Q921Y0

SS
Gene name
Mob1a (Mobk1b, Mobkl1b)
Protein name
MOB kinase activator 1A
Names
Mob1 homolog 1B , Mps one binder kinase activator-like 1B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:232157
EC number
Protein Class

Descriptions

MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. Full-length MOB1B is in the autoinhibited form, showing that the N-terminal extension blocks the LATS1 binding surface of MOB2B. Phosphorylation of Thr12 and Thr35 residues accelerates dissociation of the Switch helix from the LATS1-binding surface by the pull-the-string mechanism, thereby enabling LATS1 binding.

Autoinhibitory domains (AIDs)

1-38 (N-terminal extension including the Switch helix) SS

Target domain

41-204 (MH domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q921Y0

Entry ID Method Resolution Chain Position Source
AF-Q921Y0-F1 Predicted AlphaFoldDB

7 variants for Q921Y0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388825303 36 L>H No EVA
rs3388843728 108 K>M No EVA
rs3388837642 112 P>A No EVA
rs3388828078 116 D>G No EVA
rs3388825313 153 K>T No EVA
rs3412800570 179 L>P No EVA
rs3413054438 202 A>T No EVA

No associated diseases with Q921Y0

No regional properties for Q921Y0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q921Y0

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

2 GO annotations of biological process

Name Definition
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43563 MOB2 CBK1 kinase activator protein MOB2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40484 MOB1 DBF2 kinase activator protein MOB1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q95RA8 mats MOB kinase activator-like 1 Drosophila melanogaster (Fruit fly) SS
Q7L9L4 MOB1B MOB kinase activator 1B Homo sapiens (Human) SS
Q9H8S9 MOB1A MOB kinase activator 1A Homo sapiens (Human) EV
Q8BJG4 Mob3c MOB kinase activator 3C Mus musculus (Mouse) SS
Q8BSU7 Mob3a MOB kinase activator 3A Mus musculus (Mouse) SS
Q8VE04 Mob3b MOB kinase activator 3B Mus musculus (Mouse) SS
Q8VI63 Mob2 MOB kinase activator 2 Mus musculus (Mouse) EV
Q8BPB0 Mob1b MOB kinase activator 1B Mus musculus (Mouse) EV
Q3T1J9 Mob1a MOB kinase activator 1A Rattus norvegicus (Rat) SS
Q8GYX0 MOB1B MOB kinase activator-like 1B Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHI1 MOB1A MOB kinase activator-like 1A Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN
70 80 90 100 110 120
TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT
130 140 150 160 170 180
WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN
190 200 210
TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR