Q90891

PR
Gene name
MAP2K2 (MEK2, MKK2, PRKMK2)
Protein name
Dual specificity mitogen-activated protein kinase kinase 2
Names
MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK2
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396349
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

(Annotation based on sequence homology with Q02750)
MAP2K1 encodes for Dual specificity mitogen-activated protein kinase kinase 1, belongs to MAP2Ks family, plays an important role in MAP kinase signal transduction pathway. The α-helix 1 in the activation loop of MAP2K1 is shifted outwards from the active site because of the NRD. NRD of MAP2K1 prevents MAP2K1 changing to the active conformation. The autoinhibitory state of MAP2K1 is more stable as dimer in the absence of its own substrates or other interacting partners. The several interactions span from the N-terminal to the C-terminal to form dimer. Dimerization of MAP2K1 block access of the substrate binding site and the activation loop from macromolecules.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

209-230 (Activation loop from InterPro)

Target domain

70-367 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q90891

Entry ID Method Resolution Chain Position Source
AF-Q90891-F1 Predicted AlphaFoldDB

No variants for Q90891

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90891

No associated diseases with Q90891

5 regional properties for Q90891

Type Name Position InterPro Accession
domain Bromo adjacent homology (BAH) domain 44 - 170 IPR001025
domain AAA+ ATPase domain 505 - 656 IPR003593
domain ATPase, AAA-type, core 509 - 652 IPR003959
domain Cdc6, C-terminal 753 - 837 IPR015163
domain AAA lid domain 667 - 715 IPR041083

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32491 MKK2 MAP kinase kinase MKK2/SSP33 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32490 MKK1 MAP kinase kinase MKK1/SSP32 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9XT09 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Pan troglodytes (Chimpanzee) PR
Q1HG70 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q24324 Dsor1 Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster (Fruit fly) PR
Q13163 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens (Human) PR
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens (Human) EV
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens (Human) EV
P31938 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Mus musculus (Mouse) PR
Q9WVS7 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Mus musculus (Mouse) PR
Q63932 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Mus musculus (Mouse) PR
Q01986 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Rattus norvegicus (Rat) PR
Q62862 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Rattus norvegicus (Rat) PR
P36506 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Rattus norvegicus (Rat) SS
Q5QN75 MKK1 Mitogen-activated protein kinase kinase 1 Oryza sativa subsp japonica (Rice) PR
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q9FJV0 MKK6 Mitogen-activated protein kinase kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S7U9 MKK2 Mitogen-activated protein kinase kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A06 MKK1 Mitogen-activated protein kinase kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPAKRKPVLP ALTITPSPAE GPGPGGSAEA NLVDLQKKLE ELELDEQQKK RLEAFLTQKA
70 80 90 100 110 120
KVGELKDDDF ERISELGAGN GGVVTKVQHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL
130 140 150 160 170 180
HECNSPYIVG FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA
190 200 210 220 230 240
YLREKHQIMH RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT
250 260 270 280 290 300
HYSVQSDIWS MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPWARPPG
310 320 330 340 350 360
RPISGHGMDS RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK NPAERADLKM
370 380 390
LMNHTFIKRS EVEEVDFAGW LCKTLRLNQP STPTRAAV