AiPD: Autoinhibited Protein Database

Q92499

Gene name	DDX1
Protein name	ATP-dependent RNA helicase DDX1
Names	DEAD box protein 1, DEAD box protein retinoblastoma, DBP-RB
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1653
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-112 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

38-112 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q92499

Entry ID	Method	Resolution	Chain	Position	Source
4XW3	X-ray	200 A	A/B	72-283	PDB
8TBX	X-ray	271 A			PDB
AF-Q92499-F1	Predicted				AlphaFoldDB

477 variants for Q92499

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA42639162 rs761476299	2	A>V		No	ClinGen TOPMed gnomAD
CA345881639 rs1442129612	3	A>T		No	ClinGen TOPMed gnomAD
rs10165091 CA42639175	4	F>L		No	ClinGen ExAC TOPMed gnomAD
CA345881670 rs1406348283	5	S>C		No	ClinGen TOPMed gnomAD
CA345881671 rs1406348283	5	S>F		No	ClinGen TOPMed gnomAD
rs1182259235 CA345881666	5	S>T		No	ClinGen TOPMed
rs775600567 CA1537318	7	M>V		No	ClinGen ExAC gnomAD
rs1208606375 CA345883089	9	V>I		No	ClinGen gnomAD
CA1537319 rs201662298	10	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA42641638 rs879086962	11	P>L		No	ClinGen Ensembl
rs764339515 CA1537320	12	E>G		No	ClinGen ExAC gnomAD
rs766871564 CA42641645	12	E>Q		No	ClinGen Ensembl
rs201230296 CA1537321	13	I>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1422253406 CA345883992	15	Q>E		No	ClinGen TOPMed
CA1537323 rs199880652	17	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1246889545 CA345884072	18	E>Q		No	ClinGen gnomAD
CA1537324 rs750891600	19	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1181084423 CA345884147	20	M>V		No	ClinGen TOPMed
CA345884166 rs946814111	21	D>H		No	ClinGen gnomAD
CA42641655 rs946814111	21	D>N		No	ClinGen gnomAD
rs750850002 CA1537342	24	L>F		No	ClinGen ExAC gnomAD
rs147696327 CA1537343	26	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA345884528 rs1236045021	26	T>S		No	ClinGen TOPMed
CA1537344 rs766957264	30	A>D		No	ClinGen ExAC TOPMed gnomAD
rs1332134200 CA345884666	30	A>P		No	ClinGen TOPMed
CA42641969 rs571665866	31	E>A		No	ClinGen Ensembl
rs754483644 CA1537346	32	S>A		No	ClinGen ExAC gnomAD
CA1537348 rs2302929	35	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs996518951 CA42642033	36	I>F		No	ClinGen TOPMed
rs1426998859 CA345884891	38	G>V		No	ClinGen gnomAD
CA1537350 rs777404346	43	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1466514648 CA345884995	44	M>T		No	ClinGen TOPMed
TCGA novel	55	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345885326 rs1336837148	57	S>C		No	ClinGen TOPMed
TCGA novel	57	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1537386 rs11550369	61	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1537387 rs763523667	63	I>M		No	ClinGen ExAC gnomAD
rs753461061 CA1537388	64	V>F		No	ClinGen ExAC gnomAD
CA1537389 rs368985586	65	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1318805337 CA345885376	65	Y>N		No	ClinGen gnomAD
rs1558450549 CA345885408	67	T>I		No	ClinGen Ensembl
CA1537390 rs764996490	68	L>V		No	ClinGen ExAC gnomAD
rs1480289544 CA345885426	69	K>E		No	ClinGen TOPMed gnomAD
CA345885502 rs1333933064	72	Q>H		No	ClinGen gnomAD
CA1537391 rs750259842	73	E>K		No	ClinGen ExAC gnomAD
rs758221603 CA1537392	74	G>D		No	ClinGen ExAC gnomAD
TCGA novel	77	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel rs751468588 CA1537394	77	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
CA345885636 rs1418567211	79	T>I		No	ClinGen TOPMed
CA345885648 rs1558450568	80	T>R		No	ClinGen Ensembl
CA42643593 rs977034772	81	I>M		No	ClinGen Ensembl
CA345885656 rs1464436328	81	I>V		No	ClinGen gnomAD
rs553463267 CA42643594	82	K>R		No	ClinGen Ensembl
rs777785275 CA1537397	84	G>D		No	ClinGen ExAC gnomAD
rs749505330 CA1537398	85	A>G		No	ClinGen ExAC gnomAD
CA345887353 rs1228564172	91	W>L		No	ClinGen TOPMed
TCGA novel	92	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345887391 rs1361542771	93	M>I		No	ClinGen gnomAD
CA345887386 rs1200019793	93	M>R		No	ClinGen gnomAD
CA1537413 rs377594537	93	M>V		No	ClinGen ESP ExAC gnomAD
rs777884030 CA1537415	95	P>A		No	ClinGen ExAC gnomAD
CA1537416 rs754007875	96	Y>N		No	ClinGen ExAC gnomAD
CA345887461 rs1305700255	97	D>E		No	ClinGen gnomAD
CA1537419 rs779224512	100	S>C		No	ClinGen ExAC TOPMed gnomAD
CA1537418 rs779224512	100	S>F		No	ClinGen ExAC TOPMed gnomAD
rs531560941 CA1537430	104	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1233607382 CA345888707	104	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA345888736 rs1352684635	105	G>R		No	ClinGen TOPMed gnomAD
rs759483708 CA1537432	107	D>G		No	ClinGen ExAC gnomAD
rs1451867567 CA345888805	108	G>S		No	ClinGen gnomAD
rs1215157934 CA345888837	109	L>H		No	ClinGen gnomAD
CA345888930 rs1250695716	111	C>*		No	ClinGen gnomAD
rs767314009 CA1537433	112	Q>P		No	ClinGen ExAC gnomAD
rs1178422592 CA345889016	114	R>I		No	ClinGen TOPMed
rs1178422592 CA345889012	114	R>K		No	ClinGen TOPMed
TCGA novel	117	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472019387 CA345889168	118	E>Q		No	ClinGen TOPMed gnomAD
CA1537436 rs373201659	125	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1537435 rs373201659	125	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA345889534 rs1176323527	126	K>E		No	ClinGen TOPMed
rs1471433374 CA345889566	127	G>R		No	ClinGen TOPMed gnomAD
CA1537439 rs541637062	130	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA345890563 rs1416401709	131	G>E		No	ClinGen gnomAD
rs1303504352 CA345890603	133	H>Q		No	ClinGen gnomAD
rs1218827574 CA345890600	133	H>R		No	ClinGen gnomAD
rs1354498662 CA345890595	133	H>Y		No	ClinGen TOPMed gnomAD
CA1537461 rs552466839	134	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs192868487 CA345890654	135	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1537462 rs192868487	135	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA345890645 rs1336906997	135	Y>H		No	ClinGen TOPMed gnomAD
rs1486278039 CA345890711	137	V>L		No	ClinGen gnomAD
rs748642812 CA1537464	138	S>Y		No	ClinGen ExAC gnomAD
CA42648015 rs200330218	139	C>F		No	ClinGen Ensembl
CA345890757 rs1255814704	140	H>D		No	ClinGen gnomAD
CA1537467 rs748704428	145	C>R		No	ClinGen ExAC gnomAD
CA1537469 rs556274301	146	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA42648046 rs909561510	146	R>T		No	ClinGen TOPMed
rs771988190 CA1537471	148	G>R		No	ClinGen ExAC gnomAD
CA1537473 rs760665184	149	W>C		No	ClinGen ExAC gnomAD
rs775481415 CA1537472	149	W>G		No	ClinGen ExAC gnomAD
CA1537474 rs768676344	152	M>V		No	ClinGen ExAC gnomAD
CA345891065 rs1297315212	157	D>G		No	ClinGen gnomAD
CA345891071 rs1215241235	158	L>I		No	ClinGen TOPMed
CA345891077 rs1486988796	158	L>P		No	ClinGen TOPMed
rs1324261817 CA345891083	159	G>R		No	ClinGen gnomAD
TCGA novel	172	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373674722 CA42648414	175	H>L		No	ClinGen ESP gnomAD
rs1381273262 CA345891509	175	H>Y		No	ClinGen gnomAD
rs746753084 CA1537493	176	N>K		No	ClinGen ExAC gnomAD
rs1301879917 CA345891593	178	Q>K		No	ClinGen gnomAD
CA1537494 rs140238349	184	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781101961 CA1537512	186	F>S		No	ClinGen ExAC
CA345891997 CA1537513 rs201032703	188	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1248274132 CA345891983	188	M>V		No	ClinGen gnomAD
CA345892012 rs1295131054	189	H>R		No	ClinGen gnomAD
TCGA novel	190	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345892058 rs1188315745	191	T>N		No	ClinGen gnomAD
CA42648804 rs937240253	192	I>T		No	ClinGen Ensembl
CA1537514 rs769814818	192	I>V		No	ClinGen ExAC gnomAD
rs898033311 CA42648807	195	Y>H		No	ClinGen TOPMed
rs577309697 CA1537515	198	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1055665221 CA42648818	198	I>V		No	ClinGen Ensembl
CA42648831 rs745895894	200	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1537516 rs745895894	200	K>T		No	ClinGen ExAC TOPMed gnomAD
CA42648833 rs566964575	201	G>R		No	ClinGen TOPMed
CA1537518 rs137946800	203	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866060575 CA345892341	206	S>C		No	ClinGen TOPMed
CA42648860 rs866060575	206	S>F		No	ClinGen TOPMed
CA345892337 rs1371728012	206	S>T		No	ClinGen gnomAD
rs199550453 CA42650309	209	G>V		No	ClinGen 1000Genomes
CA1537552 rs752422924	211	D>G		No	ClinGen ExAC TOPMed gnomAD
rs376500579 CA1537550	211	D>H		No	ClinGen ESP ExAC gnomAD
CA1537551 rs752422924	211	D>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	211	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1454294029 CA345892804	212	L>I		No	ClinGen gnomAD
rs1174850621 CA345892829	213	G>R		No	ClinGen gnomAD
