Q91WT9
Gene name |
Cbs |
Protein name |
Cystathionine beta-synthase |
Names |
EC 4.2.1.22 , Beta-thionase , Serine sulfhydrase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12411 |
EC number |
4.2.1.22: Hydro-lyases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
35-409 (Catalytic domain) |
Relief mechanism |
Ligand binding, Cleavage, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Janosík M et al. (2001) "Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region", Biochemistry, 40, 10625-33
- Ereño-Orbea J et al. (2014) "Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine", Proceedings of the National Academy of Sciences of the United States of America, 111, E3845-52
Autoinhibited structure
Activated structure
1 structures for Q91WT9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91WT9-F1 | Predicted | AlphaFoldDB |
31 variants for Q91WT9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs235480183 | 15 | G>V | No | EVA | |
| rs48180803 | 58 | A>V | No | EVA | |
| rs13482947 | 59 | D>E | No | EVA | |
| rs3389449494 | 59 | D>N | No | EVA | |
| rs3389430316 | 123 | M>I | No | EVA | |
| rs3389420090 | 131 | G>E | No | EVA | |
| rs3389449427 | 139 | I>L | No | EVA | |
| rs3389409964 | 145 | G>S | No | EVA | |
| rs3389461297 | 187 | R>T | No | EVA | |
| rs3389461292 | 189 | P>L | No | EVA | |
| rs3389452842 | 256 | G>C | No | EVA | |
| rs3407925796 | 273 | K>GGQL* | No | EVA | |
| rs3406586663 | 274 | I>V | No | EVA | |
| rs241567272 | 288 | E>K | No | EVA | |
| rs3389449465 | 338 | Q>* | No | EVA | |
| rs260765752 | 359 | R>P | No | EVA | |
| rs260765752 | 359 | R>Q | No | EVA | |
| rs3389430340 | 369 | V>I | No | EVA | |
| rs3389442045 | 377 | N>I | No | EVA | |
| rs3389363704 | 386 | K>E | No | EVA | |
| rs29501189 | 407 | R>H | No | EVA | |
| rs265346779 | 429 | D>G | No | EVA | |
| rs3389449444 | 450 | A>P | No | EVA | |
| rs3389445327 | 450 | A>V | No | EVA | |
| rs3389449448 | 451 | I>V | No | EVA | |
| rs245524886 | 477 | K>R | No | EVA | |
| rs3389450300 | 484 | K>E | No | EVA | |
| rs262274481 | 501 | M>I | No | EVA | |
| rs3389458654 | 521 | G>E | No | EVA | |
| rs3389466944 | 526 | P>S | No | EVA | |
| rs3389466951 | 545 | T>N | No | EVA |
10 associated diseases with Q91WT9
[MIM: 123500]: Crouzon syndrome (CS)
An autosomal dominant syndrome characterized by craniosynostosis, hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism. {ECO:0000269|PubMed:10574673, ECO:0000269|PubMed:11173845, ECO:0000269|PubMed:11380921, ECO:0000269|PubMed:11781872, ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:7581378, ECO:0000269|PubMed:7655462, ECO:0000269|PubMed:7874170, ECO:0000269|PubMed:7987400, ECO:0000269|PubMed:8528214, ECO:0000269|PubMed:8644708, ECO:0000269|PubMed:8946174, ECO:0000269|PubMed:8956050, ECO:0000269|PubMed:9152842, ECO:0000269|PubMed:9521581, ECO:0000269|PubMed:9677057, ECO:0000269|Ref.10}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 123150]: Jackson-Weiss syndrome (JWS)
An autosomal dominant craniosynostosis syndrome characterized by craniofacial abnormalities and abnormality of the feet
[MIM: 101200]: Apert syndrome (APRS)
A syndrome characterized by facio-cranio-synostosis, osseous and membranous syndactyly of the four extremities, and midface hypoplasia. The craniosynostosis is bicoronal and results in acrocephaly of brachysphenocephalic type. Syndactyly of the fingers and toes may be total (mitten hands and sock feet) or partial affecting the second, third, and fourth digits. Intellectual deficit is frequent and often severe, usually being associated with cerebral malformations. {ECO:0000269|PubMed:11390973, ECO:0000269|PubMed:11781872, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:7668257, ECO:0000269|PubMed:7719344, ECO:0000269|PubMed:9002682, ECO:0000269|PubMed:9452027, ECO:0000269|PubMed:9677057}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 101600]: Pfeiffer syndrome (PS)
A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known
[MIM: 123790]: Beare-Stevenson cutis gyrata syndrome (BSTVS)
An autosomal dominant disease characterized by craniofacial anomalies, particularly craniosynostosis, and ear defects, cutis gyrata, acanthosis nigricans, anogenital anomalies, skin tags, and prominent umbilical stump. The skin furrows have a corrugated appearance and are widespread. Cutis gyrata variably affects the scalp, forehead, face, preauricular area, neck, trunk, hands, and feet. {ECO:0000269|PubMed:12000365, ECO:0000269|PubMed:8696350}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 609579]: Familial scaphocephaly syndrome (FSPC)
