnomAD
rs758841211 91 T>A No ExAC
gnomAD
rs1272322942 91 T>I No gnomAD
rs1448780591 98 N>S No gnomAD
rs754411628 101 K>N No 1000Genomes
ExAC
gnomAD
rs1366853824 102 D>G No TOPMed
gnomAD
rs1366853824 102 D>V No TOPMed
gnomAD
rs535530800 103 I>M No 1000Genomes
ExAC
TOPMed
gnomAD
rs1437197011 103 I>T No TOPMed
gnomAD
rs1156729575 104 S>R No TOPMed
rs1827942623 108 P>L No TOPMed
rs777366211 110 K>E No ExAC
gnomAD
rs1828053798 110 K>R No Ensembl
TCGA novel 112 L>V Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1382025307 113 E>K No Ensembl
rs1382025307 113 E>Q No Ensembl
rs1828053906 114 C>R No TOPMed
rs748979952 117 S>I No ExAC
TOPMed
gnomAD
rs748979952 117 S>N No ExAC
TOPMed
gnomAD
rs1476195765 120 L>F No TOPMed
gnomAD
rs1564140098 120 L>H No Ensembl
rs1476195765 120 L>V No TOPMed
gnomAD
rs1412787627 122 N>I No gnomAD
rs2131589095 123 C>* No Ensembl
rs377406514 128 L>V No ESP
ExAC
gnomAD
rs182096718
RCV000971048
 130 D>A No ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs1828054505 132 R>Q No TOPMed
rs771977254 133 E>Q No ExAC
gnomAD
rs1828054638 134 S>G No TOPMed
rs775300881 134 S>R No ExAC
TOPMed
gnomAD
rs1431749321 135 V>I No TOPMed
gnomAD
rs1302544606 137 K>R No TOPMed
gnomAD
rs1302544606 137 K>T No TOPMed
gnomAD
rs761932651 138 L>H No ExAC
gnomAD
COSM1103079 139 L>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1418539448 141 Q>R No TOPMed
gnomAD
rs770020996 142 L>F No ExAC
gnomAD
rs374883415 143 T>I No ESP
ExAC
gnomAD
COSM3902467 144 Y>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1283264647 147 G>S No TOPMed
gnomAD
rs1448292635 148 Y>F No gnomAD
rs1046534844 149 D>E No TOPMed
rs149318680 150 R>Q No ESP
ExAC
TOPMed
gnomAD
rs1828055443 152 D>N No gnomAD
COSM1103080 153 Q>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2131589131 153 Q>R No Ensembl
rs759833673 156 P>A No ExAC
gnomAD
rs759833673 156 P>S No ExAC
gnomAD
rs1828055784 158 S>L No Ensembl
rs201273635 160 A>T No 1000Genomes
rs1156850890 160 A>V No gnomAD
rs1251083232 161 E>K No TOPMed
rs1325404711 162 V>E No gnomAD
rs1401408342 163 D>G No gnomAD
rs753476000 165 V>M No ExAC
TOPMed
gnomAD
rs2131589159 166 D>E No Ensembl
rs756969084 166 D>G No ExAC
gnomAD
rs1232087697 167 E>D No TOPMed
gnomAD
rs2131589162 167 E>G No Ensembl
rs745616807 170 E>D No ExAC
TOPMed
gnomAD
rs1445206658 171 D>H No gnomAD
rs1828056953 172 E>K No Ensembl
rs1481491470 174 G>R No TOPMed
gnomAD
rs1200375028 174 G>V No gnomAD
rs1423224178 175 E>D No gnomAD
rs1464349905 176 D>G No gnomAD
rs1316585223 177 E>V No TOPMed
gnomAD
COSM1103081 178 E>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1340831822 179 D>G No TOPMed
rs1023323281 179 D>N No TOPMed
gnomAD
rs1397753391 180 E>K No TOPMed
gnomAD
rs71501840 181 D>A No Ensembl
rs1828180507 181 D>H No gnomAD
rs1406283932 182 D>E No TOPMed
gnomAD
rs1564141817 182 D>G No Ensembl
rs1363146642 182 D>N No gnomAD
rs1283480300 184 D>N No gnomAD
rs1828180931 184 D>V No TOPMed
rs1339906176 189 E>A No gnomAD
rs902703946 190 F>S No Ensembl
rs1223355183 191 D>V No TOPMed
gnomAD
rs781295072 192 E>D No ExAC
TOPMed
gnomAD
rs1000014447 193 E>D No TOPMed
gnomAD
rs548651278 193 E>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs554324727 193 E>G No 1000Genomes
ExAC
gnomAD
rs770948925 194 D>E No ExAC
rs1828182118 194 D>N No TOPMed
gnomAD
rs1828182118 194 D>Y No TOPMed
gnomAD
rs1828182288 195 D>G No TOPMed
rs1472704292 196 E>D No gnomAD
rs1587881586 196 E>Q No Ensembl
rs1828182442 197 D>N No Ensembl
rs1206430307 197 D>V No gnomAD
rs1474420460 199 D>V No TOPMed
gnomAD
rs1828182636 200 V>I No gnomAD
rs774602963 202 G>R No ExAC
gnomAD
rs746127276 203 D>H No ExAC
TOPMed
gnomAD
rs147068709 205 D>E No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1359422504 205 D>N No gnomAD
COSM3835258
rs1319941915
 206 D>N Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
rs761031783
COSM1103083
 207 D>N Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs761031783 207 D>Y No ExAC
TOPMed
gnomAD
COSM5130751 208 E>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs761343165 209 V>G No ExAC
gnomAD
rs370631624 209 V>I No ESP
ExAC
gnomAD
rs1330930663 211 E>* No TOPMed
gnomAD
rs1330930663 211 E>Q No TOPMed
gnomAD
rs1384813255 215 E>Q No gnomAD
rs769036871 216 F>C No ExAC
gnomAD
rs777088502 217 G>A No ExAC
gnomAD
TCGA novel 218 L>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs769329548 219 D>E No ExAC
TOPMed
rs762271758 219 D>G No ExAC
gnomAD
rs1202090461 222 D>E No gnomAD
rs1344592227 222 D>G No TOPMed
gnomAD
rs1344592227 222 D>V No TOPMed
gnomAD
rs1245351372 224 D>E No gnomAD
rs3900080 225 E>D No ExAC
TOPMed
gnomAD
rs772534076 225 E>K No ExAC
gnomAD
rs2131593129 227 E>K No Ensembl
rs2131593129 227 E>Q No Ensembl
rs2131593134 227 E>V No Ensembl
rs769811711 228 D>G No ExAC
TOPMed
gnomAD
rs1247883639 228 D>N No TOPMed
rs1196801497 230 E>D No gnomAD
rs987139 230 E>K No TOPMed
rs1335613382 231 E>D No Ensembl
rs1431018280 231 E>K No gnomAD
rs1828257596 233 E>D No Ensembl
rs1828257511 233 E>G No TOPMed
rs796129328 234 G>S No gnomAD
rs796924529 235 G>R No gnomAD
rs1587883772 237 G>S No Ensembl
rs1389054833 242 R>K No TOPMed
gnomAD
rs1169708902 244 T>R No gnomAD
rs1352619278 245 D>H No TOPMed
gnomAD
rs1828258274 245 D>M No Ensembl
rs1352619278 245 D>N No TOPMed
gnomAD
rs1828258449 245 D>V No gnomAD
rs1828258651 248 G>A No TOPMed
rs1367645400 248 G>R No TOPMed
gnomAD
rs1463455065 249 E>D No gnomAD
rs76167314
COSM4163150
 250 D>N thyroid [Cosmic] No cosmic curated
gnomAD
COSM3367467
rs112073824
 251 D>E kidney [Cosmic] No cosmic curated
TOPMed
gnomAD