rs1174850621 CA345892822	213	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1317843134 CA345892841	213	G>V		No	ClinGen TOPMed
TCGA novel	217	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1537554 rs371333614	218	I>L		No	ClinGen ESP ExAC gnomAD
CA1537555 rs184905286	218	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs777609261 CA1537557	220	P>S		No	ClinGen ExAC gnomAD
rs753759700 CA1537558	221	H>L		No	ClinGen ExAC TOPMed gnomAD
CA345892905 rs1227060875	221	H>N		No	ClinGen TOPMed
rs753759700 CA1537559	221	H>R		No	ClinGen ExAC TOPMed gnomAD
CA1537560 rs780075692	222	M>K		No	ClinGen ExAC gnomAD
CA42650387 rs866965172	222	M>V		No	ClinGen gnomAD
CA42650391 rs777276949	223	K>I		No	ClinGen Ensembl
rs1441681422 CA345892927	224	N>H		No	ClinGen gnomAD
CA345892943 rs1305544250	226	A>S		No	ClinGen TOPMed gnomAD
rs781409965 CA1537563	227	L>H		No	ClinGen ExAC gnomAD
rs768639324 CA1537562	227	L>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	229	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748385724 CA1537564	231	C>S		No	ClinGen ExAC gnomAD
rs1213239069 CA345892989	233	L>F		No	ClinGen gnomAD
CA1537565 rs770182865	234	K>R		No	ClinGen ExAC gnomAD
rs781189569 CA1537580	235	N>T		No	ClinGen ExAC gnomAD
CA345893090 rs1269781934	241	N>H		No	ClinGen Ensembl
rs770183528 CA1537582	241	N>K		No	ClinGen ExAC TOPMed gnomAD
CA1537585 rs771440165	243	G>S		No	ClinGen ExAC TOPMed gnomAD
CA1537586 rs774850505	245	E>D		No	ClinGen ExAC gnomAD
CA1537588 rs760023774	246	E>K		No	ClinGen ExAC gnomAD
CA1537587 rs760023774	246	E>Q		No	ClinGen ExAC gnomAD
CA1537589 rs774909861	249	F>S		No	ClinGen ExAC gnomAD
rs537632009 CA42650568	251	P>A		No	ClinGen TOPMed
rs1388696120 CA345893261	251	P>L		No	ClinGen gnomAD
CA42650578 rs537632009	251	P>S		No	ClinGen TOPMed
CA42650585 rs916125332	254	G>D		No	ClinGen Ensembl
CA1537590 rs140834826	255	F>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1287480010 CA345893346	256	V>G		No	ClinGen gnomAD
rs753510952 CA1537592	257	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs151049117 CA42650603	259	S>P		No	ClinGen 1000Genomes
CA345893392 rs1414302428	260	K>Q		No	ClinGen gnomAD
rs761538583 CA1537593	260	K>R		No	ClinGen ExAC gnomAD
rs750361299 CA1537595	261	A>G		No	ClinGen ExAC TOPMed gnomAD
rs144722775 CA1537594	261	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1537598 rs575508622	262	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs575508622 CA1537597	262	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749521700 CA1537601	263	D>Y		No	ClinGen ExAC gnomAD
rs1290865594 CA345893494	266	I>L		No	ClinGen Ensembl
CA345893502 rs568577067	266	I>N		No	ClinGen ExAC TOPMed gnomAD
CA1537602 rs568577067	266	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1537603 rs779201232	267	V>A		No	ClinGen ExAC gnomAD
CA345893531 rs1304384791	268	K>N		No	ClinGen gnomAD
CA1537604 rs746361180	271	H>Y		No	ClinGen ExAC gnomAD
rs762841049 CA1537613	273	G>D		No	ClinGen ExAC TOPMed gnomAD
CA345894016 rs762841049	273	G>V		No	ClinGen ExAC TOPMed gnomAD
rs958527959 CA42651317	277	V>G		No	ClinGen TOPMed
rs1447685055 CA345894049	278	T>I		No	ClinGen gnomAD
CA345894050 rs1167920388	279	Q>K		No	ClinGen gnomAD
TCGA novel	281	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751531563 CA1537615	281	K>R		No	ClinGen ExAC gnomAD
rs764331933 CA1537617	284	P>S		No	ClinGen ExAC gnomAD
CA345894085 rs764331933	284	P>T		No	ClinGen ExAC gnomAD
CA1537618 rs754095607	285	N>D		No	ClinGen ExAC gnomAD
rs367564124 CA1537619	285	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	286	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1537620 rs199998875	286	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA345894102 rs1433624339	287	P>A		No	ClinGen gnomAD
rs746176610 CA1537621 COSM181656	287	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1237044183 CA345894118	289	A>G		No	ClinGen gnomAD
CA345894121 rs1312427926	290	L>V		No	ClinGen TOPMed gnomAD
rs768141062 CA1537625	291	I>L		No	ClinGen ExAC TOPMed gnomAD
CA345894166 rs1301592031	295	S>F		No	ClinGen TOPMed
rs1463608037 CA345894169	296	R>Q		No	ClinGen gnomAD
rs146433321 CA1537626	296	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA345894238 rs1271731310	301	Q>*		No	ClinGen TOPMed
CA1537629 rs547863300	304	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA345894286 rs1376834613	305	N>D		No	ClinGen TOPMed gnomAD
