Q92072

SS
Gene name
DNMT1 (AIM, DNMT)
Protein name
DNA
Names
cytosine-5-methyltransferase 1 , Dnmt1 , EC 2.1.1.37 , DNA methyltransferase GgaI , DNA MTase GgaI , M.GgaI , MCMT
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396011
EC number
2.1.1.37: Methyltransferases
Protein Class

Descriptions

The mouse DNA methyltransferase-1 (DNMT1), composed of a replication foci-targeting domain (RFD), a DBA-binding CXXC domain, a pair of bromo-adjacent homology (BAH) domains, and a C-terminal catalytic domain bound to DNA-containing unmethylated CpG sites, mediates maintenance of genomic methylation patterns. The CXXC specifically binds to unmethylated CpG dinucleotide and positions the CXXC-BAH1 linker between the DNA and the active site of DNMT1, preventing de novo methylation. Therefore, unmethylated CpG dinucleotides are occluded from the active site to ensure that only hemimethylated CpG dinucleotides undergo methylation.

Autoinhibitory domains (AIDs)

608-642 (CXXC-BAH1 linker) SS

Target domain

1052-1514 (Methyltransferase domain)

Relief mechanism

Others

Assay

311-444 (RFTS domain) SS

Target domain

1051-1507 (Methyltransferae domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92072

Entry ID Method Resolution Chain Position Source
AF-Q92072-F1 Predicted AlphaFoldDB

No variants for Q92072

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92072

No associated diseases with Q92072

7 regional properties for Q92072

Type Name Position InterPro Accession
domain Bromo adjacent homology (BAH) domain 667 - 791 IPR001025-1
domain Bromo adjacent homology (BAH) domain 842 - 1011 IPR001025-2
domain Zinc finger, CXXC-type 558 - 604 IPR002857
domain DMAP1-binding domain 8 - 105 IPR010506
active_site DNA methylase, C-5 cytosine-specific, active site 1133 - 1145 IPR018117
domain DNA (cytosine-5)-methyltransferase 1, replication foci domain 310 - 444 IPR022702
conserved_site DNA methylase, C-5 cytosine-specific, conserved site 1488 - 1506 IPR031303

Functions

Description
EC Number 2.1.1.37 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
promoter-specific chromatin binding Binding to a section of chromatin that is associated with gene promoter sequences of DNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q24K09 DNMT1 DNA (cytosine-5)-methyltransferase 1 Bos taurus (Bovine) SS
P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 Homo sapiens (Human) EV
P13864 Dnmt1 DNA (cytosine-5)-methyltransferase 1 Mus musculus (Mouse) EV
Q9Z330 Dnmt1 DNA (cytosine-5)-methyltransferase 1 Rattus norvegicus (Rat) SS
O49139 CMT1 Putative DNA (cytosine-5)-methyltransferase CMT1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE VQRRLSALDA
70 80 90 100 110 120
DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN GCAGNGEEEW ERGGRGEDGA
130 140 150 160 170 180
MEVEEAAASS SSSSSSSSSS SSSSSSSSSL LPAPRARKAR RSRSNGESKK SPASSRVTRS
190 200 210 220 230 240
SGRQPTILSV FSKGSTKRKS EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG
250 260 270 280 290 300
SEIKDEITQV KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF
310 320 330 340 350 360
DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV KPIYDDNPCL
370 380 390 400 410 420
DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM EPSEEYAPIF ALMQEKIYMS
430 440 450 460 470 480
KIVVEFLQNN RDVSYEDLLN KIETTVPPVG LNFNRFTEDS LLRHAQFVVE QVESYDEAGD
490 500 510 520 530 540
SDEPPVLITP CMRDLIKLAG VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD
550 560 570 580 590 600
TFFSEQIEKD EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ
610 620 630 640 650 660
RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI KSDGKKDFYQ
670 680 690 700 710 720
RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG QMFHAHWFCP GSDTVLGATS
730 740 750 760 770 780
DPLELFLVDE CEDMQLSYIH GKVNVIYKPP SENWAMEGGL DMEIKMVEDD GRTYFYQMWY
790 800 810 820 830 840
DQEYARFETP PRAQPMEDNK YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN
850 860 870 880 890 900
GVQYRVGDSV YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD
910 920 930 940 950 960
PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI NLLYWSDEET
970 980 990 1000 1010 1020
TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY NAKTKSFEDP PNHARSSGNK
1030 1040 1050 1060 1070 1080
GKGKGKGKGK GKGKSSTTCE QSEPEPTELK LPKLRTLDVF SGCGGLSEGF HQAGVSETLW
1090 1100 1110 1120 1130 1140
AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP
1150 1160 1170 1180 1190 1200
CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR
1210 1220 1230 1240 1250 1260
CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA PRACQLSVVV
1270 1280 1290 1300 1310 1320
DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE ISYNGEPQSW FQRQIRGSQY
1330 1340 1350 1360 1370 1380
QPILRDHICK DMSALVAARM RHIPLAPGSD WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG
1390 1400 1410 1420 1430 1440
RSSSGALRGV CSCAEGKPCD PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT
1450 1460 1470 1480 1490 1500
VTNPEPMGKQ GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK
1510 1520 1530
AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD