Q90871

PR
Gene name
IRF8 (ICSBP)
Protein name
Interferon regulatory factor 8
Names
IRF-8, Interferon consensus sequence-binding protein, ICSBP
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396385
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-204 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q90871

Entry ID Method Resolution Chain Position Source
AF-Q90871-F1 Predicted AlphaFoldDB

19 variants for Q90871

Variant ID(s) Position Change Description Diseaes Association Provenance
rs736721114 15 I>V No Ensembl
rs735932666 16 E>G No Ensembl
rs732122683 95 V>G No Ensembl
rs737253403 126 N>D No Ensembl
rs733746104 128 S>G No Ensembl
rs731447895 156 Y>S No Ensembl
rs740195301 163 S>R No Ensembl
rs734579545 183 Q>R No Ensembl
rs732408874 216 R>G No Ensembl
rs741213245 217 L>V No Ensembl
rs733606037 218 V>G No Ensembl
rs732976633 224 S>P No Ensembl
rs737645021 233 L>P No Ensembl
rs315813555 245 T>I No Ensembl
rs735335032 299 V>G No Ensembl
rs736037017 371 V>G No Ensembl
rs739486659 372 E>G No Ensembl
rs735280668 399 E>G No Ensembl
rs739923958 402 Y>D No Ensembl

No associated diseases with Q90871

3 regional properties for Q90871

Type Name Position InterPro Accession
domain Interferon regulatory factor, DNA-binding domain 3 - 115 IPR001346
domain Interferon regulatory factor-3 204 - 384 IPR019471
conserved_site Interferon regulatory factor, conserved site 28 - 61 IPR019817

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • In resting macrophages, localizes in the cytoplasm
  • Translocated in the nucleus upon IFN-gamma induction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

18 GO annotations of biological process

Name Definition
cellular response to interferon-gamma Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to protozoan Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
dendritic cell differentiation The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
follicular B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
germinal center B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
myeloid cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
plasmacytoid dendritic cell differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.
positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of type I interferon production Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90643 IRF3 Interferon regulatory factor 3 Gallus gallus (Chicken) SS
Q98925 IRF2 Interferon regulatory factor 2 Gallus gallus (Chicken) PR
Q02556 IRF8 Interferon regulatory factor 8 Homo sapiens (Human) PR
P23611 Irf8 Interferon regulatory factor 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MCDRNGGRRL RQWLIEQIDS EQYPGLIWEN EEKTMFRIPW KHAGKQDYNQ EVDASIFKAW
70 80 90 100 110 120
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC
130 140 150 160 170 180
KIGVGNGSSL TDVGDMDCSP SAIDDLMKEP PCVDEYLGII KRSPSPPQET CRNPPIPDWW
190 200 210 220 230 240
MQQPSPSLPL VNGYTGYEQH HSGYSQMVIT FFYSGRLVGH ITTSYPEGCR LSLSQPSNHG
250 260 270 280 290 300
EKLYTPDSLE HVRFPSAEAI QNDRQKQITK KLFGHLERGV LLHSNKQGIF IKRLCQGRVF
310 320 330 340 350 360
WSGNTVVYKD RPSKLDRDEV VKIFDTNLFF RELQQYYNNQ GRFPDSRVML CFGEEFPDTV
370 380 390 400 410 420
PLRCKLILVQ VEQLCVRQVM EEAGKTCSSP MLPDDVQQEQ VYRIFQDICG PHQRPLFREN
QQIAV