Q91VJ4

SS
Gene name
Stk38
Protein name
Serine/threonine-protein kinase 38
Names
NDR1 protein kinase, Nuclear Dbf2-related kinase 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:106504
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38, called nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. MOB1 also stimulates NDR kinase activity and interacts with NDR. <br> A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

265-276 (Autoinhibitory segment) SS

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

229-241 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

278-287 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91VJ4

Entry ID Method Resolution Chain Position Source
AF-Q91VJ4-F1 Predicted AlphaFoldDB

1 variants for Q91VJ4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs45715644 269 E>A No Ensembl

No associated diseases with Q91VJ4

4 regional properties for Q91VJ4

Type Name Position InterPro Accession
repeat Leucine-rich repeat 121 - 142 IPR001611-1
repeat Leucine-rich repeat 161 - 182 IPR001611-2
domain Novel E3 ligase domain 287 - 497 IPR029487
domain LRR-containing bacterial E3 ligase, N-terminal 7 - 51 IPR032674

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein phosphorylation The process of introducing a phosphate group on to a protein.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53894 CBK1 Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
Q9NBK5 trc Serine/threonine-protein kinase tricornered Drosophila melanogaster (Fruit fly) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
Q02956 Prkcz Protein kinase C zeta type Mus musculus (Mouse) SS
Q62074 Prkci Protein kinase C iota type Mus musculus (Mouse) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
P20444 Prkca Protein kinase C alpha type Mus musculus (Mouse) SS
P63318 Prkcg Protein kinase C gamma type Mus musculus (Mouse) SS
P68404 Prkcb Protein kinase C beta type Mus musculus (Mouse) SS
Q60823 Akt2 RAC-beta serine/threonine-protein kinase Mus musculus (Mouse) PR
P31750 Akt1 RAC-alpha serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9WUA6 Akt3 RAC-gamma serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9ERE3 Sgk3 Serine/threonine-protein kinase Sgk3 Mus musculus (Mouse) PR
Q8QZV4 Stk32c Serine/threonine-protein kinase 32C Mus musculus (Mouse) PR
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE
70 80 90 100 110 120
EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL
130 140 150 160 170 180
RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK
190 200 210 220 230 240
KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA
250 260 270 280 290 300
HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN
310 320 330 340 350 360
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPVS EKAKGLILRF
370 380 390 400 410 420
CCEWEHRIGA PGVEEIKNNL FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK
430 440 450 460
PTVTTSSHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK