AiPD: Autoinhibited Protein Database

Q92630

Gene name	DYRK2
Protein name	Dual specificity tyrosine-phosphorylation-regulated kinase 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8445
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-140 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

69-140 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

367-387 (Activation loop from InterPro)

Target domain	222-535 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

24 structures for Q92630

Entry ID	Method	Resolution	Chain	Position	Source
3K2L	X-ray	236 A	A	146-552	PDB
3KVW	X-ray	228 A	A	146-552	PDB
4AZF	X-ray	255 A	A	146-540	PDB
5LXC	X-ray	215 A	A/B	146-552	PDB
5LXD	X-ray	258 A	A/B	146-552	PDB
5ZTN	X-ray	250 A	A/B	146-552	PDB
6HDP	X-ray	230 A	A	146-552	PDB
6HDR	X-ray	220 A	A	146-552	PDB
6K0J	X-ray	235 A	A	212-536	PDB
7AKF	X-ray	260 A	A	146-552	PDB
7AKH	X-ray	285 A	A	146-552	PDB
7DG4	X-ray	258 A	A	215-538	PDB
7DH3	X-ray	233 A	A	213-538	PDB
7DH9	X-ray	219 A	A	215-538	PDB
7DHC	X-ray	259 A	A	215-538	PDB
7DHH	X-ray	249 A	A	215-538	PDB
7DHK	X-ray	234 A	A	215-538	PDB
7DHN	X-ray	238 A	A	215-538	PDB
7DHO	X-ray	329 A	A	215-538	PDB
7DHV	X-ray	268 A	A	212-538	PDB
7DJO	X-ray	250 A	A	215-538	PDB
7DL6	X-ray	265 A	A	215-538	PDB
8HLT	X-ray	280 A	A/B	145-537	PDB
AF-Q92630-F1	Predicted				AlphaFoldDB

437 variants for Q92630

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs780280111 CA6675463	6	P>H		No	ClinGen ExAC gnomAD
rs747079356 CA6675464	8	A>D		No	ClinGen ExAC gnomAD
rs1047112428 CA238184713	8	A>T		No	ClinGen TOPMed gnomAD
rs537957540 CA6675466	9	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs748735512 CA6675467	9	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1309063613 CA385893798	11	P>L		No	ClinGen gnomAD
CA6675472 rs767310972	14	Y>C		No	ClinGen ExAC gnomAD
rs1170623892 CA385893840	14	Y>H		No	ClinGen TOPMed
rs767310972 CA6675471	14	Y>S		No	ClinGen ExAC gnomAD
CA6675475 rs753274270	17	G>R		No	ClinGen ExAC gnomAD
CA6675502 rs553490122	19	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA385894541 rs1236642877	20	G>E		No	ClinGen TOPMed
rs752858847 CA6675503	22	S>I		No	ClinGen ExAC TOPMed gnomAD
rs915192868 CA238185529	23	A>G		No	ClinGen Ensembl
CA385894580 rs1565801855	23	A>T		No	ClinGen Ensembl
rs756215589 CA6675504	24	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6675506 rs749747547	28	Q>R		No	ClinGen ExAC gnomAD
CA385894675 rs1592710711	29	A>S		No	ClinGen Ensembl
CA385894728 rs1433697208	32	G>E		No	ClinGen TOPMed
CA6675512 rs571967830	37	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1471007221 CA385894801	38	T>I		No	ClinGen TOPMed
rs1233232743 CA385894809	39	R>L		No	ClinGen TOPMed
rs1187042962 CA385894820	40	S>N		No	ClinGen TOPMed
rs1592710742 CA385894830	41	G>E		No	ClinGen Ensembl
rs1390937976 CA385894840	42	V>L		No	ClinGen gnomAD
CA385894836 rs1390937976	42	V>M		No	ClinGen gnomAD
rs772702866 CA6675514	43	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1320173162 CA385894889	46	P>Q		No	ClinGen gnomAD
rs1312883630 CA385894887	46	P>S		No	ClinGen TOPMed
rs1284106336 CA385894900	47	P>S		No	ClinGen TOPMed
rs766206981 CA6675516	48	S>P		No	ClinGen ExAC TOPMed gnomAD
rs751412921 CA6675517	48	S>Y		No	ClinGen ExAC gnomAD
rs759216183 CA6675518	49	P>A		No	ClinGen ExAC gnomAD
TCGA novel	49	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1270019358 CA385894924	50	I>L		No	ClinGen gnomAD
CA385894928 rs1327180470	50	I>T		No	ClinGen gnomAD
CA385894933 rs1208331375	51	A>P		No	ClinGen gnomAD
rs1376235287 CA385894958	53	P>L		No	ClinGen TOPMed
rs752910064 CA6675520	54	P>A		No	ClinGen ExAC
CA6675521 rs756266896	54	P>L		No	ClinGen ExAC gnomAD
CA238185619 rs945021919	55	L>F		No	ClinGen TOPMed
CA385895006 rs1414821350	58	S>N		No	ClinGen TOPMed
CA6675522 rs778067609	58	S>R		No	ClinGen ExAC TOPMed gnomAD
CA385895014 rs1489658953	59	N>H		No	ClinGen gnomAD
rs753955862 CA6675523	59	N>S		No	ClinGen ExAC gnomAD
CA6675525 rs557502236	65	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779248417 CA6675526	66	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1458313013 CA385889748	67	I>V		No	ClinGen TOPMed gnomAD
rs968443245 CA238190846	69	G>R		No	ClinGen gnomAD
CA238190838 rs968443245	69	G>S		No	ClinGen gnomAD
rs1370110230 CA385889766	70	S>N		No	ClinGen gnomAD
rs1217984793 CA385889775	71	K>R		No	ClinGen gnomAD
rs1301141293 CA385889787	73	T>P		No	ClinGen gnomAD
rs1230281563 CA385889796	74	M>T		No	ClinGen gnomAD
CA6675549 rs780452325	74	M>V		No	ClinGen ExAC gnomAD
rs200418247 CA238190857	75	N>S		No	ClinGen TOPMed gnomAD
rs755807656 CA6675551	76	D>H		No	ClinGen ExAC gnomAD
CA385889820 rs1592713797	77	H>P		No	ClinGen Ensembl
rs1592713803 CA385889823	78	L>M		No	ClinGen Ensembl
rs777366599 CA6675552	78	L>P		No	ClinGen ExAC gnomAD
CA385889832 rs1487358698	79	H>L		No	ClinGen gnomAD
rs748856707 CA6675553	79	H>Q		No	ClinGen ExAC gnomAD
CA6675555 rs199671497	81	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA385889848 rs1156310364	82	S>N		No	ClinGen gnomAD
rs745859869 CA6675556	82	S>R		No	ClinGen ExAC gnomAD
CA385889856 rs1407301902	83	H>R		No	ClinGen TOPMed
rs775477051 CA385889860	84	A>S		No	ClinGen ExAC gnomAD
CA6675558 rs775477051	84	A>T		No	ClinGen ExAC gnomAD
rs1481687503 CA385889867	85	H>Y		No	ClinGen TOPMed
rs376836219 COSM1476856 CA238190939	86	G>R	breast [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
rs1303135588 CA385889885	87	Q>H		No	ClinGen gnomAD
rs764431941 CA6675560	90	V>A		No	ClinGen ExAC gnomAD
rs138020482 CA238190960	90	V>F		No	ClinGen ESP gnomAD
CA385889904 rs764431941	90	V>G		No	ClinGen ExAC gnomAD
CA385889902 rs138020482	90	V>L		No	ClinGen ESP gnomAD
CA385889919 rs1328485816	92	Q>H		No	ClinGen gnomAD
rs761954038 CA6675562	94	F>C		No	ClinGen ExAC gnomAD