An autosomal dominant craniosynostosis syndrome characterized by scaphocephaly, macrocephaly, hypertelorism, maxillary retrusion, and mild intellectual disability. Scaphocephaly is the most common of the craniosynostosis conditions and is characterized by a long, narrow head. It is due to premature fusion of the sagittal suture or from external deformation. {ECO:0000269|PubMed:16061565, ECO:0000269|PubMed:17803937}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 149730]: Lacrimo-auriculo-dento-digital syndrome (LADDS)
An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269|PubMed:16501574, ECO:0000269|PubMed:18056630}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 207410]: Antley-Bixler syndrome, without genital anomalies or disordered steroidogenesis (ABS2)
A rare syndrome characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Arachnodactyly and/or camptodactyly have also been reported. {ECO:0000269|PubMed:10633130}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 614592]: Bent bone dysplasia syndrome (BBDS)
A perinatal lethal skeletal dysplasia characterized by poor mineralization of the calvarium, craniosynostosis, dysmorphic facial features, prenatal teeth, hypoplastic pubis and clavicles, osteopenia, and bent long bones. Dysmorphic facial features included low-set ears, hypertelorism, midface hypoplasia, prematurely erupted fetal teeth, and micrognathia. {ECO:0000269|PubMed:22387015}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 101400]: Saethre-Chotzen syndrome (SCS)
A craniosynostosis syndrome characterized by coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly. {ECO:0000269|PubMed:9585583}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- An autosomal dominant syndrome characterized by craniosynostosis, hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism. {ECO:0000269|PubMed:10574673, ECO:0000269|PubMed:11173845, ECO:0000269|PubMed:11380921, ECO:0000269|PubMed:11781872, ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:7581378, ECO:0000269|PubMed:7655462, ECO:0000269|PubMed:7874170, ECO:0000269|PubMed:7987400, ECO:0000269|PubMed:8528214, ECO:0000269|PubMed:8644708, ECO:0000269|PubMed:8946174, ECO:0000269|PubMed:8956050, ECO:0000269|PubMed:9152842, ECO:0000269|PubMed:9521581, ECO:0000269|PubMed:9677057, ECO:0000269|Ref.10}. Note=The disease is caused by variants affecting the gene represented in this entry.
- An autosomal dominant craniosynostosis syndrome characterized by craniofacial abnormalities and abnormality of the feet
- A syndrome characterized by facio-cranio-synostosis, osseous and membranous syndactyly of the four extremities, and midface hypoplasia. The craniosynostosis is bicoronal and results in acrocephaly of brachysphenocephalic type. Syndactyly of the fingers and toes may be total (mitten hands and sock feet) or partial affecting the second, third, and fourth digits. Intellectual deficit is frequent and often severe, usually being associated with cerebral malformations. {ECO:0000269|PubMed:11390973, ECO:0000269|PubMed:11781872, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:7668257, ECO:0000269|PubMed:7719344, ECO:0000269|PubMed:9002682, ECO:0000269|PubMed:9452027, ECO:0000269|PubMed:9677057}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known
- An autosomal dominant disease characterized by craniofacial anomalies, particularly craniosynostosis, and ear defects, cutis gyrata, acanthosis nigricans, anogenital anomalies, skin tags, and prominent umbilical stump. The skin furrows have a corrugated appearance and are widespread. Cutis gyrata variably affects the scalp, forehead, face, preauricular area, neck, trunk, hands, and feet. {ECO:0000269|PubMed:12000365, ECO:0000269|PubMed:8696350}. Note=The disease is caused by variants affecting the gene represented in this entry.
- An autosomal dominant craniosynostosis syndrome characterized by scaphocephaly, macrocephaly, hypertelorism, maxillary retrusion, and mild intellectual disability. Scaphocephaly is the most common of the craniosynostosis conditions and is characterized by a long, narrow head. It is due to premature fusion of the sagittal suture or from external deformation. {ECO:0000269|PubMed:16061565, ECO:0000269|PubMed:17803937}. Note=The disease is caused by variants affecting the gene represented in this entry.
