Q91V88
PR
Gene name |
Npnt (Neph1, Poem) |
Protein name |
Nephronectin |
Names |
Preosteoblast EGF-like repeat protein with MAM domain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:114249 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91V88
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91V88-F1 | Predicted | AlphaFoldDB |
18 variants for Q91V88
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388659410 | 49 | A>S | No | EVA | |
| rs3388660827 | 52 | S>* | No | EVA | |
| rs3388646275 | 68 | E>K | No | EVA | |
| rs50092154 | 70 | V>I | No | EVA | |
| rs3388664237 | 206 | I>T | No | EVA | |
| rs3388662670 | 216 | D>N | No | EVA | |
| rs3388660478 | 219 | S>P | No | EVA | |
| rs3388666285 | 249 | D>G | No | EVA | |
| rs3388654612 | 278 | K>N | No | EVA | |
| rs3388668465 | 319 | T>I | No | EVA | |
| rs3388663812 | 325 | Q>E | No | EVA | |
| rs3388653601 | 409 | E>A | No | EVA | |
| rs30726425 | 450 | G>E | No | EVA | |
| rs239654057 | 460 | A>V | No | EVA | |
| rs30725673 | 471 | R>P | No | EVA | |
| rs3388662559 | 480 | D>N | No | EVA | |
| rs3388653670 | 544 | G>A | No | EVA | |
| rs3388662206 | 560 | R>H | No | EVA |
No associated diseases with Q91V88
13 regional properties for Q91V88
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 104 - 115 | IPR000152-1 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 186 - 197 | IPR000152-2 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 231 - 242 | IPR000152-3 |
| domain | EGF-like domain | 59 - 87 | IPR000742-1 |
| domain | EGF-like domain | 89 - 128 | IPR000742-2 |
| domain | EGF-like domain | 132 - 168 | IPR000742-3 |
| domain | EGF-like domain | 169 - 213 | IPR000742-4 |
| domain | EGF-like domain | 214 - 254 | IPR000742-5 |
| domain | MAM domain | 417 - 561 | IPR000998 |
| domain | EGF-like calcium-binding domain | 89 - 128 | IPR001881-1 |
| domain | EGF-like calcium-binding domain | 169 - 213 | IPR001881-2 |
| domain | EGF-like calcium-binding domain | 214 - 254 | IPR001881-3 |
| conserved_site | EGF-like calcium-binding, conserved site | 214 - 240 | IPR018097 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| basement membrane | A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. |
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| smooth muscle contractile fiber | The contractile fiber of smooth muscle cells. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| integrin binding | Binding to an integrin. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| branching involved in ureteric bud morphogenesis | The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. |
| cell-cell adhesion mediated by integrin | The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. |
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| cellular response to tumor necrosis factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| pilomotor reflex | The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. |
| positive regulation of alkaline phosphatase activity | Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
| positive regulation of cell-substrate adhesion | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of osteoblast differentiation | Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of transforming growth factor beta receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. |
| smooth muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. |
| transforming growth factor beta receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| ureteric bud development | The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q868Z9 | Ppn | Papilin | Drosophila melanogaster (Fruit fly) | SS |
| Q04721 | NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens (Human) | EV |
| P46531 | NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens (Human) | EV |
| P21941 | MATN1 | Cartilage matrix protein | Homo sapiens (Human) | PR |
| Q6GUQ1 | Egfl8 | Epidermal growth factor-like protein 8 | Mus musculus (Mouse) | PR |
| Q01705 | Notch1 | Neurogenic locus notch homolog protein 1 | Mus musculus (Mouse) | SS |
| O35516 | Notch2 | Neurogenic locus notch homolog protein 2 | Mus musculus (Mouse) | SS |
| P51942 | Matn1 | Cartilage matrix protein | Mus musculus (Mouse) | PR |
| Q9QW30 | Notch2 | Neurogenic locus notch homolog protein 2 | Rattus norvegicus (Rat) | SS |
| Q07008 | Notch1 | Neurogenic locus notch homolog protein 1 | Rattus norvegicus (Rat) | SS |
| P13508 | glp-1 | Protein glp-1 | Caenorhabditis elegans | EV |
| A2RUV0 | notch1 | Neurogenic locus notch homolog protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| P46530 | notch1a | Neurogenic locus notch homolog protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVLLAAVLA | SSLYLQVAAD | FDGRWPRQIV | SSIGLCRYGG | RIDCCWGWAR | QSWGQCQPVC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPQCKHGECV | GPNKCKCHPG | FAGKTCNQDL | NECGLKPRPC | KHRCMNTFGS | YKCYCLNGYM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLPDGSCSSA | LSCSMANCQY | GCDVVKGQVR | CQCPSPGLQL | APDGRTCVDI | DECATGRVSC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRFRQCVNTF | GSYICKCHTG | FDLMYIGGKY | QCHDIDECSL | GQHQCSSYAR | CYNIHGSYKC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QCRDGYEGDG | LNCVYIPKVM | IEPSGPIHMP | ERNGTISKGD | GGHANRIPDA | GSTRWPLKTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YIPPVITNRP | TSKPTTRPTP | NPTPQPTPPP | PPPLPTEPRT | TPLPPTPERP | STRPTTIAPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSTTTRVITV | DNRIQTDPQK | PRGDVFIPRQ | PTNDLFEIFE | IERGVSADEE | VKDDPGILIH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SCNFDHGLCG | WIREKDSDLH | WETARDPAGG | QYLTVSAAKA | PGGKAARLVL | RLGHLMHSGD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LCLSFRHKVT | GLHSGTLQVF | VRKHGTHGAA | LWGRNGGHGW | RQTQITLRGA | DVKSVIFKGE |
| 550 | 560 | ||||
| KRRGHTGEIG | LDDVSLKRGR | C |