Q91VS8
Gene name |
Farp2 (Kiaa0793) |
Protein name |
FERM, ARHGEF and pleckstrin domain-containing protein 2 |
Names |
FERM domain including RhoGEF, FIR, FERM, RhoGEF and pleckstrin domain-containing protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:227377 |
EC number |
|
Protein Class |
FERM DOMAIN CONTAINING PROTEIN (PTHR45858) |
Descriptions
Farp2 is a Dbl-family quinine nucleotide exchange factor (GEF) that contains a 4.1, ezrin, radixin and moesin (FERM) domain, a Dbl-homology (DH) domain and two pleckstrin homology (PH) domains. Farp2 activates Rac1 or Cdc42 in response to upstream signals, thereby regulating neuronal axon guidance and bone homeostasis. The GEF substrate-binding site is blocked collectively by the last helix (Helix α6, 727-745, pseudosubstrate-like interaction) in the DH domain and the two PH domains (760-1025). Helix α6 and PH2 domain each can independently inhibit GEF activity of FARP2, and full activation of FARP2 requires releasing of both these two inhibitory elements. FARP2 activation involves membrane localization, binding of activators and tyrosine phosphorylation.
Autoinhibitory domains (AIDs)
Target domain |
538-729 (DH domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis, Mutagenesis experiment, Deletion assay |
Target domain |
538-729 (DH domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis, Mutagenesis experiment, Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q91VS8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4GYV | X-ray | 290 A | A/B/C/D/E/F/G/H/I | 536-749 | PDB |
| 4GZU | X-ray | 320 A | A/B | 536-1032 | PDB |
| 6D2K | X-ray | 155 A | A | 38-324 | PDB |
| AF-Q91VS8-F1 | Predicted | AlphaFoldDB |
20 variants for Q91VS8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs30360192 | 68 | V>I | No | Ensembl | |
| rs30360184 | 110 | R>Q | No | Ensembl | |
| rs30357931 | 156 | T>A | No | Ensembl | |
| rs228708756 | 162 | L>I | No | Ensembl | |
| rs234456171 | 382 | D>E | No | Ensembl | |
| rs226285065 | 422 | N>S | No | Ensembl | |
| rs216489667 | 437 | V>L | No | Ensembl | |
| rs233462713 | 448 | G>R | No | Ensembl | |
| rs251153905 | 459 | S>P | No | Ensembl | |
| rs223065274 | 467 | V>M | No | Ensembl | |
| rs243115106 | 469 | R>Q | No | Ensembl | |
| rs225706775 | 521 | A>D | No | Ensembl | |
| rs221169105 | 580 | A>T | No | Ensembl | |
| rs30361194 | 630 | M>I | No | Ensembl | |
| rs236574676 | 690 | H>Y | No | Ensembl | |
| rs211722820 | 705 | G>R | No | Ensembl | |
| rs30359609 | 707 | R>C | No | Ensembl | |
| rs30358727 | 749 | V>I | No | Ensembl | |
| rs13475988 | 821 | P>L | No | Ensembl | |
| rs258076832 | 1050 | I>N | No | Ensembl |
No associated diseases with Q91VS8
10 regional properties for Q91VS8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 538 - 729 | IPR000219 |
| domain | FERM domain | 44 - 324 | IPR000299 |
| domain | Pleckstrin homology domain | 758 - 857 | IPR001849-1 |
| domain | Pleckstrin homology domain | 930 - 1029 | IPR001849-2 |
| domain | FERM adjacent | 332 - 378 | IPR014847 |
| domain | FERM, N-terminal | 48 - 110 | IPR018979 |
| conserved_site | FERM conserved site | 98 - 127 | IPR019747 |
| domain | FERM central domain | 129 - 234 | IPR019748 |
| domain | Band 4.1 domain | 40 - 234 | IPR019749 |
| domain | FARP1/FARP2/FRMD7, FERM domain C-lobe | 221 - 341 | IPR041788 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR45858 | FERM DOMAIN CONTAINING PROTEIN |
| PANTHER Subfamily | PTHR45858:SF4 | FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2 |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| hair cycle process | A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. |
| neuron remodeling | The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. |
| osteoclast differentiation | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
| podosome assembly | The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. |
| Rac protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. |
| regulation of integrin activation | Any process that modulates the frequency, rate, or extent of integrin activation. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1P065 | FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Gallus gallus (Chicken) | SS |
| Q9Y4F1 | FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Homo sapiens (Human) | SS |
| O94887 | FARP2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 | Homo sapiens (Human) | SS |
| A2AD83 | Frmd7 | FERM domain-containing protein 7 | Mus musculus (Mouse) | PR |
| F8VPU2 | Farp1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Mus musculus (Mouse) | SS |
| F1LYQ8 | Farp1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEIEGTYRA | LPTSGTRLGG | QTAIGVSTLE | PEQSLSPRMQ | EKHMRIRVKL | LDSTVELFDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPKCDGQVLL | TQVWKHLNLI | ECDYFGLEFK | NVQSYWIWLE | PMKPIIRQVR | KPKNAVLRLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKFFPPDPGQ | LQEEYTRYLF | ALQLKRDLLE | ERLTCTANTA | ALLISHLLQS | EIGDYDETLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| REHLKANEYL | PNQEKSLEKI | LDFHQRHTGQ | TPAESDFQVL | EIARKLEMYG | IRFHMASDRE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GTKINLAVSH | MGVLVFQGTT | KINTFNWSKV | RKLSFKRKRF | LIKLHPEVHG | PYQDTLEFLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSRDECKNFW | KICVEYHTFF | RLSDQPKPKA | KAVFFSRGSS | FRYSGRTQKQ | LVDYVKDGGM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KRIPYERRHS | KTRTSLHALT | VDLPKQSVSF | TDGLRTSASL | SSANVSFYPP | PSSSLSPPGL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PNLKDSSSSL | VDPQAPVIKS | TAAERSSGPS | SSDGPSTQSA | HLPGPPVLRP | GPGFSMDSPQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSPSSLKSHL | SLCPELQAAL | STAEQGASPV | LSPVLSGAGT | ARMDNQEEQK | HKHMPEDEAY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIAKEILATE | RTYLKDLEVI | TVWFRSVLIK | EEAMPAALMA | LLFSNIDPVY | EFHRGFLHEV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EQRLALWEGP | SSAHLKGDHQ | RIGDILLRNM | RQLKEFTSYF | QRHDEVLTEL | EKATKHCKKL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EAVYKEFELQ | KVCYLPLNTF | LLKPVQRLVH | YRLLLSRLCA | HYSPGHRDYA | DCHEALKAIT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVTTELQQSL | TRLENLQKLT | ELQRDLVGVE | NLIAPGREFI | REGCLHKLTK | KGLQQRMFFL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FSDMLLYTSK | SVTGASHFRI | RGFLPLRGML | VEESENEWSV | PHCFTIYAAQ | KTIVVAASTR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LEKEKWMQDL | NAAIQAAKTI | GDSPPVLLGG | PVYTRTPRSS | DEVSLEESED | GRGNRGSLEG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NSQHRANTTM | HVCWYRNTSV | SRADHSAAVE | NQLSGYLLRK | FKNSNGWQKL | WVVFTNFCLF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FYKTHQDDYP | LASLPLLGYS | VSLPREADSI | HKDYVFKLQF | KSHVYFFRAE | SKYTFERWMD |
| 1030 | 1040 | 1050 | 1060 | ||
| VIKRASSSPG | RPPSFTQDCS | HHSPGLEAEI | REKEACPSPC | LDKNL |