Q91XM9

SS
Gene name
Dlg2 (Dlgh2)
Protein name
Disks large homolog 2
Names
Channel-associated protein of synapse-110 , Chapsyn-110 , Postsynaptic density protein PSD-93
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:23859
EC number
Protein Class

Descriptions

Dlg2 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. The activity of Dlg2 (GK domain) is autoinhibited by the PDZ domains (PDZ2 and PDZ3). In rat Dlg4 (P31016), SH3 domain also interacts with GK domain for regulation.

Autoinhibitory domains (AIDs)

158-407 (PDZ 2 and 3 domains) SS

Target domain

503-724 (GK domain)

Relief mechanism

Ligand binding, Others

Assay

542-598 (SH3 domain) SS

Target domain

503-724 (GK domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q91XM9

Entry ID Method Resolution Chain Position Source
2WL7 X-ray 203 A A 95-188 PDB
AF-Q91XM9-F1 Predicted AlphaFoldDB

38 variants for Q91XM9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3398288536 93 E>D No EVA
rs3398221037 94 Y>C No EVA
rs3388884380 102 E>D No EVA
rs3388919437 168 E>Q No EVA
rs3388928055 190 T>N No EVA
rs3388908748 256 V>A No EVA
rs3388919461 272 V>A No EVA
rs3388897865 288 Y>* No EVA
rs3388928114 296 S>C No EVA
rs3388927060 318 S>F No EVA
rs3388919507 320 P>S No EVA
rs3388919118 372 S>G No EVA
rs3388919130 380 P>L No EVA
rs3388927301 391 D>H No EVA
rs3388922091 403 R>C No EVA
rs3388897937 521 N>S No EVA
rs3388919510 529 G>E No EVA
rs3388928051 562 F>S No EVA
rs3388919135 567 I>N No EVA
rs3388908830 570 V>I No EVA
rs3388912161 581 A>P No EVA
rs3507874203 585 T>K No EVA
rs3388904214 588 G>R No EVA
rs3388912156 617 A>E No EVA
rs3388919513 622 I>N No EVA
rs3388897941 629 P>T No EVA
rs3388897864 635 G>D No EVA
rs3388927070 682 E>D No EVA
rs3388919453 687 F>L No EVA
rs3388927294 693 H>L No EVA
rs3388923350 701 Y>* No EVA
rs3388922070 714 R>G No EVA
rs3388922078 724 H>Y No EVA
rs3388928069 747 V>I No EVA
rs3388928046 763 I>S No EVA
rs3388919489 810 Q>* No EVA
rs3388908752 831 Q>* No EVA
rs3388924847 837 E>K No EVA

No associated diseases with Q91XM9

6 regional properties for Q91XM9

Type Name Position InterPro Accession
domain C2 domain 1 - 108 IPR000008
domain Formin, FH3 domain 352 - 553 IPR010472
domain Formin, GTPase-binding domain 139 - 347 IPR010473
domain Diaphanous autoregulatory (DAD) domain 1174 - 1209 IPR014767
domain Rho GTPase-binding/formin homology 3 (GBD/FH3) domain 139 - 539 IPR014768
domain Formin, FH2 domain 759 - 1199 IPR015425

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Postsynaptic density
  • Synapse
  • Membrane
  • Cell projection, axon
  • Perikaryon
  • Concentrated in soma and postsynaptic density of a subset of neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

17 GO annotations of cellular component

Name Definition
axon cytoplasm Any cytoplasm that is part of a axon.
axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
juxtaparanode region of axon A region of an axon near a node of Ranvier that is between the paranode and internode regions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

5 GO annotations of molecular function

Name Definition
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
protein phosphatase binding Binding to a protein phosphatase.
protein-containing complex binding Binding to a macromolecular complex.
structural constituent of postsynaptic density The action of a molecule that contributes to the structural integrity of a postsynaptic density.

13 GO annotations of biological process

Name Definition
anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
cellular response to potassium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
clustering of voltage-gated potassium channels The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.
embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
neuronal ion channel clustering The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
retrograde axonal protein transport The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31007 dlg1 Disks large 1 tumor suppressor protein Drosophila melanogaster (Fruit fly) EV
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q8CIS0 Card11 Caspase recruitment domain-containing protein 11 Mus musculus (Mouse) SS
Q99KF0 Card14 Caspase recruitment domain-containing protein 14 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MFFACYCALR TNVKKYRYQD EDGPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL
70 80 90 100 110 120
QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH
130 140 150 160 170 180
IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY
190 200 210 220 230 240
VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ
250 260 270 280 290 300
VGDRLLMVNN YSLEEVTHEE AVAILKNTSD VVYLKVGKPT TIYMTDPYGP PDITHSYSPP
310 320 330 340 350 360
MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLGEDDY TRPPEPVYST VNKLCDKPAS
370 380 390 400 410 420
PRHYSPVECD KSFLLSTPYP HYHLGLLPDS DMTSHSQHST ATRQPSVTLQ RAISLEGEPR
430 440 450 460 470 480
KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH
490 500 510 520 530 540
EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY
550 560 570 580 590 600
VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVTLDGDS EEMGVIPSKR
610 620 630 640 650 660
RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS YEPVTRQEIN
670 680 690 700 710 720
YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VISREQMEKD
730 740 750 760 770 780
IQEHKFIEAG QYNDNLYGTS VQSVRFVAER GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP
790 800 810 820 830 840
KSLEPLMEMN KRLTEEQAKK TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS
850
GPFIWIPSKE KL