rs766205642 CA1537631	306	I>V		No	ClinGen ExAC gnomAD
CA345894331 rs1385914831	308	Q>E		No	ClinGen gnomAD
CA345894343 rs1158501511	309	F>L		No	ClinGen TOPMed gnomAD
rs1456303550 CA345894399	312	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs370508427 CA1537633	313	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1389008261 CA345894424	314	D>N		No	ClinGen gnomAD
rs944030023 CA42651436	315	N>S		No	ClinGen TOPMed
CA345894521 rs1190941868	319	R>T		No	ClinGen TOPMed
rs753554770 CA42655761	321	L>F		No	ClinGen Ensembl
rs568982612 CA1537673	322	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs781623484 CA1537674	326	G>V		No	ClinGen ExAC TOPMed gnomAD
CA345895315 rs1453220246	329	A>D		No	ClinGen TOPMed
rs201761924 CA42655774	330	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1313727702 CA345895318 COSM1325851	330	R>Q	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs201761924 COSM1738714 CA1537675	330	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1226747930 CA345895335	332	Q>H		No	ClinGen TOPMed gnomAD
CA345895339 rs1312055064	333	L>F		No	ClinGen gnomAD
CA1537677 rs148306980	333	L>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs748866077 CA1537678	337	E>A		No	ClinGen ExAC gnomAD
rs778737731 CA1537680	339	G>E		No	ClinGen ExAC TOPMed gnomAD
CA1537704 rs768599636	340	V>A		No	ClinGen ExAC gnomAD
rs749333619 CA345896205	342	I>K		No	ClinGen ExAC gnomAD
rs749333619 CA1537706	342	I>T		No	ClinGen ExAC gnomAD
CA345896218 rs1218361018	344	V>A		No	ClinGen TOPMed gnomAD
rs1365269588 CA345896215	344	V>L		No	ClinGen gnomAD
CA1537708 rs774555403	347	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1266914881 CA345896234	347	P>S		No	ClinGen gnomAD
rs1252507841 CA345896257	351	D>N		No	ClinGen TOPMed
CA345896291 rs1413066700	356	T>A		No	ClinGen TOPMed gnomAD
rs377091883 CA42658060	360	N>Y		No	ClinGen Ensembl
CA345896325 rs1473679630	361	L>S		No	ClinGen gnomAD
CA1537712 rs376584969	362	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA345896338 rs1388026965	363	Q>R		No	ClinGen gnomAD
CA345896356 rs1461994422	366	F>L		No	ClinGen gnomAD
CA345896425 rs1344764437	374	G>R		No	ClinGen gnomAD
rs772246112 CA1537728	379	G>D		No	ClinGen ExAC gnomAD
CA345896463 rs1251441114	380	Y>C		No	ClinGen gnomAD
CA345896494 rs1443182579	384	I>T		No	ClinGen TOPMed gnomAD
CA1537730 rs199675013	387	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1245286617 CA345896516	387	M>R		No	ClinGen TOPMed
rs983830054 CA42658553	389	N>S		No	ClinGen gnomAD
CA345896541 rs1391873446 COSM476055	390	Q>H	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA345896544 rs1283102763	391	I>V		No	ClinGen TOPMed
rs764818337 CA1537734	393	Q>*		No	ClinGen ExAC gnomAD
rs1397397612 CA345896567	394	V>A		No	ClinGen gnomAD
rs991012234 CA42658616	394	V>L		No	ClinGen Ensembl
CA1537735 rs749912888	395	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1430738419 CA345896590	398	G>E		No	ClinGen TOPMed gnomAD
TCGA novel	400	R>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	400	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146515867 CA1537737 COSM570654	400	R>T	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA345896982 rs1208066678	403	V>A		No	ClinGen gnomAD
rs1463561551 CA345896975	403	V>M		No	ClinGen gnomAD
CA1537754 rs142039776	404	I>M		No	ClinGen ESP ExAC gnomAD
rs1434703372 CA345896998	405	V>I		No	ClinGen gnomAD
CA345897080 rs1472697585	411	H>R		No	ClinGen gnomAD
CA345897076 rs1573048857	411	H>Y		No	ClinGen Ensembl
rs767307613 CA1537757	414	D>G		No	ClinGen ExAC gnomAD
CA345897119 COSM1007995 rs1385838860	414	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA345897131 rs1253937214	415	V>I		No	ClinGen TOPMed
CA345897162 rs1388954268	417	K>Q		No	ClinGen gnomAD
CA345897183 rs1321951921	418	L>Q		No	ClinGen gnomAD
CA345897221 rs1237782286	421	K>E		No	ClinGen gnomAD
rs140166845 CA1537762	422	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA345897248 rs1327170253	423	M>V		No	ClinGen gnomAD
CA345897274 rs1161352665	424	H>R		No	ClinGen gnomAD
TCGA novel	426	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345897341 COSM40013 rs1266025847	429	V>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1266025847 CA345897343	429	V>L		No	ClinGen gnomAD