rs35139851 VAR_040458 CA238190995	98	S>G		No	ClinGen UniProt Ensembl dbSNP
rs1450969305 CA385889978	100	K>R		No	ClinGen TOPMed gnomAD
CA385889985 rs1220513841	101	R>Q		No	ClinGen gnomAD
CA6675564 rs368663247	101	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA385889991 rs1565804117	102	T>I		No	ClinGen Ensembl
rs758950789 CA6675565	105	T>M		No	ClinGen ExAC gnomAD
CA6675568 rs755291219	108	P>Q		No	ClinGen ExAC gnomAD
rs991964702 CA238191023	110	G>E		No	ClinGen Ensembl
rs1183261564 CA385890046	111	L>R		No	ClinGen gnomAD
CA238191026 rs893362378	112	T>I		No	ClinGen TOPMed
rs1389327643 CA385890053	113	T>A		No	ClinGen gnomAD
rs1414915327 CA385890055	113	T>I		No	ClinGen TOPMed gnomAD
CA385890061 rs777497932	114	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6675570 rs777497932	114	V>E		No	ClinGen ExAC TOPMed gnomAD
CA6675571 rs372026905	117	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6675574 rs778346638	120	P>L		No	ClinGen ExAC gnomAD
CA385890105 rs369962925	121	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs369962925 CA6675575	121	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6675576 rs772165908	122	V>G		No	ClinGen ExAC gnomAD
rs201692417 CA6675578	125	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs373326108 CA6675577	125	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA385890137 rs1592713932	127	L>V		No	ClinGen Ensembl
CA385890145 rs1377242176	128	D>G		No	ClinGen gnomAD
rs776478421 CA6675580	129	S>G		No	ClinGen ExAC gnomAD
rs61744989 CA6675581	129	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1202975759 CA385890166	131	H>R		No	ClinGen gnomAD
rs762983787 CA6675585	133	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6675584 rs762983787	133	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773201871 CA6675583	133	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs752009659 CA6675586	136	S>R		No	ClinGen ExAC gnomAD
CA385890201 rs1472255112	137	S>P		No	ClinGen TOPMed gnomAD
rs1472255112 CA385890200	137	S>T		No	ClinGen TOPMed gnomAD
rs1258548297 CA385890210	138	T>S		No	ClinGen TOPMed
COSM244174 rs1341912636 CA385890217	139	S>F	prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1217584168 CA385890218	140	L>I		No	ClinGen TOPMed
rs753092948 CA385890234	142	S>C		No	ClinGen ExAC TOPMed gnomAD
rs753092948 CA6675589	142	S>F		No	ClinGen ExAC TOPMed gnomAD
rs756911170 COSM694684 CA6675590	143	M>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	144	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385890264 rs1565804266	146	M>I		No	ClinGen Ensembl
CA238191166 rs983446748	148	K>R		No	ClinGen TOPMed
CA385890283 rs1592713977	149	V>G		No	ClinGen Ensembl
CA385890280 rs1565804270	149	V>M		No	ClinGen Ensembl
TCGA novel	151	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	154	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6675592 rs749974322	154	M>V		No	ClinGen ExAC gnomAD
CA385890358 rs1592714003	160	M>T		No	ClinGen Ensembl
rs1359691117 CA385890355	160	M>V		No	ClinGen TOPMed
TCGA novel	162	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385890372 rs1162591186	162	Q>E		No	ClinGen Ensembl
rs192078400 CA6675597	163	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs539367942 CA6675596	163	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	163	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6675598 rs747940965	164	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1269567570 CA385890386	164	M>V		No	ClinGen gnomAD
rs1220515482 CA385890394	165	Q>E		No	ClinGen gnomAD
CA6675599 rs769942888	168	T>I		No	ClinGen ExAC gnomAD
rs1389378799 CA385890415	168	T>P		No	ClinGen TOPMed
rs773437748 CA6675600	169	A>V		No	ClinGen ExAC gnomAD
CA6675604 rs774410869	170	F>L		No	ClinGen ExAC TOPMed gnomAD
CA6675602 rs569784741	170	F>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	171	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs933131402 CA238191274	175	I>V		No	ClinGen TOPMed
rs148267811 CA6675606	176	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	177	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1373066922 CA385890493	179	P>A		No	ClinGen gnomAD
rs1478650310 CA385890496	179	P>R		No	ClinGen gnomAD
rs200772204 CA6675607	180	E>D		No	ClinGen ExAC TOPMed gnomAD
CA238191289 rs923691915	181	I>L		No	ClinGen TOPMed
rs1423192672 CA385890512	182	Y>H		No	ClinGen TOPMed gnomAD
CA385890525 rs1321525009	183	F>L		No	ClinGen gnomAD
