Q922R0
Gene name |
Prkx (Pkare) |
Protein name |
cAMP-dependent protein kinase catalytic subunit PRKX |
Names |
PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, PKA-related protein kinase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19108 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
186-206 (Activation loop from InterPro)
Target domain |
46-300 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q922R0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q922R0-F1 | Predicted | AlphaFoldDB |
30 variants for Q922R0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217940284 | 4 | P>L | No | EVA | |
| rs3389563528 | 9 | A>V | No | EVA | |
| rs3389579062 | 13 | D>N | No | EVA | |
| rs231116765 | 28 | A>V | No | EVA | |
| rs3389560831 | 39 | A>G | No | EVA | |
| rs3389560352 | 59 | R>H | No | EVA | |
| rs3410655480 | 74 | L>* | No | EVA | |
| rs3389515065 | 77 | M>I | No | EVA | |
| rs3389563496 | 88 | E>D | No | EVA | |
| rs3389566686 | 112 | T>A | No | EVA | |
| rs3389545938 | 127 | P>L | No | EVA | |
| rs3389579088 | 141 | F>L | No | EVA | |
| rs3411395255 | 147 | V>L* | No | EVA | |
| rs3410810088 | 150 | A>G | No | EVA | |
| rs3409393175 | 152 | E>D | No | EVA | |
| rs3410388670 | 152 | E>Q | No | EVA | |
| rs3410760864 | 153 | I>N | No | EVA | |
| rs3409393040 | 154 | V>L | No | EVA | |
| rs3411135442 | 156 | A>G | No | EVA | |
| rs3411022215 | 157 | I>V | No | EVA | |
| rs3389581531 | 169 | D>N | No | EVA | |
| rs3410914887 | 198 | T>A | No | EVA | |
| rs3411022200 | 199 | W>* | No | EVA | |
| rs3389576666 | 238 | F>I | No | EVA | |
| rs3389563474 | 250 | Y>H | No | EVA | |
| rs3389545956 | 257 | K>E | No | EVA | |
| rs213422169 | 311 | R>K | No | EVA | |
| rs3389514975 | 324 | D>E | No | EVA | |
| rs3389566621 | 333 | Y>C | No | EVA | |
| rs3410879511 | 334 | P>T | No | EVA |
No associated diseases with Q922R0
5 regional properties for Q922R0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PDZ domain | 115 - 196 | IPR001478-1 |
| domain | PDZ domain | 223 - 301 | IPR001478-2 |
| domain | PDZ domain | 329 - 412 | IPR001478-3 |
| domain | PDZ domain | 467 - 548 | IPR001478-4 |
| domain | PDZ domain 6 | 492 - 532 | IPR041489 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cAMP-dependent protein kinase activity | cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell-substrate adhesion | The attachment of a cell to the underlying substrate via adhesion molecules. |
| endothelial cell migration | The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| endothelial cell proliferation | The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| epithelial tube morphogenesis | The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. |
| kidney morphogenesis | Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. |
| myeloid cell differentiation | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of epithelial cell differentiation involved in kidney development | Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00517 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (Bovine) | PR |
| Q03043 | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B | Drosophila melanogaster (Fruit fly) | SS |
| P16911 | Pka-C2 | cAMP-dependent protein kinase catalytic subunit 2 | Drosophila melanogaster (Fruit fly) | PR |
| P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (Human) | PR |
| P05132 | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (Mouse) | PR |
| P0C605 | Prkg1 | cGMP-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| Q61410 | Prkg2 | cGMP-dependent protein kinase 2 | Mus musculus (Mouse) | PR |
| P36887 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Sus scrofa (Pig) | PR |
| O62846 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Macaca mulatta (Rhesus macaque) | PR |
| P21137 | kin-1 | cAMP-dependent protein kinase catalytic subunit | Caenorhabditis elegans | PR |
| Q7JP68 | F47F2.1 | cAMP-dependent protein kinase, catalytic subunit-like | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPPAGAAAT | VKDPDHDPVK | TKVSAPAADP | KPRTSSQKAG | HSLQDWDTIA | TVGTGTFGRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NLVKEKTGRQ | YCALKIMSIP | DVIRLKQEQH | VQNEKAVLKE | INHPFLIKLL | WTGHDNRFLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MLMEFVPGGE | LFTYLRNRGR | FSSVASVFYA | TEIVCAIEYL | HSKEIVYRDL | KPENILLDRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GHIKLTDFGF | AKKLVDRTWT | LCGTPEYLAP | EVIQSKGHGR | AVDWWALGIL | IFEMLSGFPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FFDDNPFGIY | QKILACKIDF | PRQLDFTSKD | LIKKLLVVDR | TRRLGNMKNG | AEDIKRHRWF |
| 310 | 320 | 330 | 340 | 350 | |
| RGVEWESVPQ | RKLKPPIVPK | LSGDGDISNF | ETYPESELDK | TPSVSDKDLE | TFKNF |