Q924I2

PR
Gene name
Map4k3
Protein name
Mitogen-activated protein kinase kinase kinase kinase 3
Names
Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:170920
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

388-540 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

153-176 (Activation loop from InterPro)

Target domain

16-273 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q924I2

Entry ID Method Resolution Chain Position Source
AF-Q924I2-F1 Predicted AlphaFoldDB

2 variants for Q924I2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3320730899 370 G>V No EVA
rs3320748707 596 V>I No EVA

No associated diseases with Q924I2

4 regional properties for Q924I2

Type Name Position InterPro Accession
domain Helicase, C-terminal 377 - 536 IPR001650
domain DEAD/DEAH box helicase domain 152 - 337 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 147 - 365 IPR014001
domain RNA helicase, DEAD-box type, Q motif 126 - 156 IPR014014

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to tumor necrosis factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens (Human) PR
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens (Human) EV
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens (Human) EV
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens (Human) SS
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
P70218 Map4k1 Mitogen-activated protein kinase kinase kinase kinase 1 Mus musculus (Mouse) PR
Q8BPM2 Map4k5 Mitogen-activated protein kinase kinase kinase kinase 5 Mus musculus (Mouse) PR
Q99JP0 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Mus musculus (Mouse) SS
O88506 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Rattus norvegicus (Rat) PR
B0LT89 Stk24 Serine/threonine-protein kinase 24 Rattus norvegicus (Rat) PR
E9PTG8 Stk10 Serine/threonine-protein kinase 10 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ
70 80 90 100 110 120
EIIMMKDCKH ANIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET
130 140 150 160 170 180
LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP
190 200 210 220 230 240
EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKL
250 260 270 280 290 300
KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQPLTRS LAIELLDKVN NPDHSTYHDF
310 320 330 340 350 360
DDDDPEPLVA VPHRIPSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH ELDLQLEYGQ
370 380 390 400 410 420
GHQSNYFLGG NKSLLKSVEE ELHQRGHVAH LEDDEGDDDD SKHSTLKAKV PPPLPPKPKS
430 440 450 460 470 480
ISIPQDTHSS EDSNQGTIKR CPSSGSPAKP SHVPPRPPPP RLPPQKPAVL GNGVSSFQLN
490 500 510 520 530 540
GERDGSVHQQ QSEQRGTNLS RKEKKDVPKP ISNGLPPTPK VHMGACFSKV FNGCPLKIHC
550 560 570 580 590 600
ATSWINPDTR DQYLIFGAEE GIYTLNLNEL HETSMEQLFP RRCTWLYVMN NCLLSVSGKA
610 620 630 640 650 660
SQLYSHNLPG LFDYARQMQK LPVAIPAHKL PDRILPRKFA VSAKIPETKW CQKCCVVRNP
670 680 690 700 710 720
YTGHKYLCGA LQTSIVLLEW VEPMQKFMLI KHIEFPMPCP LRMFEMLVVP EQEYPLVCVG
730 740 750 760 770 780
VSRGRDFNQV VRFETVNPNS TSSWFTESDT PQTNVTHVTQ LERDTILVCL DCCIKIVNLQ
790 800 810 820 830 840
GRLKSSRKLS SELTFDFQIE SIVCLQDSVL AFWKHGMQGR SFRSNEVTQE ISDNTRIFRL
850 860 870
LGSDRVVVLE SRPTDNPTAN SNLYILAGHE NSY