TCGA novel	186	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6675612 rs751088641	186	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6675613 rs754908658	188	A>T		No	ClinGen ExAC gnomAD
rs893457223 CA238191368	191	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6675614 rs368931012	191	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6675615 rs555625707	192	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1192820626 CA385890584	193	G>S		No	ClinGen gnomAD
CA6675616 rs372952031	194	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6675617 rs777979634	196	G>D		No	ClinGen ExAC TOPMed gnomAD
CA385890620 rs1384093596 COSM13317 VAR_040459	198	P>L	central_nervous_system a glioblastoma multiforme sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt TOPMed dbSNP
rs142946655 CA6675618	199	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs376533757 CA6675619	200	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	200	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6675620 rs774463586	201	G>D		No	ClinGen ExAC TOPMed gnomAD
CA385890643 rs1413857309	202	G>D		No	ClinGen gnomAD
CA385890640 rs1565804395	202	G>S		No	ClinGen Ensembl
CA385890680 rs1175748064	207	Q>*		No	ClinGen gnomAD
CA238191460 CA238191443 rs202065816	208	G>R		No	ClinGen Ensembl
CA385890694 rs1565804402	209	S>*		No	ClinGen Ensembl
CA6675623 rs776005627	212	Q>R		No	ClinGen ExAC gnomAD
rs1036201941 CA238191504	213	V>M		No	ClinGen TOPMed gnomAD
rs1388269280 CA385890726	214	P>L		No	ClinGen gnomAD
CA385890722 rs1391210769	214	P>S		No	ClinGen gnomAD
CA385890734 rs762739744	215	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA385890738 rs1565804436	216	D>N		No	ClinGen Ensembl
CA6675628 rs147455307	218	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6675630 rs754464541	224	V>L		No	ClinGen ExAC gnomAD
CA385890811 rs1211974320	226	K>N		No	ClinGen gnomAD
CA385890809 rs1195090573	226	K>R		No	ClinGen TOPMed
TCGA novel	226	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767371517 CA6675631	227	V>A		No	ClinGen ExAC gnomAD
rs1252799146 CA385890850	232	S>I		No	ClinGen TOPMed
rs1181416862 CA385890871	235	Q>R		No	ClinGen gnomAD
CA6675633 rs756005590	236	V>A		No	ClinGen ExAC gnomAD
CA6675634 rs777603041	237	V>A		No	ClinGen ExAC gnomAD
CA6675635 rs749061660	238	K>R		No	ClinGen ExAC gnomAD
rs1232441898 CA385890923	243	K>E		No	ClinGen TOPMed
rs779069592 CA6675637	244	V>I		No	ClinGen ExAC TOPMed gnomAD
VAR_040460 CA6675638 rs34166200	245	H>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1348111007 CA385890938	245	H>R		No	ClinGen gnomAD
CA385890948 rs1390291213	246	Q>H		No	ClinGen gnomAD
CA6675639 rs772122553	247	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA385890959 rs1247519517	248	V>M		No	ClinGen gnomAD
rs777171478 CA6675643	252	M>L		No	ClinGen ExAC TOPMed gnomAD
rs777171478 CA385890982	252	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6675645 rs766149027	254	R>Q		No	ClinGen ExAC gnomAD
CA385890996 rs762225112	254	R>W		No	ClinGen ExAC gnomAD
CA385891004 rs1479719943	255	N>S		No	ClinGen gnomAD
CA6675647 rs758976485	257	K>N		No	ClinGen ExAC gnomAD
rs767125464 CA6675648	258	R>C		No	ClinGen ExAC gnomAD
CA385891025 rs1394921227	258	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1181905344 CA385891038	260	H>Y		No	ClinGen gnomAD
rs752139842 CA6675649	261	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA238191704 rs941930561	261	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs545402235 CA6675650	264	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385891070 rs1288368147	265	E>G		No	ClinGen gnomAD
rs987294602 CA238191759	267	I>M		No	ClinGen TOPMed
rs1403651059 CA385891089	268	R>*		No	ClinGen gnomAD
rs1403651059 CA385891088	268	R>G		No	ClinGen gnomAD
rs756999508 CA6675653	268	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA238191761 rs923758075	271	E>G		No	ClinGen TOPMed gnomAD
rs201048832 CA6675655	274	R>G		No	ClinGen ExAC TOPMed gnomAD
CA238191848 rs150646275	274	R>L		No	ClinGen ESP TOPMed gnomAD
rs150646275 COSM942818 CA238191829	274	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
rs201048832 CA6675656	274	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6675658 rs747024511	278	K>E		No	ClinGen ExAC TOPMed gnomAD
CA6675659 rs769314299	281	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6675660 rs755603146	281	T>R		No	ClinGen ExAC gnomAD
CA238191887 rs149820247	282	M>I		No	ClinGen ESP