TCGA novel	431	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147728753 CA345897431	435	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1537764 rs147728753	435	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1161011326 CA345897448	436	S>C		No	ClinGen TOPMed gnomAD
rs376947292 CA1537766	437	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs770285687 CA1537768	440	T>S		No	ClinGen ExAC gnomAD
rs1438055578 CA345897509	441	V>L		No	ClinGen TOPMed
rs891689465 CA42660136	444	V>L		No	ClinGen TOPMed gnomAD
CA1537772 rs773770521	445	V>I		No	ClinGen ExAC gnomAD
CA42660144 rs1029494543	446	V>A		No	ClinGen TOPMed
CA1537775 rs767032016	449	N>H		No	ClinGen ExAC gnomAD
CA1537774 rs767032016	449	N>Y		No	ClinGen ExAC gnomAD
rs1177959325 CA345897619	450	P>T		No	ClinGen TOPMed
CA345897631 rs1410750774	451	K>E		No	ClinGen TOPMed gnomAD
CA345897638 rs760398181	451	K>R		No	ClinGen ExAC TOPMed gnomAD
rs760398181 CA1537776	451	K>T		No	ClinGen ExAC TOPMed gnomAD
CA1537777 rs763944785	453	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1537778 rs753763793	454	R>K		No	ClinGen ExAC gnomAD
CA1537779 rs757191221	456	W>R		No	ClinGen ExAC gnomAD
CA42660217 rs1021479352	458	R>G		No	ClinGen gnomAD
rs766451073 CA1537780	459	L>H		No	ClinGen ExAC gnomAD
rs751544101 CA1537781	460	G>E		No	ClinGen ExAC gnomAD
CA345897711 rs1467161519	461	K>N		No	ClinGen TOPMed
rs1006939598 CA42660228	463	H>R		No	ClinGen TOPMed
CA345897728 rs1342620510	464	I>V		No	ClinGen gnomAD
CA42660744 rs763790527	467	D>G		No	ClinGen Ensembl
rs1558458561 CA345897766	468	D>N		No	ClinGen Ensembl
rs767762546 CA1537802	469	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1558458568 CA345897790	471	A>G		No	ClinGen Ensembl
rs752942556 CA1537804	472	K>E		No	ClinGen ExAC gnomAD
CA1537805 rs756442471	473	D>G		No	ClinGen ExAC gnomAD
TCGA novel	473	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345897816 rs1259188059	475	T>A		No	ClinGen Ensembl
rs1464666031 CA345897818	475	T>I		No	ClinGen gnomAD
rs1336126402 CA345897827	476	R>S		No	ClinGen gnomAD
CA345897824 rs1270073034	476	R>T		No	ClinGen TOPMed
rs749562135 CA1537807	478	G>V		No	ClinGen ExAC gnomAD
TCGA novel	479	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1295264073 CA345897849	480	N>S		No	ClinGen gnomAD
CA345897866 rs1573049360	482	P>L		No	ClinGen Ensembl
CA1537828 rs752140647	484	M>L		No	ClinGen ExAC gnomAD
rs755375571 CA1537829	485	W>C		No	ClinGen ExAC gnomAD
CA345898119 rs1222834302	486	S>C		No	ClinGen gnomAD
rs750873356 CA1537830	488	A>G		No	ClinGen ExAC gnomAD
CA345898151 rs1426536129	489	I>L		No	ClinGen TOPMed
CA345898158 rs1190958879	489	I>T		No	ClinGen TOPMed
rs1489969037 CA345898173	490	K>T		No	ClinGen TOPMed
rs1198973265 CA345898192	491	I>M		No	ClinGen gnomAD
CA42662147 rs1042254947	494	G>E		No	ClinGen TOPMed gnomAD
CA345898207 rs1461255538	494	G>R		No	ClinGen Ensembl
rs758946709 CA1537831	498	V>I		No	ClinGen ExAC TOPMed gnomAD
CA1537832 rs758946709	498	V>L		No	ClinGen ExAC TOPMed gnomAD
CA345898238 rs1166773972	499	R>Q		No	ClinGen gnomAD
CA42662178 rs780158807	499	R>W		No	ClinGen gnomAD
rs746473980 CA1537833	501	I>M		No	ClinGen ExAC gnomAD
rs371887533 CA1537834	503	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs780702989 CA1537835	504	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1308316556 CA345898270	504	H>Y		No	ClinGen gnomAD
rs1278421903 CA345898292	507	D>N		No	ClinGen gnomAD
rs149350581 CA1537838	510	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1357759250 CA345898341	512	F>L		No	ClinGen TOPMed gnomAD
CA42662208 rs868656378	513	C>S		No	ClinGen Ensembl
CA1537839 rs200944773	517	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA345898415 rs1558459254	517	I>T		No	ClinGen Ensembl
CA1537840 rs200944773	517	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	518	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA42662226 rs957929615	521	N>I		No	ClinGen gnomAD
TCGA novel	524	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1009005522 CA42668104	524	Q>R		No	ClinGen TOPMed
CA345898719 rs1484141914	525	Y>N		No	ClinGen gnomAD
rs12995839 CA42668119	528	Q>H		No	ClinGen Ensembl
CA1537841 rs774440382	529	Q>K		No	ClinGen ExAC gnomAD
rs767883275 CA42668139	531	G>A		No	ClinGen Ensembl
CA345898783 rs1241237908	532	G>A		No	ClinGen gnomAD
CA42670234 rs148117214	533	P>R		No	ClinGen ESP TOPMed
TCGA novel	537	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1537858 rs201143228	540	F>L		No	ClinGen ExAC TOPMed gnomAD