- An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269|PubMed:16501574, ECO:0000269|PubMed:18056630}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A rare syndrome characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Arachnodactyly and/or camptodactyly have also been reported. {ECO:0000269|PubMed:10633130}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A perinatal lethal skeletal dysplasia characterized by poor mineralization of the calvarium, craniosynostosis, dysmorphic facial features, prenatal teeth, hypoplastic pubis and clavicles, osteopenia, and bent long bones. Dysmorphic facial features included low-set ears, hypertelorism, midface hypoplasia, prematurely erupted fetal teeth, and micrognathia. {ECO:0000269|PubMed:22387015}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A craniosynostosis syndrome characterized by coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly. {ECO:0000269|PubMed:9585583}. Note=The disease is caused by variants affecting the gene represented in this entry.
16 regional properties for Q91WT9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 481 - 770 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 481 - 757 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 53 - 114 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 170 - 238 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 269 - 349 | IPR003598-3 |
| domain | Immunoglobulin subtype | 47 - 125 | IPR003599-1 |
| domain | Immunoglobulin subtype | 164 - 249 | IPR003599-2 |
| domain | Immunoglobulin subtype | 263 - 360 | IPR003599-3 |
| domain | Immunoglobulin-like domain | 39 - 125 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 154 - 247 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 256 - 358 | IPR007110-3 |
| active_site | Tyrosine-protein kinase, active site | 622 - 634 | IPR008266 |
| domain | Immunoglobulin I-set | 172 - 248 | IPR013098-1 |
| domain | Immunoglobulin I-set | 264 - 359 | IPR013098-2 |
| binding_site | Protein kinase, ATP binding site | 487 - 517 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 481 - 757 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.22 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
14 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbon monoxide binding | Binding to carbon monoxide (CO). |
| cystathionine beta-synthase activity | Catalysis of the reaction |
| cysteine synthase activity | Catalysis of the reaction |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| L-cysteine desulfhydrase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
| modified amino acid binding | Binding to a modified amino acid. |
| nitric oxide binding | Binding to nitric oxide (NO). |
| nitrite reductase (NO-forming) activity | Catalysis of the reaction |
| oxygen binding | Binding to oxygen (O2). |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| S-adenosyl-L-methionine binding | Binding to S-adenosyl-L-methionine. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| blood vessel diameter maintenance | Any process that modulates the diameter of blood vessels. |
| blood vessel remodeling | The reorganization or renovation of existing blood vessels. |
| cartilage development involved in endochondral bone morphogenesis | The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| cerebellum morphogenesis | The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
| cysteine biosynthetic process | The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. |
| cysteine biosynthetic process from serine | The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. |
| cysteine biosynthetic process via cystathionine | The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. |
| DNA protection | Any process in which DNA is protected from damage by, for example, oxidative stress. |
| endochondral ossification | Replacement ossification wherein bone tissue replaces cartilage. |
| homocysteine catabolic process | The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. |
| homocysteine metabolic process | The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. |
| hydrogen sulfide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. |
| L-cysteine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. |
| L-serine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
| L-serine metabolic process | The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
| maternal process involved in female pregnancy | A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| regulation of nitric oxide mediated signal transduction | Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). |
| response to folic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. |
| superoxide metabolic process | The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. |
| transsulfuration | The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSGTSQCED | GSAGGFQHLD | MHSEKRQLEK | GPSGDKDRVW | IRPDTPSRCT | WQLGRAMADS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PHYHTVLTKS | PKILPDILRK | IGNTPMVRIN | KISKNAGLKC | ELLAKCEFFN | AGGSVKDRIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRMIEDAERA | GNLKPGDTII | EPTSGNTGIG | LALAAAVKGY | RCIIVMPEKM | SMEKVDVLRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGAEIVRTPT | NARFDSPESH | VGVAWRLKNE | IPNSHILDQY | RNASNPLAHY | DDTAEEILQQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CDGKLDMLVA | SAGTGGTITG | IARKLKEKCP | GCKIIGVDPE | GSILAEPEEL | NQTEQTAYEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGIGYDFIPT | VLDRAVVDKW | FKSNDEDSFA | FARMLIAQEG | LLCGGSSGSA | MAVAVKAARE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQEGQRCVVI | LPDSVRNYMS | KFLSDKWMLQ | KGFMKEELSV | KRPWWWRLRV | QELSLSAPLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLPTVTCEDT | IAILREKGFD | QAPVVNESGA | ILGMVTLGNM | LSSLLAGKVR | PSDEVCKVLY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KQFKPIHLTD | TLGTLSHILE | MDHFALVVHE | QIQSRDQAWS | GVVGGPTDCS | NGMSSKQQMV |
| 550 | 560 | ||||
| FGVVTAIDLL | NFVAAREQTQ | T |