Q91VJ1
SS
Gene name |
Aim2 |
Protein name |
Interferon-inducible protein AIM2 |
Names |
Interferon-inducible protein 210, Ifi-210, Interferon-inducible protein p210 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:383619 |
EC number |
|
Protein Class |
|
Descriptions
Interferon-inducible protein AIM2 have been identified as DNA receptors that induce inflammasome formation. AIM2 contains a C-terminal DNA-binding HIN domain and an N-terminal PYD domain belonging to the death domain superfamily of signaling modules. AIM2 PYD domain inhibits the HIN:DNA interaction. PYD domain binds to the HIN domain from the intramolecular complex, which hinders the DNA binding of HIN domain.
Autoinhibitory domains (AIDs)
Target domain |
144-341 (HIN domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q91VJ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2N00 | NMR | - | A | 1-95 | PDB |
| 4JBM | X-ray | 222 A | A/B | 158-349 | PDB |
| AF-Q91VJ1-F1 | Predicted | AlphaFoldDB |
5 variants for Q91VJ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31606216 | 60 | S>C | No | Ensembl | |
| rs31610204 | 92 | L>F | No | Ensembl | |
| rs261408982 | 124 | D>G | No | Ensembl | |
| rs31607756 | 216 | S>T | No | Ensembl | |
| rs232868069 | 236 | V>A | No | Ensembl |
No associated diseases with Q91VJ1
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| AIM2 inflammasome complex | An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| identical protein binding | Binding to an identical protein or proteins. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of innate immune response | Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to interferon-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. |
| cellular response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| negative regulation of NF-kappaB transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. |
| NLRP3 inflammasome complex assembly | The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell. |
| positive regulation of cysteine-type endopeptidase activity | Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity. |
| positive regulation of defense response to virus by host | Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. |
| positive regulation of interleukin-1 beta production | Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| pyroptosis | A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. |
| pyroptosome complex assembly | The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex. |
| tumor necrosis factor-mediated signaling pathway | The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESEYREMLL | LTGLDHITEE | ELKRFKYFAL | TEFQIARSTL | DVADRTELAD | HLIQSAGAAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVTKAINIFQ | KLNYMHIANA | LEEKKKEAER | KLMTNTKKRG | TQKVENRSQA | ENCSAASATR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDNDFKEQAA | TEVCPQAKPQ | KKQMVAEQEA | IREDLQKDPL | VVTVLKAINP | FECETQEGRQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIFHATVATE | TDFFFVKVLN | AQFKDKFIPK | RTIKISNYLW | HSNFMEVTSS | SVVVDVESNH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVPNNVVKRA | RETPRISKLK | IQPCGTIVNG | LFKVQKITEE | KDRVLYGIHD | KTGTMEVLVL |
| 310 | 320 | 330 | 340 | 350 | |
| GNPSKTKCEE | GDKIRLTFFE | VSKNGVKIQL | KSGPCSFFKV | IKAAKPKTDM | KSVE |