rs770857804 CA1537859	541	S>L		No	ClinGen ExAC TOPMed gnomAD
rs369671200 CA1537860	542	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs745860829 CA345898862	544	C>G		No	ClinGen ExAC TOPMed gnomAD
CA1537861 rs745860829	544	C>R		No	ClinGen ExAC TOPMed gnomAD
rs768600120 CA1537862	547	G>A		No	ClinGen ExAC gnomAD
CA345898910 rs1334083526	550	K>N		No	ClinGen gnomAD
CA1537864 rs761832183	552	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1257959426 CA345898974	559	E>G		No	ClinGen gnomAD
rs775313016 CA1537883	564	G>E		No	ClinGen ExAC gnomAD
rs530158385 CA1537882	564	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA42670975 rs1055971691	565	D>Y		No	ClinGen TOPMed
rs200312494 CA42670995	566	V>A		No	ClinGen 1000Genomes TOPMed
CA345899033 rs1558460406	566	V>I		No	ClinGen Ensembl
CA1537884 rs373130115	567	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	567	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769829948 CA1537885	568	F>C		No	ClinGen ExAC gnomAD
rs1477280372 CA345899074	572	T>A		No	ClinGen gnomAD
CA42671016 rs146084775	573	D>E		No	ClinGen ESP TOPMed gnomAD
rs1025093957 CA42671019	574	V>I		No	ClinGen TOPMed
rs971214803 CA42671037	581	I>S		No	ClinGen TOPMed
rs766697244 CA1537888	582	H>R		No	ClinGen ExAC gnomAD
rs201951630 CA345899145	583	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs201951630 CA1537890	583	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1014513976 CA42671072	584	V>I		No	ClinGen gnomAD
rs1314132812 CA345899196	589	N>S		No	ClinGen gnomAD
CA345899200 rs1342555645	590	V>I		No	ClinGen gnomAD
rs773905294 CA42671133	591	T>A		No	ClinGen Ensembl
rs774565569 CA1537907	593	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1537908 rs759875462	594	D>N		No	ClinGen ExAC TOPMed gnomAD
CA1537909 rs759875462	594	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA1537911 rs761137218	598	N>S		No	ClinGen ExAC gnomAD
rs753361392 CA1537913	600	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA345899280 rs1385040010	602	R>*		No	ClinGen gnomAD
rs1385040010 CA345899279	602	R>G		No	ClinGen gnomAD
rs1450410081 CA345899281	602	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA42671176 rs930357520	603	I>T		No	ClinGen TOPMed
CA345899294 rs1172827467	604	G>D		No	ClinGen gnomAD
rs1352970984 CA345899336	611	R>G		No	ClinGen TOPMed gnomAD
CA345899382 rs1193890743	616	I>V		No	ClinGen TOPMed
CA345899394 rs1286190727	618	L>M		No	ClinGen TOPMed
rs1374820282 CA345899460	626	V>I		No	ClinGen gnomAD
TCGA novel	628	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1537953 rs747321017	630	V>A		No	ClinGen ExAC gnomAD
rs1225975665 CA345899493	630	V>I		No	ClinGen gnomAD
CA1537954 rs769148712	634	R>C		No	ClinGen ExAC gnomAD
rs777275353 CA1537955	634	R>H		No	ClinGen ExAC TOPMed gnomAD
CA345899542 rs748713059	637	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1537956 rs748713059	637	G>E		No	ClinGen ExAC TOPMed gnomAD
rs772556624 CA1537958	640	N>D		No	ClinGen ExAC TOPMed gnomAD
CA345899567 rs1175428555	641	T>A		No	ClinGen gnomAD
CA42671753 rs1040858885	642	R>G		No	ClinGen gnomAD
rs762546378 CA1537959	643	L>R		No	ClinGen ExAC gnomAD
rs1245341922 CA345899587	644	K>R		No	ClinGen gnomAD
rs139597816 CA1537960	646	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1537961 rs139597816	646	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1537962 rs139597816	646	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA345899613 rs1379036033	648	G>D		No	ClinGen TOPMed
rs1054962638 CA42671769	650	T>S		No	ClinGen TOPMed gnomAD
CA345899635 rs1573053513	651	I>M		No	ClinGen Ensembl
rs1355783107 CA345899630	651	I>V		No	ClinGen gnomAD
rs1191353174 CA345899661	655	E>K		No	ClinGen TOPMed
rs1448427597 CA345899675	656	M>I		No	ClinGen TOPMed
CA345899681 rs1373203879	657	Q>R		No	ClinGen gnomAD
rs773858668 CA1537980	661	E>A		No	ClinGen ExAC gnomAD
TCGA novel	663	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371196534 CA42671983	664	E>D		No	ClinGen Ensembl
rs767271793 CA1537982	667	N>K		No	ClinGen ExAC gnomAD
rs1463789788 CA345899769	668	C>S		No	ClinGen TOPMed
rs1463789788 CA345899767	668	C>Y		No	ClinGen TOPMed
TCGA novel	670	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146317353 CA1537984	670	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1537983 rs775228001	670	I>V		No	ClinGen ExAC gnomAD
