Q91VC3
PR
Gene name |
Eif4a3 (Ddx48) |
Protein name |
Eukaryotic initiation factor 4A-III |
Names |
eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic translation initiation factor 4A isoform 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192170 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91VC3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91VC3-F1 | Predicted | AlphaFoldDB |
21 variants for Q91VC3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs242066711 | 4 | N>K | No | EVA | |
| rs212652137 | 4 | N>T | No | EVA | |
| rs3389223140 | 65 | Q>L | No | EVA | |
| rs251013860 | 94 | V>I | No | EVA | |
| rs3389227766 | 149 | D>V | No | EVA | |
| rs3389221427 | 182 | K>N | No | EVA | |
| rs3389223076 | 205 | Y>N | No | EVA | |
| rs3389196616 | 241 | V>M | No | EVA | |
| rs3389217620 | 264 | K>* | No | EVA | |
| rs3389196591 | 309 | G>V | No | EVA | |
| rs3389238055 | 326 | G>V | No | EVA | |
| rs3389158063 | 328 | S>I | No | EVA | |
| rs3389185226 | 335 | D>A | No | EVA | |
| rs3389238064 | 364 | R>K | No | EVA | |
| rs3389211757 | 371 | Y>N | No | EVA | |
| rs3403038220 | 387 | R>Q | No | EVA | |
| rs3402179569 | 389 | L>R | No | EVA | |
| rs3389221506 | 393 | E>D | No | EVA | |
| rs3389238084 | 394 | Q>* | No | EVA | |
| rs3389226215 | 408 | A>T | No | EVA | |
| rs3389192480 | 410 | L>V | No | EVA |
No associated diseases with Q91VC3
5 regional properties for Q91VC3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 185 - 193 | IPR000629 |
| domain | Helicase, C-terminal | 250 - 411 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 63 - 225 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 57 - 254 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 38 - 66 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| exon-exon junction complex | A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynaptic cytosol | The region of the cytosol consisting of all cytosol that is part of the postsynapse. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| U2-type catalytic step 1 spliceosome | A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| poly(A) binding | Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| RNA stem-loop binding | Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
| selenocysteine insertion sequence binding | Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. |
| translation regulator activity | Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| embryonic cranial skeleton morphogenesis | The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| negative regulation of excitatory postsynaptic potential | Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of selenocysteine incorporation | Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation. |
| negative regulation of selenocysteine insertion sequence binding | Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding. |
| negative regulation of translation | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| positive regulation of mRNA splicing, via spliceosome | Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
| regulation of mRNA binding | Any process that modulates the frequency, rate or extent of mRNA binding. |
| regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. |
| regulation of translation at postsynapse, modulating synaptic transmission | Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12099 | FAL1 | ATP-dependent RNA helicase FAL1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2NL22 | EIF4A3 | Eukaryotic initiation factor 4A-III | Bos taurus (Bovine) | PR |
| Q5ZM36 | EIF4A3 | Eukaryotic initiation factor 4A-III | Gallus gallus (Chicken) | PR |
| Q9VHS8 | CG7483 | Eukaryotic initiation factor 4A-III | Drosophila melanogaster (Fruit fly) | PR |
| P38919 | EIF4A3 | Eukaryotic initiation factor 4A-III | Homo sapiens (Human) | PR |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| A6M931 | EIF4A3 | Eukaryotic initiation factor 4A-III | Sus scrofa (Pig) | PR |
| Q3B8Q2 | Eif4a3 | Eukaryotic initiation factor 4A-III | Rattus norvegicus (Rat) | PR |
| Q10I26 | EIF4A3B | Eukaryotic initiation factor 4A-III homolog B | Oryza sativa subsp japonica (Rice) | PR |
| Q5VNM3 | EIF4A3A | Eukaryotic initiation factor 4A-III homolog A | Oryza sativa subsp japonica (Rice) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B7ZTW1 | eif4a3 | Eukaryotic initiation factor 4A-III | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZVA6 | eif4a3 | Eukaryotic initiation factor 4A-III | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAANATMATS | GSARKRLLKE | EDMTKVEFET | SEEVDVTPTF | DTMGLREDLL | RGIYAYGFEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSAIQQRAIK | QIIKGRDVIA | QSQSGTGKTA | TFSVSVLQCL | DIQVRETQAL | ILAPTRELAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QIQKGLLALG | DYMNVQCHAC | IGGTNVGEDI | RKLDYGQHVV | AGTPGRVFDM | IRRRSLRTRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKMLVLDEAD | EMLNKGFKEQ | IYDVYRYLPP | ATQVVLISAT | LPHEILEMTN | KFMTDPIRIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKRDELTLEG | IKQFFVAVER | EEWKFDTLCD | LYDTLTITQA | VIFCNTKRKV | DWLTEKMREA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NFTVSSMHGD | MPQKERESIM | KEFRSGASRV | LISTDVWARG | LDVPQVSLII | NYDLPNNREL |
| 370 | 380 | 390 | 400 | 410 | |
| YIHRIGRSGR | YGRKGVAINF | VKNDDIRILR | DIEQYYSTQI | DEMPMNVADL | I |