CA385891177 rs1484253683	282	M>V		No	ClinGen gnomAD
rs1202032875 CA385891184	283	N>H		No	ClinGen gnomAD
CA385891188 rs1242736782	283	N>S		No	ClinGen gnomAD
CA385891209 rs1417367747	286	H>R		No	ClinGen gnomAD
CA6675665 rs771602708	287	M>K		No	ClinGen ExAC gnomAD
CA6675664 rs759295442	287	M>V		No	ClinGen ExAC gnomAD
CA6675666 rs775106036	288	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA385891233 rs1402440118	290	N>D		No	ClinGen TOPMed
rs1477617122 CA385891249	292	T>A		No	ClinGen gnomAD
CA385891248 rs1477617122	292	T>P		No	ClinGen gnomAD
CA385891252 rs1157672577	292	T>S		No	ClinGen TOPMed
CA6675667 rs760064592	295	N>H		No	ClinGen ExAC gnomAD
CA6675668 VAR_040461 rs56293072	295	N>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6675670 rs761733010 CA385891297	299	M>L		No	ClinGen ExAC TOPMed gnomAD
CA385891298 rs761733010	299	M>V		No	ClinGen ExAC TOPMed gnomAD
rs575789813 CA6675671	300	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6675673 rs758682432	302	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1412777406 CA385891331	304	L>V		No	ClinGen TOPMed gnomAD
rs1221731740 CA385891369	309	Y>S		No	ClinGen gnomAD
CA385891376 rs1262829028	310	E>Q		No	ClinGen gnomAD
CA385891392 rs1279596422	312	I>T		No	ClinGen TOPMed
CA6675677 rs781766417	315	N>K		No	ClinGen ExAC gnomAD
CA385891427 rs1592714401	317	F>L		No	ClinGen Ensembl
rs748735454 CA6675678	321	S>R		No	ClinGen ExAC gnomAD
CA238192005 rs371001500	326	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA385891488 rs371001500	326	R>G		No	ClinGen TOPMed gnomAD
CA6675679 rs770414447	326	R>H		No	ClinGen ExAC gnomAD
rs770414447 CA385891489	326	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6675681 rs749584629	327	K>R		No	ClinGen ExAC gnomAD
rs372007678 CA6675682	328	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA385891531 rs1411974809	329	A>G		No	ClinGen gnomAD
CA6675683 rs774958958	330	H>L		No	ClinGen ExAC gnomAD
CA385891556 rs1292029023	331	S>L		No	ClinGen TOPMed
rs760193763 CA6675684	332	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1592714432 CA385891571	333	L>V		No	ClinGen Ensembl
CA238192058 rs956671053	334	Q>R		No	ClinGen Ensembl
rs140715500 CA6675685	336	L>V		No	ClinGen ESP ExAC TOPMed
rs1453459826 CA385891636	337	D>E		No	ClinGen gnomAD
rs1013657932 CA238192074	337	D>G		No	ClinGen Ensembl
TCGA novel	337	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776105144 CA6675686	338	A>T		No	ClinGen ExAC gnomAD
CA385891665 rs1398608442	340	H>D		No	ClinGen TOPMed
rs776636794 CA6675687	340	H>L		No	ClinGen ExAC gnomAD
CA238192083 rs776636794	340	H>R		No	ClinGen ExAC gnomAD
rs765054404 CA6675688	341	K>R		No	ClinGen ExAC
TCGA novel	345	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867552772 CA238192086	346	H>Y		No	ClinGen Ensembl
TCGA novel	352	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751667499 CA6675692	354	I>V		No	ClinGen ExAC gnomAD
TCGA novel	357	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA238192121 rs1024997230	358	Q>H		No	ClinGen TOPMed
rs1415544661 CA385892321	359	Q>E		No	ClinGen TOPMed
rs761933866 CA6675693	363	G>S		No	ClinGen ExAC gnomAD
CA385892355 rs1472997035	364	I>V		No	ClinGen TOPMed
rs1267222237 CA385892390	369	F>L		No	ClinGen gnomAD
CA385892408 rs1241323221	371	S>F		No	ClinGen TOPMed
CA385892438 rs1175160975	375	E>V		No	ClinGen gnomAD
rs1445530136 CA385892451	377	Q>E		No	ClinGen TOPMed
CA6675696 rs374322116	377	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs756730510 CA6675697	378	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6675698 COSM1363807 rs543503984	378	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs749689088 CA6675699	379	V>I		No	ClinGen ExAC gnomAD
CA6675700 COSM942822 rs757508984	381	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	385	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	386	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768271747 CA6675703	388	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	391	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772964517 CA6675707	398	R>S		No	ClinGen ExAC
CA6675706 rs769792355	398	R>T		No	ClinGen ExAC TOPMed gnomAD
CA385892603 rs1221700522	400	G>D		No	ClinGen gnomAD
CA385892615 rs1327851018	402	P>S		No	ClinGen TOPMed
rs886587503 CA238192202	405	M>I		No	ClinGen TOPMed gnomAD
CA385892638 rs1275229370	405	M>T		No	ClinGen gnomAD
rs981026091 CA238192217	407	S>I		No	ClinGen Ensembl