TCGA novel	671	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345899788 rs1474818068	671	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA345899798 rs1573053697	673	V>L		No	ClinGen Ensembl
CA345899808 rs1429387422	674	E>V		No	ClinGen gnomAD
rs753819618 CA1537986	675	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1395854521 CA345899817	676	D>H		No	ClinGen gnomAD
CA42672004 rs990384030	677	I>M		No	ClinGen Ensembl
rs766539109 CA1537988	677	I>V		No	ClinGen ExAC gnomAD
CA1537989 rs369172740	678	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1537990 rs755208682	678	K>R		No	ClinGen ExAC gnomAD
CA1537991 rs547598727	680	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1225420700 CA345899872	684	F>S		No	ClinGen gnomAD
rs1558460887 CA345899887	686	G>E		No	ClinGen Ensembl
rs778134003 CA1537994	687	K>E		No	ClinGen ExAC gnomAD
CA345899919 rs1269140881	691	G>C		No	ClinGen TOPMed gnomAD
CA345899917 rs1269140881	691	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA42672071 rs923271125	693	K>E		No	ClinGen Ensembl
rs1334709422 CA345899940	694	R>K		No	ClinGen TOPMed
rs1468988945 CA345899990	700	S>N		No	ClinGen gnomAD
TCGA novel	700	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs116312370 CA1538010	702	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA42672470 rs866682309	702	K>R		No	ClinGen Ensembl
CA1538011 rs778246765	703	G>D		No	ClinGen ExAC gnomAD
rs754266526 CA1538012	706	D>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	707	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1538014 rs779421358	709	A>S		No	ClinGen ExAC gnomAD
CA345900054 rs1410540149	710	P>T		No	ClinGen TOPMed
CA1538015 rs745328114	711	T>A		No	ClinGen ExAC TOPMed gnomAD
CA345900069 rs1333901556	712	V>A		No	ClinGen gnomAD
rs139636088 CA1538016	721	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	722	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1538017 rs556029393	722	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	723	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768315888 CA1538019	724	T>A		No	ClinGen ExAC TOPMed gnomAD
CA1538020 rs768315888	724	T>S		No	ClinGen ExAC TOPMed gnomAD
CA1538022 rs769796012	726	F>C		No	ClinGen ExAC gnomAD
rs1573054079 CA345900163	726	F>L		No	ClinGen Ensembl
rs576509752 CA1538023	728	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759681065 CA1538024	729	L>V		No	ClinGen ExAC gnomAD
rs1239184395 CA345900189	731	Y>H		No	ClinGen TOPMed
rs1374443535 CA345900209	734	N>D		No	ClinGen TOPMed
rs1187666037 CA345900212	734	N>S		No	ClinGen Ensembl
CA345900224 rs1573054123	736	L>M		No	ClinGen Ensembl
rs775550327 CA1538026	736	L>P		No	ClinGen ExAC gnomAD
TCGA novel	738	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA42672554 rs537023761	739	T>P		No	ClinGen 1000Genomes gnomAD
rs537023761 CA345900244	739	T>S		No	ClinGen 1000Genomes gnomAD
rs760995496 CA345900259	741	F>L		No	ClinGen ExAC gnomAD
CA345900258 rs1329519126	741	F>R		No	ClinGen TOPMed
CA1538027 rs760995496	741	F>S		No	ClinGen ExAC gnomAD

No associated diseases with Q92499

6 regional properties for Q92499

Type	Name	Position	InterPro Accession
domain	Chromo/chromo shadow domain	58 - 111	IPR000953
repeat	Ankyrin repeat	572 - 665	IPR002110-1
repeat	Ankyrin repeat	666 - 698	IPR002110-2
repeat	Ankyrin repeat	699 - 728	IPR002110-3
conserved_site	Chromo domain, conserved site	76 - 96	IPR023779
domain	Chromo domain	59 - 109	IPR023780

Functions

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Cytoplasm Cytoplasmic granule Cytoplasm, cytosol Mitochondrion	Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress Localized with CSTF2 in cleavage bodies Forms large aggregates called DDX1 bodies Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment Colocalized with RELA in the nucleus upon TNF-alpha induction Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264) Colocalizes in the cytosol with DDX21, DHX36 and TICAM1 Colocalizes in the mitochondria with TICAM1 and poly(I:C) RNA ligand The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) stimulation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cleavage body	A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.
tRNA-splicing ligase complex	A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.