No associated diseases with Q92688

2 regional properties for Q92688

Type Name Position InterPro Accession
domain BTB/POZ domain 192 - 297 IPR000210
domain MATH/TRAF domain 31 - 161 IPR002083

Functions

Description
EC Number
Subcellular Localization
  • [Isoform 1]: Nucleus
  • Cytoplasm
  • Accumulates in the nuclei at the S phase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
RNA polymerase binding Binding to an RNA polymerase molecule or complex.

9 GO annotations of biological process

Name Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of protein export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
ventricular system development The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q3SZC6 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Bos taurus (Bovine) SS
Q5F4A3 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Gallus gallus (Chicken) SS
Q5ZMN0 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Gallus gallus (Chicken) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Homo sapiens (Human) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
O43423 ANP32CP Putative uncharacterized protein ANP32CP Homo sapiens (Human) SS
O35381 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Mus musculus (Mouse) SS
P97822 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Mus musculus (Mouse) SS
Q9EST5 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Mus musculus (Mouse) SS
Q5XIE0 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Rattus norvegicus (Rat) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q9EST6 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q6P1U7 anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6NUW5 anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI NVGLISVSNL
70 80 90 100 110 120
PKLPKLKKLE LSENRIFGGL DMLAEKLPNL THLNLSGNKL KDISTLEPLK KLECLKSLDL
130 140 150 160 170 180
FNCEVTNLND YRESVFKLLP QLTYLDGYDR EDQEAPDSDA EVDGVDEEEE DEEGEDEEDE
190 200 210 220 230 240
DDEDGEEEEF DEEDDEDEDV EGDEDDDEVS EEEEEFGLDE EDEDEDEDEE EEEGGKGEKR
250
KRETDDEGED D