Q91994
Gene name |
otx1b (otx1) |
Protein name |
Homeobox protein OTX1 B |
Names |
zOtx1, Orthodenticle homolog 1 B |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:30500 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91994
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91994-F1 | Predicted | AlphaFoldDB |
No variants for Q91994
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q91994 | |||||
No associated diseases with Q91994
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| inner ear morphogenesis | The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. |
| lateral semicircular canal development | The progession of the lateral semicircular canal from its initial formation to the mature structure. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| retinal pigment epithelium development | The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XSK0 | CRX | Cone-rod homeobox protein | Bos taurus (Bovine) | PR |
| O73592 | Homeobox protein MIXL1 | Gallus gallus (Chicken) | PR | |
| O43186 | CRX | Cone-rod homeobox protein | Homo sapiens (Human) | PR |
| P32243 | OTX2 | Homeobox protein OTX2 | Homo sapiens (Human) | PR |
| P80206 | Otx2 | Homeobox protein OTX2 | Mus musculus (Mouse) | PR |
| O54751 | Crx | Cone-rod homeobox protein | Mus musculus (Mouse) | PR |
| Q6H6S3 | HOX24 | Homeobox-leucine zipper protein HOX24 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XUJ5 | HOX22 | Homeobox-leucine zipper protein HOX22 | Oryza sativa subsp japonica (Rice) | PR |
| A3BYC1 | HOX25 | Homeobox-leucine zipper protein HOX25 | Oryza sativa subsp japonica (Rice) | PR |
| Q9M276 | ATHB-12 | Homeobox-leucine zipper protein ATHB-12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28FN6 | otx2 | Homeobox protein OTX2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMSYLKQPPY | AMNGLGLSGA | AMDLLHPSVG | YPATPRKQRR | ERTTFTRSQL | DILEALFAKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RYPDIFMREE | VALKINLPES | RVQVWFKNRR | AKCRQQQQSG | SSTKTRPAKK | KSSPTRESTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SESSGQFTPP | AVSSAGSSSS | SSSSTNNTGI | SSTSTSISTV | SSIWSPAISP | GSAPPSVSLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPVAPSNTSC | MQRSVSGTAS | STYPMPYNQT | TGYSQGYPTP | SGSYFSGVDC | GSYLAPMHSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HHPHQLSPMT | ASSMPTHPHH | HISQSSGHHH | HHHHQAYSGT | GLAFNSSDCL | DYKEQTASSW |
| 310 | 320 | ||||
| KLNFNTTDCL | DYKDQASWRF | QVL |