TCGA novel	409	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762808815 CA385892696	413	A>G		No	ClinGen ExAC gnomAD
rs762808815 CA6675708	413	A>V		No	ClinGen ExAC gnomAD
rs1472923708 CA385892707	415	L>F		No	ClinGen gnomAD
rs766155721 CA6675709	416	L>M		No	ClinGen ExAC gnomAD
CA6675710 rs140246773	417	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6675714 rs369177246	419	Y>C		No	ClinGen ESP ExAC gnomAD
TCGA novel	421	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1392220162 CA385892751	422	L>F		No	ClinGen TOPMed
TCGA novel	426	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380359510 CA385892777	426	D>V		No	ClinGen gnomAD
CA6675720 rs754652492	428	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1415818234 CA385892821	433	C>R		No	ClinGen Ensembl
rs1224337591 CA385892834	434	M>I		No	ClinGen TOPMed
rs1251231036 CA385892832	434	M>T		No	ClinGen TOPMed
CA238192323 rs755504526	435	I>T		No	ClinGen Ensembl
TCGA novel	439	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	439	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747669756 CA6675722	440	M>T		No	ClinGen ExAC gnomAD
rs772776286 CA6675724	443	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1442442913 CA385892893	443	Q>R		No	ClinGen TOPMed gnomAD
CA385892903 rs1240844937	444	K>N		No	ClinGen TOPMed gnomAD
rs1565804953 CA385892908	445	L>R		No	ClinGen Ensembl
rs1028929571 CA238192392	446	L>V		No	ClinGen TOPMed
CA385892915 rs1460296462	447	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs777428293 CA238192405	447	D>Y		No	ClinGen Ensembl
rs749243922 CA6675725	450	K>R		No	ClinGen ExAC TOPMed gnomAD
VAR_040462 rs35688869 CA238192426	451	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen UniProt Ensembl NCI-TCGA dbSNP
rs1476684276 CA385892958	454	N>D		No	ClinGen gnomAD
TCGA novel	454	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs954680330 CA238192445	454	N>K		No	ClinGen TOPMed gnomAD
CA238192436 rs943106175	454	N>S		No	ClinGen Ensembl
CA238192456 rs55774594 VAR_040463	455	F>Y		No	ClinGen UniProt dbSNP gnomAD
rs774328160 CA6675727	456	V>L		No	ClinGen ExAC gnomAD
CA6675728 rs759368728	459	K>E		No	ClinGen ExAC TOPMed gnomAD
CA385892999 rs1370996112	460	G>A		No	ClinGen TOPMed
rs748885684 CA238192465	460	G>S		No	ClinGen gnomAD
CA385893004 rs1327918255	461	Y>C		No	ClinGen TOPMed gnomAD
rs772449209 CA6675729	461	Y>N		No	ClinGen ExAC gnomAD
rs1393303851 CA385893016	463	R>C		No	ClinGen TOPMed
CA238192516 rs573469138	463	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	464	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1269480999 CA385893027	465	C>S		No	ClinGen gnomAD
rs61733656 CA385893039	466	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs61733656 CA6675732	466	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385893051 rs1232806533	468	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1484208488 CA385893060	470	L>F		No	ClinGen TOPMed
rs1484208488 CA385893059	470	L>V		No	ClinGen TOPMed
rs765688297 CA6675735	472	D>G		No	ClinGen ExAC gnomAD
CA6675736 rs750808823	474	S>C		No	ClinGen ExAC gnomAD
CA6675737 rs758703731	475	V>A		No	ClinGen ExAC gnomAD
CA6675738 rs780826338	476	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1209661639 CA385893095	476	V>I		No	ClinGen TOPMed
CA385893135 rs1191720584	479	G>R		No	ClinGen gnomAD
CA385893143 rs1242025281	480	G>S		No	ClinGen gnomAD
CA6675740 rs755779810	481	R>C		No	ClinGen ExAC gnomAD
rs777199119 CA6675741	481	R>H		No	ClinGen ExAC TOPMed gnomAD
CA385893161 rs777199119	481	R>L		No	ClinGen ExAC TOPMed gnomAD
rs200239121 CA6675743	483	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6675742 rs748801595	483	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs77455066 CA238192593	486	K>E		No	ClinGen Ensembl
rs1160117059 CA385893221	486	K>I		No	ClinGen gnomAD
CA385893226 rs778950423	486	K>N		No	ClinGen ExAC TOPMed gnomAD
CA385893263 rs1412074118	490	P>T		No	ClinGen TOPMed gnomAD
rs1331591899 CA385893301	492	E>D		No	ClinGen gnomAD
rs1406629248 CA385893309	493	S>N		No	ClinGen gnomAD
rs56178357 CA385893318	493	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs989198070 CA238192604	496	W>C		No	ClinGen TOPMed
rs1228664271 CA385893358	496	W>S		No	ClinGen gnomAD
rs760852696 CA6675748	498	N>H		No	ClinGen ExAC gnomAD
rs535674843 CA6675750	498	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768889751 CA6675749	498	N>S		No	ClinGen ExAC TOPMed gnomAD
