Q924U5
Gene name |
Tesk2 |
Protein name |
Dual specificity testis-specific protein kinase 2 |
Names |
Testicular protein kinase 2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:170908 |
EC number |
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
196-221 (Activation loop from InterPro)
Target domain |
58-335 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q924U5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q924U5-F1 | Predicted | AlphaFoldDB |
No variants for Q924U5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q924U5 | |||||
No associated diseases with Q924U5
4 regional properties for Q924U5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 58 - 313 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 61 - 308 | IPR001245 |
| active_site | Tyrosine-protein kinase, active site | 172 - 184 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 64 - 87 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.1 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q96S53 | TESK2 | Dual specificity testis-specific protein kinase 2 | Homo sapiens (Human) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8VCT9 | Tesk2 | Dual specificity testis-specific protein kinase 2 | Mus musculus (Mouse) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRSKRNSIA | GFPPRVERLE | EFEGGGGGDG | NTVQVGRVSS | SSYRAIISAF | SRLTSLDDFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REKIGSGFFS | EVFKVRHRAS | GQVMALKMNT | LSSNRANLLK | EMQLMNRLSH | PNILRFMGVC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VHQGQLHALT | EYINSGNLEQ | LLDSNLYLPW | TVRVKLAYDI | AVGLSYLHFK | GIFHRDLTSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NCLIKRDENG | YSAVVADFGL | AEKIPDASIG | SEKLAVVGSP | FWMAPEVLRD | EPYNEKADVF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SYGIILCEII | ARIQADPDYL | PRTENFGLDY | DAFQHMVGDC | PSDFLQLTFN | CCNMDPKLRP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFEEIGKTLE | EIMSRLQEEE | LERDRKLQPT | AKGLLEKVPG | GKRLSSLDDK | IPHKSPRPRR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TIWLSRSQSD | IFSRKPPRTV | NVLDPYYQPR | DGATHTPKVN | PFSARQDLKG | GKVKFFDLPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KSVISLVFDL | DAPGPGTVSL | ADCQEPLAPS | SRRWRSLPGS | PEFLHQACPF | VGCEESLSDG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPPRLSSLKY | RVREIPPFRT | SALSATSAHE | AMDCSNPQEE | NGFVPRPKGT | SPCSGAASEE |
| 550 | 560 | ||||
| MEVEEERPRR | APVHFSISGI | SLQTQGEQDG |