Q91987

SS
Gene name
NTRK2 (TRKB)
Protein name
BDNF/NT-3 growth factors receptor
Names
EC 2.7.10.1 , Neurotrophic tyrosine kinase receptor type 2 , TrkB tyrosine kinase , Trk-B
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396157
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

NTRK2 is a receptor for brain-derived neurotrophic factor (BDNF), and is involved in survival, differentiation, development, and maturation of the central and peripheral nervous system. The autoinhibitory region of NTRK2 is the extracellular juxtamembrane motif (EJM). In the inactivated form, the two intracellular kinase domains (IKDs) are separated by the conformation set by EJM. Deletion of the EJM facilitates dimer formation and increases the amount of preformed dimers.

Autoinhibitory domains (AIDs)

281-394 (Ig2 domain) SS

Target domain

534-803 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

578-590 (αC helix) SS

Target domain

534-803 (Protein kinase domain)

Relief mechanism

Others

Assay

Accessory elements

689-714 (Activation loop from InterPro)

Target domain

534-803 (Protein kinase domain)

Relief mechanism

Assay

689-714 (Activation loop from InterPro)

Target domain

534-803 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91987

Entry ID Method Resolution Chain Position Source
AF-Q91987-F1 Predicted AlphaFoldDB

No variants for Q91987

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91987

1 associated diseases with Q91987

[MIM: 613722]: Developmental and epileptic encephalopathy 12 (DEE12)

A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. {ECO:0000269|PubMed:20833646}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. {ECO:0000269|PubMed:20833646}. Note=The disease is caused by variants affecting the gene represented in this entry.

8 regional properties for Q91987

Type Name Position InterPro Accession
domain C2 domain 656 - 786 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 316 - 468 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 540 - 656 IPR001711
conserved_site Phospholipase C-beta, conserved site 905 - 942 IPR009535
domain Phospholipase C-beta, C-terminal domain 1004 - 1172 IPR014815
domain Phosphoinositide-specific phospholipase C, EF-hand-like domain 216 - 307 IPR015359
domain 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, EF hand motif 153 - 303 IPR028400
domain PLC-beta, PH domain 18 - 148 IPR037862

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Endosome membrane ; Single-pass type I membrane protein
  • Cell projection, axon
  • Cell projection, dendrite
  • Cytoplasm, perinuclear region
  • Postsynaptic density
  • Internalized to endosomes upon ligand-binding
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
endosome membrane The lipid bilayer surrounding an endosome.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
brain-derived neurotrophic factor binding Binding to brain-derived neurotrophic factor.
brain-derived neurotrophic factor receptor activity Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
GPI-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity.
neurotrophin binding Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
protein homodimerization activity Binding to an identical protein to form a homodimer.
voltage-gated monoatomic ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

21 GO annotations of biological process

Name Definition
brain-derived neurotrophic factor receptor signaling pathway The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.
cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
cerebral cortex development The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
collateral sprouting The process in which outgrowths develop from the shafts of existing axons.
learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of collateral sprouting Any process that activates or increases the frequency, rate or extent of collateral sprouting.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of dendrite extension Any process that modulates the frequency, rate or extent of dendrite extension.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
trans-synaptic signaling by neuropeptide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.

41 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
Q5F3X2 DDR1 receptor protein-tyrosine kinase Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
Q98949 TYRO3 Tyrosine-protein kinase receptor TYRO3 Gallus gallus (Chicken) PR
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q5IS37 NTRK3 NT-3 growth factor receptor Pan troglodytes (Chimpanzee) SS
Q24488 Ror Tyrosine-protein kinase transmembrane receptor Ror Drosophila melanogaster (Fruit fly) SS
Q9V6K3 Nrk Tyrosine-protein kinase transmembrane receptor Ror2 Drosophila melanogaster (Fruit fly) SS
Q16288 NTRK3 NT-3 growth factor receptor Homo sapiens (Human) SS
Q01973 ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Homo sapiens (Human) PR
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase Homo sapiens (Human) EV
Q01974 ROR2 Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens (Human) EV
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens (Human) EV
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens (Human) EV
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
G5EGK5 cam-1 Tyrosine-protein kinase receptor cam-1 Caenorhabditis elegans SS
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFG1 At3g53590 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVSWRRRPGP GLARLWGLCC LVLGCWRGAL GCPASCRCSS WRIWCSEPVP GITSFPVPQR
70 80 90 100 110 120
STEDDNVTEI YIANQRKLES INDNEVGFYV GLKNLTVVDS GLRFVSRQAF VKNINLQYIN
130 140 150 160 170 180
LSRNKLSSLS KKPFRHLGLS DLILVDNPFK CSCEIMWIKK FQETKFYTEA QDIYCVDDNN
190 200 210 220 230 240
KRIALMDMKV PNCDLPSANL SNYNITVVEG KSITLYCDTT GGPPPNVSWV LTNLVSNHES
250 260 270 280 290 300
DTSKNPASLT IKNVSSMDSG LWISCVAENI VGEVQTSAEL TVFFAPNITF IESPTPDHHW
310 320 330 340 350 360
CIPFTVKGNP KPTLQWFYEG AILNESEYIC TKIHVINQSE YHGCLQLDNP THLNNGAYTL
370 380 390 400 410 420
LAKNEYGEDE KRVDAHFMSV PGDGSGPIVD PDVYEYETTP NDLGDTTNNS NQITSPDVSN
430 440 450 460 470 480
KENEDSITVY VVVGIAALVC TGLVIMLIIL KFGRHSKFGM KGPSSVISND DDSASPLHHI
490 500 510 520 530 540
SNGSNTPSSS EGGPDAVIIG MTKIPVIENP QYFGITNSQL KPDTFVQHIK RHNIVLKREL
550 560 570 580 590 600
GEGAFGKVFL AECYNLCPEQ DKILVAVKTL KDASDNARKD FHREAELLTN LQHEHIVKFY
610 620 630 640 650 660
GVCVEGDPLI MVFEYMKHGD LNKFLRAHGP DAVLMAEGNR PAELTQSQML HIAQQIAAGM
670 680 690 700 710 720
VYLASQHFVH RDLATRNCLV GENLLVKIGD FGMSRDVYST DYYRVGGHTM LPIRWMPPES
730 740 750 760 770 780
IMYRKFTTES DVWSLGVVLW EIFTYGKQPW YQLSNNEVIE CITQGRVLQR PRTCPKEVYD
790 800 810
LMLGCWQREP HMRLNIKEIH SLLQNLAKAS PVYLDILG