Q921C5

SS
Gene name
Bicd2 (Kiaa0699)
Protein name
Protein bicaudal D homolog 2
Names
Bic-D 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76895
EC number
Protein Class

Descriptions

Protein bicaudal D homolog 1 (BICD1) is a protein that regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Autoinhibition of BICD1 involves the C-terminal coiled-coil region (CC3) binding to the N-terminal coiled-coil region (CC1), preventing interaction with cytoplasmic dynein. This interaction inhibits the association with cytoplasmic dynein and its cargo-binding function. A structural rearrangement of the core packing in a homodimeric coiled-coil stimulates the release of CC1 from the CC3 region following cargo-binding. Additionally, the three residues (Glu772, Ile784, and Lys787), which are required for Rab6 binding, play a critical role in maintaining the autoinhibitory state through direct interaction with the N-terminal CC1 region.

Autoinhibitory domains (AIDs)

709-806 (CC3 region) SS

Target domain

10-317 (CC1 region)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q921C5

Entry ID Method Resolution Chain Position Source
AF-Q921C5-F1 Predicted AlphaFoldDB

40 variants for Q921C5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389280311 59 L>Q No EVA
rs247811360 98 S>R No EVA
rs3389256262 128 L>M No EVA
rs3389266518 216 E>D No EVA
rs3389210037 250 E>K No EVA
rs3389274091 277 Q>H No EVA
rs3389278954 289 T>I No EVA
rs3389256279 295 N>I No EVA
rs3389282051 304 G>A No EVA
rs3389292272 318 K>N No EVA
rs3389274098 349 K>N No EVA
rs3389282135 357 M>R No EVA
rs3389282112 368 L>V No EVA
rs3389284121 396 L>P No EVA
rs3550187592 408 R>Q No EVA
rs3389284160 409 Q>H No EVA
rs3389284093 418 R>H No EVA
rs3389284113 420 S>N No EVA
rs3389282503 424 G>D No EVA
rs3389266534 465 R>C No EVA
rs3389210068 469 H>Q No EVA
rs3389282455 473 K>T No EVA
rs3389274059 484 T>I No EVA
rs3389274059 484 T>N No EVA
rs3550331284 489 L>M No EVA
rs3389297484 509 K>M No EVA
rs3389278775 527 D>E No EVA
rs3389256322 564 G>R No EVA
rs3389210066 566 A>G No EVA
rs3389292238 574 R>C No EVA
rs223348890 590 E>D No EVA
rs3389297466 596 G>D No EVA
rs3389279013 601 N>K No EVA
rs3389289436 627 I>N No EVA
rs3389282476 643 R>H No EVA
rs3389278785 645 T>S No EVA
rs3389266560 678 L>Q No EVA
rs3389289441 733 K>N No EVA
rs3389279035 762 R>W No EVA
rs225275605 810 A>T No EVA

No associated diseases with Q921C5

5 regional properties for Q921C5

Type Name Position InterPro Accession
domain Protein kinase domain 12 - 264 IPR000719
domain NAF domain 294 - 351 IPR004041
active_site Serine/threonine-protein kinase, active site 130 - 142 IPR008271
binding_site Protein kinase, ATP binding site 18 - 41 IPR017441
domain NAF/FISL domain 291 - 315 IPR018451

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus
  • Cytoplasm, cytoskeleton
  • Cytoplasm
  • Nucleus, nuclear pore complex
  • Nucleus envelope
  • In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508)
  • Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
annulate lamellae Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
cytoskeletal anchor activity The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
dynactin binding Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
dynein light intermediate chain binding Binding to a light intermediate chain of the dynein complex.
small GTPase binding Binding to a small monomeric GTPase.

9 GO annotations of biological process

Name Definition
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
microtubule anchoring at microtubule organizing center Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
minus-end-directed organelle transport along microtubule The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P16568 BicD Protein bicaudal D Drosophila melanogaster (Fruit fly) EV
Q96G01 BICD1 Protein bicaudal D homolog 1 Homo sapiens (Human) SS
Q8TD16 BICD2 Protein bicaudal D homolog 2 Homo sapiens (Human) SS
Q8BR07 Bicd1 Protein bicaudal D homolog 1 Mus musculus (Mouse) EV
10 20 30 40 50 60
MSAPSEEEEY ARLVMEAQPE WLRAEVKRLS HELAETTREK IQAAEYGLAV LEEKHQLKLQ
70 80 90 100 110 120
FEELEVDYEA IRSEMEQLKE AFGQAHTNHK KVAADGESRE ESLIQESASK EQYYVRKVLE
130 140 150 160 170 180
LQTELKQLRN VLTNTQSENE RLTSVAQELK EINQNVEIQR GRLRDDIKEY KFREARLLQD
190 200 210 220 230 240
YSELEEENIS LQKQVSVLRQ NQVEFEGLKH EIKRLEEETE YLNSQLEDAI RLKEISERQL
250 260 270 280 290 300
EEALETLKTE REQKNNLRKE LSHYMSINDS FYTSHLQVSL DGLKFSDDTV TAEPNNDAEA
310 320 330 340 350 360
LVNGFEHSGL VKSSLDNKTS TPRKDGLAPP SPSLVSDLLS ELHISEIQKL KQQLVQMERE
370 380 390 400 410 420
KVGLLATLQD TQKQLEQARG TLSEQHEKVN RLTENLSALR RLQAGKERQT SLDNEKDRDS
430 440 450 460 470 480
HEDGDYYEVD INGPEILACK YHVAVAEAGE LREQLKALRS THEAREAQHA EEKGRYEAEG
490 500 510 520 530 540
QALTEKISLL EKASHQDREL LAHLEKELKK VSDVAGETQG SLNVAQDELV TFSEELANLY
550 560 570 580 590 600
HHVCMCNNET PNRVMLDYYR EGQGKAGRTS PEGRGRRSPV LLPKGLLATE VGRADGGTGD
610 620 630 640 650 660
NSPSPSSSLP SPLSDPRREP MNIYNLIAII RDQIKHLQAA VDRTTELSRQ RIASQELGPA
670 680 690 700 710 720
VDKDKEALME EILKLKSLLS TKREQITTLR TVLKANKQTA EVALANLKSK YENEKAMVTE
730 740 750 760 770 780
TMMKLRNELK ALKEDAATFS SLRAMFATRC DEYITQLDEM QRQLAAAEDE KKTLNSLLRM
790 800 810
AIQQKLALTQ RLELLELDHE QTRRGRSKAA SKAKPASPSL