rs765747136 CA6675752	499	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6675753 rs138614034	499	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs766785374 CA6675755	503	C>G		No	ClinGen ExAC TOPMed gnomAD
CA385893447 rs1405916623	503	C>Y		No	ClinGen Ensembl
rs1391114366 CA385893464	504	D>V		No	ClinGen gnomAD
rs751932333 CA6675756	504	D>Y		No	ClinGen ExAC gnomAD
rs919160707 CA238192743	507	L>F		No	ClinGen Ensembl
TCGA novel	507	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755763829 CA6675757	510	D>E		No	ClinGen ExAC gnomAD
COSM3417085 CA6675758 rs777442529	511	F>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs753315158 CA385893576	513	K>R		No	ClinGen ExAC TOPMed gnomAD
rs753315158 CA6675759	513	K>T		No	ClinGen ExAC TOPMed gnomAD
CA6675761 rs535142121	514	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
CA6675762 rs745870753	517	E>K		No	ClinGen ExAC gnomAD
TCGA novel	518	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385893669 rs1237799158	519	D>N		No	ClinGen gnomAD
rs1281526619 CA385893714	521	A>S		No	ClinGen TOPMed
CA385893730 rs1351055632	522	V>A		No	ClinGen TOPMed
TCGA novel	523	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780031437 COSM416101 CA6675764	523	R>H	kidney urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	524	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385893760 rs1290177833	524	M>V		No	ClinGen TOPMed gnomAD
rs1592714818 CA385893803	526	P>A		No	ClinGen Ensembl
CA385893820 rs1196436890	527	G>A		No	ClinGen TOPMed gnomAD
rs776854870 CA6675767 CA6675768	528	Q>H		No	ClinGen ExAC gnomAD
rs910196972 CA238192809	528	Q>R		No	ClinGen Ensembl
rs769926495 CA6675769	529	A>P		No	ClinGen ExAC gnomAD
rs773264334 COSM3812867 CA6675770	531	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA238192862 rs867420742	531	R>W		No	ClinGen TOPMed gnomAD
CA238192893 rs936839760	533	P>S		No	ClinGen TOPMed gnomAD
rs1164918558 CA385893974	536	R>S		No	ClinGen TOPMed
rs188321581 CA6675774	538	R>Q		No	ClinGen ExAC gnomAD
COSM356727 CA6675773 rs774611484	538	R>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs753467166 CA6675778	545	G>R		No	ClinGen ExAC gnomAD
rs1249894970 CA385894078	545	G>V		No	ClinGen TOPMed gnomAD
rs753467166 CA6675777	545	G>W		No	ClinGen ExAC gnomAD
rs575700478 CA6675779	548	T>M		No	ClinGen ExAC gnomAD
CA6675781 rs758437734	550	V>A		No	ClinGen ExAC gnomAD
rs1239810338 CA385894146	551	K>E		No	ClinGen TOPMed
CA6675783 rs577987133	554	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385894215 rs1253174889	555	E>D		No	ClinGen gnomAD
rs1565805244 CA385894202	555	E>Q		No	ClinGen Ensembl
rs754735753 CA6675784	557	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754735753 CA385894240	557	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6675786 rs748460025	558	G>S		No	ClinGen ExAC gnomAD
rs769979169 CA6675787	558	G>V		No	ClinGen ExAC gnomAD
CA6675788 rs369329175	561	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6675790 rs771451192	563	I>M		No	ClinGen ExAC gnomAD
rs749326516 CA6675789	563	I>V		No	ClinGen ExAC gnomAD
CA6675791 rs774866895	567	P>L		No	ClinGen ExAC gnomAD
rs767994749 CA6675793	568	P>L		No	ClinGen ExAC gnomAD
rs373302349 CA6675792	568	P>S		No	ClinGen ESP ExAC gnomAD
rs1565805288 CA385894364	569	P>S		No	ClinGen Ensembl
CA238193024 rs544724491	570	S>C		No	ClinGen TOPMed gnomAD
rs544724491 CA238193032	570	S>F		No	ClinGen TOPMed gnomAD
rs138264226 CA6675794	570	S>T		No	ClinGen ESP ExAC gnomAD
CA385894393 rs1454973785	571	S>I		No	ClinGen TOPMed gnomAD
CA385894431 rs1361505810	574	S>C		No	ClinGen TOPMed
CA385894446 rs1383304882	575	K>I		No	ClinGen TOPMed gnomAD
CA385894510 rs1324814676	579	N>D		No	ClinGen gnomAD
rs749972090 CA6675797	581	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1325747299 CA385894596	583	M>T		No	ClinGen TOPMed
rs1392417267 CA385894583	583	M>V		No	ClinGen gnomAD
rs1456842370 CA385894629	584	T>P		No	ClinGen TOPMed
rs1325933269 CA385894667	585	D>V		No	ClinGen gnomAD
CA385894709 rs1592714941	587	N>S		No	ClinGen Ensembl
CA6675800 rs751580966	590	I>M		No	ClinGen ExAC
CA385894790 rs1370520694	593	R>K		No	ClinGen TOPMed
TCGA novel	593	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747908377 CA6675803	595	V>E		No	ClinGen ExAC gnomAD
CA385894857 rs1592714957	598	K>E		No	ClinGen Ensembl
CA385894870 rs1428340864	599	L>V		No	ClinGen TOPMed
rs1427465540 CA385894906	601	S>R		No	ClinGen gnomAD
CA238193106 rs759178764	602	S>C		No	ClinGen Ensembl