12 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA/RNA helicase activity	Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.
double-stranded RNA binding	Binding to double-stranded RNA.
exonuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
nuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids.
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.
transcription coregulator activity	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

12 GO annotations of biological process

Name	Definition
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
DNA duplex unwinding	The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
nucleic acid phosphodiester bond hydrolysis	The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of myeloid dendritic cell cytokine production	Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
protein localization to cytoplasmic stress granule	A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
regulation of translational initiation	Any process that modulates the frequency, rate or extent of translational initiation.
response to exogenous dsRNA	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
spliceosomal complex assembly	The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
tRNA splicing, via endonucleolytic cleavage and ligation	Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0IIK5	DDX1	ATP-dependent RNA helicase DDX1	Bos taurus (Bovine)	PR
Q90WU3	DDX1	ATP-dependent RNA helicase DDX1	Gallus gallus (Chicken)	PR
Q8NHQ9	DDX55	ATP-dependent RNA helicase DDX55	Homo sapiens (Human)	PR
P60842	EIF4A1	Eukaryotic initiation factor 4A-I	Homo sapiens (Human)	PR
Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	Homo sapiens (Human)	PR
Q9Y6V7	DDX49	Probable ATP-dependent RNA helicase DDX49	Homo sapiens (Human)	PR
Q9H0S4	DDX47	Probable ATP-dependent RNA helicase DDX47	Homo sapiens (Human)	PR
Q8TDD1	DDX54	ATP-dependent RNA helicase DDX54	Homo sapiens (Human)	PR
Q9GZR7	DDX24	ATP-dependent RNA helicase DDX24	Homo sapiens (Human)	PR
Q9NY93	DDX56	Probable ATP-dependent RNA helicase DDX56	Homo sapiens (Human)	PR
Q9NUL7	DDX28	Probable ATP-dependent RNA helicase DDX28	Homo sapiens (Human)	PR
Q7L014	DDX46	Probable ATP-dependent RNA helicase DDX46	Homo sapiens (Human)	PR
Q91VR5	Ddx1	ATP-dependent RNA helicase DDX1	Mus musculus (Mouse)	PR
Q641Y8	Ddx1	ATP-dependent RNA helicase DDX1	Rattus norvegicus (Rat)	PR
Q5XH91	ddx1	ATP-dependent RNA helicase DDX1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MAAFSEMGVM	PEIAQAVEEM	DWLLPTDIQA	ESIPLILGGG	DVLMAAETGS	GKTGAFSIPV
70	80	90	100	110	120
IQIVYETLKD	QQEGKKGKTT	IKTGASVLNK	WQMNPYDRGS	AFAIGSDGLC	CQSREVKEWH
130	140	150	160	170	180
GCRATKGLMK	GKHYYEVSCH	DQGLCRVGWS	TMQASLDLGT	DKFGFGFGGT	GKKSHNKQFD
190	200	210	220	230	240
NYGEEFTMHD	TIGCYLDIDK	GHVKFSKNGK	DLGLAFEIPP	HMKNQALFPA	CVLKNAELKF
250	260	270	280	290	300
NFGEEEFKFP	PKDGFVALSK	APDGYIVKSQ	HSGNAQVTQT	KFLPNAPKAL	IVEPSRELAE
310	320	330	340	350	360
QTLNNIKQFK	KYIDNPKLRE	LLIIGGVAAR	DQLSVLENGV	DIVVGTPGRL	DDLVSTGKLN
370	380	390	400	410	420
LSQVRFLVLD	EADGLLSQGY	SDFINRMHNQ	IPQVTSDGKR	LQVIVCSATL	HSFDVKKLSE
430	440	450	460	470	480
KIMHFPTWVD	LKGEDSVPDT	VHHVVVPVNP	KTDRLWERLG	KSHIRTDDVH	AKDNTRPGAN
490	500	510	520	530	540
SPEMWSEAIK	ILKGEYAVRA	IKEHKMDQAI	IFCRTKIDCD	NLEQYFIQQG	GGPDKKGHQF
550	560	570	580	590	600
SCVCLHGDRK	PHERKQNLER	FKKGDVRFLI	CTDVAARGID	IHGVPYVINV	TLPDEKQNYV
610	620	630	640	650	660
HRIGRVGRAE	RMGLAISLVA	TEKEKVWYHV	CSSRGKGCYN	TRLKEDGGCT	IWYNEMQLLS
670	680	690	700	710	720
EIEEHLNCTI	SQVEPDIKVP	VDEFDGKVTY	GQKRAAGGGS	YKGHVDILAP	TVQELAALEK
730
EAQTSFLHLG	YLPNQLFRTF