Q90XF2

SS
Gene name
prkci (hal)
Protein name
Protein kinase C iota type
Names
EC 2.7.11.13 , Atypical protein kinase C-lambda/iota , aPKC-lambda/iota , Heart and soul protein , nPKC-iota
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:117507
EC number
2.7.11.-: Protein-serine/threonine kinases
Protein Class

Descriptions

PRKCI, an atypical PKC (aPKC) isoform, is an important kinase in multiple cellular processes and regulated by the phosphatidylinositol 3-kinase product phosphatidylinositol 3,4,5-(PO4)3 (PIP3). In aPKC molecule, the arginine motif (123-140) in the pseudosubstrate region on the regulatory domain binds to acidic residues in the substrate-binding region on the catalytic domain, leading to the off state of aPKCs. The autoinhibition of aPKC is released by binding with the acidic ligand PIP3 and consequently exposing the substrate-binding site.

Autoinhibitory domains (AIDs)

116-133 (Pseudosubstrate region) SS

Target domain

225-588 (Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota)

Relief mechanism

Ligand binding

Assay

Accessory elements

387-410 (Activation loop from InterPro)

Target domain

225-588 (Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota)

Relief mechanism

Assay

387-410 (Activation loop from InterPro)

Target domain

225-588 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q90XF2

Entry ID Method Resolution Chain Position Source
AF-Q90XF2-F1 Predicted AlphaFoldDB

No variants for Q90XF2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90XF2

No associated diseases with Q90XF2

2 regional properties for Q90XF2

Type Name Position InterPro Accession
domain Sec7 domain 646 - 841 IPR000904
domain IQ motif and SEC7 domain-containing protein, PH domain 861 - 998 IPR033742

Functions

Description
EC Number 2.7.11.- Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
zonula adherens A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol-dependent serine/threonine kinase activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

29 GO annotations of biological process

Name Definition
adherens junction maintenance The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
adherens junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
apical protein localization Any process in which a protein is transported to, or maintained in, apical regions of the cell.
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell-cell junction maintenance The maintenance of junctions between cells.
cell-cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
digestive tract mesoderm development The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism.
digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
dorsal motor nucleus of vagus nerve development The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.
embryonic heart tube development The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
establishment or maintenance of polarity of embryonic epithelium Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.
generation of neurons The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
maintenance of epithelial cell apical/basal polarity The maintenance of the apicobasal polarity of an epithelial cell.
mesodermal cell migration The orderly movement of mesodermal cells from one site to another.
morphogenesis of a polarized epithelium The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
photoreceptor cell outer segment organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.
pronephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state.
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized.
ventricular system development The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P24583 PKC1 Protein kinase C-like 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A1Z9X0 aPKC Atypical protein kinase C Drosophila melanogaster (Fruit fly) SS
Q05513 PRKCZ Protein kinase C zeta type Homo sapiens (Human) SS
P41743 PRKCI Protein kinase C iota type Homo sapiens (Human) EV
Q02956 Prkcz Protein kinase C zeta type Mus musculus (Mouse) SS
Q62074 Prkci Protein kinase C iota type Mus musculus (Mouse) SS
P09217 Prkcz Protein kinase C zeta type Rattus norvegicus (Rat) SS
F1M7Y5 Prkci Protein kinase C iota type Rattus norvegicus (Rat) SS
Q19266 pkc-3 Protein kinase C-like 3 Caenorhabditis elegans SS
A7MBL8 pkn2 Serine/threonine-protein kinase N2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7SY24 prkcbb Protein kinase C beta type Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPTLRDSTMS HPGENPHQVR VKAYYRGDIM ITHFEPSISY EGLCNEVRDM CSMDNDQLFT
70 80 90 100 110 120
MKWIDEEGDP CTVSSQLELE EALRLYELNK DSELIIHVFP CVPEKPGMPC PGEDKSIYRR
130 140 150 160 170 180
GARRWRKLYY ATGHAFQAKR FNRRAHCAIC TDRIWGLGRQ GYKCINCKLL VHKKCHKLVT
190 200 210 220 230 240
VECGRQVIQD PMIGRIDPGS THPEHPDQVL GKKNSTESIN HEGEEHEAVG SRESGKAVSS
250 260 270 280 290 300
LGLIDFDLLR VIGRGSYAKV LLVRLKKTER IYAMKVVKKE LVNDDEDIDW VQTEKHVFEQ
310 320 330 340 350 360
ASNHPFLVGL HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY SAEISLALNY
370 380 390 400 410 420
LHERGIIYRD LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN YIAPEILRGE
430 440 450 460 470 480
DYGFSVDWWA LGVLMFEMMA GRSPFDIVGS SDNPDQNTED YLFQVILEKQ IRIPRSLSVK
490 500 510 520 530 540
AASVLKGFLN KESKERLGCH PQTGFADIMA HPFFRNVDWD LMEQKQVVPP FKPNISGEFG
550 560 570 580
LDNFDAQFTN EPIQLTPDDD DAVKKIDQSE FEGFEYINPL LMSAEECV