No associated diseases with Q92630

3 regional properties for Q92630

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	222 - 535	IPR000719
active_site	Serine/threonine-protein kinase, active site	344 - 356	IPR008271
binding_site	Protein kinase, ATP binding site	228 - 251	IPR017441

Functions

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	Cytoplasm Nucleus	Translocates into the nucleus following DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.
ubiquitin ligase complex	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding	Binding to a magnesium (Mg) ion.
manganese ion binding	Binding to a manganese ion (Mn).
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

9 GO annotations of biological process

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
negative regulation of calcineurin-NFAT signaling cascade	Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of glycogen biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
smoothened signaling pathway	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (Human)	PR
Q9H422	HIPK3	Homeodomain-interacting protein kinase 3	Homo sapiens (Human)	SS
Q8NE63	HIPK4	Homeodomain-interacting protein kinase 4	Homo sapiens (Human)	PR
Q9H2X6	HIPK2	Homeodomain-interacting protein kinase 2	Homo sapiens (Human)	EV
Q9NR20	DYRK4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens (Human)	PR
Q8BI55	Dyrk4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Mus musculus (Mouse)	PR
Q3V016	Hipk4	Homeodomain-interacting protein kinase 4	Mus musculus (Mouse)	PR
Q61214	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (Mouse)	PR
Q9QZR5	Hipk2	Homeodomain-interacting protein kinase 2	Mus musculus (Mouse)	SS
Q4V793	Hipk4	Homeodomain-interacting protein kinase 4	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MLTRKPSAAA	PAAYPTGRGG	DSAVRQLQAS	PGLGAGATRS	GVGTGPPSPI	ALPPLRASNA
70	80	90	100	110	120
AAAAHTIGGS	KHTMNDHLHV	GSHAHGQIQV	QQLFEDNSNK	RTVLTTQPNG	LTTVGKTGLP
130	140	150	160	170	180
VVPERQLDSI	HRRQGSSTSL	KSMEGMGKVK	ATPMTPEQAM	KQYMQKLTAF	EHHEIFSYPE
190	200	210	220	230	240
IYFLGLNAKK	RQGMTGGPNN	GGYDDDQGSY	VQVPHDHVAY	RYEVLKVIGK	GSFGQVVKAY
250	260	270	280	290	300
DHKVHQHVAL	KMVRNEKRFH	RQAAEEIRIL	EHLRKQDKDN	TMNVIHMLEN	FTFRNHICMT
310	320	330	340	350	360
FELLSMNLYE	LIKKNKFQGF	SLPLVRKFAH	SILQCLDALH	KNRIIHCDLK	PENILLKQQG
370	380	390	400	410	420
RSGIKVIDFG	SSCYEHQRVY	TYIQSRFYRA	PEVILGARYG	MPIDMWSLGC	ILAELLTGYP
430	440	450	460	470	480
LLPGEDEGDQ	LACMIELLGM	PSQKLLDASK	RAKNFVSSKG	YPRYCTVTTL	SDGSVVLNGG
490	500	510	520	530	540
RSRRGKLRGP	PESREWGNAL	KGCDDPLFLD	FLKQCLEWDP	AVRMTPGQAL	RHPWLRRRLP
550	560	570	580	590	600
KPPTGEKTSV	KRITESTGAI	TSISKLPPPS	SSASKLRTNL	AQMTDANGNI	QQRTVLPKLV

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